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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21580

FusionGeneSummary for MED4_DCLK1

check button Fusion gene summary
Fusion gene informationFusion gene name: MED4_DCLK1
Fusion gene ID: 21580
HgeneTgene
Gene symbol

MED4

DCLK1

Gene ID

29079

9201

Gene namemediator complex subunit 4doublecortin like kinase 1
SynonymsARC36|DRIP36|HSPC126|TRAP36|VDRIPCL1|CLICK1|DCAMKL1|DCDC3A|DCLK
Cytomap

13q14.2

13q13.3

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 4TRAP/SMCC/PC2 subunit p36activator-recruited cofactor 36 kDa componentmediator, 34-kD subunit, homologvitamin D receptor-interacting protein, 36-kDvitamin D3 receptor-interacting protein complex 36serine/threonine-protein kinase DCLK1doublecortin domain-containing protein 3Adoublecortin-like and CAM kinase-like 1
Modification date2018052320180527
UniProtAcc

Q9NPJ6

O15075

Ensembl transtripts involved in fusion geneENST00000495013, ENST00000258648, 
ENST00000378586, 
ENST00000360631, 
ENST00000255448, ENST00000379892, 
ENST00000379893, ENST00000460982, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 4 X 4=64
# samples 54
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MED4 [Title/Abstract] AND DCLK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMED4

GO:0006366

transcription by RNA polymerase II

10882111

HgeneMED4

GO:0006367

transcription initiation from RNA polymerase II promoter

12218053

HgeneMED4

GO:0030518

intracellular steroid hormone receptor signaling pathway

11867769

HgeneMED4

GO:0030521

androgen receptor signaling pathway

12218053

HgeneMED4

GO:0045893

positive regulation of transcription, DNA-templated

10198638


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-J4-A67K-01AMED4chr13

48651289

-DCLK1chr13

36521594

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000495013ENST00000360631MED4chr13

48651289

-DCLK1chr13

36521594

-
5UTR-3CDSENST00000495013ENST00000255448MED4chr13

48651289

-DCLK1chr13

36521594

-
5UTR-3CDSENST00000495013ENST00000379892MED4chr13

48651289

-DCLK1chr13

36521594

-
5UTR-intronENST00000495013ENST00000379893MED4chr13

48651289

-DCLK1chr13

36521594

-
5UTR-intronENST00000495013ENST00000460982MED4chr13

48651289

-DCLK1chr13

36521594

-
intron-3CDSENST00000258648ENST00000360631MED4chr13

48651289

-DCLK1chr13

36521594

-
intron-3CDSENST00000258648ENST00000255448MED4chr13

48651289

-DCLK1chr13

36521594

-
intron-3CDSENST00000258648ENST00000379892MED4chr13

48651289

-DCLK1chr13

36521594

-
intron-intronENST00000258648ENST00000379893MED4chr13

48651289

-DCLK1chr13

36521594

-
intron-intronENST00000258648ENST00000460982MED4chr13

48651289

-DCLK1chr13

36521594

-
intron-3CDSENST00000378586ENST00000360631MED4chr13

48651289

-DCLK1chr13

36521594

-
intron-3CDSENST00000378586ENST00000255448MED4chr13

48651289

-DCLK1chr13

36521594

-
intron-3CDSENST00000378586ENST00000379892MED4chr13

48651289

-DCLK1chr13

36521594

-
intron-intronENST00000378586ENST00000379893MED4chr13

48651289

-DCLK1chr13

36521594

-
intron-intronENST00000378586ENST00000460982MED4chr13

48651289

-DCLK1chr13

36521594

-

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FusionProtFeatures for MED4_DCLK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED4

Q9NPJ6

DCLK1

O15075

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developingbrain. May also participate in functions of the mature nervoussystem.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MED4_DCLK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MED4_DCLK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MED4TNFAIP8, AP2M1, MCRS1, MED10, MED9, MED29, MED19, MED28, MED26, MED30, MED1, RPAP2, PCBD2, MED18, EMD, MED12, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, VDR, CTDP1, PUM2, MED13, WDTC1, FOXJ3, ELAVL1, COPS2, MED6, MED8, MED14, MED16, MED24, MED11, MED27, MED21, MED22, NIFK, FBXW7, EPAS1, ESR2, CDK8, CDK19, RPA3, RPA2, RPA1, NDE1, AES, KIFC3, SDCBP, SMARCD1, SMARCE1, LRRFIP1, SSX3, NDC80, FTCD, CCHCR1, CTNNBL1, CCDC146, USHBP1, IFT20, CCDC101, HAUS1, FRMD6, MAB21L3, C1orf216, AMOT, TXLNA, FAM13C, NXF1, MED7, CCNC, SEC13, NR1I3, TCL1B, MED17, HUWE1, MED15, MED20, PPM1G, PCM1, CEP131, OFD1, CCDC138, HAUS6, PCNT, AHNAK, PIBF1, CCDC14, KIAA0753, HAUS5, HAUS3, CD2AP, CEP170, MIB1, GIT1, CCDC18, KIF7, HAUS4, CEP350, NBN, FLNB, CEP290, KIF3A, MED13L, SQSTM1, KIF5B, CKAP5, TBC1D31, CEP72, DVL2, SSX2IP, HAUS8, MYCBP2, CEP55, POLR2A, XRN1, ERC1, EXOC4, LUZP1, ARHGEF7, ANKRD26, DCTN2, KIF11, CSPP1, GIT2, ACTR1A, EPB41L3, SRP68, CCDC61, CEP162, NSFL1C, ADSL, TLN1, EDRF1, SLK, SPAG5, MAP1B, HAUS2, MPHOSPH9, CCDC77, NIN, CEP152, DBT, DLG5, RAI14, KIF5A, TBK1, PSMD7, ODF2, PAICS, IFT74, TP53BP2, ECD, HAUS7, TXLNG, MAP7D3, CCP110, MED31, SPICE1, TTLL5, IFIT5, ATG2B, EPS15L1, SPAG9, CCDC66, CLINT1, KEAP1, MICAL3, ODF2L, UBE2O, CAMSAP1, EDC4, IFT81, SDCCAG3, PSMA2, TRIM25, ALMS1, SKA3, CCDC22, WRAP73, SPC24, BUB1B, CNOT10, LRBA, PDLIM5, UTRN, WDR90, CNOT1, CNTROB, KIAA1598, CNOT11, EIF3M, EPB41, WNK1, TTC28, C2CD3, CYLD, DCTN3, DPYSL3, ERBB2IP, FAM101B, KANK2, KIAA1524, LSM12, PSMB1, RBM11, SH3GLB2, SNX1, USP15, ZFYVE16, ZYX, PDIA6, CEP135, CPSF3, FAM111B, FAM91A1, KIF14, SCRIB, SNAP29, DENND4C, DST, FGFR1OP, NAV1, NEK9, TCHP, MED23, ATP5F1, PDCD6, AMD1, DHX40, LARP7, MOGS, NUFIP2, SCO1, ZC3H15, DNAJB1, RRP1, SRSF5, TNRC6B, ATP5H, SDE2, EEF1E1, FIP1L1, GLYR1, GNAO1, HBB, MESDC2, MRPS17, NOP2, PIP4K2A, RAB5A, RANBP9, SEC61A1, TAX1BP1, TXNDC9, WDR33, BAG6, CSNK2A2, ATPIF1, LRRC47, CRIPT, AP2A1, ATP6V1B2, HBA2, MRRF, ZMAT2, MED25, NCAPG, GTF2F1, FAM50A, CAP2, SRRM1, ARRB2, BRIX1, EXOC1, NOP56, PMAIP1, CYCS, MANF, EXOSC8, SPTAN1, CDK11A, F5, RBM27, SUPT16H, XRCC4, CP, HADHB, A2M, SERF1A, ZNF638, CORO1C, THOC2, GLUD2, RSL1D1, SSNA1, KARS, ARHGEF6, MOB2, PIP5K1A, FLII, SKA1, TCEA1, SNRPG, ALB, HPX, DZIP3, ERCC3, RBM14, HOMER1, RNPS1, RSRC2, ATP5C1, CPSF7, HSPBP1, PIP4K2B, POLR2B, PI4KA, C3, PIP4K2C, QPCT, MRFAP1, MAP3K7, GTF2B, HADHA, PSME3, PDAP1, UBAP2L, THRAP3, BCLAF1, ACAP2, RAE1, RIOK1, CCAR1, EWSR1, AHI1, CEP120, CEP128, CEP63, CEP89, CNTRL, POC5, LCA5, SASS6, KRAS, MYH11, POLR2G, KIF21B, PTPN22, TPTE2, TXLNB, PSMC5, BIRC5, LRRCC1, TRIP11, CHPFDCLK1APP, CFTR, HAX1, NUFIP1, CDCA8, DGUOK, DNAAF2, DCX, SLC4A1AP, CEP170, SPICE1, CEP128, DCTN1, LCA5, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, ZNF638, SRSF12, SYDE1, RTKN, MAST3, PPM1H, AGAP1, CDC25B, CDK16, DENND4C, FAM110B, USP21, FAM53C, ANKRD34A, MAPKAP1, FAM110A, CGN, HDAC4, TBC1D25, NF1, NADK, CBY1, TIAM1, PHLDB2, KIAA1804, RASAL2, GAB2, CAMSAP2, MELK, PLEKHA7, CDC25C, LPIN3, KIF1C, GIGYF2, DEPDC1B, NAV1, MLLT4, DENND4A, PTPN14, STARD13, RPTOR, PLEKHA5, SH3BP4, HDAC7, EDC3, SH3RF3, LARP1, RAB3IP, INPP5E


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MED4_DCLK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MED4_DCLK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMED4C0014175Endometriosis1CTD_human
TgeneDCLK1C0005586Bipolar Disorder1PSYGENET
TgeneDCLK1C0009404Colorectal Neoplasms1CTD_human
TgeneDCLK1C0036341Schizophrenia1PSYGENET