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Fusion gene ID: 21555 |
FusionGeneSummary for MED25_ST8SIA6 |
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Fusion gene information | Fusion gene name: MED25_ST8SIA6 | Fusion gene ID: 21555 | Hgene | Tgene | Gene symbol | MED25 | ST8SIA6 | Gene ID | 81857 | 338596 |
Gene name | mediator complex subunit 25 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 | |
Synonyms | ACID1|ARC92|BVSYS|CMT2B2|P78|PTOV2|TCBAP0758 | SIA8F|SIAT8-F|SIAT8F|ST8SIA-VI|ST8SiaVI | |
Cytomap | 19q13.33 | 10p12.33 | |
Type of gene | protein-coding | protein-coding | |
Description | mediator of RNA polymerase II transcription subunit 25ARC/mediator transcriptional coactivator subunitactivator interaction domain-containing protein 1activator-recruited cofactor 92 kDa componentmediator of RNA polymerase II transcription, subunit 25 | alpha-2,8-sialyltransferase 8FST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 6sialyltransferase 8F (alpha-2, 8-sialyltransferase)sialyltransferase St8Sia VI | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q71SY5 | P61647 | |
Ensembl transtripts involved in fusion gene | ENST00000312865, ENST00000538643, | ENST00000377602, | |
Fusion gene scores | * DoF score | 6 X 3 X 4=72 | 5 X 4 X 4=80 |
# samples | 6 | 5 | |
** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MED25 [Title/Abstract] AND ST8SIA6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MED25 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17641689 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-ER-A3EV-06A | MED25 | chr19 | 50322553 | + | ST8SIA6 | chr10 | 17432619 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000312865 | ENST00000377602 | MED25 | chr19 | 50322553 | + | ST8SIA6 | chr10 | 17432619 | - |
intron-3CDS | ENST00000538643 | ENST00000377602 | MED25 | chr19 | 50322553 | + | ST8SIA6 | chr10 | 17432619 | - |
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FusionProtFeatures for MED25_ST8SIA6 |
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Hgene | Tgene |
MED25 | ST8SIA6 |
Prefers O-glycans to N-glycans or glycolipids asacceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of theircarbohydrate groups (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >ST8SIA6 | chr19:50322553 | chr10:17432619 | ENST00000377602 | - | 1 | 8 | 236_238 | 66 | 399 | Region | Substrate binding |
Tgene | >ST8SIA6 | chr19:50322553 | chr10:17432619 | ENST00000377602 | - | 1 | 8 | 322_324 | 66 | 399 | Region | Substrate binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 200_381 | 101 | 748 | Compositional bias | Note=Pro-rich |
Hgene | >MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 565_735 | 101 | 748 | Compositional bias | Note=Pro-rich |
Hgene | >MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 200_381 | 0 | 535 | Compositional bias | Note=Pro-rich |
Hgene | >MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 565_735 | 0 | 535 | Compositional bias | Note=Pro-rich |
Hgene | >MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 646_650 | 101 | 748 | Motif | Note=LXXLL motif |
Hgene | >MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 646_650 | 0 | 535 | Motif | Note=LXXLL motif |
Tgene | ST8SIA6 | chr19:50322553 | chr10:17432619 | ENST00000377602 | - | 1 | 8 | 1_3 | 66 | 399 | Topological domain | Cytoplasmic |
Tgene | ST8SIA6 | chr19:50322553 | chr10:17432619 | ENST00000377602 | - | 1 | 8 | 25_398 | 66 | 399 | Topological domain | Lumenal |
Tgene | ST8SIA6 | chr19:50322553 | chr10:17432619 | ENST00000377602 | - | 1 | 8 | 4_24 | 66 | 399 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for MED25_ST8SIA6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_MED25_ENST00000312865_chr19_50322553_+_ST8SIA6_ENST00000377602_chr10_17432619_-_434aa MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS AYEFVTWLDGINTYLNEKSLQLTEKCKNLQYGIESFSNKTKGYSENDYLQIITDIQSCPWKRQAEEYANFRAKLASCCDAVQNFVVSQNN TPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTNLVTI NPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGL |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_MED25_ENST00000312865_chr19_50322553_+_ST8SIA6_ENST00000377602_chr10_17432619_-_1302nt ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC TATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACACAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGC GCCTATGAGTTTGTCACCTGGCTCGATGGCATTAACACATATCTGAATGAGAAGTCGCTCCAACTGACGGAGAAATGCAAAAATCTGCAA TATGGCATTGAGTCTTTCTCTAACAAAACGAAAGGGTATTCAGAGAACGACTACCTTCAGATTATCACAGATATACAGAGTTGTCCATGG AAACGGCAAGCAGAAGAATATGCAAATTTTAGAGCCAAACTTGCTTCCTGCTGTGATGCTGTTCAAAACTTTGTTGTTTCTCAGAATAAC ACTCCAGTTGGGACTAATATGAGTTACGAGGTGGAAAGCAAAAAAGAAATCCCAATTAAGAAGAACATTTTTCATATGTTTCCAGTGTCC CAGCCTTTTGTGGACTACCCTTATAATCAGTGTGCAGTGGTCGGAAATGGGGGAATTCTGAATAAGTCTCTCTGTGGAACTGAAATAGAT AAATCCGACTTCGTTTTTAGGTGTAACCTACCCCCAACCACAGGAGATGTTAGTAAAGATGTTGGCAGTAAAACAAATCTTGTGACTATA AATCCAAGCATCATAACTCTGAAATATGGGAACTTAAAGGAAAAAAAAGCCCTATTTCTGGAGGACATTGCAACCTATGGAGATGCATTT TTTCTTCTGCCAGCATTTTCCTTCAGGGCCAACACGGGTACCTCTTTCAAAGTATACTACACGCTCGAAGAGTCTAAAGCAAGACAAAAG GTTCTATTTTTCCATCCCAAGTACCTGAAAGATCTGGCCCTTTTCTGGAGAACTAAAGGTGTGACTGCATACCGCTTGTCCACCGGCTTG ATGATCACAAGTGTTGCAGTGGAACTGTGTAAAAATGTGAAGCTGTATGGATTCTGGCCCTTCTCTAAAACTGTAGAAGACATACCTGTC AGCCATCACTATTATGACAACAAGCTACCTAAACATGGTTTCCATCAGATGCCCAAAGAATACAGCCAGATCCTCCAACTTCACATGAAA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_MED25_ENST00000312865_chr19_50322553_+_ST8SIA6_ENST00000377602_chr10_17432619_-_2359nt ATTCCGCGGCGTCGGCTGCGGCTGCAGTGGTGGTGGCGGGTACCGCACGGGGTATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGA GCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCCTACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGG CCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGACTATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACA CAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGCGCCTATGAGTTTGTCACCTGGCTCGATGGCATTAACA CATATCTGAATGAGAAGTCGCTCCAACTGACGGAGAAATGCAAAAATCTGCAATATGGCATTGAGTCTTTCTCTAACAAAACGAAAGGGT ATTCAGAGAACGACTACCTTCAGATTATCACAGATATACAGAGTTGTCCATGGAAACGGCAAGCAGAAGAATATGCAAATTTTAGAGCCA AACTTGCTTCCTGCTGTGATGCTGTTCAAAACTTTGTTGTTTCTCAGAATAACACTCCAGTTGGGACTAATATGAGTTACGAGGTGGAAA GCAAAAAAGAAATCCCAATTAAGAAGAACATTTTTCATATGTTTCCAGTGTCCCAGCCTTTTGTGGACTACCCTTATAATCAGTGTGCAG TGGTCGGAAATGGGGGAATTCTGAATAAGTCTCTCTGTGGAACTGAAATAGATAAATCCGACTTCGTTTTTAGGTGTAACCTACCCCCAA CCACAGGAGATGTTAGTAAAGATGTTGGCAGTAAAACAAATCTTGTGACTATAAATCCAAGCATCATAACTCTGAAATATGGGAACTTAA AGGAAAAAAAAGCCCTATTTCTGGAGGACATTGCAACCTATGGAGATGCATTTTTTCTTCTGCCAGCATTTTCCTTCAGGGCCAACACGG GTACCTCTTTCAAAGTATACTACACGCTCGAAGAGTCTAAAGCAAGACAAAAGGTTCTATTTTTCCATCCCAAGTACCTGAAAGATCTGG CCCTTTTCTGGAGAACTAAAGGTGTGACTGCATACCGCTTGTCCACCGGCTTGATGATCACAAGTGTTGCAGTGGAACTGTGTAAAAATG TGAAGCTGTATGGATTCTGGCCCTTCTCTAAAACTGTAGAAGACATACCTGTCAGCCATCACTATTATGACAACAAGCTACCTAAACATG GTTTCCATCAGATGCCCAAAGAATACAGCCAGATCCTCCAACTTCACATGAAAGGAATCCTCAAACTGCAATTTAGCAAATGTGAAGTCG CCTAAACAAAGTATCTTAAAATGGGAATAATTTTAATATAATGCAGTAGGTGATTAACAATGTCTCCAAACACCAAAGGAGGTGGCTAAA GAGTATTTTGAGATGAGCCCCAAAATTTGGTTTGACCAAAGCTTCCCCACTCATTTTGCAATGATGGCAAGTCATTCAATCCTTCTCATC TTCATTTTTTCTCCTTATAACATGGACACCATATCTGACTCATACAAATTTTTATAATTTATGAAAATTATTGGCATGGCCTTTGGTGTG AGGTAGGGACTCAAAGAATATTTCTTTCTTACTATTTATACCAGCCATCTCCACCTTCACCAGACCGATAATAAAAGCATGCTTTCTTGG AGATCTCTTCTAAAGAGAATAGCTGCATTACCAGTATCCATTGGATTTCTTTCTGTGGCAGGTCTCTATCAATAATATCCTTCCCATTTT TCTGTCTCAAAGACTGCATGCAAGAAAATTATATACTTAAGCAAAAAGTTCTTGATCATTCGGGAATGAAATTCTTCTCTGAGTATGGCA GTATGCCTGCTTCTGATTAAATTCACTTTTAATAGTAGCTGTGATGATATTTTGGTTGAATTTAAGCCATTTATTTTCCTCTTATGTCTA CATTTCTTCATCACTTAATAATTTTATTTTAACTTCCTGCCTCATTCTTACACTTTTTTCTCTCTCACTTATACGATATACTTCAAGGAC GTGAACAGTTACAATACCCAGTCTTTCTTACCTGTTGTCTTGCCTGTGGGGTCACTCACTCAATTTTATTTTAAAATTACTGAATAACTA CTTCATGCCAGGCCCTGCACCAGGCTCTGTGAGAGGACAAGAAGGATTATTGCCTCTTGTAGGAGAAAACAGATGTGCATATCATTAATT ATGATGGGGTATGATAAGTATTACAATGACAAAAGCTATGAATAAAGTGCTACAAGGAACAGAAGCAGGGATAATTAAATCCATTTCAGT |
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FusionGenePPI for MED25_ST8SIA6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MED25 | MED10, MED9, MED29, MED19, MED28, MED26, MED15, CDK8, MED6, MED1, TRRAP, MED12, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, SREBF1, MED13, MED14, MED23, MED25, MED16, MED17, MED7, RARA, RXRA, THRA, ESR1, NR3C1, CREBBP, CTDP1, NOTCH1, EPAS1, MED24, MED4, POLR2F, MED18, MED21, CCNC, FEZ1 | ST8SIA6 | PTEN |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 395_545 | 101 | 748 | CREBBP |
Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 395_545 | 0 | 535 | CREBBP |
Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 564_653 | 101 | 748 | RARA |
Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 640_707 | 101 | 748 | RARA |
Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 564_653 | 0 | 535 | RARA |
Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 640_707 | 0 | 535 | RARA |
Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 1_226 | 101 | 748 | the Mediator complex |
Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 1_226 | 0 | 535 | the Mediator complex |
Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000312865 | + | 3 | 18 | 389_543 | 101 | 748 | VP16 |
Hgene | MED25 | chr19:50322553 | chr10:17432619 | ENST00000538643 | + | 1 | 13 | 389_543 | 0 | 535 | VP16 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MED25_ST8SIA6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MED25_ST8SIA6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MED25 | C1854150 | Charcot-Marie-Tooth disease, Type 2B2 | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | MED25 | C4225323 | BASEL-VANAGAITE-SMIRIN-YOSEF SYNDROME | 1 | ORPHANET;UNIPROT |