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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21576

FusionGeneSummary for MED28_GINS2

check button Fusion gene summary
Fusion gene informationFusion gene name: MED28_GINS2
Fusion gene ID: 21576
HgeneTgene
Gene symbol

MED28

GINS2

Gene ID

80306

51659

Gene namemediator complex subunit 28GINS complex subunit 2
Synonyms1500003D12Rik|EG1|magicinHSPC037|PSF2|Pfs2
Cytomap

4p15.32

16q24.1

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 28endothelial-derived gene 1endothelial-derived protein 1mediator of RNA polymerase II transcription, subunit 28 homologmerlin and Grb2-interacting cytoskeletal proteintumor angiogenesis marker EG-1DNA replication complex GINS protein PSF2GINS complex subunit 2 (Psf2 homolog)
Modification date2018052320180523
UniProtAcc

Q9H204

Q9Y248

Ensembl transtripts involved in fusion geneENST00000237380, ENST00000499786, 
ENST00000253462, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: MED28 [Title/Abstract] AND GINS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE907417MED28chr4

17625565

+GINS2chr16

85722480

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000237380ENST00000253462MED28chr4

17625565

+GINS2chr16

85722480

-
intron-3CDSENST00000499786ENST00000253462MED28chr4

17625565

+GINS2chr16

85722480

-

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FusionProtFeatures for MED28_GINS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED28

Q9H204

GINS2

Q9Y248

Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. May be part of a complex containingNF2/merlin that participates in cellular signaling to the actincytoskeleton downstream of tyrosine kinase signaling pathways.{ECO:0000269|PubMed:15467741}. The GINS complex plays an essential role in theinitiation of DNA replication, and progression of DNA replicationforks. GINS complex seems to bind preferentially to single-stranded DNA. {ECO:0000269|PubMed:17417653}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MED28_GINS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MED28_GINS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MED28_GINS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MED28_GINS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMED28C0027627Neoplasm Metastasis1CTD_human
HgeneMED28C1458155Mammary Neoplasms1CTD_human
TgeneGINS2C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneGINS2C0036095Salivary Gland Neoplasms1CTD_human