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Fusion gene ID: 21553 |
FusionGeneSummary for MED25_MAPK15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MED25_MAPK15 | Fusion gene ID: 21553 | Hgene | Tgene | Gene symbol | MED25 | MAPK15 | Gene ID | 81857 | 225689 |
| Gene name | mediator complex subunit 25 | mitogen-activated protein kinase 15 | |
| Synonyms | ACID1|ARC92|BVSYS|CMT2B2|P78|PTOV2|TCBAP0758 | ERK7|ERK8 | |
| Cytomap | 19q13.33 | - | |
| Type of gene | protein-coding | protein-coding | |
| Description | mediator of RNA polymerase II transcription subunit 25ARC/mediator transcriptional coactivator subunitactivator interaction domain-containing protein 1activator-recruited cofactor 92 kDa componentmediator of RNA polymerase II transcription, subunit 25 | mitogen-activated protein kinase 15ERK-7ERK-8MAP kinase 15MAPK 15extracellular regulated kinase 8 deltaextracellular signal-regulated kinase 7extracellular signal-regulated kinase 8 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q71SY5 | Q8TD08 | |
| Ensembl transtripts involved in fusion gene | ENST00000312865, ENST00000538643, | ENST00000338033, ENST00000395107, ENST00000395108, | |
| Fusion gene scores | * DoF score | 6 X 3 X 4=72 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MED25 [Title/Abstract] AND MAPK15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MED25 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17641689 |
| Tgene | MAPK15 | GO:0010506 | regulation of autophagy | 22948227 |
| Tgene | MAPK15 | GO:0032212 | positive regulation of telomere maintenance via telomerase | 21531765 |
| Tgene | MAPK15 | GO:0046777 | protein autophosphorylation | 11875070 |
| Tgene | MAPK15 | GO:0051973 | positive regulation of telomerase activity | 21531765 |
| Tgene | MAPK15 | GO:0090494 | dopamine uptake | 28842414 |
| Tgene | MAPK15 | GO:1904355 | positive regulation of telomere capping | 21531765 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-OL-A66I-01A | MED25 | chr19 | 50335672 | + | MAPK15 | chr8 | 144799864 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000312865 | ENST00000338033 | MED25 | chr19 | 50335672 | + | MAPK15 | chr8 | 144799864 | + |
| In-frame | ENST00000312865 | ENST00000395107 | MED25 | chr19 | 50335672 | + | MAPK15 | chr8 | 144799864 | + |
| In-frame | ENST00000312865 | ENST00000395108 | MED25 | chr19 | 50335672 | + | MAPK15 | chr8 | 144799864 | + |
| In-frame | ENST00000538643 | ENST00000338033 | MED25 | chr19 | 50335672 | + | MAPK15 | chr8 | 144799864 | + |
| In-frame | ENST00000538643 | ENST00000395107 | MED25 | chr19 | 50335672 | + | MAPK15 | chr8 | 144799864 | + |
| In-frame | ENST00000538643 | ENST00000395108 | MED25 | chr19 | 50335672 | + | MAPK15 | chr8 | 144799864 | + |
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FusionProtFeatures for MED25_MAPK15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MED25 | MAPK15 |
| Atypical MAPK protein that regulates several processsuch as autophagy, ciliogenesis, protein trafficking/secretion andgenome integrity, in a kinase activity-dependent manner(PubMed:22948227, PubMed:24618899, PubMed:29021280,PubMed:21847093, PubMed:20733054). Controls both, basal andstarvation-induced autophagy throught its interaction withGABARAP, MAP1LC3B and GABARAPL1 leading to autophagosomeformation, SQSTM1 degradation and reduced MAP1LC3B inhibitoryphosphorylation (PubMed:22948227). Regulates primary ciliumformation and the localization of ciliary proteins involved incilium structure, transport, and signaling (PubMed:29021280).Prevents the relocation of the sugar-adding enzymes from the Golgito the endoplasmic reticulum, thereby restricting the productionof sugar-coated proteins (PubMed:24618899). Upon amino-acidstarvation, mediates transitional endoplasmic reticulum sitedisassembly and inhibition of secretion (PubMed:21847093). Bindsto chromatin leading to MAPK15 activation and interaction withPCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DAtransporter (DAT) activity and protein expression via activationof RhoA (PubMed:28842414). In response to H(2)O(2) treatmentphosphorylates ELAVL1, thus preventing it from binding to thePDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 andleading to its degradation and loss of protein expression(PubMed:26595526). Also functions in a kinase activity-independentmanner as a negative regulator of growth (By similarity).Phosphorylates in vitro FOS and MBP (PubMed:11875070,PubMed:16484222, PubMed:20638370, PubMed:19166846). During oocytematuration, plays a key role in the microtubule organization andmeiotic cell cycle progression in oocytes, fertilized eggs, andearly embryos (By similarity). Interacts with ESRRA promoting itsre-localization from the nucleus to the cytoplasm and thenprevents its transcriptional activity (PubMed:21190936).{ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6,ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222,ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370,ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936,ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227,ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526,ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MED25 | chr19:50335672 | chr8:144799864 | ENST00000312865 | + | 13 | 18 | 200_381 | 494 | 748 | Compositional bias | Note=Pro-rich |
| Tgene | >MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000338033 | + | 0 | 14 | 175_177 | 22 | 545 | Motif | Note=TXY |
| Tgene | >MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000395107 | + | 0 | 8 | 175_177 | 22 | 278 | Motif | Note=TXY |
| Tgene | >MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000395108 | + | 0 | 8 | 175_177 | 22 | 255 | Motif | Note=TXY |
| Tgene | >MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000338033 | + | 0 | 14 | 19_27 | 22 | 545 | Nucleotide binding | ATP |
| Tgene | >MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000395107 | + | 0 | 8 | 19_27 | 22 | 278 | Nucleotide binding | ATP |
| Tgene | >MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000395108 | + | 0 | 8 | 19_27 | 22 | 255 | Nucleotide binding | ATP |
| Tgene | >MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000338033 | + | 0 | 14 | 265_285 | 22 | 545 | Region | Necessary to interact with ESRRA%2C to regulate its subcellular localization and to inhibit its transcriptional activity |
| Tgene | >MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000395107 | + | 0 | 8 | 265_285 | 22 | 278 | Region | Necessary to interact with ESRRA%2C to regulate its subcellular localization and to inhibit its transcriptional activity |
| Tgene | >MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000395108 | + | 0 | 8 | 265_285 | 22 | 255 | Region | Necessary to interact with ESRRA%2C to regulate its subcellular localization and to inhibit its transcriptional activity |
| Tgene | >MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000338033 | + | 0 | 14 | 371_375 | 22 | 545 | Repeat | PXXXP motif |
| Tgene | >MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000338033 | + | 0 | 14 | 378_382 | 22 | 545 | Repeat | PXXXP motif |
| Tgene | >MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000395107 | + | 0 | 8 | 371_375 | 22 | 278 | Repeat | PXXXP motif |
| Tgene | >MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000395107 | + | 0 | 8 | 378_382 | 22 | 278 | Repeat | PXXXP motif |
| Tgene | >MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000395108 | + | 0 | 8 | 371_375 | 22 | 255 | Repeat | PXXXP motif |
| Tgene | >MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000395108 | + | 0 | 8 | 378_382 | 22 | 255 | Repeat | PXXXP motif |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MED25 | chr19:50335672 | chr8:144799864 | ENST00000312865 | + | 13 | 18 | 565_735 | 494 | 748 | Compositional bias | Note=Pro-rich |
| Hgene | >MED25 | chr19:50335672 | chr8:144799864 | ENST00000538643 | + | 8 | 13 | 200_381 | 281 | 535 | Compositional bias | Note=Pro-rich |
| Hgene | >MED25 | chr19:50335672 | chr8:144799864 | ENST00000538643 | + | 8 | 13 | 565_735 | 281 | 535 | Compositional bias | Note=Pro-rich |
| Hgene | >MED25 | chr19:50335672 | chr8:144799864 | ENST00000312865 | + | 13 | 18 | 646_650 | 494 | 748 | Motif | Note=LXXLL motif |
| Hgene | >MED25 | chr19:50335672 | chr8:144799864 | ENST00000538643 | + | 8 | 13 | 646_650 | 281 | 535 | Motif | Note=LXXLL motif |
| Tgene | MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000338033 | + | 0 | 14 | 13_304 | 22 | 545 | Domain | Protein kinase |
| Tgene | MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000395107 | + | 0 | 8 | 13_304 | 22 | 278 | Domain | Protein kinase |
| Tgene | MAPK15 | chr19:50335672 | chr8:144799864 | ENST00000395108 | + | 0 | 8 | 13_304 | 22 | 255 | Domain | Protein kinase |
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FusionGeneSequence for MED25_MAPK15 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MED25_ENST00000312865_chr19_50335672_+_MAPK15_ENST00000338033_chr8_144799864_+_1017aa MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS AYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHF SIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPP QYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTA QPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIM QLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG DHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGL ARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSG CRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSR VYQMILECGGSSGTSREKGPEGVSPSQAHLHKPRADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQTALLGNGE RPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAAQVANQALIRGDWNRGGGVRVASVQQVPPRLPPEARPGRRMFSTSALQGAQGGARALL >In-frame_MED25_ENST00000312865_chr19_50335672_+_MAPK15_ENST00000395107_chr8_144799864_+_750aa MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS AYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHF SIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPP QYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTA QPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIM QLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG DHPNIISLLDVIRAENDRDIYLVFEFMGCPPSPPPPTAVRTLSADTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPS NVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELIL >In-frame_MED25_ENST00000312865_chr19_50335672_+_MAPK15_ENST00000395108_chr8_144799864_+_727aa MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS AYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHF SIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPP QYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTA QPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIM QLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG DHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGL ARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEGAQTACRS >In-frame_MED25_ENST00000538643_chr19_50335672_+_MAPK15_ENST00000338033_chr8_144799864_+_804aa MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRF SPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQ SVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESL KGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNA VIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLS SHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLL RRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSSGTSREKGPEGVSPSQAHLHKP RADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQTALLGNGERPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAA >In-frame_MED25_ENST00000538643_chr19_50335672_+_MAPK15_ENST00000395107_chr8_144799864_+_537aa MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRF SPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQ SVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESL KGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMGCPPSP PPPTAVRTLSADTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAV >In-frame_MED25_ENST00000538643_chr19_50335672_+_MAPK15_ENST00000395108_chr8_144799864_+_514aa MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRF SPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQ SVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESL KGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNA VIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MED25_ENST00000312865_chr19_50335672_+_MAPK15_ENST00000338033_chr8_144799864_+_3051nt ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC TATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACACAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGC GCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAGTTCATGGGCGGGGGTGGTGAGAGCTGCAGCCTCATCGCGGAAGGACTCAGCACA GCCTTGCAGCTGTTTGATGACTTCAAGAAGATGCGCGAGCAGATTGGCCAGACGCACCGGGTCTGCCTCCTCATCTGCAACTCACCCCCA TACTTGTTGCCTGCTGTTGAGAGCACCACGTACTCTGGATGCACAACTGAGAATCTTGTGCAGCAGATTGGGGAGCGGGGGATCCACTTC TCCATTGTGTCTCCCCGGAAGCTGCCTGCGCTTCGGCTTCTGTTTGAGAAGGCAGCCCCCCCGGCCTTGCTGGAGCCGCTGCAGCCTCCG ACAGATGTGAGCCAGGACCCGAGGCACATGGTGCTGGTTCGGGGACTCGTGCTGCCTGTTGGGGGTGGCTCAGCCCCAGGCCCCCTCCAG TCAAAGCAGCCAGTCCCCCTGCCTCCCGCCGCACCCTCAGGTGCCACTCTCTCAGCAGCCCCCCAGCAGCCTCTGCCCCCCGTCCCCCCG CAGTACCAGGTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGC CCTCGCTTCTCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCA GGACCCCCTGGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCA CAGCCCGGGGCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGT GGGCAGCAGTCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAAC ACCAAGCTGACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATG CAGCTCATCCCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTG GAGTCTCTCAAAGGCCTCTACCGCATCATGGGCAACGGCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTC GTGGCCATCAAGAAAATCTTTGATGCTTTTAGGGATAAGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGG GACCATCCCAACATCATCAGCCTCCTTGACGTGATCCGGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGACACTGAC CTGAACGCAGTCATCCGGAAGGGCGGCCTGCTGCAGGACGTCCACGTGCGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTC CACTCGGGGCACGTTGTGCACCGGGACCAGAAGCCGTCCAATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTG GCCCGCTCCCTGGGCGACCTCCCCGAGGGGCCTGAGGACCAGGCCGTGACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTG CTGCTCTCTTCGCACCGATACACCCTTGGGGTGGACATGTGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTC CCCGGCACGTCCACCCTCCACCAGCTGGAGCTGATCCTGGAGACCATCCCACCGCCATCTGAGGAGGACCTCCTGGCTCTCGGCTCAGGC TGCCGTGCCTCTGTGCTGCACCAGCTGGGGTCCCGGCCACGACAGACGCTGGATGCCCTCCTACCGCCAGACACCTCCCCAGAGGCCTTG GACCTCCTTAGGCGACTCCTGGTGTTCGCCCCGGACAAGCGGTTAAGCGCGACCCAGGCACTGCAGCACCCCTACGTGCAGAGGTTCCAC TGCCCCAGCGACGAGTGGGCACGAGAGGCAGATGTGCGGCCCCGGGCACACGAAGGGGTCCAGCTCTCTGTGCCTGAGTACCGCAGCCGC GTCTATCAGATGATCCTGGAGTGTGGAGGCAGCAGCGGCACCTCGAGAGAGAAGGGCCCGGAGGGTGTCTCCCCAAGCCAGGCACACCTG CACAAACCCAGAGCCGACCCTCAGCTGCCTTCTAGGACACCTGTGCAGGGTCCCAGACCCAGGCCCCAGAGCAGCCCAGGCCATGACCCT GCCGAGCACGAGTCCCCCCGTGCAGCCAAGAACGTTCCCAGGCAGAACTCCGCTCCCCTGCTCCAAACTGCTCTCCTAGGGAATGGGGAA AGGCCCCCTGGGGCGAAGGAAGCGCCCCCCTTGACACTCTCGCTGGTGAAGCCAAGCGGGAGGGGAGCTGCGCCCTCCCTGACCTCCCAG GCTGCGGCTCAGGTGGCCAACCAGGCCCTGATCCGGGGTGACTGGAACCGGGGCGGTGGGGTGAGGGTGGCCAGCGTACAACAGGTCCCT CCCCGGCTTCCTCCGGAGGCCCGGCCCGGCCGGAGGATGTTCAGCACCTCTGCCTTGCAGGGTGCCCAGGGGGGTGCCAGGGCTTTGCTT >In-frame_MED25_ENST00000312865_chr19_50335672_+_MAPK15_ENST00000395107_chr8_144799864_+_2250nt ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC TATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACACAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGC GCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAGTTCATGGGCGGGGGTGGTGAGAGCTGCAGCCTCATCGCGGAAGGACTCAGCACA GCCTTGCAGCTGTTTGATGACTTCAAGAAGATGCGCGAGCAGATTGGCCAGACGCACCGGGTCTGCCTCCTCATCTGCAACTCACCCCCA TACTTGTTGCCTGCTGTTGAGAGCACCACGTACTCTGGATGCACAACTGAGAATCTTGTGCAGCAGATTGGGGAGCGGGGGATCCACTTC TCCATTGTGTCTCCCCGGAAGCTGCCTGCGCTTCGGCTTCTGTTTGAGAAGGCAGCCCCCCCGGCCTTGCTGGAGCCGCTGCAGCCTCCG ACAGATGTGAGCCAGGACCCGAGGCACATGGTGCTGGTTCGGGGACTCGTGCTGCCTGTTGGGGGTGGCTCAGCCCCAGGCCCCCTCCAG TCAAAGCAGCCAGTCCCCCTGCCTCCCGCCGCACCCTCAGGTGCCACTCTCTCAGCAGCCCCCCAGCAGCCTCTGCCCCCCGTCCCCCCG CAGTACCAGGTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGC CCTCGCTTCTCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCA GGACCCCCTGGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCA CAGCCCGGGGCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGT GGGCAGCAGTCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAAC ACCAAGCTGACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATG CAGCTCATCCCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTG GAGTCTCTCAAAGGCCTCTACCGCATCATGGGCAACGGCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTC GTGGCCATCAAGAAAATCTTTGATGCTTTTAGGGATAAGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGG GACCATCCCAACATCATCAGCCTCCTTGACGTGATCCGGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGGTTGCCCC CCCAGCCCCCCACCCCCGACTGCAGTGCGCACCCTCTCTGCAGACACTGACCTGAACGCAGTCATCCGGAAGGGCGGCCTGCTGCAGGAC GTCCACGTGCGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTCCACTCGGGGCACGTTGTGCACCGGGACCAGAAGCCGTCC AATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTGGCCCGCTCCCTGGGCGACCTCCCCGAGGGGCCTGAGGAC CAGGCCGTGACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTGCTGCTCTCTTCGCACCGATACACCCTTGGGGTGGACATG TGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTCCCCGGCACGTCCACCCTCCACCAGCTGGAGCTGATCCTG GAGACCATCCCACCGCCATCTGAGGAGGACCTCCTGGCTCTCGGCTCAGGCTGCCGTGCCTCTGTGCTGCACCAGCTGGGGTCCCGGTGA >In-frame_MED25_ENST00000312865_chr19_50335672_+_MAPK15_ENST00000395108_chr8_144799864_+_2181nt ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC TATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACACAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGC GCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAGTTCATGGGCGGGGGTGGTGAGAGCTGCAGCCTCATCGCGGAAGGACTCAGCACA GCCTTGCAGCTGTTTGATGACTTCAAGAAGATGCGCGAGCAGATTGGCCAGACGCACCGGGTCTGCCTCCTCATCTGCAACTCACCCCCA TACTTGTTGCCTGCTGTTGAGAGCACCACGTACTCTGGATGCACAACTGAGAATCTTGTGCAGCAGATTGGGGAGCGGGGGATCCACTTC TCCATTGTGTCTCCCCGGAAGCTGCCTGCGCTTCGGCTTCTGTTTGAGAAGGCAGCCCCCCCGGCCTTGCTGGAGCCGCTGCAGCCTCCG ACAGATGTGAGCCAGGACCCGAGGCACATGGTGCTGGTTCGGGGACTCGTGCTGCCTGTTGGGGGTGGCTCAGCCCCAGGCCCCCTCCAG TCAAAGCAGCCAGTCCCCCTGCCTCCCGCCGCACCCTCAGGTGCCACTCTCTCAGCAGCCCCCCAGCAGCCTCTGCCCCCCGTCCCCCCG CAGTACCAGGTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGC CCTCGCTTCTCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCA GGACCCCCTGGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCA CAGCCCGGGGCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGT GGGCAGCAGTCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAAC ACCAAGCTGACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATG CAGCTCATCCCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTG GAGTCTCTCAAAGGCCTCTACCGCATCATGGGCAACGGCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTC GTGGCCATCAAGAAAATCTTTGATGCTTTTAGGGATAAGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGG GACCATCCCAACATCATCAGCCTCCTTGACGTGATCCGGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGACACTGAC CTGAACGCAGTCATCCGGAAGGGCGGCCTGCTGCAGGACGTCCACGTGCGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTC CACTCGGGGCACGTTGTGCACCGGGACCAGAAGCCGTCCAATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTG GCCCGCTCCCTGGGCGACCTCCCCGAGGGGCCTGAGGACCAGGCCGTGACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTG CTGCTCTCTTCGCACCGATACACCCTTGGGGTGGACATGTGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTC CCCGGCACGTCCACCCTCCACCAGCTGGAGCTGATCCTGGAGACCATCCCACCGCCATCTGAGGAGGGGGCCCAGACTGCCTGCAGGTCA >In-frame_MED25_ENST00000538643_chr19_50335672_+_MAPK15_ENST00000338033_chr8_144799864_+_2412nt ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC GTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTC TCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCT GGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGG GCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAG TCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTG ACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATC CCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTC AAAGGCCTCTACCGCATCATGGGCAACGGCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCCATC AAGAAAATCTTTGATGCTTTTAGGGATAAGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGGGACCATCCC AACATCATCAGCCTCCTTGACGTGATCCGGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGACACTGACCTGAACGCA GTCATCCGGAAGGGCGGCCTGCTGCAGGACGTCCACGTGCGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTCCACTCGGGG CACGTTGTGCACCGGGACCAGAAGCCGTCCAATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTGGCCCGCTCC CTGGGCGACCTCCCCGAGGGGCCTGAGGACCAGGCCGTGACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTGCTGCTCTCT TCGCACCGATACACCCTTGGGGTGGACATGTGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTCCCCGGCACG TCCACCCTCCACCAGCTGGAGCTGATCCTGGAGACCATCCCACCGCCATCTGAGGAGGACCTCCTGGCTCTCGGCTCAGGCTGCCGTGCC TCTGTGCTGCACCAGCTGGGGTCCCGGCCACGACAGACGCTGGATGCCCTCCTACCGCCAGACACCTCCCCAGAGGCCTTGGACCTCCTT AGGCGACTCCTGGTGTTCGCCCCGGACAAGCGGTTAAGCGCGACCCAGGCACTGCAGCACCCCTACGTGCAGAGGTTCCACTGCCCCAGC GACGAGTGGGCACGAGAGGCAGATGTGCGGCCCCGGGCACACGAAGGGGTCCAGCTCTCTGTGCCTGAGTACCGCAGCCGCGTCTATCAG ATGATCCTGGAGTGTGGAGGCAGCAGCGGCACCTCGAGAGAGAAGGGCCCGGAGGGTGTCTCCCCAAGCCAGGCACACCTGCACAAACCC AGAGCCGACCCTCAGCTGCCTTCTAGGACACCTGTGCAGGGTCCCAGACCCAGGCCCCAGAGCAGCCCAGGCCATGACCCTGCCGAGCAC GAGTCCCCCCGTGCAGCCAAGAACGTTCCCAGGCAGAACTCCGCTCCCCTGCTCCAAACTGCTCTCCTAGGGAATGGGGAAAGGCCCCCT GGGGCGAAGGAAGCGCCCCCCTTGACACTCTCGCTGGTGAAGCCAAGCGGGAGGGGAGCTGCGCCCTCCCTGACCTCCCAGGCTGCGGCT CAGGTGGCCAACCAGGCCCTGATCCGGGGTGACTGGAACCGGGGCGGTGGGGTGAGGGTGGCCAGCGTACAACAGGTCCCTCCCCGGCTT CCTCCGGAGGCCCGGCCCGGCCGGAGGATGTTCAGCACCTCTGCCTTGCAGGGTGCCCAGGGGGGTGCCAGGGCTTTGCTTGGAGGCTAC >In-frame_MED25_ENST00000538643_chr19_50335672_+_MAPK15_ENST00000395107_chr8_144799864_+_1611nt ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC GTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTC TCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCT GGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGG GCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAG TCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTG ACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATC CCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTC AAAGGCCTCTACCGCATCATGGGCAACGGCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCCATC AAGAAAATCTTTGATGCTTTTAGGGATAAGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGGGACCATCCC AACATCATCAGCCTCCTTGACGTGATCCGGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGGTTGCCCCCCCAGCCCC CCACCCCCGACTGCAGTGCGCACCCTCTCTGCAGACACTGACCTGAACGCAGTCATCCGGAAGGGCGGCCTGCTGCAGGACGTCCACGTG CGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTCCACTCGGGGCACGTTGTGCACCGGGACCAGAAGCCGTCCAATGTGCTC CTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTGGCCCGCTCCCTGGGCGACCTCCCCGAGGGGCCTGAGGACCAGGCCGTG ACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTGCTGCTCTCTTCGCACCGATACACCCTTGGGGTGGACATGTGGAGTCTG GGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTCCCCGGCACGTCCACCCTCCACCAGCTGGAGCTGATCCTGGAGACCATC >In-frame_MED25_ENST00000538643_chr19_50335672_+_MAPK15_ENST00000395108_chr8_144799864_+_1542nt ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC GTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTC TCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCT GGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGG GCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAG TCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTG ACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATC CCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTC AAAGGCCTCTACCGCATCATGGGCAACGGCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCCATC AAGAAAATCTTTGATGCTTTTAGGGATAAGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGGGACCATCCC AACATCATCAGCCTCCTTGACGTGATCCGGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGACACTGACCTGAACGCA GTCATCCGGAAGGGCGGCCTGCTGCAGGACGTCCACGTGCGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTCCACTCGGGG CACGTTGTGCACCGGGACCAGAAGCCGTCCAATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTGGCCCGCTCC CTGGGCGACCTCCCCGAGGGGCCTGAGGACCAGGCCGTGACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTGCTGCTCTCT TCGCACCGATACACCCTTGGGGTGGACATGTGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTCCCCGGCACG TCCACCCTCCACCAGCTGGAGCTGATCCTGGAGACCATCCCACCGCCATCTGAGGAGGGGGCCCAGACTGCCTGCAGGTCAGGCACAGGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MED25_ENST00000312865_chr19_50335672_+_MAPK15_ENST00000338033_chr8_144799864_+_3311nt ATTCCGCGGCGTCGGCTGCGGCTGCAGTGGTGGTGGCGGGTACCGCACGGGGTATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGA GCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCCTACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGG CCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGACTATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACA CAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGCGCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAGT TCATGGGCGGGGGTGGTGAGAGCTGCAGCCTCATCGCGGAAGGACTCAGCACAGCCTTGCAGCTGTTTGATGACTTCAAGAAGATGCGCG AGCAGATTGGCCAGACGCACCGGGTCTGCCTCCTCATCTGCAACTCACCCCCATACTTGTTGCCTGCTGTTGAGAGCACCACGTACTCTG GATGCACAACTGAGAATCTTGTGCAGCAGATTGGGGAGCGGGGGATCCACTTCTCCATTGTGTCTCCCCGGAAGCTGCCTGCGCTTCGGC TTCTGTTTGAGAAGGCAGCCCCCCCGGCCTTGCTGGAGCCGCTGCAGCCTCCGACAGATGTGAGCCAGGACCCGAGGCACATGGTGCTGG TTCGGGGACTCGTGCTGCCTGTTGGGGGTGGCTCAGCCCCAGGCCCCCTCCAGTCAAAGCAGCCAGTCCCCCTGCCTCCCGCCGCACCCT CAGGTGCCACTCTCTCAGCAGCCCCCCAGCAGCCTCTGCCCCCCGTCCCCCCGCAGTACCAGGTTCCCGGGAACCTGAGTGCAGCTCAGG TGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTCTCGCCCATCACCCCTCTCCAACAAGCTG CTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCTGGCGCCCCCAAGCCACCACCTGCTTCCC AGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGGGCACCGTCCATGGCAGGCACTGTGGCCC CAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAGTCAGTCTCCAATAAGCTTCTGGCCTGGA GCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTGACGCGGTCACTGCCCTGCCAGGTCTACG TGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATCCCCCAGCAGCTGCTGACCACCCTGGGCC CTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTCAAAGGCCTCTACCGCATCATGGGCAACG GCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCCATCAAGAAAATCTTTGATGCTTTTAGGGATA AGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGGGACCATCCCAACATCATCAGCCTCCTTGACGTGATCC GGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGACACTGACCTGAACGCAGTCATCCGGAAGGGCGGCCTGCTGCAGG ACGTCCACGTGCGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTCCACTCGGGGCACGTTGTGCACCGGGACCAGAAGCCGT CCAATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTGGCCCGCTCCCTGGGCGACCTCCCCGAGGGGCCTGAGG ACCAGGCCGTGACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTGCTGCTCTCTTCGCACCGATACACCCTTGGGGTGGACA TGTGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTCCCCGGCACGTCCACCCTCCACCAGCTGGAGCTGATCC TGGAGACCATCCCACCGCCATCTGAGGAGGACCTCCTGGCTCTCGGCTCAGGCTGCCGTGCCTCTGTGCTGCACCAGCTGGGGTCCCGGC CACGACAGACGCTGGATGCCCTCCTACCGCCAGACACCTCCCCAGAGGCCTTGGACCTCCTTAGGCGACTCCTGGTGTTCGCCCCGGACA AGCGGTTAAGCGCGACCCAGGCACTGCAGCACCCCTACGTGCAGAGGTTCCACTGCCCCAGCGACGAGTGGGCACGAGAGGCAGATGTGC GGCCCCGGGCACACGAAGGGGTCCAGCTCTCTGTGCCTGAGTACCGCAGCCGCGTCTATCAGATGATCCTGGAGTGTGGAGGCAGCAGCG GCACCTCGAGAGAGAAGGGCCCGGAGGGTGTCTCCCCAAGCCAGGCACACCTGCACAAACCCAGAGCCGACCCTCAGCTGCCTTCTAGGA CACCTGTGCAGGGTCCCAGACCCAGGCCCCAGAGCAGCCCAGGCCATGACCCTGCCGAGCACGAGTCCCCCCGTGCAGCCAAGAACGTTC CCAGGCAGAACTCCGCTCCCCTGCTCCAAACTGCTCTCCTAGGGAATGGGGAAAGGCCCCCTGGGGCGAAGGAAGCGCCCCCCTTGACAC TCTCGCTGGTGAAGCCAAGCGGGAGGGGAGCTGCGCCCTCCCTGACCTCCCAGGCTGCGGCTCAGGTGGCCAACCAGGCCCTGATCCGGG GTGACTGGAACCGGGGCGGTGGGGTGAGGGTGGCCAGCGTACAACAGGTCCCTCCCCGGCTTCCTCCGGAGGCCCGGCCCGGCCGGAGGA TGTTCAGCACCTCTGCCTTGCAGGGTGCCCAGGGGGGTGCCAGGGCTTTGCTTGGAGGCTACTCCCAAGCCTACGGGACTGTCTGCCACT CGGCACTGGGCCACCTGCCCCTGCTGGAGGGGCACCATGTGTGAGCCGCCCTACTCCCTTCACCTGGCCCTCTGTTCCTGCCCCAGCCCC TTCCCCAGACCCCTCTCCAGTCTCCTGCACCCCTTAGCCCTCCCTGCTTTGCCTGGCCCGTTGAAGTTCCAGGGAGCTTGCCCGGGTCTC >In-frame_MED25_ENST00000312865_chr19_50335672_+_MAPK15_ENST00000395107_chr8_144799864_+_2303nt ATTCCGCGGCGTCGGCTGCGGCTGCAGTGGTGGTGGCGGGTACCGCACGGGGTATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGA GCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCCTACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGG CCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGACTATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACA CAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGCGCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAGT TCATGGGCGGGGGTGGTGAGAGCTGCAGCCTCATCGCGGAAGGACTCAGCACAGCCTTGCAGCTGTTTGATGACTTCAAGAAGATGCGCG AGCAGATTGGCCAGACGCACCGGGTCTGCCTCCTCATCTGCAACTCACCCCCATACTTGTTGCCTGCTGTTGAGAGCACCACGTACTCTG GATGCACAACTGAGAATCTTGTGCAGCAGATTGGGGAGCGGGGGATCCACTTCTCCATTGTGTCTCCCCGGAAGCTGCCTGCGCTTCGGC TTCTGTTTGAGAAGGCAGCCCCCCCGGCCTTGCTGGAGCCGCTGCAGCCTCCGACAGATGTGAGCCAGGACCCGAGGCACATGGTGCTGG TTCGGGGACTCGTGCTGCCTGTTGGGGGTGGCTCAGCCCCAGGCCCCCTCCAGTCAAAGCAGCCAGTCCCCCTGCCTCCCGCCGCACCCT CAGGTGCCACTCTCTCAGCAGCCCCCCAGCAGCCTCTGCCCCCCGTCCCCCCGCAGTACCAGGTTCCCGGGAACCTGAGTGCAGCTCAGG TGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTCTCGCCCATCACCCCTCTCCAACAAGCTG CTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCTGGCGCCCCCAAGCCACCACCTGCTTCCC AGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGGGCACCGTCCATGGCAGGCACTGTGGCCC CAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAGTCAGTCTCCAATAAGCTTCTGGCCTGGA GCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTGACGCGGTCACTGCCCTGCCAGGTCTACG TGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATCCCCCAGCAGCTGCTGACCACCCTGGGCC CTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTCAAAGGCCTCTACCGCATCATGGGCAACG GCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCCATCAAGAAAATCTTTGATGCTTTTAGGGATA AGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGGGACCATCCCAACATCATCAGCCTCCTTGACGTGATCC GGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGGTTGCCCCCCCAGCCCCCCACCCCCGACTGCAGTGCGCACCCTCT CTGCAGACACTGACCTGAACGCAGTCATCCGGAAGGGCGGCCTGCTGCAGGACGTCCACGTGCGCTCCATCTTCTACCAGCTCCTGCGGG CCACCCGGTTCCTCCACTCGGGGCACGTTGTGCACCGGGACCAGAAGCCGTCCAATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGT GTGACTTTGGCCTGGCCCGCTCCCTGGGCGACCTCCCCGAGGGGCCTGAGGACCAGGCCGTGACAGAGTACGTGGCCACACGCTGGTACC GAGCACCGGAGGTGCTGCTCTCTTCGCACCGATACACCCTTGGGGTGGACATGTGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGG GGAGACCCCTGTTCCCCGGCACGTCCACCCTCCACCAGCTGGAGCTGATCCTGGAGACCATCCCACCGCCATCTGAGGAGGACCTCCTGG >In-frame_MED25_ENST00000312865_chr19_50335672_+_MAPK15_ENST00000395108_chr8_144799864_+_2234nt ATTCCGCGGCGTCGGCTGCGGCTGCAGTGGTGGTGGCGGGTACCGCACGGGGTATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGA GCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCCTACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGG CCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGACTATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACA CAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGCGCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAGT TCATGGGCGGGGGTGGTGAGAGCTGCAGCCTCATCGCGGAAGGACTCAGCACAGCCTTGCAGCTGTTTGATGACTTCAAGAAGATGCGCG AGCAGATTGGCCAGACGCACCGGGTCTGCCTCCTCATCTGCAACTCACCCCCATACTTGTTGCCTGCTGTTGAGAGCACCACGTACTCTG GATGCACAACTGAGAATCTTGTGCAGCAGATTGGGGAGCGGGGGATCCACTTCTCCATTGTGTCTCCCCGGAAGCTGCCTGCGCTTCGGC TTCTGTTTGAGAAGGCAGCCCCCCCGGCCTTGCTGGAGCCGCTGCAGCCTCCGACAGATGTGAGCCAGGACCCGAGGCACATGGTGCTGG TTCGGGGACTCGTGCTGCCTGTTGGGGGTGGCTCAGCCCCAGGCCCCCTCCAGTCAAAGCAGCCAGTCCCCCTGCCTCCCGCCGCACCCT CAGGTGCCACTCTCTCAGCAGCCCCCCAGCAGCCTCTGCCCCCCGTCCCCCCGCAGTACCAGGTTCCCGGGAACCTGAGTGCAGCTCAGG TGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTCTCGCCCATCACCCCTCTCCAACAAGCTG CTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCTGGCGCCCCCAAGCCACCACCTGCTTCCC AGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGGGCACCGTCCATGGCAGGCACTGTGGCCC CAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAGTCAGTCTCCAATAAGCTTCTGGCCTGGA GCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTGACGCGGTCACTGCCCTGCCAGGTCTACG TGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATCCCCCAGCAGCTGCTGACCACCCTGGGCC CTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTCAAAGGCCTCTACCGCATCATGGGCAACG GCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCCATCAAGAAAATCTTTGATGCTTTTAGGGATA AGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGGGACCATCCCAACATCATCAGCCTCCTTGACGTGATCC GGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGACACTGACCTGAACGCAGTCATCCGGAAGGGCGGCCTGCTGCAGG ACGTCCACGTGCGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTCCACTCGGGGCACGTTGTGCACCGGGACCAGAAGCCGT CCAATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTGGCCCGCTCCCTGGGCGACCTCCCCGAGGGGCCTGAGG ACCAGGCCGTGACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTGCTGCTCTCTTCGCACCGATACACCCTTGGGGTGGACA TGTGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTCCCCGGCACGTCCACCCTCCACCAGCTGGAGCTGATCC >In-frame_MED25_ENST00000538643_chr19_50335672_+_MAPK15_ENST00000338033_chr8_144799864_+_2619nt ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC GTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTC TCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCT GGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGG GCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAG TCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTG ACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATC CCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTC AAAGGCCTCTACCGCATCATGGGCAACGGCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCCATC AAGAAAATCTTTGATGCTTTTAGGGATAAGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGGGACCATCCC AACATCATCAGCCTCCTTGACGTGATCCGGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGACACTGACCTGAACGCA GTCATCCGGAAGGGCGGCCTGCTGCAGGACGTCCACGTGCGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTCCACTCGGGG CACGTTGTGCACCGGGACCAGAAGCCGTCCAATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTGGCCCGCTCC CTGGGCGACCTCCCCGAGGGGCCTGAGGACCAGGCCGTGACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTGCTGCTCTCT TCGCACCGATACACCCTTGGGGTGGACATGTGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTCCCCGGCACG TCCACCCTCCACCAGCTGGAGCTGATCCTGGAGACCATCCCACCGCCATCTGAGGAGGACCTCCTGGCTCTCGGCTCAGGCTGCCGTGCC TCTGTGCTGCACCAGCTGGGGTCCCGGCCACGACAGACGCTGGATGCCCTCCTACCGCCAGACACCTCCCCAGAGGCCTTGGACCTCCTT AGGCGACTCCTGGTGTTCGCCCCGGACAAGCGGTTAAGCGCGACCCAGGCACTGCAGCACCCCTACGTGCAGAGGTTCCACTGCCCCAGC GACGAGTGGGCACGAGAGGCAGATGTGCGGCCCCGGGCACACGAAGGGGTCCAGCTCTCTGTGCCTGAGTACCGCAGCCGCGTCTATCAG ATGATCCTGGAGTGTGGAGGCAGCAGCGGCACCTCGAGAGAGAAGGGCCCGGAGGGTGTCTCCCCAAGCCAGGCACACCTGCACAAACCC AGAGCCGACCCTCAGCTGCCTTCTAGGACACCTGTGCAGGGTCCCAGACCCAGGCCCCAGAGCAGCCCAGGCCATGACCCTGCCGAGCAC GAGTCCCCCCGTGCAGCCAAGAACGTTCCCAGGCAGAACTCCGCTCCCCTGCTCCAAACTGCTCTCCTAGGGAATGGGGAAAGGCCCCCT GGGGCGAAGGAAGCGCCCCCCTTGACACTCTCGCTGGTGAAGCCAAGCGGGAGGGGAGCTGCGCCCTCCCTGACCTCCCAGGCTGCGGCT CAGGTGGCCAACCAGGCCCTGATCCGGGGTGACTGGAACCGGGGCGGTGGGGTGAGGGTGGCCAGCGTACAACAGGTCCCTCCCCGGCTT CCTCCGGAGGCCCGGCCCGGCCGGAGGATGTTCAGCACCTCTGCCTTGCAGGGTGCCCAGGGGGGTGCCAGGGCTTTGCTTGGAGGCTAC TCCCAAGCCTACGGGACTGTCTGCCACTCGGCACTGGGCCACCTGCCCCTGCTGGAGGGGCACCATGTGTGAGCCGCCCTACTCCCTTCA CCTGGCCCTCTGTTCCTGCCCCAGCCCCTTCCCCAGACCCCTCTCCAGTCTCCTGCACCCCTTAGCCCTCCCTGCTTTGCCTGGCCCGTT GAAGTTCCAGGGAGCTTGCCCGGGTCTCCTCGGGGGAGCAGATGAGGGCCCTGCCCCCGCCCCACTGACTTCCTCCAATAAAGTCATGTC >In-frame_MED25_ENST00000538643_chr19_50335672_+_MAPK15_ENST00000395107_chr8_144799864_+_1611nt ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC GTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTC TCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCT GGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGG GCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAG TCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTG ACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATC CCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTC AAAGGCCTCTACCGCATCATGGGCAACGGCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCCATC AAGAAAATCTTTGATGCTTTTAGGGATAAGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGGGACCATCCC AACATCATCAGCCTCCTTGACGTGATCCGGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGGTTGCCCCCCCAGCCCC CCACCCCCGACTGCAGTGCGCACCCTCTCTGCAGACACTGACCTGAACGCAGTCATCCGGAAGGGCGGCCTGCTGCAGGACGTCCACGTG CGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTCCACTCGGGGCACGTTGTGCACCGGGACCAGAAGCCGTCCAATGTGCTC CTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTGGCCCGCTCCCTGGGCGACCTCCCCGAGGGGCCTGAGGACCAGGCCGTG ACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTGCTGCTCTCTTCGCACCGATACACCCTTGGGGTGGACATGTGGAGTCTG GGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTCCCCGGCACGTCCACCCTCCACCAGCTGGAGCTGATCCTGGAGACCATC >In-frame_MED25_ENST00000538643_chr19_50335672_+_MAPK15_ENST00000395108_chr8_144799864_+_1542nt ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC GTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTC TCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCT GGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGG GCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAG TCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTG ACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATC CCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTC AAAGGCCTCTACCGCATCATGGGCAACGGCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCCATC AAGAAAATCTTTGATGCTTTTAGGGATAAGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGGGACCATCCC AACATCATCAGCCTCCTTGACGTGATCCGGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGACACTGACCTGAACGCA GTCATCCGGAAGGGCGGCCTGCTGCAGGACGTCCACGTGCGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTCCACTCGGGG CACGTTGTGCACCGGGACCAGAAGCCGTCCAATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTGGCCCGCTCC CTGGGCGACCTCCCCGAGGGGCCTGAGGACCAGGCCGTGACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTGCTGCTCTCT TCGCACCGATACACCCTTGGGGTGGACATGTGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTCCCCGGCACG TCCACCCTCCACCAGCTGGAGCTGATCCTGGAGACCATCCCACCGCCATCTGAGGAGGGGGCCCAGACTGCCTGCAGGTCAGGCACAGGG |
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FusionGenePPI for MED25_MAPK15 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MED25 | MED10, MED9, MED29, MED19, MED28, MED26, MED15, CDK8, MED6, MED1, TRRAP, MED12, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, SREBF1, MED13, MED14, MED23, MED25, MED16, MED17, MED7, RARA, RXRA, THRA, ESR1, NR3C1, CREBBP, CTDP1, NOTCH1, EPAS1, MED24, MED4, POLR2F, MED18, MED21, CCNC, FEZ1 | MAPK15 | CLIC3, PCNA, HSP90AA1, GABARAP, GABARAPL1, MAP1LC3B, MAPK12, ESYT2, LTF, WDR81, CACNA1H, RBM14, PIGR, B2M, CDK2, EGFR, NAMPT, CCT2, CCT3, CCT6B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | MED25 | chr19:50335672 | chr8:144799864 | ENST00000312865 | + | 13 | 18 | 1_226 | 494 | 748 | the Mediator complex |
| Hgene | MED25 | chr19:50335672 | chr8:144799864 | ENST00000538643 | + | 8 | 13 | 1_226 | 281 | 535 | the Mediator complex |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MED25 | chr19:50335672 | chr8:144799864 | ENST00000312865 | + | 13 | 18 | 395_545 | 494 | 748 | CREBBP |
| Hgene | MED25 | chr19:50335672 | chr8:144799864 | ENST00000538643 | + | 8 | 13 | 395_545 | 281 | 535 | CREBBP |
| Hgene | MED25 | chr19:50335672 | chr8:144799864 | ENST00000312865 | + | 13 | 18 | 564_653 | 494 | 748 | RARA |
| Hgene | MED25 | chr19:50335672 | chr8:144799864 | ENST00000312865 | + | 13 | 18 | 640_707 | 494 | 748 | RARA |
| Hgene | MED25 | chr19:50335672 | chr8:144799864 | ENST00000538643 | + | 8 | 13 | 564_653 | 281 | 535 | RARA |
| Hgene | MED25 | chr19:50335672 | chr8:144799864 | ENST00000538643 | + | 8 | 13 | 640_707 | 281 | 535 | RARA |
| Hgene | MED25 | chr19:50335672 | chr8:144799864 | ENST00000312865 | + | 13 | 18 | 389_543 | 494 | 748 | VP16 |
| Hgene | MED25 | chr19:50335672 | chr8:144799864 | ENST00000538643 | + | 8 | 13 | 389_543 | 281 | 535 | VP16 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MED25_MAPK15 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MED25_MAPK15 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MED25 | C1854150 | Charcot-Marie-Tooth disease, Type 2B2 | 1 | CTD_human;ORPHANET;UNIPROT |
| Hgene | MED25 | C4225323 | BASEL-VANAGAITE-SMIRIN-YOSEF SYNDROME | 1 | ORPHANET;UNIPROT |
| Tgene | MAPK15 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
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