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Fusion gene ID: 21570 |
FusionGeneSummary for MED26_ZNF99 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MED26_ZNF99 | Fusion gene ID: 21570 | Hgene | Tgene | Gene symbol | MED26 | ZNF99 | Gene ID | 9441 | 7652 |
| Gene name | mediator complex subunit 26 | zinc finger protein 99 | |
| Synonyms | CRSP7|CRSP70 | C19orf9|F8281 | |
| Cytomap | 19p13.11 | 19p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mediator of RNA polymerase II transcription subunit 26ARC70CRSP complex subunit 7activator-recruited cofactor 70 kDa componentcofactor required for Sp1 transcriptional activation subunit 7cofactor required for Sp1 transcriptional activation, subunit | zinc finger protein 99zinc finger protein ENSP00000375192 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O95402 | A8MXY4 | |
| Ensembl transtripts involved in fusion gene | ENST00000263390, | ENST00000397104, ENST00000596209, | |
| Fusion gene scores | * DoF score | 15 X 6 X 10=900 | 2 X 1 X 1=2 |
| # samples | 15 | 1 | |
| ** MAII score | log2(15/900*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/2*10)=2.32192809488736 | |
| Context | PubMed: MED26 [Title/Abstract] AND ZNF99 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MED26 | GO:0006357 | regulation of transcription by RNA polymerase II | 15989967 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-B5-A5OE-01A | MED26 | chr19 | 16738683 | - | ZNF99 | chr19 | 22952126 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000263390 | ENST00000397104 | MED26 | chr19 | 16738683 | - | ZNF99 | chr19 | 22952126 | - |
| In-frame | ENST00000263390 | ENST00000596209 | MED26 | chr19 | 16738683 | - | ZNF99 | chr19 | 22952126 | - |
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FusionProtFeatures for MED26_ZNF99 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MED26 | ZNF99 |
| Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpre-initiation complex with RNA polymerase II and the generaltranscription factors. | May be involved in transcriptional regulation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 173_195 | 22 | 1038 | Zinc finger | C2H2-type 1 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 201_223 | 22 | 1038 | Zinc finger | C2H2-type 2%3B degenerate |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 229_251 | 22 | 1038 | Zinc finger | C2H2-type 3%3B degenerate |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 257_279 | 22 | 1038 | Zinc finger | C2H2-type 4 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 285_307 | 22 | 1038 | Zinc finger | C2H2-type 5 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 313_335 | 22 | 1038 | Zinc finger | C2H2-type 6 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 341_363 | 22 | 1038 | Zinc finger | C2H2-type 7 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 369_391 | 22 | 1038 | Zinc finger | C2H2-type 8%3B degenerate |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 397_419 | 22 | 1038 | Zinc finger | C2H2-type 9 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 425_447 | 22 | 1038 | Zinc finger | C2H2-type 10 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 453_475 | 22 | 1038 | Zinc finger | C2H2-type 11 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 481_503 | 22 | 1038 | Zinc finger | C2H2-type 12 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 509_531 | 22 | 1038 | Zinc finger | C2H2-type 13 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 537_559 | 22 | 1038 | Zinc finger | C2H2-type 14 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 565_587 | 22 | 1038 | Zinc finger | C2H2-type 15 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 593_615 | 22 | 1038 | Zinc finger | C2H2-type 16 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 621_643 | 22 | 1038 | Zinc finger | C2H2-type 17 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 649_671 | 22 | 1038 | Zinc finger | C2H2-type 18 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 677_699 | 22 | 1038 | Zinc finger | C2H2-type 19 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 705_727 | 22 | 1038 | Zinc finger | C2H2-type 20 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 733_755 | 22 | 1038 | Zinc finger | C2H2-type 21 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 761_783 | 22 | 1038 | Zinc finger | C2H2-type 22 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 789_811 | 22 | 1038 | Zinc finger | C2H2-type 23 |
| Tgene | >ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 817_839 | 22 | 1038 | Zinc finger | C2H2-type 24 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MED26 | chr19:16738683 | chr19:22952126 | ENST00000263390 | - | 1 | 3 | 228_325 | 24 | 601 | Compositional bias | Note=Pro-rich |
| Hgene | >MED26 | chr19:16738683 | chr19:22952126 | ENST00000263390 | - | 1 | 3 | 10_87 | 24 | 601 | Domain | TFIIS N-terminal |
| Tgene | ZNF99 | chr19:16738683 | chr19:22952126 | ENST00000397104 | - | 0 | 8 | 4_75 | 22 | 1038 | Domain | KRAB |
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FusionGeneSequence for MED26_ZNF99 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MED26_ENST00000263390_chr19_16738683_-_ZNF99_ENST00000397104_chr19_22952126_-_1040aa MTAAPASPQQIRDRLLQAIDPQSNGSLTFWDVTIEFALEEWQCLDMAQQNLYRNVMLENYRNLVFLGIAVSKLDLITCLKQGKEPWNMKR HEMVTKPPVISSHFTQDFWPDQSIKDSFQEIILRTYARCGHKNLRLRKDCESVNEGKMHEEAYNKLNQCWTTTQGKIFQCNKYVKVFHKY SNSNRYKIIHTGKKPYKCEECGKAFKQSSHLTRHKAIHTGEKPYKCEECGKAFNHFSALRKHQIIHTGKKPYKCEECGKAFSQSSTLRKH EIIHTEEKPYKYEECGKAFSNLSALRKHEIIHTGQKPYKCEECGKAFKWSSKLTVHKVIHTAEKPCKCEECGKAFKRFSALRKHKIIHTG KQPYKCEECSKAFSNFSALRKHEIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHMEEKPCKCEECGKAFKHFSALRKHKIIHTGKKPYKC EECGKAFNNSSTLMKHKIIHTGKKPYKCEECGKAFKQSSHLTRHKAIHTGEKPYKCEECGKAFNHFSALRKHQIIHTGKKPYKCEECGKA FSQSSTLRKHEIIHTGEKPYKCEECGKAFKWSSHLTRHKVIHTEEKPYKCEECGKAFNHFSALRKHKIIHTGKKPYKCEECGKAFSQSST LRKHEIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHTAEKPCKCEECGKAFKHFSALRKHKIIHTGKKPYKCEECGKAFNNSSTLRKHEI IHTGEKSYKCEECALRKHEIIHTGKKPYKCEECGKAFNNSSTLRKHKIIYTGKKPYKCEECGKAFKQSSHLTRHKAVHTGEKPYKCGECG KAFNNSSTLKKHKLIHTREKSYKCEECGKAFSNFSALRKHKIIHTGEKPYKCEECECGKAFNNSSTLMKHKIIHTGEKPYKCEECGKGFN NFSTLMKHKIIHTGEKPYKCEECGKAFKQSSHLTKHKSIHTGEKPYKCEERGKAFSHFSRLTKHRIIHTGKKPYKCEECGEKPYKCEECG >In-frame_MED26_ENST00000263390_chr19_16738683_-_ZNF99_ENST00000596209_chr19_22952126_-_888aa MTAAPASPQQIRDRLLQAIDPQSNGSLTFWDVTIEFALEEWQCLDMAQQNLYRNVMLENYRNLVFLGIAVSKLDLITCLKQGKEPWNMKR HEMVTKPPVISSHFTQDFWPDQSIKDSFQEIILRTYARCGHKNLRLRKDCESVNEGKMHEEAYNKLNQCWTTTQGKIFQCNKYVKVFHKY SNSNRYKIRHTKKKTFKCMKCSKSFFMLSHLIQHKRIHTRENIYKCEERGKAFKWFSTLIKHKIIHTEDKPYKYKKCGKAFNISSMFTKC KIIHTGKKPCKCEECGKVFNNSSTLMKHKIIHTGKKPYKCEECGKAFKQSSHLTRHKAIHTGEKPYKCEECGKAFNHFSALRKHQIIHTG KKPYKCEECGKAFSQSSTLRKHEIIHTEEKPYKYEECGKAFSNLSALRKHEIIHTGQKPYKCEECGKAFKWSSKLTVHKVIHTAEKPCKC EECGKAFKRFSALRKHKIIHTGKQPYKCEECSKAFSNFSALRKHEIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHMEEKPCKCEECGKA FKHFSALRKHKIIHTGKKPYKCEECGKAFNNSSTLMKHKIIHTGKKPYKCEECGKAFKQSSHLTRHKAIHTGEKPYKCEECGKAFNHFSA LRKHQIIHTGKKPYKCEECGKAFSQSSTLRKHEIIHTGEKPYKCEECGKAFKWSSHLTRHKVIHTEEKPYKCEECGKAFNHFSALRKHKI IHTGKKPYKCEECGKAFSQSSTLRKHEIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHTAEKPCKCEECGKAFKHFSALRKHKIIHTGKK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MED26_ENST00000263390_chr19_16738683_-_ZNF99_ENST00000397104_chr19_22952126_-_3120nt ATGACAGCGGCTCCGGCGTCTCCGCAGCAGATCAGGGACCGGCTGCTGCAGGCCATCGACCCCCAGAGCAACGGATCGTTGACATTTTGG GATGTGACCATAGAATTCGCTCTGGAGGAGTGGCAATGCCTGGACATGGCTCAGCAGAATTTATATAGGAATGTTATGTTAGAGAACTAC AGAAACCTGGTCTTCCTGGGTATCGCTGTCTCTAAGCTAGACTTGATAACTTGTCTGAAGCAAGGGAAAGAGCCTTGGAATATGAAGAGA CATGAGATGGTAACTAAACCCCCAGTTATTAGTTCTCATTTTACACAAGACTTTTGGCCAGATCAGAGCATAAAAGATTCTTTCCAAGAA ATAATATTGAGAACATATGCAAGATGTGGACATAAGAATTTACGATTAAGAAAAGATTGTGAAAGTGTCAATGAGGGTAAGATGCACGAA GAAGCTTATAATAAACTTAACCAATGTTGGACAACTACCCAGGGAAAAATATTTCAGTGTAACAAATATGTGAAAGTCTTTCATAAATAT TCAAATTCAAATAGATATAAGATAATTCATACTGGGAAGAAACCATATAAATGTGAAGAATGTGGCAAAGCTTTTAAGCAATCCTCACAC CTTACTAGACATAAAGCAATTCATACTGGAGAGAAACCCTACAAATGCGAAGAATGTGGCAAAGCTTTTAACCATTTCTCAGCCCTTAGA AAACATCAGATAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAGCCAGTCCTCAACCCTTAGAAAACAT GAGATAATTCATACTGAAGAGAAACCCTACAAATATGAAGAATGCGGCAAAGCTTTTAGCAATTTGTCAGCCCTTAGAAAACATGAGATA ATTCATACTGGACAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCTTTTAAGTGGTCCTCAAAACTTACTGTACATAAGGTAATTCAT ACTGCAGAGAAACCCTGCAAATGTGAAGAATGTGGCAAAGCTTTTAAGCGTTTCTCAGCCCTTAGAAAACATAAGATAATTCATACTGGA AAGCAACCCTACAAATGTGAAGAATGCAGCAAAGCTTTTAGCAATTTTTCAGCCCTTAGAAAACATGAGATAATTCATACTGGAGAGAAA CCCTACAAATGTGAAGAATGTGGTAAAGCTTTTAAGTGGTCCTCAAAACTTACTGTACATAAGGTAATTCATATGGAAGAGAAACCTTGC AAATGTGAAGAATGTGGCAAAGCTTTTAAGCATTTCTCAGCCCTTAGAAAACATAAGATAATTCATACTGGAAAGAAACCCTACAAATGT GAAGAATGTGGCAAAGCTTTTAACAATTCCTCAACCCTTATGAAACATAAGATAATTCATACTGGGAAGAAACCATACAAATGTGAAGAA TGTGGCAAAGCTTTTAAGCAATCTTCACATCTTACTAGACATAAAGCAATTCATACTGGGGAGAAACCCTACAAATGTGAAGAATGTGGC AAAGCTTTTAACCACTTCTCAGCCCTTAGAAAACATCAGATAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCT TTTAGCCAGTCCTCAACCCTTAGAAAACATGAGATAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCTTTTAAG TGGTCCTCACACCTTACTAGACATAAAGTAATTCATACTGAAGAGAAACCCTACAAATGTGAAGAATGTGGCAAGGCTTTTAACCATTTC TCAGCCCTTAGGAAACATAAGATAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAGCCAGTCCTCAACT CTTAGAAAACATGAGATAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCTTTTAAGTGGTCCTCAAAACTTACT GTACATAAGGTAATTCATACTGCAGAGAAACCCTGCAAATGTGAAGAATGTGGCAAAGCTTTTAAGCATTTCTCAGCCCTTAGAAAACAT AAGATAATTCATACTGGAAAGAAACCCTATAAATGTGAAGAATGTGGCAAAGCTTTTAACAATTCCTCAACCCTTAGAAAACATGAGATA ATTCATACTGGAGAGAAATCCTACAAATGTGAAGAATGTGCCCTTAGAAAACATGAGATAATTCATACTGGAAAGAAACCCTACAAATGT GAAGAATGTGGCAAAGCTTTTAACAATTCCTCAACCCTTAGGAAACATAAGATAATTTATACTGGGAAGAAACCATACAAATGTGAAGAA TGTGGCAAAGCTTTTAAGCAGTCCTCACACCTTACTAGACATAAAGCAGTTCATACTGGGGAGAAGCCCTACAAATGTGGAGAATGTGGA AAAGCTTTTAACAATTCCTCAACCCTTAAGAAACATAAGCTAATTCATACTAGGGAGAAATCGTACAAATGTGAAGAATGTGGCAAAGCT TTTAGCAATTTCTCAGCCCTTAGGAAACATAAGATAATTCATACTGGGGAGAAACCATACAAATGTGAAGAATGTGAATGTGGCAAAGCT TTTAACAATTCCTCAACCCTTATGAAACATAAGATAATTCATACTGGGGAGAAACCGTACAAATGTGAAGAATGTGGCAAAGGTTTTAAC AATTTCTCGACCCTTATGAAACATAAGATAATTCATACTGGGGAGAAACCGTACAAATGTGAAGAATGTGGCAAAGCTTTTAAGCAATCC TCACACCTTACTAAACATAAATCAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAACGTGGCAAAGCTTTTAGCCATTTCTCACGC CTTACTAAACATAGGATAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAGTGTGGAGAGAAACCCTACAAATGTGAAGAATGTGGC AAAGCCTTTAACCAGTCCTCACACCTTACTCAACATAAAACAATTCATACTGGAGGGAAAACCTACAAATGTGAAGAATGTGGCAAAGCT >In-frame_MED26_ENST00000263390_chr19_16738683_-_ZNF99_ENST00000596209_chr19_22952126_-_2664nt ATGACAGCGGCTCCGGCGTCTCCGCAGCAGATCAGGGACCGGCTGCTGCAGGCCATCGACCCCCAGAGCAACGGATCGTTGACATTTTGG GATGTGACCATAGAATTCGCTCTGGAGGAGTGGCAATGCCTGGACATGGCTCAGCAGAATTTATATAGGAATGTTATGTTAGAGAACTAC AGAAACCTGGTCTTCCTGGGTATCGCTGTCTCTAAGCTAGACTTGATAACTTGTCTGAAGCAAGGGAAAGAGCCTTGGAATATGAAGAGA CATGAGATGGTAACTAAACCCCCAGTTATTAGTTCTCATTTTACACAAGACTTTTGGCCAGATCAGAGCATAAAAGATTCTTTCCAAGAA ATAATATTGAGAACATATGCAAGATGTGGACATAAGAATTTACGATTAAGAAAAGATTGTGAAAGTGTCAATGAGGGTAAGATGCACGAA GAAGCTTATAATAAACTTAACCAATGTTGGACAACTACCCAGGGAAAAATATTTCAGTGTAACAAATATGTGAAAGTCTTTCATAAATAT TCAAATTCAAATAGATATAAGATTAGACACACTAAAAAGAAAACTTTCAAATGTATGAAATGTAGCAAATCATTTTTCATGCTTTCACAC TTAATTCAACATAAGAGAATTCATACTAGAGAGAATATCTACAAATGTGAAGAACGTGGCAAAGCCTTTAAATGGTTCTCAACCCTTATT AAACATAAGATAATTCATACTGAAGACAAACCCTACAAATATAAGAAATGTGGCAAAGCTTTTAACATCTCTTCAATGTTCACTAAATGT AAGATAATTCATACTGGAAAGAAACCCTGCAAATGTGAAGAATGTGGCAAAGTTTTTAACAATTCCTCAACCCTTATGAAACATAAGATA ATTCATACTGGGAAGAAACCATATAAATGTGAAGAATGTGGCAAAGCTTTTAAGCAATCCTCACACCTTACTAGACATAAAGCAATTCAT ACTGGAGAGAAACCCTACAAATGCGAAGAATGTGGCAAAGCTTTTAACCATTTCTCAGCCCTTAGAAAACATCAGATAATTCATACTGGA AAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAGCCAGTCCTCAACCCTTAGAAAACATGAGATAATTCATACTGAAGAGAAA CCCTACAAATATGAAGAATGCGGCAAAGCTTTTAGCAATTTGTCAGCCCTTAGAAAACATGAGATAATTCATACTGGACAGAAACCCTAC AAATGTGAAGAATGTGGTAAAGCTTTTAAGTGGTCCTCAAAACTTACTGTACATAAGGTAATTCATACTGCAGAGAAACCCTGCAAATGT GAAGAATGTGGCAAAGCTTTTAAGCGTTTCTCAGCCCTTAGAAAACATAAGATAATTCATACTGGAAAGCAACCCTACAAATGTGAAGAA TGCAGCAAAGCTTTTAGCAATTTTTCAGCCCTTAGAAAACATGAGATAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGT AAAGCTTTTAAGTGGTCCTCAAAACTTACTGTACATAAGGTAATTCATATGGAAGAGAAACCTTGCAAATGTGAAGAATGTGGCAAAGCT TTTAAGCATTTCTCAGCCCTTAGAAAACATAAGATAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAAC AATTCCTCAACCCTTATGAAACATAAGATAATTCATACTGGGAAGAAACCATACAAATGTGAAGAATGTGGCAAAGCTTTTAAGCAATCT TCACATCTTACTAGACATAAAGCAATTCATACTGGGGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAACCACTTCTCAGCC CTTAGAAAACATCAGATAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAGCCAGTCCTCAACCCTTAGA AAACATGAGATAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCTTTTAAGTGGTCCTCACACCTTACTAGACAT AAAGTAATTCATACTGAAGAGAAACCCTACAAATGTGAAGAATGTGGCAAGGCTTTTAACCATTTCTCAGCCCTTAGGAAACATAAGATA ATTCATACTGGAAAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAGCCAGTCCTCAACTCTTAGAAAACATGAGATAATTCAT ACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCTTTTAAGTGGTCCTCAAAACTTACTGTACATAAGGTAATTCATACTGCA GAGAAACCCTGCAAATGTGAAGAATGTGGCAAAGCTTTTAAGCATTTCTCAGCCCTTAGAAAACATAAGATAATTCATACTGGAAAGAAA CCCTATAAATGTGAAGAATGTGGCAAAGCTTTTAACAATTCCTCAACCCTTAGAAAACATGAGATAATTCATACTGGAGAGAAATCCTAC AAATGTGAAGAATGTGGTAAAGCTTTTCAGTGGTCCTCAAAACTTACTTTACATAAGGTAATTCATATGGAGAGAAACCCTGCAAATGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MED26_ENST00000263390_chr19_16738683_-_ZNF99_ENST00000397104_chr19_22952126_-_3383nt TCACTGGAGTTTGGTTCTCGAGGCGGCGGCAGCGAGCGGCGGCGGCTCCGGCGGCTCCTCCTCCTCCTTTGGTGGCGGCGGCGGCCCGGG ACCGAGACCCGGCCCCGGCTCCCCTCTCCGCCACCCCGCGCGCCCCCAACCCCCCGGCGCCGCGGGGAACATGCGGCTCCGGCTCCCGGA GGCCGGCGAGTGAGTGACCCCCGTCCCCCGCCTCAGCCCGCCCGCCCGCTGGCCCGGCCGCAACCCCCCGCCTCGCCCAGGCAATGACAG CGGCTCCGGCGTCTCCGCAGCAGATCAGGGACCGGCTGCTGCAGGCCATCGACCCCCAGAGCAACGGATCGTTGACATTTTGGGATGTGA CCATAGAATTCGCTCTGGAGGAGTGGCAATGCCTGGACATGGCTCAGCAGAATTTATATAGGAATGTTATGTTAGAGAACTACAGAAACC TGGTCTTCCTGGGTATCGCTGTCTCTAAGCTAGACTTGATAACTTGTCTGAAGCAAGGGAAAGAGCCTTGGAATATGAAGAGACATGAGA TGGTAACTAAACCCCCAGTTATTAGTTCTCATTTTACACAAGACTTTTGGCCAGATCAGAGCATAAAAGATTCTTTCCAAGAAATAATAT TGAGAACATATGCAAGATGTGGACATAAGAATTTACGATTAAGAAAAGATTGTGAAAGTGTCAATGAGGGTAAGATGCACGAAGAAGCTT ATAATAAACTTAACCAATGTTGGACAACTACCCAGGGAAAAATATTTCAGTGTAACAAATATGTGAAAGTCTTTCATAAATATTCAAATT CAAATAGATATAAGATAATTCATACTGGGAAGAAACCATATAAATGTGAAGAATGTGGCAAAGCTTTTAAGCAATCCTCACACCTTACTA GACATAAAGCAATTCATACTGGAGAGAAACCCTACAAATGCGAAGAATGTGGCAAAGCTTTTAACCATTTCTCAGCCCTTAGAAAACATC AGATAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAGCCAGTCCTCAACCCTTAGAAAACATGAGATAA TTCATACTGAAGAGAAACCCTACAAATATGAAGAATGCGGCAAAGCTTTTAGCAATTTGTCAGCCCTTAGAAAACATGAGATAATTCATA CTGGACAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCTTTTAAGTGGTCCTCAAAACTTACTGTACATAAGGTAATTCATACTGCAG AGAAACCCTGCAAATGTGAAGAATGTGGCAAAGCTTTTAAGCGTTTCTCAGCCCTTAGAAAACATAAGATAATTCATACTGGAAAGCAAC CCTACAAATGTGAAGAATGCAGCAAAGCTTTTAGCAATTTTTCAGCCCTTAGAAAACATGAGATAATTCATACTGGAGAGAAACCCTACA AATGTGAAGAATGTGGTAAAGCTTTTAAGTGGTCCTCAAAACTTACTGTACATAAGGTAATTCATATGGAAGAGAAACCTTGCAAATGTG AAGAATGTGGCAAAGCTTTTAAGCATTTCTCAGCCCTTAGAAAACATAAGATAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAAT GTGGCAAAGCTTTTAACAATTCCTCAACCCTTATGAAACATAAGATAATTCATACTGGGAAGAAACCATACAAATGTGAAGAATGTGGCA AAGCTTTTAAGCAATCTTCACATCTTACTAGACATAAAGCAATTCATACTGGGGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTT TTAACCACTTCTCAGCCCTTAGAAAACATCAGATAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAGCC AGTCCTCAACCCTTAGAAAACATGAGATAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCTTTTAAGTGGTCCT CACACCTTACTAGACATAAAGTAATTCATACTGAAGAGAAACCCTACAAATGTGAAGAATGTGGCAAGGCTTTTAACCATTTCTCAGCCC TTAGGAAACATAAGATAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAGCCAGTCCTCAACTCTTAGAA AACATGAGATAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCTTTTAAGTGGTCCTCAAAACTTACTGTACATA AGGTAATTCATACTGCAGAGAAACCCTGCAAATGTGAAGAATGTGGCAAAGCTTTTAAGCATTTCTCAGCCCTTAGAAAACATAAGATAA TTCATACTGGAAAGAAACCCTATAAATGTGAAGAATGTGGCAAAGCTTTTAACAATTCCTCAACCCTTAGAAAACATGAGATAATTCATA CTGGAGAGAAATCCTACAAATGTGAAGAATGTGCCCTTAGAAAACATGAGATAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAAT GTGGCAAAGCTTTTAACAATTCCTCAACCCTTAGGAAACATAAGATAATTTATACTGGGAAGAAACCATACAAATGTGAAGAATGTGGCA AAGCTTTTAAGCAGTCCTCACACCTTACTAGACATAAAGCAGTTCATACTGGGGAGAAGCCCTACAAATGTGGAGAATGTGGAAAAGCTT TTAACAATTCCTCAACCCTTAAGAAACATAAGCTAATTCATACTAGGGAGAAATCGTACAAATGTGAAGAATGTGGCAAAGCTTTTAGCA ATTTCTCAGCCCTTAGGAAACATAAGATAATTCATACTGGGGAGAAACCATACAAATGTGAAGAATGTGAATGTGGCAAAGCTTTTAACA ATTCCTCAACCCTTATGAAACATAAGATAATTCATACTGGGGAGAAACCGTACAAATGTGAAGAATGTGGCAAAGGTTTTAACAATTTCT CGACCCTTATGAAACATAAGATAATTCATACTGGGGAGAAACCGTACAAATGTGAAGAATGTGGCAAAGCTTTTAAGCAATCCTCACACC TTACTAAACATAAATCAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAACGTGGCAAAGCTTTTAGCCATTTCTCACGCCTTACTA AACATAGGATAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAGTGTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCCT TTAACCAGTCCTCACACCTTACTCAACATAAAACAATTCATACTGGAGGGAAAACCTACAAATGTGAAGAATGTGGCAAAGCTTTTAACC >In-frame_MED26_ENST00000263390_chr19_16738683_-_ZNF99_ENST00000596209_chr19_22952126_-_2927nt TCACTGGAGTTTGGTTCTCGAGGCGGCGGCAGCGAGCGGCGGCGGCTCCGGCGGCTCCTCCTCCTCCTTTGGTGGCGGCGGCGGCCCGGG ACCGAGACCCGGCCCCGGCTCCCCTCTCCGCCACCCCGCGCGCCCCCAACCCCCCGGCGCCGCGGGGAACATGCGGCTCCGGCTCCCGGA GGCCGGCGAGTGAGTGACCCCCGTCCCCCGCCTCAGCCCGCCCGCCCGCTGGCCCGGCCGCAACCCCCCGCCTCGCCCAGGCAATGACAG CGGCTCCGGCGTCTCCGCAGCAGATCAGGGACCGGCTGCTGCAGGCCATCGACCCCCAGAGCAACGGATCGTTGACATTTTGGGATGTGA CCATAGAATTCGCTCTGGAGGAGTGGCAATGCCTGGACATGGCTCAGCAGAATTTATATAGGAATGTTATGTTAGAGAACTACAGAAACC TGGTCTTCCTGGGTATCGCTGTCTCTAAGCTAGACTTGATAACTTGTCTGAAGCAAGGGAAAGAGCCTTGGAATATGAAGAGACATGAGA TGGTAACTAAACCCCCAGTTATTAGTTCTCATTTTACACAAGACTTTTGGCCAGATCAGAGCATAAAAGATTCTTTCCAAGAAATAATAT TGAGAACATATGCAAGATGTGGACATAAGAATTTACGATTAAGAAAAGATTGTGAAAGTGTCAATGAGGGTAAGATGCACGAAGAAGCTT ATAATAAACTTAACCAATGTTGGACAACTACCCAGGGAAAAATATTTCAGTGTAACAAATATGTGAAAGTCTTTCATAAATATTCAAATT CAAATAGATATAAGATTAGACACACTAAAAAGAAAACTTTCAAATGTATGAAATGTAGCAAATCATTTTTCATGCTTTCACACTTAATTC AACATAAGAGAATTCATACTAGAGAGAATATCTACAAATGTGAAGAACGTGGCAAAGCCTTTAAATGGTTCTCAACCCTTATTAAACATA AGATAATTCATACTGAAGACAAACCCTACAAATATAAGAAATGTGGCAAAGCTTTTAACATCTCTTCAATGTTCACTAAATGTAAGATAA TTCATACTGGAAAGAAACCCTGCAAATGTGAAGAATGTGGCAAAGTTTTTAACAATTCCTCAACCCTTATGAAACATAAGATAATTCATA CTGGGAAGAAACCATATAAATGTGAAGAATGTGGCAAAGCTTTTAAGCAATCCTCACACCTTACTAGACATAAAGCAATTCATACTGGAG AGAAACCCTACAAATGCGAAGAATGTGGCAAAGCTTTTAACCATTTCTCAGCCCTTAGAAAACATCAGATAATTCATACTGGAAAGAAAC CCTACAAATGTGAAGAATGTGGCAAAGCTTTTAGCCAGTCCTCAACCCTTAGAAAACATGAGATAATTCATACTGAAGAGAAACCCTACA AATATGAAGAATGCGGCAAAGCTTTTAGCAATTTGTCAGCCCTTAGAAAACATGAGATAATTCATACTGGACAGAAACCCTACAAATGTG AAGAATGTGGTAAAGCTTTTAAGTGGTCCTCAAAACTTACTGTACATAAGGTAATTCATACTGCAGAGAAACCCTGCAAATGTGAAGAAT GTGGCAAAGCTTTTAAGCGTTTCTCAGCCCTTAGAAAACATAAGATAATTCATACTGGAAAGCAACCCTACAAATGTGAAGAATGCAGCA AAGCTTTTAGCAATTTTTCAGCCCTTAGAAAACATGAGATAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCTT TTAAGTGGTCCTCAAAACTTACTGTACATAAGGTAATTCATATGGAAGAGAAACCTTGCAAATGTGAAGAATGTGGCAAAGCTTTTAAGC ATTTCTCAGCCCTTAGAAAACATAAGATAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAACAATTCCT CAACCCTTATGAAACATAAGATAATTCATACTGGGAAGAAACCATACAAATGTGAAGAATGTGGCAAAGCTTTTAAGCAATCTTCACATC TTACTAGACATAAAGCAATTCATACTGGGGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAACCACTTCTCAGCCCTTAGAA AACATCAGATAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAGCCAGTCCTCAACCCTTAGAAAACATG AGATAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCTTTTAAGTGGTCCTCACACCTTACTAGACATAAAGTAA TTCATACTGAAGAGAAACCCTACAAATGTGAAGAATGTGGCAAGGCTTTTAACCATTTCTCAGCCCTTAGGAAACATAAGATAATTCATA CTGGAAAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAGCCAGTCCTCAACTCTTAGAAAACATGAGATAATTCATACTGGAG AGAAACCCTACAAATGTGAAGAATGTGGTAAAGCTTTTAAGTGGTCCTCAAAACTTACTGTACATAAGGTAATTCATACTGCAGAGAAAC CCTGCAAATGTGAAGAATGTGGCAAAGCTTTTAAGCATTTCTCAGCCCTTAGAAAACATAAGATAATTCATACTGGAAAGAAACCCTATA AATGTGAAGAATGTGGCAAAGCTTTTAACAATTCCTCAACCCTTAGAAAACATGAGATAATTCATACTGGAGAGAAATCCTACAAATGTG AAGAATGTGGTAAAGCTTTTCAGTGGTCCTCAAAACTTACTTTACATAAGGTAATTCATATGGAGAGAAACCCTGCAAATGTGAAGAATG |
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FusionGenePPI for MED26_ZNF99 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MED26 | MED10, MED9, MED29, MED19, MED28, MED13L, MED13, MED12, MED1, MED14, MED23, MED15, MED24, MED16, MED25, MED17, CDK8, CDK19, MED27, MED4, MED6, MED7, MED8, MED18, MED20, MED30, MED21, MED22, MED11, MED31, POLR2J, POLR2D, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2L, CEBPB, TRRAP, SREBF1, ZC3H13, QKI, TADA2A, CTDP1, EPAS1, EAF1, ELL, CDK9, TAF1, TAF4, TAF6, CCNT1, CCNT2, TCEA1, TCEB3, AFF4, MLLT3, TBP, CCNC, POLR2K, TAF2, TAF3, TAF4B, TAF5, TAF7, TAF8, TAF9, TAF10, TAF11, TAF13, TAF15, ELL2, EAF2, AFF1, MLLT1, ICE1, ICE2, EWSR1, MASTL, AURKA, TRIM25 | ZNF99 | DUSP26 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MED26_ZNF99 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MED26_ZNF99 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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