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Fusion gene ID: 21555 |
FusionGeneSummary for MED25_ST8SIA6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MED25_ST8SIA6 | Fusion gene ID: 21555 | Hgene | Tgene | Gene symbol | MED25 | ST8SIA6 | Gene ID | 81857 | 338596 |
| Gene name | mediator complex subunit 25 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 | |
| Synonyms | ACID1|ARC92|BVSYS|CMT2B2|P78|PTOV2|TCBAP0758 | SIA8F|SIAT8-F|SIAT8F|ST8SIA-VI|ST8SiaVI | |
| Cytomap | 19q13.33 | 10p12.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mediator of RNA polymerase II transcription subunit 25ARC/mediator transcriptional coactivator subunitactivator interaction domain-containing protein 1activator-recruited cofactor 92 kDa componentmediator of RNA polymerase II transcription, subunit 25 | alpha-2,8-sialyltransferase 8FST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 6sialyltransferase 8F (alpha-2, 8-sialyltransferase)sialyltransferase St8Sia VI | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q71SY5 | P61647 | |
| Ensembl transtripts involved in fusion gene | ENST00000312865, ENST00000538643, | ENST00000377602, | |
| Fusion gene scores | * DoF score | 6 X 3 X 4=72 | 5 X 4 X 4=80 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MED25 [Title/Abstract] AND ST8SIA6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MED25 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17641689 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-ER-A3EV-06A | MED25 | chr19 | 50322553 | + | ST8SIA6 | chr10 | 17432619 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000312865 | ENST00000377602 | MED25 | chr19 | 50322553 | + | ST8SIA6 | chr10 | 17432619 | - |
| intron-3CDS | ENST00000538643 | ENST00000377602 | MED25 | chr19 | 50322553 | + | ST8SIA6 | chr10 | 17432619 | - |
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FusionProtFeatures for MED25_ST8SIA6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MED25 | ST8SIA6 |
| Prefers O-glycans to N-glycans or glycolipids asacceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of theircarbohydrate groups (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ST8SIA6 | chr19:50322553 | chr10:17432619 | ENST00000377602 | - | 1 | 8 | 236_238 | 66 | 399 | Region | Substrate binding |
| Tgene | >ST8SIA6 | chr19:50322553 | chr10:17432619 | ENST00000377602 | - | 1 | 8 | 322_324 | 66 | 399 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 200_381 | 101 | 748 | Compositional bias | Note=Pro-rich |
| Hgene | >MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 565_735 | 101 | 748 | Compositional bias | Note=Pro-rich |
| Hgene | >MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 200_381 | 0 | 535 | Compositional bias | Note=Pro-rich |
| Hgene | >MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 565_735 | 0 | 535 | Compositional bias | Note=Pro-rich |
| Hgene | >MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 646_650 | 101 | 748 | Motif | Note=LXXLL motif |
| Hgene | >MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 646_650 | 0 | 535 | Motif | Note=LXXLL motif |
| Tgene | ST8SIA6 | chr19:50322553 | chr10:17432619 | ENST00000377602 | - | 1 | 8 | 1_3 | 66 | 399 | Topological domain | Cytoplasmic |
| Tgene | ST8SIA6 | chr19:50322553 | chr10:17432619 | ENST00000377602 | - | 1 | 8 | 25_398 | 66 | 399 | Topological domain | Lumenal |
| Tgene | ST8SIA6 | chr19:50322553 | chr10:17432619 | ENST00000377602 | - | 1 | 8 | 4_24 | 66 | 399 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for MED25_ST8SIA6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MED25_ENST00000312865_chr19_50322553_+_ST8SIA6_ENST00000377602_chr10_17432619_-_434aa MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS AYEFVTWLDGINTYLNEKSLQLTEKCKNLQYGIESFSNKTKGYSENDYLQIITDIQSCPWKRQAEEYANFRAKLASCCDAVQNFVVSQNN TPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTNLVTI NPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MED25_ENST00000312865_chr19_50322553_+_ST8SIA6_ENST00000377602_chr10_17432619_-_1302nt ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC TATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACACAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGC GCCTATGAGTTTGTCACCTGGCTCGATGGCATTAACACATATCTGAATGAGAAGTCGCTCCAACTGACGGAGAAATGCAAAAATCTGCAA TATGGCATTGAGTCTTTCTCTAACAAAACGAAAGGGTATTCAGAGAACGACTACCTTCAGATTATCACAGATATACAGAGTTGTCCATGG AAACGGCAAGCAGAAGAATATGCAAATTTTAGAGCCAAACTTGCTTCCTGCTGTGATGCTGTTCAAAACTTTGTTGTTTCTCAGAATAAC ACTCCAGTTGGGACTAATATGAGTTACGAGGTGGAAAGCAAAAAAGAAATCCCAATTAAGAAGAACATTTTTCATATGTTTCCAGTGTCC CAGCCTTTTGTGGACTACCCTTATAATCAGTGTGCAGTGGTCGGAAATGGGGGAATTCTGAATAAGTCTCTCTGTGGAACTGAAATAGAT AAATCCGACTTCGTTTTTAGGTGTAACCTACCCCCAACCACAGGAGATGTTAGTAAAGATGTTGGCAGTAAAACAAATCTTGTGACTATA AATCCAAGCATCATAACTCTGAAATATGGGAACTTAAAGGAAAAAAAAGCCCTATTTCTGGAGGACATTGCAACCTATGGAGATGCATTT TTTCTTCTGCCAGCATTTTCCTTCAGGGCCAACACGGGTACCTCTTTCAAAGTATACTACACGCTCGAAGAGTCTAAAGCAAGACAAAAG GTTCTATTTTTCCATCCCAAGTACCTGAAAGATCTGGCCCTTTTCTGGAGAACTAAAGGTGTGACTGCATACCGCTTGTCCACCGGCTTG ATGATCACAAGTGTTGCAGTGGAACTGTGTAAAAATGTGAAGCTGTATGGATTCTGGCCCTTCTCTAAAACTGTAGAAGACATACCTGTC AGCCATCACTATTATGACAACAAGCTACCTAAACATGGTTTCCATCAGATGCCCAAAGAATACAGCCAGATCCTCCAACTTCACATGAAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MED25_ENST00000312865_chr19_50322553_+_ST8SIA6_ENST00000377602_chr10_17432619_-_2359nt ATTCCGCGGCGTCGGCTGCGGCTGCAGTGGTGGTGGCGGGTACCGCACGGGGTATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGA GCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCCTACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGG CCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGACTATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACA CAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGCGCCTATGAGTTTGTCACCTGGCTCGATGGCATTAACA CATATCTGAATGAGAAGTCGCTCCAACTGACGGAGAAATGCAAAAATCTGCAATATGGCATTGAGTCTTTCTCTAACAAAACGAAAGGGT ATTCAGAGAACGACTACCTTCAGATTATCACAGATATACAGAGTTGTCCATGGAAACGGCAAGCAGAAGAATATGCAAATTTTAGAGCCA AACTTGCTTCCTGCTGTGATGCTGTTCAAAACTTTGTTGTTTCTCAGAATAACACTCCAGTTGGGACTAATATGAGTTACGAGGTGGAAA GCAAAAAAGAAATCCCAATTAAGAAGAACATTTTTCATATGTTTCCAGTGTCCCAGCCTTTTGTGGACTACCCTTATAATCAGTGTGCAG TGGTCGGAAATGGGGGAATTCTGAATAAGTCTCTCTGTGGAACTGAAATAGATAAATCCGACTTCGTTTTTAGGTGTAACCTACCCCCAA CCACAGGAGATGTTAGTAAAGATGTTGGCAGTAAAACAAATCTTGTGACTATAAATCCAAGCATCATAACTCTGAAATATGGGAACTTAA AGGAAAAAAAAGCCCTATTTCTGGAGGACATTGCAACCTATGGAGATGCATTTTTTCTTCTGCCAGCATTTTCCTTCAGGGCCAACACGG GTACCTCTTTCAAAGTATACTACACGCTCGAAGAGTCTAAAGCAAGACAAAAGGTTCTATTTTTCCATCCCAAGTACCTGAAAGATCTGG CCCTTTTCTGGAGAACTAAAGGTGTGACTGCATACCGCTTGTCCACCGGCTTGATGATCACAAGTGTTGCAGTGGAACTGTGTAAAAATG TGAAGCTGTATGGATTCTGGCCCTTCTCTAAAACTGTAGAAGACATACCTGTCAGCCATCACTATTATGACAACAAGCTACCTAAACATG GTTTCCATCAGATGCCCAAAGAATACAGCCAGATCCTCCAACTTCACATGAAAGGAATCCTCAAACTGCAATTTAGCAAATGTGAAGTCG CCTAAACAAAGTATCTTAAAATGGGAATAATTTTAATATAATGCAGTAGGTGATTAACAATGTCTCCAAACACCAAAGGAGGTGGCTAAA GAGTATTTTGAGATGAGCCCCAAAATTTGGTTTGACCAAAGCTTCCCCACTCATTTTGCAATGATGGCAAGTCATTCAATCCTTCTCATC TTCATTTTTTCTCCTTATAACATGGACACCATATCTGACTCATACAAATTTTTATAATTTATGAAAATTATTGGCATGGCCTTTGGTGTG AGGTAGGGACTCAAAGAATATTTCTTTCTTACTATTTATACCAGCCATCTCCACCTTCACCAGACCGATAATAAAAGCATGCTTTCTTGG AGATCTCTTCTAAAGAGAATAGCTGCATTACCAGTATCCATTGGATTTCTTTCTGTGGCAGGTCTCTATCAATAATATCCTTCCCATTTT TCTGTCTCAAAGACTGCATGCAAGAAAATTATATACTTAAGCAAAAAGTTCTTGATCATTCGGGAATGAAATTCTTCTCTGAGTATGGCA GTATGCCTGCTTCTGATTAAATTCACTTTTAATAGTAGCTGTGATGATATTTTGGTTGAATTTAAGCCATTTATTTTCCTCTTATGTCTA CATTTCTTCATCACTTAATAATTTTATTTTAACTTCCTGCCTCATTCTTACACTTTTTTCTCTCTCACTTATACGATATACTTCAAGGAC GTGAACAGTTACAATACCCAGTCTTTCTTACCTGTTGTCTTGCCTGTGGGGTCACTCACTCAATTTTATTTTAAAATTACTGAATAACTA CTTCATGCCAGGCCCTGCACCAGGCTCTGTGAGAGGACAAGAAGGATTATTGCCTCTTGTAGGAGAAAACAGATGTGCATATCATTAATT ATGATGGGGTATGATAAGTATTACAATGACAAAAGCTATGAATAAAGTGCTACAAGGAACAGAAGCAGGGATAATTAAATCCATTTCAGT |
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FusionGenePPI for MED25_ST8SIA6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MED25 | MED10, MED9, MED29, MED19, MED28, MED26, MED15, CDK8, MED6, MED1, TRRAP, MED12, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, SREBF1, MED13, MED14, MED23, MED25, MED16, MED17, MED7, RARA, RXRA, THRA, ESR1, NR3C1, CREBBP, CTDP1, NOTCH1, EPAS1, MED24, MED4, POLR2F, MED18, MED21, CCNC, FEZ1 | ST8SIA6 | PTEN |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 395_545 | 101 | 748 | CREBBP |
| Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 395_545 | 0 | 535 | CREBBP |
| Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 564_653 | 101 | 748 | RARA |
| Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 640_707 | 101 | 748 | RARA |
| Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 564_653 | 0 | 535 | RARA |
| Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 640_707 | 0 | 535 | RARA |
| Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 1_226 | 101 | 748 | the Mediator complex |
| Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 1_226 | 0 | 535 | the Mediator complex |
| Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 389_543 | 101 | 748 | VP16 |
| Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 389_543 | 0 | 535 | VP16 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MED25_ST8SIA6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MED25_ST8SIA6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MED25 | C1854150 | Charcot-Marie-Tooth disease, Type 2B2 | 1 | CTD_human;ORPHANET;UNIPROT |
| Hgene | MED25 | C4225323 | BASEL-VANAGAITE-SMIRIN-YOSEF SYNDROME | 1 | ORPHANET;UNIPROT |
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