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Fusion gene ID: 21576 |
FusionGeneSummary for MED28_GINS2 |
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Fusion gene information | Fusion gene name: MED28_GINS2 | Fusion gene ID: 21576 | Hgene | Tgene | Gene symbol | MED28 | GINS2 | Gene ID | 80306 | 51659 |
Gene name | mediator complex subunit 28 | GINS complex subunit 2 | |
Synonyms | 1500003D12Rik|EG1|magicin | HSPC037|PSF2|Pfs2 | |
Cytomap | 4p15.32 | 16q24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | mediator of RNA polymerase II transcription subunit 28endothelial-derived gene 1endothelial-derived protein 1mediator of RNA polymerase II transcription, subunit 28 homologmerlin and Grb2-interacting cytoskeletal proteintumor angiogenesis marker EG-1 | DNA replication complex GINS protein PSF2GINS complex subunit 2 (Psf2 homolog) | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9H204 | Q9Y248 | |
Ensembl transtripts involved in fusion gene | ENST00000237380, ENST00000499786, | ENST00000253462, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 1 | 1 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: MED28 [Title/Abstract] AND GINS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE907417 | MED28 | chr4 | 17625565 | + | GINS2 | chr16 | 85722480 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000237380 | ENST00000253462 | MED28 | chr4 | 17625565 | + | GINS2 | chr16 | 85722480 | - |
intron-3CDS | ENST00000499786 | ENST00000253462 | MED28 | chr4 | 17625565 | + | GINS2 | chr16 | 85722480 | - |
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FusionProtFeatures for MED28_GINS2 |
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Hgene | Tgene |
MED28 | GINS2 |
Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. May be part of a complex containingNF2/merlin that participates in cellular signaling to the actincytoskeleton downstream of tyrosine kinase signaling pathways.{ECO:0000269|PubMed:15467741}. | The GINS complex plays an essential role in theinitiation of DNA replication, and progression of DNA replicationforks. GINS complex seems to bind preferentially to single-stranded DNA. {ECO:0000269|PubMed:17417653}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MED28_GINS2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MED28_GINS2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MED28_GINS2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MED28_GINS2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MED28 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | MED28 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | GINS2 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Tgene | GINS2 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |