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Fusion gene ID: 21552 |
FusionGeneSummary for MED25_CCDC155 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MED25_CCDC155 | Fusion gene ID: 21552 | Hgene | Tgene | Gene symbol | MED25 | CCDC155 | Gene ID | 81857 | 147872 |
| Gene name | mediator complex subunit 25 | coiled-coil domain containing 155 | |
| Synonyms | ACID1|ARC92|BVSYS|CMT2B2|P78|PTOV2|TCBAP0758 | KASH5 | |
| Cytomap | 19q13.33 | 19q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mediator of RNA polymerase II transcription subunit 25ARC/mediator transcriptional coactivator subunitactivator interaction domain-containing protein 1activator-recruited cofactor 92 kDa componentmediator of RNA polymerase II transcription, subunit 25 | protein KASH5KASH domain-containing protein 5 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q71SY5 | Q8N6L0 | |
| Ensembl transtripts involved in fusion gene | ENST00000312865, ENST00000538643, | ENST00000447857, ENST00000593725, | |
| Fusion gene scores | * DoF score | 6 X 3 X 4=72 | 6 X 5 X 6=180 |
| # samples | 6 | 6 | |
| ** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MED25 [Title/Abstract] AND CCDC155 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MED25 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17641689 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-B5-A5OD-01A | MED25 | chr19 | 50335672 | + | CCDC155 | chr19 | 49910143 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000312865 | ENST00000447857 | MED25 | chr19 | 50335672 | + | CCDC155 | chr19 | 49910143 | + |
| 5CDS-intron | ENST00000312865 | ENST00000593725 | MED25 | chr19 | 50335672 | + | CCDC155 | chr19 | 49910143 | + |
| In-frame | ENST00000538643 | ENST00000447857 | MED25 | chr19 | 50335672 | + | CCDC155 | chr19 | 49910143 | + |
| 5CDS-intron | ENST00000538643 | ENST00000593725 | MED25 | chr19 | 50335672 | + | CCDC155 | chr19 | 49910143 | + |
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FusionProtFeatures for MED25_CCDC155 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MED25 | CCDC155 |
| As a component of the LINC (LInker of Nucleoskeleton andCytoskeleton) complex, involved in the connection between thenuclear lamina and the cytoskeleton. The nucleocytoplasmicinteractions established by the LINC complex play an importantrole in the transmission of mechanical forces across the nuclearenvelope and in nuclear movement and positioning. Required fortelomere attachment to nuclear envelope in the prophase of meiosisand for rapid telomere prophase movements implicating aSUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act atleast partial redundantly. Required for homologue pairing duringmeiotic prophase in spermatocytes and probably oocytes. Essentialfor male and female gametogenesis. Recruits cytoplasmic dynein totelomere attachment sites at the nuclear envelope inspermatocytes. In oocytes is involved in meiotic resumption andspindle formation. {ECO:0000250|UniProtKB:Q80VJ8}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MED25 | chr19:50335672 | chr19:49910143 | ENST00000312865 | + | 13 | 18 | 200_381 | 494 | 748 | Compositional bias | Note=Pro-rich |
| Tgene | >CCDC155 | chr19:50335672 | chr19:49910143 | ENST00000447857 | + | 8 | 20 | 448_451 | 266 | 563 | Compositional bias | Note=Poly-Glu |
| Tgene | >CCDC155 | chr19:50335672 | chr19:49910143 | ENST00000447857 | + | 8 | 20 | 528_536 | 266 | 563 | Compositional bias | Note=Poly-Leu |
| Tgene | >CCDC155 | chr19:50335672 | chr19:49910143 | ENST00000447857 | + | 8 | 20 | 543_562 | 266 | 563 | Topological domain | Perinuclear space |
| Tgene | >CCDC155 | chr19:50335672 | chr19:49910143 | ENST00000447857 | + | 8 | 20 | 522_542 | 266 | 563 | Transmembrane | Helical%3B Anchor for type IV membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MED25 | chr19:50335672 | chr19:49910143 | ENST00000312865 | + | 13 | 18 | 565_735 | 494 | 748 | Compositional bias | Note=Pro-rich |
| Hgene | >MED25 | chr19:50335672 | chr19:49910143 | ENST00000538643 | + | 8 | 13 | 200_381 | 281 | 535 | Compositional bias | Note=Pro-rich |
| Hgene | >MED25 | chr19:50335672 | chr19:49910143 | ENST00000538643 | + | 8 | 13 | 565_735 | 281 | 535 | Compositional bias | Note=Pro-rich |
| Hgene | >MED25 | chr19:50335672 | chr19:49910143 | ENST00000312865 | + | 13 | 18 | 646_650 | 494 | 748 | Motif | Note=LXXLL motif |
| Hgene | >MED25 | chr19:50335672 | chr19:49910143 | ENST00000538643 | + | 8 | 13 | 646_650 | 281 | 535 | Motif | Note=LXXLL motif |
| Tgene | CCDC155 | chr19:50335672 | chr19:49910143 | ENST00000447857 | + | 8 | 20 | 164_349 | 266 | 563 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CCDC155 | chr19:50335672 | chr19:49910143 | ENST00000447857 | + | 8 | 20 | 1_521 | 266 | 563 | Topological domain | Cytoplasmic |
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FusionGeneSequence for MED25_CCDC155 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MED25_ENST00000312865_chr19_50335672_+_CCDC155_ENST00000447857_chr19_49910143_+_791aa MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS AYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHF SIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPP QYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTA QPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIM QLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFNGKLLAERDGVKKRSQELAMEKDTLKRQLFECEHLICQRDTILSER TRDVESLAQTLEEYRVTTQELRLEISRLEEQLSQTYEGPDELPEGAQLRRVGWTELLPPSLGLEIEAIRQKQEVATADLSNPLCGVWQWE EVIHETSEETEFPSEAPAGGQRNFQGEPAHPEEGRKEPSMWLTRREEEEDAESQVTADLPVPLGAPRPGDIPENPPERPARRELQQALVP >In-frame_MED25_ENST00000538643_chr19_50335672_+_CCDC155_ENST00000447857_chr19_49910143_+_578aa MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRF SPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQ SVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESL KGLYRIMGNGFNGKLLAERDGVKKRSQELAMEKDTLKRQLFECEHLICQRDTILSERTRDVESLAQTLEEYRVTTQELRLEISRLEEQLS QTYEGPDELPEGAQLRRVGWTELLPPSLGLEIEAIRQKQEVATADLSNPLCGVWQWEEVIHETSEETEFPSEAPAGGQRNFQGEPAHPEE GRKEPSMWLTRREEEEDAESQVTADLPVPLGAPRPGDIPENPPERPARRELQQALVPVMKKLVPVRRRAWGQLCLPPQRLRVTRHPLIPA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MED25_ENST00000312865_chr19_50335672_+_CCDC155_ENST00000447857_chr19_49910143_+_2373nt ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC TATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACACAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGC GCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAGTTCATGGGCGGGGGTGGTGAGAGCTGCAGCCTCATCGCGGAAGGACTCAGCACA GCCTTGCAGCTGTTTGATGACTTCAAGAAGATGCGCGAGCAGATTGGCCAGACGCACCGGGTCTGCCTCCTCATCTGCAACTCACCCCCA TACTTGTTGCCTGCTGTTGAGAGCACCACGTACTCTGGATGCACAACTGAGAATCTTGTGCAGCAGATTGGGGAGCGGGGGATCCACTTC TCCATTGTGTCTCCCCGGAAGCTGCCTGCGCTTCGGCTTCTGTTTGAGAAGGCAGCCCCCCCGGCCTTGCTGGAGCCGCTGCAGCCTCCG ACAGATGTGAGCCAGGACCCGAGGCACATGGTGCTGGTTCGGGGACTCGTGCTGCCTGTTGGGGGTGGCTCAGCCCCAGGCCCCCTCCAG TCAAAGCAGCCAGTCCCCCTGCCTCCCGCCGCACCCTCAGGTGCCACTCTCTCAGCAGCCCCCCAGCAGCCTCTGCCCCCCGTCCCCCCG CAGTACCAGGTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGC CCTCGCTTCTCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCA GGACCCCCTGGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCA CAGCCCGGGGCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGT GGGCAGCAGTCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAAC ACCAAGCTGACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATG CAGCTCATCCCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTG GAGTCTCTCAAAGGCCTCTACCGCATCATGGGCAACGGCTTCAACGGGAAGCTGCTTGCCGAGCGGGATGGAGTGAAAAAGAGAAGTCAG GAGCTGGCCATGGAGAAGGACACTTTGAAGCGGCAGCTCTTTGAGTGTGAACACCTCATTTGCCAAAGAGACACCATCCTCTCTGAGCGC ACTCGCGATGTGGAGAGCCTGGCCCAGACCCTGGAAGAATACAGAGTGACGACGCAGGAACTGAGGCTGGAGATTTCACGCCTGGAGGAG CAGCTGAGTCAGACCTATGAGGGGCCCGATGAGCTACCTGAAGGGGCCCAGCTGAGAAGAGTGGGCTGGACCGAGCTGCTACCCCCATCG CTGGGCTTGGAGATCGAGGCCATTCGACAGAAACAGGAAGTGGCAACTGCTGATCTCTCCAACCCTCTGTGTGGGGTGTGGCAGTGGGAG GAAGTCATCCATGAGACCAGTGAGGAAACTGAGTTTCCATCTGAAGCCCCAGCTGGGGGACAGAGAAACTTCCAGGGAGAGCCAGCGCAC CCTGAAGAAGGAAGGAAGGAGCCATCCATGTGGTTGACCAGAAGAGAGGAAGAGGAGGATGCAGAGAGCCAGGTCACGGCTGATCTCCCT GTCCCTCTAGGAGCCCCTCGCCCTGGAGACATCCCAGAAAACCCTCCAGAGAGACCTGCGCGGCGGGAACTCCAGCAAGCCCTGGTGCCT GTGATGAAAAAGCTGGTCCCAGTCAGGAGGAGGGCCTGGGGCCAGCTCTGCCTGCCCCCACAGCGGCTCAGAGTCACTCGACATCCACTG ATCCCAGCTCCTGTCCTGGGCCTGCTGCTGCTGCTGCTGCTCTCTGTCCTGCTGCTTGGCCCGTCCCCACCTCCCACCTGGCCCCACCTC >In-frame_MED25_ENST00000538643_chr19_50335672_+_CCDC155_ENST00000447857_chr19_49910143_+_1734nt ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC GTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTC TCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCT GGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGG GCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAG TCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTG ACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATC CCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTC AAAGGCCTCTACCGCATCATGGGCAACGGCTTCAACGGGAAGCTGCTTGCCGAGCGGGATGGAGTGAAAAAGAGAAGTCAGGAGCTGGCC ATGGAGAAGGACACTTTGAAGCGGCAGCTCTTTGAGTGTGAACACCTCATTTGCCAAAGAGACACCATCCTCTCTGAGCGCACTCGCGAT GTGGAGAGCCTGGCCCAGACCCTGGAAGAATACAGAGTGACGACGCAGGAACTGAGGCTGGAGATTTCACGCCTGGAGGAGCAGCTGAGT CAGACCTATGAGGGGCCCGATGAGCTACCTGAAGGGGCCCAGCTGAGAAGAGTGGGCTGGACCGAGCTGCTACCCCCATCGCTGGGCTTG GAGATCGAGGCCATTCGACAGAAACAGGAAGTGGCAACTGCTGATCTCTCCAACCCTCTGTGTGGGGTGTGGCAGTGGGAGGAAGTCATC CATGAGACCAGTGAGGAAACTGAGTTTCCATCTGAAGCCCCAGCTGGGGGACAGAGAAACTTCCAGGGAGAGCCAGCGCACCCTGAAGAA GGAAGGAAGGAGCCATCCATGTGGTTGACCAGAAGAGAGGAAGAGGAGGATGCAGAGAGCCAGGTCACGGCTGATCTCCCTGTCCCTCTA GGAGCCCCTCGCCCTGGAGACATCCCAGAAAACCCTCCAGAGAGACCTGCGCGGCGGGAACTCCAGCAAGCCCTGGTGCCTGTGATGAAA AAGCTGGTCCCAGTCAGGAGGAGGGCCTGGGGCCAGCTCTGCCTGCCCCCACAGCGGCTCAGAGTCACTCGACATCCACTGATCCCAGCT CCTGTCCTGGGCCTGCTGCTGCTGCTGCTGCTCTCTGTCCTGCTGCTTGGCCCGTCCCCACCTCCCACCTGGCCCCACCTCCAGCTCTGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MED25_ENST00000312865_chr19_50335672_+_CCDC155_ENST00000447857_chr19_49910143_+_2910nt ATTCCGCGGCGTCGGCTGCGGCTGCAGTGGTGGTGGCGGGTACCGCACGGGGTATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGA GCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCCTACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGG CCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGACTATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACA CAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGCGCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAGT TCATGGGCGGGGGTGGTGAGAGCTGCAGCCTCATCGCGGAAGGACTCAGCACAGCCTTGCAGCTGTTTGATGACTTCAAGAAGATGCGCG AGCAGATTGGCCAGACGCACCGGGTCTGCCTCCTCATCTGCAACTCACCCCCATACTTGTTGCCTGCTGTTGAGAGCACCACGTACTCTG GATGCACAACTGAGAATCTTGTGCAGCAGATTGGGGAGCGGGGGATCCACTTCTCCATTGTGTCTCCCCGGAAGCTGCCTGCGCTTCGGC TTCTGTTTGAGAAGGCAGCCCCCCCGGCCTTGCTGGAGCCGCTGCAGCCTCCGACAGATGTGAGCCAGGACCCGAGGCACATGGTGCTGG TTCGGGGACTCGTGCTGCCTGTTGGGGGTGGCTCAGCCCCAGGCCCCCTCCAGTCAAAGCAGCCAGTCCCCCTGCCTCCCGCCGCACCCT CAGGTGCCACTCTCTCAGCAGCCCCCCAGCAGCCTCTGCCCCCCGTCCCCCCGCAGTACCAGGTTCCCGGGAACCTGAGTGCAGCTCAGG TGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTCTCGCCCATCACCCCTCTCCAACAAGCTG CTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCTGGCGCCCCCAAGCCACCACCTGCTTCCC AGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGGGCACCGTCCATGGCAGGCACTGTGGCCC CAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAGTCAGTCTCCAATAAGCTTCTGGCCTGGA GCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTGACGCGGTCACTGCCCTGCCAGGTCTACG TGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATCCCCCAGCAGCTGCTGACCACCCTGGGCC CTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTCAAAGGCCTCTACCGCATCATGGGCAACG GCTTCAACGGGAAGCTGCTTGCCGAGCGGGATGGAGTGAAAAAGAGAAGTCAGGAGCTGGCCATGGAGAAGGACACTTTGAAGCGGCAGC TCTTTGAGTGTGAACACCTCATTTGCCAAAGAGACACCATCCTCTCTGAGCGCACTCGCGATGTGGAGAGCCTGGCCCAGACCCTGGAAG AATACAGAGTGACGACGCAGGAACTGAGGCTGGAGATTTCACGCCTGGAGGAGCAGCTGAGTCAGACCTATGAGGGGCCCGATGAGCTAC CTGAAGGGGCCCAGCTGAGAAGAGTGGGCTGGACCGAGCTGCTACCCCCATCGCTGGGCTTGGAGATCGAGGCCATTCGACAGAAACAGG AAGTGGCAACTGCTGATCTCTCCAACCCTCTGTGTGGGGTGTGGCAGTGGGAGGAAGTCATCCATGAGACCAGTGAGGAAACTGAGTTTC CATCTGAAGCCCCAGCTGGGGGACAGAGAAACTTCCAGGGAGAGCCAGCGCACCCTGAAGAAGGAAGGAAGGAGCCATCCATGTGGTTGA CCAGAAGAGAGGAAGAGGAGGATGCAGAGAGCCAGGTCACGGCTGATCTCCCTGTCCCTCTAGGAGCCCCTCGCCCTGGAGACATCCCAG AAAACCCTCCAGAGAGACCTGCGCGGCGGGAACTCCAGCAAGCCCTGGTGCCTGTGATGAAAAAGCTGGTCCCAGTCAGGAGGAGGGCCT GGGGCCAGCTCTGCCTGCCCCCACAGCGGCTCAGAGTCACTCGACATCCACTGATCCCAGCTCCTGTCCTGGGCCTGCTGCTGCTGCTGC TGCTCTCTGTCCTGCTGCTTGGCCCGTCCCCACCTCCCACCTGGCCCCACCTCCAGCTCTGCTACCTCCAGCCCCCTCCAGTGTGAGAGG CTCTACTTGCCCCTCAGAGCAGTGTCTAGCTCAATAAATCCCCTGGCCCTCTCTCCACTGGGATCCCCATTGTTAGTCCACTGTTGCGCA GGCTTACCCTAGATAGAGTACAGGGGATCCACATCCCTGTATTTTTATGTGAAGTCTCCTAGTTTTTTAATGCTGACATTTCTTAACAAT AGCAAAACTCCCCCAGTAATGGATTAAGCACTAAGGATTATTCCCTCACAAAACAAGCCTGGCGAGGGCAGCTGTGGGCACACAGCTAAG TCTCGGTTGCCTTGGGGTCAGGGCCTCAGTGATTCTCCTGTCCCCTCCCTCATGCTCAGGAGTTGGCAGTTGTAGCTTCCTACATCACAT CTGCGGGAAACGGAAATTTCTTCCTTCCTTTTTATAAAGAGAGGCAGTAGCCTCAGTGTGCAGTGGGTAGATTCAAATCATATTCATAAT >In-frame_MED25_ENST00000538643_chr19_50335672_+_CCDC155_ENST00000447857_chr19_49910143_+_2218nt ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC GTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTC TCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCT GGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGG GCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAG TCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTG ACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATC CCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTC AAAGGCCTCTACCGCATCATGGGCAACGGCTTCAACGGGAAGCTGCTTGCCGAGCGGGATGGAGTGAAAAAGAGAAGTCAGGAGCTGGCC ATGGAGAAGGACACTTTGAAGCGGCAGCTCTTTGAGTGTGAACACCTCATTTGCCAAAGAGACACCATCCTCTCTGAGCGCACTCGCGAT GTGGAGAGCCTGGCCCAGACCCTGGAAGAATACAGAGTGACGACGCAGGAACTGAGGCTGGAGATTTCACGCCTGGAGGAGCAGCTGAGT CAGACCTATGAGGGGCCCGATGAGCTACCTGAAGGGGCCCAGCTGAGAAGAGTGGGCTGGACCGAGCTGCTACCCCCATCGCTGGGCTTG GAGATCGAGGCCATTCGACAGAAACAGGAAGTGGCAACTGCTGATCTCTCCAACCCTCTGTGTGGGGTGTGGCAGTGGGAGGAAGTCATC CATGAGACCAGTGAGGAAACTGAGTTTCCATCTGAAGCCCCAGCTGGGGGACAGAGAAACTTCCAGGGAGAGCCAGCGCACCCTGAAGAA GGAAGGAAGGAGCCATCCATGTGGTTGACCAGAAGAGAGGAAGAGGAGGATGCAGAGAGCCAGGTCACGGCTGATCTCCCTGTCCCTCTA GGAGCCCCTCGCCCTGGAGACATCCCAGAAAACCCTCCAGAGAGACCTGCGCGGCGGGAACTCCAGCAAGCCCTGGTGCCTGTGATGAAA AAGCTGGTCCCAGTCAGGAGGAGGGCCTGGGGCCAGCTCTGCCTGCCCCCACAGCGGCTCAGAGTCACTCGACATCCACTGATCCCAGCT CCTGTCCTGGGCCTGCTGCTGCTGCTGCTGCTCTCTGTCCTGCTGCTTGGCCCGTCCCCACCTCCCACCTGGCCCCACCTCCAGCTCTGC TACCTCCAGCCCCCTCCAGTGTGAGAGGCTCTACTTGCCCCTCAGAGCAGTGTCTAGCTCAATAAATCCCCTGGCCCTCTCTCCACTGGG ATCCCCATTGTTAGTCCACTGTTGCGCAGGCTTACCCTAGATAGAGTACAGGGGATCCACATCCCTGTATTTTTATGTGAAGTCTCCTAG TTTTTTAATGCTGACATTTCTTAACAATAGCAAAACTCCCCCAGTAATGGATTAAGCACTAAGGATTATTCCCTCACAAAACAAGCCTGG CGAGGGCAGCTGTGGGCACACAGCTAAGTCTCGGTTGCCTTGGGGTCAGGGCCTCAGTGATTCTCCTGTCCCCTCCCTCATGCTCAGGAG TTGGCAGTTGTAGCTTCCTACATCACATCTGCGGGAAACGGAAATTTCTTCCTTCCTTTTTATAAAGAGAGGCAGTAGCCTCAGTGTGCA |
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FusionGenePPI for MED25_CCDC155 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MED25 | MED10, MED9, MED29, MED19, MED28, MED26, MED15, CDK8, MED6, MED1, TRRAP, MED12, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, SREBF1, MED13, MED14, MED23, MED25, MED16, MED17, MED7, RARA, RXRA, THRA, ESR1, NR3C1, CREBBP, CTDP1, NOTCH1, EPAS1, MED24, MED4, POLR2F, MED18, MED21, CCNC, FEZ1 | CCDC155 | CCDC87, KDM1A, BCL2L2, MS4A1, CRABP2, GALNT2, GPR25, HMOX1, CXCL9, MMP14, PDGFRA, PLP2, SGTA, SLN, STX5, VAMP1, UPK1B, UPK2, SLC30A2, MALL, VAMP4, STBD1, CLDN8, ADIPOQ, ITM2B, BAG5, GOSR2, BET1, OLFM4, MTX2, FTCD, ATF7, GABARAPL2, TCF25, LARP1, NSG1, FIS1, MARCH2, CDKL3, TMEM14C, GPATCH4, FAM90A1, TMPRSS4, NRIP3, SMCO4, TSHZ3, CXCL16, ZNF250, SENP2, RSRC2, LENG1, C17orf62, CDC73, TRAF3IP3, RNF146, SLC41A2, FAM161A, JAGN1, ABHD1, MFSD5, FATE1, TMEM41A, CIB3, FRA10AC1, RIPPLY2, TMEM199, PPP1R18, LHFPL5, RTP2, SERP2, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | MED25 | chr19:50335672 | chr19:49910143 | ENST00000312865 | + | 13 | 18 | 1_226 | 494 | 748 | the Mediator complex |
| Hgene | MED25 | chr19:50335672 | chr19:49910143 | ENST00000538643 | + | 8 | 13 | 1_226 | 281 | 535 | the Mediator complex |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MED25 | chr19:50335672 | chr19:49910143 | ENST00000312865 | + | 13 | 18 | 395_545 | 494 | 748 | CREBBP |
| Hgene | MED25 | chr19:50335672 | chr19:49910143 | ENST00000538643 | + | 8 | 13 | 395_545 | 281 | 535 | CREBBP |
| Hgene | MED25 | chr19:50335672 | chr19:49910143 | ENST00000312865 | + | 13 | 18 | 564_653 | 494 | 748 | RARA |
| Hgene | MED25 | chr19:50335672 | chr19:49910143 | ENST00000312865 | + | 13 | 18 | 640_707 | 494 | 748 | RARA |
| Hgene | MED25 | chr19:50335672 | chr19:49910143 | ENST00000538643 | + | 8 | 13 | 564_653 | 281 | 535 | RARA |
| Hgene | MED25 | chr19:50335672 | chr19:49910143 | ENST00000538643 | + | 8 | 13 | 640_707 | 281 | 535 | RARA |
| Hgene | MED25 | chr19:50335672 | chr19:49910143 | ENST00000312865 | + | 13 | 18 | 389_543 | 494 | 748 | VP16 |
| Hgene | MED25 | chr19:50335672 | chr19:49910143 | ENST00000538643 | + | 8 | 13 | 389_543 | 281 | 535 | VP16 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MED25_CCDC155 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MED25_CCDC155 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MED25 | C1854150 | Charcot-Marie-Tooth disease, Type 2B2 | 1 | CTD_human;ORPHANET;UNIPROT |
| Hgene | MED25 | C4225323 | BASEL-VANAGAITE-SMIRIN-YOSEF SYNDROME | 1 | ORPHANET;UNIPROT |
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