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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 21546

FusionGeneSummary for MED24_SLC4A1

check button Fusion gene summary
Fusion gene informationFusion gene name: MED24_SLC4A1
Fusion gene ID: 21546
HgeneTgene
Gene symbol

MED24

SLC4A1

Gene ID

9862

6521

Gene namemediator complex subunit 24solute carrier family 4 member 1 (Diego blood group)
SynonymsARC100|CRSP100|CRSP4|DRIP100|MED5|THRAP4|TRAP100AE1|BND3|CD233|CHC|DI|EMPB3|EPB3|FR|RTA1A|SAO|SPH4|SW|WD|WD1|WR
Cytomap

17q21.1

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 24CRSP complex subunit 4activator-recruited cofactor 100 kDa componentcofactor required for Sp1 transcriptional activation subunit 4cofactor required for Sp1 transcriptional activation, subunit 4, 10band 3 anion transport proteinDiego blood groupFroese blood groupSwann blood groupWaldner blood groupWright blood groupanion exchange protein 1anion exchanger-1erythrocyte membrane protein band 3erythroid anion exchange proteinsolute carrier fam
Modification date2018052320180523
UniProtAcc

O75448

P02730

Ensembl transtripts involved in fusion geneENST00000394126, ENST00000356271, 
ENST00000394128, ENST00000394127, 
ENST00000501516, ENST00000479829, 
ENST00000262418, ENST00000471005, 
Fusion gene scores* DoF score14 X 9 X 8=10081 X 1 X 1=1
# samples 151
** MAII scorelog2(15/1008*10)=-2.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: MED24 [Title/Abstract] AND SLC4A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMED24

GO:0006367

transcription initiation from RNA polymerase II promoter

12218053

HgeneMED24

GO:0030518

intracellular steroid hormone receptor signaling pathway

11867769

HgeneMED24

GO:0030521

androgen receptor signaling pathway

12218053

HgeneMED24

GO:0045893

positive regulation of transcription, DNA-templated

10198638

TgeneSLC4A1

GO:0006820

anion transport

14734552

TgeneSLC4A1

GO:0015701

bicarbonate transport

24121512


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0B7-01AMED24chr17

38179384

-SLC4A1chr17

42328700

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000394126ENST00000262418MED24chr17

38179384

-SLC4A1chr17

42328700

-
5CDS-intronENST00000394126ENST00000471005MED24chr17

38179384

-SLC4A1chr17

42328700

-
Frame-shiftENST00000356271ENST00000262418MED24chr17

38179384

-SLC4A1chr17

42328700

-
5CDS-intronENST00000356271ENST00000471005MED24chr17

38179384

-SLC4A1chr17

42328700

-
Frame-shiftENST00000394128ENST00000262418MED24chr17

38179384

-SLC4A1chr17

42328700

-
5CDS-intronENST00000394128ENST00000471005MED24chr17

38179384

-SLC4A1chr17

42328700

-
Frame-shiftENST00000394127ENST00000262418MED24chr17

38179384

-SLC4A1chr17

42328700

-
5CDS-intronENST00000394127ENST00000471005MED24chr17

38179384

-SLC4A1chr17

42328700

-
In-frameENST00000501516ENST00000262418MED24chr17

38179384

-SLC4A1chr17

42328700

-
5CDS-intronENST00000501516ENST00000471005MED24chr17

38179384

-SLC4A1chr17

42328700

-
intron-3CDSENST00000479829ENST00000262418MED24chr17

38179384

-SLC4A1chr17

42328700

-
intron-intronENST00000479829ENST00000471005MED24chr17

38179384

-SLC4A1chr17

42328700

-

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FusionProtFeatures for MED24_SLC4A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED24

O75448

SLC4A1

P02730

Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. {ECO:0000269|PubMed:12218053,ECO:0000269|PubMed:16595664}. Functions both as a transporter that mediateselectroneutral anion exchange across the cell membrane and as astructural protein. Major integral membrane glycoprotein of theerythrocyte membrane; required for normal flexibility andstability of the erythrocyte membrane and for normal erythrocyteshape via the interactions of its cytoplasmic domain withcytoskeletal proteins, glycolytic enzymes, and hemoglobin.Functions as a transporter that mediates the 1:1 exchange ofinorganic anions across the erythrocyte membrane. Mediateschloride-bicarbonate exchange in the kidney, and is required fornormal acidification of the urine. {ECO:0000269|PubMed:10926824,ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405,ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED24chr17:38179384chr17:42328700ENST00000356271-1925128_132737977MotifNote=LXXLL motif 1
HgeneMED24chr17:38179384chr17:42328700ENST00000356271-1925344_348737977MotifNote=LXXLL motif 2
HgeneMED24chr17:38179384chr17:42328700ENST00000356271-1925448_452737977MotifNote=LXXLL motif 3
HgeneMED24chr17:38179384chr17:42328700ENST00000356271-1925557_561737977MotifNote=LXXLL motif 4
HgeneMED24chr17:38179384chr17:42328700ENST00000394127-1925128_132737977MotifNote=LXXLL motif 1
HgeneMED24chr17:38179384chr17:42328700ENST00000394127-1925344_348737977MotifNote=LXXLL motif 2
HgeneMED24chr17:38179384chr17:42328700ENST00000394127-1925448_452737977MotifNote=LXXLL motif 3
HgeneMED24chr17:38179384chr17:42328700ENST00000394127-1925557_561737977MotifNote=LXXLL motif 4
HgeneMED24chr17:38179384chr17:42328700ENST00000394128-2026128_132750990MotifNote=LXXLL motif 1
HgeneMED24chr17:38179384chr17:42328700ENST00000394128-2026344_348750990MotifNote=LXXLL motif 2
HgeneMED24chr17:38179384chr17:42328700ENST00000394128-2026448_452750990MotifNote=LXXLL motif 3
HgeneMED24chr17:38179384chr17:42328700ENST00000394128-2026557_561750990MotifNote=LXXLL motif 4
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720839_869827912IntramembraneDiscontinuously helical
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720870_911827912Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED24chr17:38179384chr17:42328700ENST00000356271-1925788_792737977MotifNote=LXXLL motif 5
HgeneMED24chr17:38179384chr17:42328700ENST00000356271-1925857_861737977MotifNote=LXXLL motif 6
HgeneMED24chr17:38179384chr17:42328700ENST00000394127-1925788_792737977MotifNote=LXXLL motif 5
HgeneMED24chr17:38179384chr17:42328700ENST00000394127-1925857_861737977MotifNote=LXXLL motif 6
HgeneMED24chr17:38179384chr17:42328700ENST00000394128-2026788_792750990MotifNote=LXXLL motif 5
HgeneMED24chr17:38179384chr17:42328700ENST00000394128-2026857_861750990MotifNote=LXXLL motif 6
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720304_357827912RegionNote=Dimerization arm
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720559_630827912RegionNote=Involved in anion transport
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-172055_290827912RegionNote=Globular
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-17201_403827912Topological domainCytoplasmic
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720428_435827912Topological domainExtracellular
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720457_459827912Topological domainCytoplasmic
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720477_485827912Topological domainExtracellular
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720507_518827912Topological domainCytoplasmic
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720542_570827912Topological domainExtracellular
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720592_602827912Topological domainCytoplasmic
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720624_663827912Topological domainExtracellular
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720685_700827912Topological domainCytoplasmic
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720738_760827912Topological domainCytoplasmic
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720801_838827912Topological domainCytoplasmic
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720404_427827912TransmembraneHelical%3B Name%3D1
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720436_456827912TransmembraneHelical%3B Name%3D2
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720460_476827912TransmembraneDiscontinuously helical%3B Name%3D3
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720519_541827912TransmembraneHelical%3B Name%3D5
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720571_591827912TransmembraneHelical%3B Name%3D6
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720603_623827912TransmembraneHelical%3B Name%3D7
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720664_684827912TransmembraneHelical%3B Name%3D8
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720701_719827912TransmembraneHelical%3B Name%3D9
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720720_737827912TransmembraneDiscontinuously helical%3B Name%3D10
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720761_781827912TransmembraneHelical%3B Name%3D11
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720782_800827912TransmembraneHelical%3B Name%3D12


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FusionGeneSequence for MED24_SLC4A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MED24_ENST00000394126_chr17_38179384_-_SLC4A1_ENST00000262418_chr17_42328700_-_860aa
MSFSLAPFLSPQSWPPPLPPAQSEIMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLK
YAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGE
KQLAMCLQRLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVH
AVILLEGTMNLTGETQSLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVN
CAFEFLLKLTPLLDKADQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNILKTMD
ADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSE
SRTGAEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKI
TDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLFSENTLQFYNERVVIMNSILERMCADVLQQTATQIKFPSTGVDTM
PYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFV

>In-frame_MED24_ENST00000501516_chr17_38179384_-_SLC4A1_ENST00000262418_chr17_42328700_-_854aa
MKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSR
DLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHI
AKLEEASLHTSQGLGQGGTRANQPTASWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVHAVILLE
GTMNLTGETQSLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFL
LKLTPLLDKADQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNILKTMDADHSKS
PEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAE
VPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKG
KVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLFSENTLQFYNERVVIMNSILERMCADVLQQTATQIKFPSTGVDTMPYWNLL
PPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFVLILTVP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MED24_ENST00000394126_chr17_38179384_-_SLC4A1_ENST00000262418_chr17_42328700_-_2580nt
ATGTCCTTTTCTTTAGCTCCATTTCTTTCACCTCAAAGCTGGCCGCCACCGCTGCCACCTGCTCAGAGTGAAATAATGAAGGTGGTCAAC
CTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCAACATGAAGAAATTCTTTCCTAAAGGAGCC
ACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCCCCAATCCTCTCATCTTGTCCTACCTGAAG
TATGCCATTAGTTCCCAGATGGTGTCCTACTCTTCTGTCCTCACAGCCATCAGTAAGTTTGATGACTTTTCTCGGGACCTGTGTGTCCAG
GCATTGCTGGACATCATGGACATGTTTTGTGACCGTCTGAGCTGTCACGGCAAAGCAGAGGAATGCATCGGACTGTGCCGAGCCCTTCTT
AGCGCCCTCCACTGGCTGCTGCGCTGCACGGCAGCCTCTGCAGAGCGGCTGCGGGAGGGGCTGGAGGCCGGCACTCCAGCCGCTGGGGAG
AAGCAGCTTGCCATGTGCCTTCAGCGCCTGGAGAAAACCCTCAGCAGCACCAAGAACCGGGCCCTGCTGCACATCGCCAAACTAGAGGAG
GCCTCTTCTTGGACTGCCATCGAGCATTCTCTCTTGAAACTTGGAGAGATCCTGGCCAATCTCAGCAACCCGCAGCTCCGGAGTCAGGCC
GAGCAGTGTGGCACCCTCATTAGGAGCATCCCCACGATGCTGTCTGTGCATGCGGAGCAGATGCACAAGACCGGCTTCCCCACTGTCCAC
GCCGTGATCCTGCTCGAGGGCACCATGAACCTGACAGGCGAGACGCAGTCCCTGGTGGAGCAGCTGACGATGGTGAAGCGCATGCAGCAT
ATCCCCACCCCACTTTTTGTCCTGGAGATCTGGAAAGCTTGCTTCGTGGGGCTCATTGAGTCTCCCGAGGGTACGGAGGAGCTCAAGTGG
ACAGCTTTCACTTTCCTCAAGATTCCACAGGTTTTGGTGAAGTTGAAGAAGTACTCTCATGGAGACAAGGACTTCACTGAGGATGTCAAC
TGTGCTTTTGAGTTCCTGCTGAAGCTCACCCCCTTGTTGGACAAAGCTGACCAGCGCTGCAACTGTGACTGTACAAACTTCCTGCTCCAA
GAATGTGGCAAGCAGGGGCTTCTGTCTGAGGCCAGCGTCAACAACCTTATGGCTAAGCGCAAAGCGGACCGAGAGCACGCACCCCAGCAG
AAATCGGGAGAGAATGCCAACATCCAGCCCAACATCCAGCTGATCCTCCGGGCGGAGCCCACTGTCACAAACATCCTCAAGACGATGGAT
GCAGACCACTCTAAGTCACCGGAGGGACTGCTGGGAGTCCTGGGCCACATGCTGTCCGGGAAGAGTCTGGACTTGCTGCTGGCTGCCGCC
GCCGCCACTGGAAAGCTGAAATCCTTCGCCCGGAAATTCATCAATTTGAATGAATTCACAACCTATGGCAGCGAAGAAAGCACCAAACCG
GCCTCCGTCCGGGCCCTGCTGTTTGACATCTCCTTCCTCATGCTGTGCCATGTGGCCCAGACCTATGGTTCAGAGGTGATTCTGTCCGAG
TCGCGCACAGGAGCTGAGGTGCCCTTCTTCGAGACCTGGATGCAGACCTGCATGCCTGAGGAGGGCAAGATCCTGAACCCTGACCACCCC
TGCTTCCGCCCCGACTCCACCAAAGTGGAGTCCCTGGTGGCCCTGCTCAACAACTCCTCGGAGATGAAGCTAGTGCAGATGAAGTGGCAT
GAGGCCTGTCTCAGCATCTCAGCCGCCATCTTGGAAATCCTCAATGCCTGGGAGAATGGGGTCCTGGCCTTCGAGTCCATCCAGAAAATC
ACTGATAACATCAAAGGGAAGGTATGCAGTCTGGCGGTGTGTGCTGTGGCTTGGCTTGTGGCCCACGTCCGGATGCTGGGGCTGGATGAG
CGTGAGAAGTCGCTGCAGATGATCCGCCAGCTGGCAGGGCCACTGTTTAGTGAGAACACCCTGCAGTTCTACAATGAGAGGGTGGTGATC
ATGAACTCGATCCTGGAGCGCATGTGTGCCGACGTGCTGCAGCAGACAGCCACGCAGATCAAGTTTCCCTCCACCGGGGTGGACACAATG
CCCTACTGGAACCTGCTGCCCCCCAAGCGGCCCATCAAAGAGGTGCTGACGGACATTTTTGCCAAGGTGCTGGAGAAGGGCTGGGTGGAC
AGCCGCTCCATCCACATCTTTGACACCCTGCTGCACATGGGCGGCGTCTACTGGTTCTGCAACAACCTGATTAAGGTGAAGACCTGGCGC
ATGCACTTATTCACGGGCATCCAGATCATCTGCCTGGCAGTGCTGTGGGTGGTGAAGTCCACGCCGGCCTCCCTGGCCCTGCCCTTCGTC
CTCATCCTCACTGTGCCGCTGCGGCGCGTCCTGCTGCCGCTCATCTTCAGGAACGTGGAGCTTCAGTGTCTGGATGCTGATGATGCCAAG

>In-frame_MED24_ENST00000501516_chr17_38179384_-_SLC4A1_ENST00000262418_chr17_42328700_-_2562nt
ATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCAACATGAAGAAATTC
TTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCCCCAATCCTCTCATC
TTGTCCTACCTGAAGTATGCCATTAGTTCCCAGATGGTGTCCTACTCTTCTGTCCTCACAGCCATCAGTAAGTTTGATGACTTTTCTCGG
GACCTGTGTGTCCAGGCATTGCTGGACATCATGGACATGTTTTGTGACCGTCTGAGCTGTCACGGCAAAGCAGAGGAATGCATCGGACTG
TGCCGAGCCCTTCTTAGCGCCCTCCACTGGCTGCTGCGCTGCACGGCAGCCTCTGCAGAGCGGCTGCGGGAGGGGCTGGAGGCCGGCACT
CCAGCCGCTGGGGAGAAGCAGCTTGCCATGTGCCTTCAGCGCCTGGAGAAAACCCTCAGCAGCACCAAGAACCGGGCCCTGCTGCACATC
GCCAAACTAGAGGAGGCCTCATTGCACACATCCCAGGGACTTGGGCAGGGTGGCACCCGAGCCAATCAACCAACAGCTTCTTGGACTGCC
ATCGAGCATTCTCTCTTGAAACTTGGAGAGATCCTGGCCAATCTCAGCAACCCGCAGCTCCGGAGTCAGGCCGAGCAGTGTGGCACCCTC
ATTAGGAGCATCCCCACGATGCTGTCTGTGCATGCGGAGCAGATGCACAAGACCGGCTTCCCCACTGTCCACGCCGTGATCCTGCTCGAG
GGCACCATGAACCTGACAGGCGAGACGCAGTCCCTGGTGGAGCAGCTGACGATGGTGAAGCGCATGCAGCATATCCCCACCCCACTTTTT
GTCCTGGAGATCTGGAAAGCTTGCTTCGTGGGGCTCATTGAGTCTCCCGAGGGTACGGAGGAGCTCAAGTGGACAGCTTTCACTTTCCTC
AAGATTCCACAGGTTTTGGTGAAGTTGAAGAAGTACTCTCATGGAGACAAGGACTTCACTGAGGATGTCAACTGTGCTTTTGAGTTCCTG
CTGAAGCTCACCCCCTTGTTGGACAAAGCTGACCAGCGCTGCAACTGTGACTGTACAAACTTCCTGCTCCAAGAATGTGGCAAGCAGGGG
CTTCTGTCTGAGGCCAGCGTCAACAACCTTATGGCTAAGCGCAAAGCGGACCGAGAGCACGCACCCCAGCAGAAATCGGGAGAGAATGCC
AACATCCAGCCCAACATCCAGCTGATCCTCCGGGCGGAGCCCACTGTCACAAACATCCTCAAGACGATGGATGCAGACCACTCTAAGTCA
CCGGAGGGACTGCTGGGAGTCCTGGGCCACATGCTGTCCGGGAAGAGTCTGGACTTGCTGCTGGCTGCCGCCGCCGCCACTGGAAAGCTG
AAATCCTTCGCCCGGAAATTCATCAATTTGAATGAATTCACAACCTATGGCAGCGAAGAAAGCACCAAACCGGCCTCCGTCCGGGCCCTG
CTGTTTGACATCTCCTTCCTCATGCTGTGCCATGTGGCCCAGACCTATGGTTCAGAGGTGATTCTGTCCGAGTCGCGCACAGGAGCTGAG
GTGCCCTTCTTCGAGACCTGGATGCAGACCTGCATGCCTGAGGAGGGCAAGATCCTGAACCCTGACCACCCCTGCTTCCGCCCCGACTCC
ACCAAAGTGGAGTCCCTGGTGGCCCTGCTCAACAACTCCTCGGAGATGAAGCTAGTGCAGATGAAGTGGCATGAGGCCTGTCTCAGCATC
TCAGCCGCCATCTTGGAAATCCTCAATGCCTGGGAGAATGGGGTCCTGGCCTTCGAGTCCATCCAGAAAATCACTGATAACATCAAAGGG
AAGGTATGCAGTCTGGCGGTGTGTGCTGTGGCTTGGCTTGTGGCCCACGTCCGGATGCTGGGGCTGGATGAGCGTGAGAAGTCGCTGCAG
ATGATCCGCCAGCTGGCAGGGCCACTGTTTAGTGAGAACACCCTGCAGTTCTACAATGAGAGGGTGGTGATCATGAACTCGATCCTGGAG
CGCATGTGTGCCGACGTGCTGCAGCAGACAGCCACGCAGATCAAGTTTCCCTCCACCGGGGTGGACACAATGCCCTACTGGAACCTGCTG
CCCCCCAAGCGGCCCATCAAAGAGGTGCTGACGGACATTTTTGCCAAGGTGCTGGAGAAGGGCTGGGTGGACAGCCGCTCCATCCACATC
TTTGACACCCTGCTGCACATGGGCGGCGTCTACTGGTTCTGCAACAACCTGATTAAGGTGAAGACCTGGCGCATGCACTTATTCACGGGC
ATCCAGATCATCTGCCTGGCAGTGCTGTGGGTGGTGAAGTCCACGCCGGCCTCCCTGGCCCTGCCCTTCGTCCTCATCCTCACTGTGCCG
CTGCGGCGCGTCCTGCTGCCGCTCATCTTCAGGAACGTGGAGCTTCAGTGTCTGGATGCTGATGATGCCAAGGCAACCTTTGATGAGGAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_MED24_ENST00000394126_chr17_38179384_-_SLC4A1_ENST00000262418_chr17_42328700_-_5072nt
GGTGCGATCTCGGCTCACCCCAACAACCTCCGCCTCCCGGGTTCAAGCGATTCTACTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGC
ATGCACCACCAAGCCCGGCTAATTTTGTATTTTTAGTGGAGACGAGGTTTCTCCATGTTGGTCAGGCTAGTCTCGAACTCCTGACCTCCG
GTGATTCGCCCGCCTCTGCCTCCCGAAGTGCTGGGATTACAGGTGCGAGCCACTGCGCTCGGCCGATACTTTCTTAGTGCCCCAGTTTAA
GGAAGGGCGGTTCAGGAGGAGAGAGTCTGACAGGATCTTACTTTATCCCTTTAGCTCTTTTTCTTTCAAATTCCTCTGTCTCGCTTAAAT
CTTCCCGCATCTTCTCCTTTCTATTTAATTCTGCCTTCCCCGGTTCTCCTTAGAACCTCATGTCCTTTTCTTTAGCTCCATTTCTTTCAC
CTCAAAGCTGGCCGCCACCGCTGCCACCTGCTCAGAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGG
AGCGCTGGAGTGACTACCAATGGGCAATCAACATGAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGT
TACTAGAGCAGGCCATGATTGGACCATCCCCCAATCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGATGGTGTCCTACT
CTTCTGTCCTCACAGCCATCAGTAAGTTTGATGACTTTTCTCGGGACCTGTGTGTCCAGGCATTGCTGGACATCATGGACATGTTTTGTG
ACCGTCTGAGCTGTCACGGCAAAGCAGAGGAATGCATCGGACTGTGCCGAGCCCTTCTTAGCGCCCTCCACTGGCTGCTGCGCTGCACGG
CAGCCTCTGCAGAGCGGCTGCGGGAGGGGCTGGAGGCCGGCACTCCAGCCGCTGGGGAGAAGCAGCTTGCCATGTGCCTTCAGCGCCTGG
AGAAAACCCTCAGCAGCACCAAGAACCGGGCCCTGCTGCACATCGCCAAACTAGAGGAGGCCTCTTCTTGGACTGCCATCGAGCATTCTC
TCTTGAAACTTGGAGAGATCCTGGCCAATCTCAGCAACCCGCAGCTCCGGAGTCAGGCCGAGCAGTGTGGCACCCTCATTAGGAGCATCC
CCACGATGCTGTCTGTGCATGCGGAGCAGATGCACAAGACCGGCTTCCCCACTGTCCACGCCGTGATCCTGCTCGAGGGCACCATGAACC
TGACAGGCGAGACGCAGTCCCTGGTGGAGCAGCTGACGATGGTGAAGCGCATGCAGCATATCCCCACCCCACTTTTTGTCCTGGAGATCT
GGAAAGCTTGCTTCGTGGGGCTCATTGAGTCTCCCGAGGGTACGGAGGAGCTCAAGTGGACAGCTTTCACTTTCCTCAAGATTCCACAGG
TTTTGGTGAAGTTGAAGAAGTACTCTCATGGAGACAAGGACTTCACTGAGGATGTCAACTGTGCTTTTGAGTTCCTGCTGAAGCTCACCC
CCTTGTTGGACAAAGCTGACCAGCGCTGCAACTGTGACTGTACAAACTTCCTGCTCCAAGAATGTGGCAAGCAGGGGCTTCTGTCTGAGG
CCAGCGTCAACAACCTTATGGCTAAGCGCAAAGCGGACCGAGAGCACGCACCCCAGCAGAAATCGGGAGAGAATGCCAACATCCAGCCCA
ACATCCAGCTGATCCTCCGGGCGGAGCCCACTGTCACAAACATCCTCAAGACGATGGATGCAGACCACTCTAAGTCACCGGAGGGACTGC
TGGGAGTCCTGGGCCACATGCTGTCCGGGAAGAGTCTGGACTTGCTGCTGGCTGCCGCCGCCGCCACTGGAAAGCTGAAATCCTTCGCCC
GGAAATTCATCAATTTGAATGAATTCACAACCTATGGCAGCGAAGAAAGCACCAAACCGGCCTCCGTCCGGGCCCTGCTGTTTGACATCT
CCTTCCTCATGCTGTGCCATGTGGCCCAGACCTATGGTTCAGAGGTGATTCTGTCCGAGTCGCGCACAGGAGCTGAGGTGCCCTTCTTCG
AGACCTGGATGCAGACCTGCATGCCTGAGGAGGGCAAGATCCTGAACCCTGACCACCCCTGCTTCCGCCCCGACTCCACCAAAGTGGAGT
CCCTGGTGGCCCTGCTCAACAACTCCTCGGAGATGAAGCTAGTGCAGATGAAGTGGCATGAGGCCTGTCTCAGCATCTCAGCCGCCATCT
TGGAAATCCTCAATGCCTGGGAGAATGGGGTCCTGGCCTTCGAGTCCATCCAGAAAATCACTGATAACATCAAAGGGAAGGTATGCAGTC
TGGCGGTGTGTGCTGTGGCTTGGCTTGTGGCCCACGTCCGGATGCTGGGGCTGGATGAGCGTGAGAAGTCGCTGCAGATGATCCGCCAGC
TGGCAGGGCCACTGTTTAGTGAGAACACCCTGCAGTTCTACAATGAGAGGGTGGTGATCATGAACTCGATCCTGGAGCGCATGTGTGCCG
ACGTGCTGCAGCAGACAGCCACGCAGATCAAGTTTCCCTCCACCGGGGTGGACACAATGCCCTACTGGAACCTGCTGCCCCCCAAGCGGC
CCATCAAAGAGGTGCTGACGGACATTTTTGCCAAGGTGCTGGAGAAGGGCTGGGTGGACAGCCGCTCCATCCACATCTTTGACACCCTGC
TGCACATGGGCGGCGTCTACTGGTTCTGCAACAACCTGATTAAGGTGAAGACCTGGCGCATGCACTTATTCACGGGCATCCAGATCATCT
GCCTGGCAGTGCTGTGGGTGGTGAAGTCCACGCCGGCCTCCCTGGCCCTGCCCTTCGTCCTCATCCTCACTGTGCCGCTGCGGCGCGTCC
TGCTGCCGCTCATCTTCAGGAACGTGGAGCTTCAGTGTCTGGATGCTGATGATGCCAAGGCAACCTTTGATGAGGAGGAAGGTCGGGATG
AATACGACGAAGTGGCCATGCCTGTGTGAGGGGCGGGCCCAGGCCCTAGACCCTCCCCCACCATTCCACATCCCCACCTTCCAAGGAAAA
GCAGAAGTTCATGGGCACCTCATGGACTCCAGGATCCTCCTGGAGCAGCAGCTGAGGCCCCAGGGCTGTGGGTGGGGAAGGAAGGCGTGT
CCAGGAGACCTTCCACAAAGGGTAGCCTGGCTTTTCTGGCTGGGGATGGCCGATGGGGCCCACATTAGGGGGTTTGTTGCACAGTCCCTC
CTGTTGCCACACTTTCACTGGGGATCCCGTGCTGGAAGACTTAGATCTGAGCCCTCCCTCTTCCCAGCACAGGCAGGGGTAGAAGCAAAG
GCAGGAGGTGGGTGAGCGGGTGGGGTGCTTGCTGTGTGACCTTGGGCAAGTCCCTTGACCTTTCCAGCCTATATTTCCTCTTCTGTAAAA
TGGGTATATTGATGATAATACCCACATTACAGGATGGTTACTGAGGACCAAAGATACATGTAAAATAGGGCTTTGTAAACTCCACAGGGA
CTGTTCTATAGCAGTCATCATTTGTCTTTGAACGTACCCAAGGTCACATAGCTGGGATTTGAACTGAGCCGTGCAGCTGGGATTTGAACC
AGGCCTTCTGATTTCAAGGTCCGAGCTCTGTCCTCTGTCAGTCATGCGTCCACTTTCCCTTCCCCTGTGACTCCTCCCTTCCCCACTCTG
CTCCCAGCCCCTACCTTGAGACCCTCTTCTCTGGGCCCAGAGAGAGGCGTCCTGGTGAGGACAAGGTACAGGCAAGGATGATCCAGGGAT
TGGGCCTGGGACTCAGGCCTCCTAAGTGTTTGGTTCCTCCCTCCAAACACTCATTAGTTCACTCATTCATTCATTCCACAAACATTTACT
GAGGGCCCCGGAATCAGTGGACTCCGAGGGGACTGAGACAAGCCCTGCCCTGGGGTGGGGGTGGGGGGCAAGGTACAGTTGATTCTACAT
TTGGATAGGGAGTGGGGGAGGGTGGGAAGGTAGGGGCGGGAGAGTGAGGGGGTTTGTAATTTATTAATTGCGTATTTTCTAAGAGTTTTC
AACATAGTTTGGCTTCACACACAACTTCAGGCCCCTCATTTGAGAGCCATTATCCTCAACTCCATCTAAACTGAATCTTGGGGAGAACCC
AGATCTGACCAATTGGGGTAGGAGACAGCAGGCTCTCCAAGAACATGGGCAAATTTATTTTTTTATAAAACAAAAAGATAAAAAGAGTTG
AAAGACGTGAAAGTGGTGAGAGATGGAGGAAACAGAATCAGGAAGTGGTAGAAAAGAGAGGAGGTGGCTGGGCGCAGTGGCTCACGTTTG
TAATCCCAGCACTTTGGGAGGCCAAGTTGGGCGGATCATTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCGTTA
CTACTAAAAATACAAAAATTAGCTGGGTGTCTCGTGGCAGGCACCTGTAATCCCAGCTACTTAGAAGGCTGAGGCAAGAGAATCACCTGA
ACCCAGGAGGTGGAGGTTGCAGTGAGCCAAGATTGCACCACTGCACTCCAGCCTGGGCAACAGAGCGAGACCCTGTCTCAAAAAAAAAAA
AAAAAAAAAAAAAAAAACGGAAGGAAACATCAGCCTTGGGGGCCACAGACTCAACATGTGTGTGTGGTGGGGTTCCAGCCCAACATAGAG
TAACATTATTTGTACCTCCCAGGCTAGCTCAGTCCATGGGAGGCTCTCCTGTCCCTGAAAGCTGACACCCACCTTTCACCACTTCGCCCA
TGCTACAGTTCAGTTTCCTCGTCTGTAAAATGGGGATGATAATGGTACCTACCTTGCAGTGTTGTTATAAGGATTAAAGGAGACAGTGCA
AGAAAAGGCCTTGGTTGGTGAAGAGCCCAACCTCGGAGGGGAGCTGCTGGGATCCTCCTTATCTTGACTGGGATGTCCCTGTCTCCCCCT
CCCCTTGCTCCTTGAACATGGCCAAGGAAAGTGAAAAACAAAAATTATTCACTCTGCTAGCACCCTTCCCCTTGATGCCTGGGAATAGGT

>In-frame_MED24_ENST00000501516_chr17_38179384_-_SLC4A1_ENST00000262418_chr17_42328700_-_4645nt
GAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCAACAT
GAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCCCCAA
TCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGATGGTGTCCTACTCTTCTGTCCTCACAGCCATCAGTAAGTTTGATGA
CTTTTCTCGGGACCTGTGTGTCCAGGCATTGCTGGACATCATGGACATGTTTTGTGACCGTCTGAGCTGTCACGGCAAAGCAGAGGAATG
CATCGGACTGTGCCGAGCCCTTCTTAGCGCCCTCCACTGGCTGCTGCGCTGCACGGCAGCCTCTGCAGAGCGGCTGCGGGAGGGGCTGGA
GGCCGGCACTCCAGCCGCTGGGGAGAAGCAGCTTGCCATGTGCCTTCAGCGCCTGGAGAAAACCCTCAGCAGCACCAAGAACCGGGCCCT
GCTGCACATCGCCAAACTAGAGGAGGCCTCATTGCACACATCCCAGGGACTTGGGCAGGGTGGCACCCGAGCCAATCAACCAACAGCTTC
TTGGACTGCCATCGAGCATTCTCTCTTGAAACTTGGAGAGATCCTGGCCAATCTCAGCAACCCGCAGCTCCGGAGTCAGGCCGAGCAGTG
TGGCACCCTCATTAGGAGCATCCCCACGATGCTGTCTGTGCATGCGGAGCAGATGCACAAGACCGGCTTCCCCACTGTCCACGCCGTGAT
CCTGCTCGAGGGCACCATGAACCTGACAGGCGAGACGCAGTCCCTGGTGGAGCAGCTGACGATGGTGAAGCGCATGCAGCATATCCCCAC
CCCACTTTTTGTCCTGGAGATCTGGAAAGCTTGCTTCGTGGGGCTCATTGAGTCTCCCGAGGGTACGGAGGAGCTCAAGTGGACAGCTTT
CACTTTCCTCAAGATTCCACAGGTTTTGGTGAAGTTGAAGAAGTACTCTCATGGAGACAAGGACTTCACTGAGGATGTCAACTGTGCTTT
TGAGTTCCTGCTGAAGCTCACCCCCTTGTTGGACAAAGCTGACCAGCGCTGCAACTGTGACTGTACAAACTTCCTGCTCCAAGAATGTGG
CAAGCAGGGGCTTCTGTCTGAGGCCAGCGTCAACAACCTTATGGCTAAGCGCAAAGCGGACCGAGAGCACGCACCCCAGCAGAAATCGGG
AGAGAATGCCAACATCCAGCCCAACATCCAGCTGATCCTCCGGGCGGAGCCCACTGTCACAAACATCCTCAAGACGATGGATGCAGACCA
CTCTAAGTCACCGGAGGGACTGCTGGGAGTCCTGGGCCACATGCTGTCCGGGAAGAGTCTGGACTTGCTGCTGGCTGCCGCCGCCGCCAC
TGGAAAGCTGAAATCCTTCGCCCGGAAATTCATCAATTTGAATGAATTCACAACCTATGGCAGCGAAGAAAGCACCAAACCGGCCTCCGT
CCGGGCCCTGCTGTTTGACATCTCCTTCCTCATGCTGTGCCATGTGGCCCAGACCTATGGTTCAGAGGTGATTCTGTCCGAGTCGCGCAC
AGGAGCTGAGGTGCCCTTCTTCGAGACCTGGATGCAGACCTGCATGCCTGAGGAGGGCAAGATCCTGAACCCTGACCACCCCTGCTTCCG
CCCCGACTCCACCAAAGTGGAGTCCCTGGTGGCCCTGCTCAACAACTCCTCGGAGATGAAGCTAGTGCAGATGAAGTGGCATGAGGCCTG
TCTCAGCATCTCAGCCGCCATCTTGGAAATCCTCAATGCCTGGGAGAATGGGGTCCTGGCCTTCGAGTCCATCCAGAAAATCACTGATAA
CATCAAAGGGAAGGTATGCAGTCTGGCGGTGTGTGCTGTGGCTTGGCTTGTGGCCCACGTCCGGATGCTGGGGCTGGATGAGCGTGAGAA
GTCGCTGCAGATGATCCGCCAGCTGGCAGGGCCACTGTTTAGTGAGAACACCCTGCAGTTCTACAATGAGAGGGTGGTGATCATGAACTC
GATCCTGGAGCGCATGTGTGCCGACGTGCTGCAGCAGACAGCCACGCAGATCAAGTTTCCCTCCACCGGGGTGGACACAATGCCCTACTG
GAACCTGCTGCCCCCCAAGCGGCCCATCAAAGAGGTGCTGACGGACATTTTTGCCAAGGTGCTGGAGAAGGGCTGGGTGGACAGCCGCTC
CATCCACATCTTTGACACCCTGCTGCACATGGGCGGCGTCTACTGGTTCTGCAACAACCTGATTAAGGTGAAGACCTGGCGCATGCACTT
ATTCACGGGCATCCAGATCATCTGCCTGGCAGTGCTGTGGGTGGTGAAGTCCACGCCGGCCTCCCTGGCCCTGCCCTTCGTCCTCATCCT
CACTGTGCCGCTGCGGCGCGTCCTGCTGCCGCTCATCTTCAGGAACGTGGAGCTTCAGTGTCTGGATGCTGATGATGCCAAGGCAACCTT
TGATGAGGAGGAAGGTCGGGATGAATACGACGAAGTGGCCATGCCTGTGTGAGGGGCGGGCCCAGGCCCTAGACCCTCCCCCACCATTCC
ACATCCCCACCTTCCAAGGAAAAGCAGAAGTTCATGGGCACCTCATGGACTCCAGGATCCTCCTGGAGCAGCAGCTGAGGCCCCAGGGCT
GTGGGTGGGGAAGGAAGGCGTGTCCAGGAGACCTTCCACAAAGGGTAGCCTGGCTTTTCTGGCTGGGGATGGCCGATGGGGCCCACATTA
GGGGGTTTGTTGCACAGTCCCTCCTGTTGCCACACTTTCACTGGGGATCCCGTGCTGGAAGACTTAGATCTGAGCCCTCCCTCTTCCCAG
CACAGGCAGGGGTAGAAGCAAAGGCAGGAGGTGGGTGAGCGGGTGGGGTGCTTGCTGTGTGACCTTGGGCAAGTCCCTTGACCTTTCCAG
CCTATATTTCCTCTTCTGTAAAATGGGTATATTGATGATAATACCCACATTACAGGATGGTTACTGAGGACCAAAGATACATGTAAAATA
GGGCTTTGTAAACTCCACAGGGACTGTTCTATAGCAGTCATCATTTGTCTTTGAACGTACCCAAGGTCACATAGCTGGGATTTGAACTGA
GCCGTGCAGCTGGGATTTGAACCAGGCCTTCTGATTTCAAGGTCCGAGCTCTGTCCTCTGTCAGTCATGCGTCCACTTTCCCTTCCCCTG
TGACTCCTCCCTTCCCCACTCTGCTCCCAGCCCCTACCTTGAGACCCTCTTCTCTGGGCCCAGAGAGAGGCGTCCTGGTGAGGACAAGGT
ACAGGCAAGGATGATCCAGGGATTGGGCCTGGGACTCAGGCCTCCTAAGTGTTTGGTTCCTCCCTCCAAACACTCATTAGTTCACTCATT
CATTCATTCCACAAACATTTACTGAGGGCCCCGGAATCAGTGGACTCCGAGGGGACTGAGACAAGCCCTGCCCTGGGGTGGGGGTGGGGG
GCAAGGTACAGTTGATTCTACATTTGGATAGGGAGTGGGGGAGGGTGGGAAGGTAGGGGCGGGAGAGTGAGGGGGTTTGTAATTTATTAA
TTGCGTATTTTCTAAGAGTTTTCAACATAGTTTGGCTTCACACACAACTTCAGGCCCCTCATTTGAGAGCCATTATCCTCAACTCCATCT
AAACTGAATCTTGGGGAGAACCCAGATCTGACCAATTGGGGTAGGAGACAGCAGGCTCTCCAAGAACATGGGCAAATTTATTTTTTTATA
AAACAAAAAGATAAAAAGAGTTGAAAGACGTGAAAGTGGTGAGAGATGGAGGAAACAGAATCAGGAAGTGGTAGAAAAGAGAGGAGGTGG
CTGGGCGCAGTGGCTCACGTTTGTAATCCCAGCACTTTGGGAGGCCAAGTTGGGCGGATCATTTGAGGTCAGGAGTTTGAGACCAGCCTG
GCCAACATGGTGAAACCCCGTTACTACTAAAAATACAAAAATTAGCTGGGTGTCTCGTGGCAGGCACCTGTAATCCCAGCTACTTAGAAG
GCTGAGGCAAGAGAATCACCTGAACCCAGGAGGTGGAGGTTGCAGTGAGCCAAGATTGCACCACTGCACTCCAGCCTGGGCAACAGAGCG
AGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAACGGAAGGAAACATCAGCCTTGGGGGCCACAGACTCAACATGTGTGTGTGG
TGGGGTTCCAGCCCAACATAGAGTAACATTATTTGTACCTCCCAGGCTAGCTCAGTCCATGGGAGGCTCTCCTGTCCCTGAAAGCTGACA
CCCACCTTTCACCACTTCGCCCATGCTACAGTTCAGTTTCCTCGTCTGTAAAATGGGGATGATAATGGTACCTACCTTGCAGTGTTGTTA
TAAGGATTAAAGGAGACAGTGCAAGAAAAGGCCTTGGTTGGTGAAGAGCCCAACCTCGGAGGGGAGCTGCTGGGATCCTCCTTATCTTGA
CTGGGATGTCCCTGTCTCCCCCTCCCCTTGCTCCTTGAACATGGCCAAGGAAAGTGAAAAACAAAAATTATTCACTCTGCTAGCACCCTT


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FusionGenePPI for MED24_SLC4A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MED24MED10, MED9, MED29, MED19, MED28, MED26, CDK8, THRA, VDR, PPARA, PPARG, RXRA, MED1, HNF4A, ESR1, ESR2, MED30, BRD4, RPAP2, AR, PARP1, SMAD1, SMAD2, SMAD3, TRRAP, SREBF1, MED12, MED18, ZC3H13, TRIP4, OBFC1, QKI, TRA, MED14, GSK3B, TNFSF11, RPS6KA6, CTDP1, APP, MED13, MED8, MED16, MED17, MED4, MED11, MED21, MED22, PPP6R1, TFIP11, FBXW7, EPAS1, CDK19, MED7, CCNC, NR1I3, TCL1B, MED15, MED20, MED23, MED6, MED25, MED27, KPNB1, XRCC3, EMC2, PPP4R1, ZWINT, KIFAP3, MMGT1, SUCO, LMO2SLC4A1SLC4A1AP, SLC4A1, CA2, CA4, ANK1, EPB42, CANX, SYK, CLU, HBA1, CDKN2A, KAT2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSLC4A1chr17:38179384chr17:42328700ENST00000262418-1720176_185827912ANK1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MED24_SLC4A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MED24_SLC4A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLC4A1C2675212Spherocytosis, Type 416CTD_human;UNIPROT
TgeneSLC4A1C1704380Distal Renal Tubular Acidosis5HPO;ORPHANET;UNIPROT
TgeneSLC4A1C1969038RENAL TUBULAR ACIDOSIS, DISTAL, WITH HEMOLYTIC ANEMIA (disorder)4CTD_human;ORPHANET;UNIPROT
TgeneSLC4A1C0001126Renal tubular acidosis2CTD_human;HPO
TgeneSLC4A1C0002878Anemia, Hemolytic1CTD_human;HPO
TgeneSLC4A1C0013902Elliptocytosis, Hereditary1CTD_human;HPO
TgeneSLC4A1C0018939Hematological Disease1CTD_human
TgeneSLC4A1C0037889Hereditary spherocytosis1CTD_human;ORPHANET
TgeneSLC4A1C1861453Pseudohyperkalemia Cardiff1ORPHANET;UNIPROT