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Fusion gene ID: 21580 |
FusionGeneSummary for MED4_DCLK1 |
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Fusion gene information | Fusion gene name: MED4_DCLK1 | Fusion gene ID: 21580 | Hgene | Tgene | Gene symbol | MED4 | DCLK1 | Gene ID | 29079 | 9201 |
Gene name | mediator complex subunit 4 | doublecortin like kinase 1 | |
Synonyms | ARC36|DRIP36|HSPC126|TRAP36|VDRIP | CL1|CLICK1|DCAMKL1|DCDC3A|DCLK | |
Cytomap | 13q14.2 | 13q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | mediator of RNA polymerase II transcription subunit 4TRAP/SMCC/PC2 subunit p36activator-recruited cofactor 36 kDa componentmediator, 34-kD subunit, homologvitamin D receptor-interacting protein, 36-kDvitamin D3 receptor-interacting protein complex 36 | serine/threonine-protein kinase DCLK1doublecortin domain-containing protein 3Adoublecortin-like and CAM kinase-like 1 | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q9NPJ6 | O15075 | |
Ensembl transtripts involved in fusion gene | ENST00000495013, ENST00000258648, ENST00000378586, | ENST00000360631, ENST00000255448, ENST00000379892, ENST00000379893, ENST00000460982, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 4 X 4 X 4=64 |
# samples | 5 | 4 | |
** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MED4 [Title/Abstract] AND DCLK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MED4 | GO:0006366 | transcription by RNA polymerase II | 10882111 |
Hgene | MED4 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 12218053 |
Hgene | MED4 | GO:0030518 | intracellular steroid hormone receptor signaling pathway | 11867769 |
Hgene | MED4 | GO:0030521 | androgen receptor signaling pathway | 12218053 |
Hgene | MED4 | GO:0045893 | positive regulation of transcription, DNA-templated | 10198638 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-J4-A67K-01A | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000495013 | ENST00000360631 | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
5UTR-3CDS | ENST00000495013 | ENST00000255448 | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
5UTR-3CDS | ENST00000495013 | ENST00000379892 | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
5UTR-intron | ENST00000495013 | ENST00000379893 | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
5UTR-intron | ENST00000495013 | ENST00000460982 | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
intron-3CDS | ENST00000258648 | ENST00000360631 | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
intron-3CDS | ENST00000258648 | ENST00000255448 | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
intron-3CDS | ENST00000258648 | ENST00000379892 | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
intron-intron | ENST00000258648 | ENST00000379893 | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
intron-intron | ENST00000258648 | ENST00000460982 | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
intron-3CDS | ENST00000378586 | ENST00000360631 | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
intron-3CDS | ENST00000378586 | ENST00000255448 | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
intron-3CDS | ENST00000378586 | ENST00000379892 | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
intron-intron | ENST00000378586 | ENST00000379893 | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
intron-intron | ENST00000378586 | ENST00000460982 | MED4 | chr13 | 48651289 | - | DCLK1 | chr13 | 36521594 | - |
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FusionProtFeatures for MED4_DCLK1 |
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Hgene | Tgene |
MED4 | DCLK1 |
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developingbrain. May also participate in functions of the mature nervoussystem. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MED4_DCLK1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MED4_DCLK1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MED4 | TNFAIP8, AP2M1, MCRS1, MED10, MED9, MED29, MED19, MED28, MED26, MED30, MED1, RPAP2, PCBD2, MED18, EMD, MED12, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, VDR, CTDP1, PUM2, MED13, WDTC1, FOXJ3, ELAVL1, COPS2, MED6, MED8, MED14, MED16, MED24, MED11, MED27, MED21, MED22, NIFK, FBXW7, EPAS1, ESR2, CDK8, CDK19, RPA3, RPA2, RPA1, NDE1, AES, KIFC3, SDCBP, SMARCD1, SMARCE1, LRRFIP1, SSX3, NDC80, FTCD, CCHCR1, CTNNBL1, CCDC146, USHBP1, IFT20, CCDC101, HAUS1, FRMD6, MAB21L3, C1orf216, AMOT, TXLNA, FAM13C, NXF1, MED7, CCNC, SEC13, NR1I3, TCL1B, MED17, HUWE1, MED15, MED20, PPM1G, PCM1, CEP131, OFD1, CCDC138, HAUS6, PCNT, AHNAK, PIBF1, CCDC14, KIAA0753, HAUS5, HAUS3, CD2AP, CEP170, MIB1, GIT1, CCDC18, KIF7, HAUS4, CEP350, NBN, FLNB, CEP290, KIF3A, MED13L, SQSTM1, KIF5B, CKAP5, TBC1D31, CEP72, DVL2, SSX2IP, HAUS8, MYCBP2, CEP55, POLR2A, XRN1, ERC1, EXOC4, LUZP1, ARHGEF7, ANKRD26, DCTN2, KIF11, CSPP1, GIT2, ACTR1A, EPB41L3, SRP68, CCDC61, CEP162, NSFL1C, ADSL, TLN1, EDRF1, SLK, SPAG5, MAP1B, HAUS2, MPHOSPH9, CCDC77, NIN, CEP152, DBT, DLG5, RAI14, KIF5A, TBK1, PSMD7, ODF2, PAICS, IFT74, TP53BP2, ECD, HAUS7, TXLNG, MAP7D3, CCP110, MED31, SPICE1, TTLL5, IFIT5, ATG2B, EPS15L1, SPAG9, CCDC66, CLINT1, KEAP1, MICAL3, ODF2L, UBE2O, CAMSAP1, EDC4, IFT81, SDCCAG3, PSMA2, TRIM25, ALMS1, SKA3, CCDC22, WRAP73, SPC24, BUB1B, CNOT10, LRBA, PDLIM5, UTRN, WDR90, CNOT1, CNTROB, KIAA1598, CNOT11, EIF3M, EPB41, WNK1, TTC28, C2CD3, CYLD, DCTN3, DPYSL3, ERBB2IP, FAM101B, KANK2, KIAA1524, LSM12, PSMB1, RBM11, SH3GLB2, SNX1, USP15, ZFYVE16, ZYX, PDIA6, CEP135, CPSF3, FAM111B, FAM91A1, KIF14, SCRIB, SNAP29, DENND4C, DST, FGFR1OP, NAV1, NEK9, TCHP, MED23, ATP5F1, PDCD6, AMD1, DHX40, LARP7, MOGS, NUFIP2, SCO1, ZC3H15, DNAJB1, RRP1, SRSF5, TNRC6B, ATP5H, SDE2, EEF1E1, FIP1L1, GLYR1, GNAO1, HBB, MESDC2, MRPS17, NOP2, PIP4K2A, RAB5A, RANBP9, SEC61A1, TAX1BP1, TXNDC9, WDR33, BAG6, CSNK2A2, ATPIF1, LRRC47, CRIPT, AP2A1, ATP6V1B2, HBA2, MRRF, ZMAT2, MED25, NCAPG, GTF2F1, FAM50A, CAP2, SRRM1, ARRB2, BRIX1, EXOC1, NOP56, PMAIP1, CYCS, MANF, EXOSC8, SPTAN1, CDK11A, F5, RBM27, SUPT16H, XRCC4, CP, HADHB, A2M, SERF1A, ZNF638, CORO1C, THOC2, GLUD2, RSL1D1, SSNA1, KARS, ARHGEF6, MOB2, PIP5K1A, FLII, SKA1, TCEA1, SNRPG, ALB, HPX, DZIP3, ERCC3, RBM14, HOMER1, RNPS1, RSRC2, ATP5C1, CPSF7, HSPBP1, PIP4K2B, POLR2B, PI4KA, C3, PIP4K2C, QPCT, MRFAP1, MAP3K7, GTF2B, HADHA, PSME3, PDAP1, UBAP2L, THRAP3, BCLAF1, ACAP2, RAE1, RIOK1, CCAR1, EWSR1, AHI1, CEP120, CEP128, CEP63, CEP89, CNTRL, POC5, LCA5, SASS6, KRAS, MYH11, POLR2G, KIF21B, PTPN22, TPTE2, TXLNB, PSMC5, BIRC5, LRRCC1, TRIP11, CHPF | DCLK1 | APP, CFTR, HAX1, NUFIP1, CDCA8, DGUOK, DNAAF2, DCX, SLC4A1AP, CEP170, SPICE1, CEP128, DCTN1, LCA5, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, ZNF638, SRSF12, SYDE1, RTKN, MAST3, PPM1H, AGAP1, CDC25B, CDK16, DENND4C, FAM110B, USP21, FAM53C, ANKRD34A, MAPKAP1, FAM110A, CGN, HDAC4, TBC1D25, NF1, NADK, CBY1, TIAM1, PHLDB2, KIAA1804, RASAL2, GAB2, CAMSAP2, MELK, PLEKHA7, CDC25C, LPIN3, KIF1C, GIGYF2, DEPDC1B, NAV1, MLLT4, DENND4A, PTPN14, STARD13, RPTOR, PLEKHA5, SH3BP4, HDAC7, EDC3, SH3RF3, LARP1, RAB3IP, INPP5E |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MED4_DCLK1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MED4_DCLK1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MED4 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | DCLK1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | DCLK1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | DCLK1 | C0036341 | Schizophrenia | 1 | PSYGENET |