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Fusion gene ID: 21517 |
FusionGeneSummary for MED1_PIP4K2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MED1_PIP4K2B | Fusion gene ID: 21517 | Hgene | Tgene | Gene symbol | MED1 | PIP4K2B | Gene ID | 8930 | 8396 |
| Gene name | methyl-CpG binding domain 4, DNA glycosylase | phosphatidylinositol-5-phosphate 4-kinase type 2 beta | |
| Synonyms | MED1 | PI5P4KB|PIP5K2B|PIP5KIIB|PIP5KIIbeta|PIP5P4KB | |
| Cytomap | 3q21.3 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methyl-CpG-binding domain protein 43,N(4)-ethenocytosine glycosylaseG/5-fluorouracil mismatch glycosylase with biphasic kineticsG/T mismatch glycosylaseG/U mismatch glycosylasemethyl-CpG binding domain protein 4methyl-CpG-binding endonuclease 1meth | phosphatidylinositol 5-phosphate 4-kinase type-2 beta1-phosphatidylinositol 5-phosphate 4-kinase 2-beta1-phosphatidylinositol-4-phosphate kinasePI(5)P 4-kinase type II betaPIP4KII-betaPTDINS(4)P-5-kinasediphosphoinositide kinase 2-betaphosphatidyli | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q15648 | P78356 | |
| Ensembl transtripts involved in fusion gene | ENST00000394287, ENST00000300651, | ENST00000269554, ENST00000311500, | |
| Fusion gene scores | * DoF score | 25 X 11 X 9=2475 | 7 X 6 X 4=168 |
| # samples | 25 | 9 | |
| ** MAII score | log2(25/2475*10)=-3.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MED1 [Title/Abstract] AND PIP4K2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-D8-A1XJ-01A | MED1 | chr17 | 37607291 | - | PIP4K2B | chr17 | 36943173 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394287 | ENST00000269554 | MED1 | chr17 | 37607291 | - | PIP4K2B | chr17 | 36943173 | - |
| 5CDS-5UTR | ENST00000394287 | ENST00000311500 | MED1 | chr17 | 37607291 | - | PIP4K2B | chr17 | 36943173 | - |
| In-frame | ENST00000300651 | ENST00000269554 | MED1 | chr17 | 37607291 | - | PIP4K2B | chr17 | 36943173 | - |
| 5CDS-5UTR | ENST00000300651 | ENST00000311500 | MED1 | chr17 | 37607291 | - | PIP4K2B | chr17 | 36943173 | - |
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FusionProtFeatures for MED1_PIP4K2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MED1 | PIP4K2B |
| Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors (PubMed:10406464, PubMed:11867769,PubMed:12037571, PubMed:12218053, PubMed:12556447,PubMed:14636573, PubMed:15340084, PubMed:15471764,PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as acoactivator for GATA1-mediated transcriptional activation duringerythroid differentiation of K562 erythroleukemia cells(PubMed:24245781). {ECO:0000269|PubMed:10406464,ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571,ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447,ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084,ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967,ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781,ECO:0000269|PubMed:9653119}. | Participates in the biosynthesis of phosphatidylinositol4,5-bisphosphate. {ECO:0000269|PubMed:9038203}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MED1 | chr17:37607291 | chr17:36943173 | ENST00000300651 | - | 1 | 17 | 1078_1482 | 8 | 1582 | Compositional bias | Note=Ser-rich |
| Hgene | >MED1 | chr17:37607291 | chr17:36943173 | ENST00000300651 | - | 1 | 17 | 1496_1529 | 8 | 1582 | Compositional bias | Note=Lys-rich |
| Hgene | >MED1 | chr17:37607291 | chr17:36943173 | ENST00000394287 | - | 1 | 18 | 1078_1482 | 8 | 557 | Compositional bias | Note=Ser-rich |
| Hgene | >MED1 | chr17:37607291 | chr17:36943173 | ENST00000394287 | - | 1 | 18 | 1496_1529 | 8 | 557 | Compositional bias | Note=Lys-rich |
| Hgene | >MED1 | chr17:37607291 | chr17:36943173 | ENST00000300651 | - | 1 | 17 | 604_608 | 8 | 1582 | Motif | Note=LXXLL motif 1 |
| Hgene | >MED1 | chr17:37607291 | chr17:36943173 | ENST00000300651 | - | 1 | 17 | 645_649 | 8 | 1582 | Motif | Note=LXXLL motif 2 |
| Hgene | >MED1 | chr17:37607291 | chr17:36943173 | ENST00000394287 | - | 1 | 18 | 604_608 | 8 | 557 | Motif | Note=LXXLL motif 1 |
| Hgene | >MED1 | chr17:37607291 | chr17:36943173 | ENST00000394287 | - | 1 | 18 | 645_649 | 8 | 557 | Motif | Note=LXXLL motif 2 |
| Tgene | PIP4K2B | chr17:37607291 | chr17:36943173 | ENST00000269554 | - | 0 | 10 | 38_415 | 53 | 417 | Domain | PIPK |
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FusionGeneSequence for MED1_PIP4K2B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MED1_ENST00000394287_chr17_37607291_-_PIP4K2B_ENST00000269554_chr17_36943173_-_372aa MKAQGETEDQXAEQCSCSCHANARXLQSLQQDQGGQSSLQXGEPAQPLXVXGVLPHGVPKPSGEVWNXXSGLPEFSDAQRPHQQXQPGSV WHAFPHHLRPALCHQDCVQRGRGGDAQHLKEIPPVYSGVSWQHAFATVPGHVPPDRGWCGNLHGGYQERVQPSAHCASQVXPQGFYGCQR SERQGEGQGLANIQRQXLPQXRAEAACGRGEXKELPGETEAGRXVLGTAEDHGLQPAGGHPRRGPGRAGGDGGGGAGRGRGVXEXWGGWQ PTLLLWHTSGQPWQPPQLSSVLWSWGIRPLCXRLCHEKPXKFPQEGGVFHGHHXYPHAIRYKEESCTCCQNGETRGRGRDLDCEPXAVLQ >In-frame_MED1_ENST00000300651_chr17_37607291_-_PIP4K2B_ENST00000269554_chr17_36943173_-_372aa MKAQGETEDQXAEQCSCSCHANARXLQSLQQDQGGQSSLQXGEPAQPLXVXGVLPHGVPKPSGEVWNXXSGLPEFSDAQRPHQQXQPGSV WHAFPHHLRPALCHQDCVQRGRGGDAQHLKEIPPVYSGVSWQHAFATVPGHVPPDRGWCGNLHGGYQERVQPSAHCASQVXPQGFYGCQR SERQGEGQGLANIQRQXLPQXRAEAACGRGEXKELPGETEAGRXVLGTAEDHGLQPAGGHPRRGPGRAGGDGGGGAGRGRGVXEXWGGWQ PTLLLWHTSGQPWQPPQLSSVLWSWGIRPLCXRLCHEKPXKFPQEGGVFHGHHXYPHAIRYKEESCTCCQNGETRGRGRDLDCEPXAVLQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MED1_ENST00000394287_chr17_37607291_-_PIP4K2B_ENST00000269554_chr17_36943173_-_1117nt ATGAAAGCTCAGGGGGAAACCGAGGATCAATGAGCTGAGCAATGTTCCTGTTCCTGTCATGCTAATGCCAGATGACTTCAAAGCCTACAG CAAGATCAAGGTGGACAATCATCTCTTCAATAAGGAGAACCTGCCCAGCCGCTTTAAGTTTAAGGAGTATTGCCCCATGGTGTTCCGAAA CCTTCGGGAGAGGTTTGGAATTGATGATCAGGATTACCAGAATTCAGTGACGCGCAGCGCCCCCATCAACAGTGACAGCCAGGGTCGGTG TGGCACGCGTTTCCTCACCACCTACGACCGGCGCTTTGTCATCAAGACTGTGTCCAGCGAGGACGTGGCGGAGATGCACAACATCTTAAA GAAATACCACCAGTTTATAGTGGAGTGTCATGGCAACACGCTTTTGCCACAGTTCCTGGGCATGTACCGCCTGACCGTGGATGGTGTGGA AACCTACATGGTGGTTACCAGGAACGTGTTCAGCCATCGGCTCACTGTGCATCGCAAGTATGACCTCAAGGGTTCTACGGTTGCCAGAGA AGCGAGCGACAAGGAGAAGGCCAAGGACTTGCCAACATTCAAAGACAATGACTTCCTCAATGAAGGGCAGAAGCTGCATGTGGGAGAGGA GAGTAAAAAGAACTTCCTGGAGAAACTGAAGCGGGACGTTGAGTTCTTGGCACAGCTGAAGATCATGGACTACAGCCTGCTGGTGGGCAT CCACGACGTGGACCGGGCAGAGCAGGAGGAGATGGAGGTGGAGGAGCGGGCAGAGGACGAGGAGTGTGAGAATGATGGGGTGGGTGGCAA CCTACTCTGCTCCTATGGCACACCTCCGGACAGCCCTGGCAACCTCCTCAGCTTTCCTCGGTTCTTTGGTCCTGGGGAATTCGACCCCTC TGTTGACGTCTATGCCATGAAAAGCCATGAAAGTTCCCCCAAGAAGGAGGTGTATTTCATGGCCATCATTGATATCCTCACGCCATACGA TACAAAGAAGAAAGCTGCACATGCTGCCAAAACGGTGAAACACGGGGCAGGGGCCGAGATCTCGACTGTGAACCCTGAGCAGTACTCCAA >In-frame_MED1_ENST00000300651_chr17_37607291_-_PIP4K2B_ENST00000269554_chr17_36943173_-_1117nt ATGAAAGCTCAGGGGGAAACCGAGGATCAATGAGCTGAGCAATGTTCCTGTTCCTGTCATGCTAATGCCAGATGACTTCAAAGCCTACAG CAAGATCAAGGTGGACAATCATCTCTTCAATAAGGAGAACCTGCCCAGCCGCTTTAAGTTTAAGGAGTATTGCCCCATGGTGTTCCGAAA CCTTCGGGAGAGGTTTGGAATTGATGATCAGGATTACCAGAATTCAGTGACGCGCAGCGCCCCCATCAACAGTGACAGCCAGGGTCGGTG TGGCACGCGTTTCCTCACCACCTACGACCGGCGCTTTGTCATCAAGACTGTGTCCAGCGAGGACGTGGCGGAGATGCACAACATCTTAAA GAAATACCACCAGTTTATAGTGGAGTGTCATGGCAACACGCTTTTGCCACAGTTCCTGGGCATGTACCGCCTGACCGTGGATGGTGTGGA AACCTACATGGTGGTTACCAGGAACGTGTTCAGCCATCGGCTCACTGTGCATCGCAAGTATGACCTCAAGGGTTCTACGGTTGCCAGAGA AGCGAGCGACAAGGAGAAGGCCAAGGACTTGCCAACATTCAAAGACAATGACTTCCTCAATGAAGGGCAGAAGCTGCATGTGGGAGAGGA GAGTAAAAAGAACTTCCTGGAGAAACTGAAGCGGGACGTTGAGTTCTTGGCACAGCTGAAGATCATGGACTACAGCCTGCTGGTGGGCAT CCACGACGTGGACCGGGCAGAGCAGGAGGAGATGGAGGTGGAGGAGCGGGCAGAGGACGAGGAGTGTGAGAATGATGGGGTGGGTGGCAA CCTACTCTGCTCCTATGGCACACCTCCGGACAGCCCTGGCAACCTCCTCAGCTTTCCTCGGTTCTTTGGTCCTGGGGAATTCGACCCCTC TGTTGACGTCTATGCCATGAAAAGCCATGAAAGTTCCCCCAAGAAGGAGGTGTATTTCATGGCCATCATTGATATCCTCACGCCATACGA TACAAAGAAGAAAGCTGCACATGCTGCCAAAACGGTGAAACACGGGGCAGGGGCCGAGATCTCGACTGTGAACCCTGAGCAGTACTCCAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MED1_ENST00000394287_chr17_37607291_-_PIP4K2B_ENST00000269554_chr17_36943173_-_5325nt TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGATCAATGAGCTGAGCAATGTTCCTGTTCCTGTCATGCTA ATGCCAGATGACTTCAAAGCCTACAGCAAGATCAAGGTGGACAATCATCTCTTCAATAAGGAGAACCTGCCCAGCCGCTTTAAGTTTAAG GAGTATTGCCCCATGGTGTTCCGAAACCTTCGGGAGAGGTTTGGAATTGATGATCAGGATTACCAGAATTCAGTGACGCGCAGCGCCCCC ATCAACAGTGACAGCCAGGGTCGGTGTGGCACGCGTTTCCTCACCACCTACGACCGGCGCTTTGTCATCAAGACTGTGTCCAGCGAGGAC GTGGCGGAGATGCACAACATCTTAAAGAAATACCACCAGTTTATAGTGGAGTGTCATGGCAACACGCTTTTGCCACAGTTCCTGGGCATG TACCGCCTGACCGTGGATGGTGTGGAAACCTACATGGTGGTTACCAGGAACGTGTTCAGCCATCGGCTCACTGTGCATCGCAAGTATGAC CTCAAGGGTTCTACGGTTGCCAGAGAAGCGAGCGACAAGGAGAAGGCCAAGGACTTGCCAACATTCAAAGACAATGACTTCCTCAATGAA GGGCAGAAGCTGCATGTGGGAGAGGAGAGTAAAAAGAACTTCCTGGAGAAACTGAAGCGGGACGTTGAGTTCTTGGCACAGCTGAAGATC ATGGACTACAGCCTGCTGGTGGGCATCCACGACGTGGACCGGGCAGAGCAGGAGGAGATGGAGGTGGAGGAGCGGGCAGAGGACGAGGAG TGTGAGAATGATGGGGTGGGTGGCAACCTACTCTGCTCCTATGGCACACCTCCGGACAGCCCTGGCAACCTCCTCAGCTTTCCTCGGTTC TTTGGTCCTGGGGAATTCGACCCCTCTGTTGACGTCTATGCCATGAAAAGCCATGAAAGTTCCCCCAAGAAGGAGGTGTATTTCATGGCC ATCATTGATATCCTCACGCCATACGATACAAAGAAGAAAGCTGCACATGCTGCCAAAACGGTGAAACACGGGGCAGGGGCCGAGATCTCG ACTGTGAACCCTGAGCAGTACTCCAAACGCTTCAACGAGTTTATGTCCAACATCCTGACGTAGTTCTCTTCTACCTTCAGCCAGAGCCAG AGAGCTGGATATGGGGTCGGGGATCGGGAGTTAGGGAGAAGGGTGTATTTGGGCTAGATGGGAGGGTGGGAGCAGAGTCGGGTTTGGGAG GGCTTTAGCAATGAGACTGCAGCCTGTGACACCGAAAGAGACTTTAGCTGAAGAGGAGGGGGATGTGCTGTGTGTGCACCTGCTCACAGG ATGTAACCCCACCTTCTGCTTACCCTTGATTTTTTCTCCCCATTTGACACCCAGGTTAAAAAGGGGTTCCCTTTTTGGTACCTTGTAACC TTTTAAGATACCTTGGGGCTAGAGATGACTTCGTGGGTTTATTTGGGTTTTGTTTCTGAAATTTCATTGCTCCAGGTTTGCTATTTATAA TCATATTTCATCAGCCTACCCACCCTCCCCATCTTTGCTGAGCTCTCAGTTCCCTTCAATTAAAGAGATACCCGGTAGACCCAGCACAAG GGTCCTTCCAGAACCAAGTGCTATGGATGCCAGATTGGAGAGGTCAGACACCTCGCCCTGCTGCATTTGCTCTTGTCTGGATTAACTTTG TAATTTATGGAGTATTGTGCACAACTTCCTCCACCTTTCCCTTGGATTCAAGTGAAAACTGTTGCATTATTCCTCCATCCTGTCTGGAAT ACACCAGGTCAACACCAGAGATCTCAGATCAGAATCAGAGATCTCAGAGGGGAATAAGTTCATCCTCATGGGATGGTGAGGGGCAGGAAA GCGGCTGGGCTCTTGGACACCTGGTTCTCAGAGAACCCTGTGATGATCACCCAAGCCCCAGGCTGTCTTAGCCCCTGGAGTTCAGAAGTC CTCTCTGTAAAGCCTGCCTCCCACTAGGTCAAGAGGAACTAGAGTACCTTTGGATTTATCAGGACCCTCATGTTTAAATGGTTATTTCCC TTTGGGAAAACTTCAGAAACTGATGTATCAAATGAGGCCCTGTGCCCTCGATCTATTTCCTTCTTCCTTCTGACCTCCTCCCAGGCACTC TTACTTCTAGCCGAACTCTTAGCTCTGGGCAGATCTCCAAGCGCCTGGAGTGCTTTTTAGCAGAGACACCTCGTTAAGCTCCGGGATGAC CTTGTAGGAGATCTGTCTCCCTGTGCCTGGAGAGTTACAGCCAGCAAGGTGCCCCCATCTTAGAGTGTGGTGTCCAAACGTGAGGTGGCT TCCTAGTTACATGAGGATGTGATCCAGGAAATCCAGTTTGGAGGCTTGATGTGGGTTTTGACCTGGCCTCAGCCTTGGGGCTGTTTTTCC TTGTTGCCCCGCTCTAGACTTTTAGCAGATCTGCAGCCCACAGGCTTTTTTGGAAGGAGTGGCTTCCTGCAGGTGTTCCACCTGCCTTCG GAGCCTGCCACCCAGGCCCTCAGAACTGAGCCACAGGCTGCTCTGGCCAGGAGAGAAACAGCTCTGTTGTTCTGCATTGGGGGAGGTACA TTCCTGCATCTTCTCACCCCCTCAACCAGGAACTGGGGATTTGGGATGAGATATGGTCAGACTTGTAGATAACCCCAAAGATGTGAAGAT CGCTTGTGAAACCATTTTGAATGAATAGATTGGTTTCCTGTGGCTCCCTCCAAACCTGGCCAAGCCCAGCTTCCGAAGCAGGAACCAGCA CTGTCTCTGTGCCTGACTCACAGCATATAGGTCAGGAAAGAATGGAGACGGCATTCTTGGACTTCACTGGGGCTGCTGGATTGGATGGGA AACCTTCTGGAAGAGGCAGATGGGGGTCAAACCACTGCCTTGGCCCCAGGAAGGGGCCATAGGTAGGTCTGAACAACTGCCGCAAGACCA CTACATGACTTAGGGAACTTGAAACCAACTGGCTCATGGAGAAAACAAATTTGACTTGGGAAAGGGATTATGTAGGAATAATGTTTGGAC TTGATTTCCCCACGTCATAATGAAGAATGGAAGTTTGGATCTGCTCCTCGTCAGGCGCAGCATCTCTGAAGCTTGGAAAGCTGTCTTCCA GCAGCCTCCGTGGCCTCGGGTTCCTACCGGCTTCTCTGCATTTGGTCTGCTGATCATGTTGCCATAATGTGTATGGAAAGTGTAACACAT TCTTACTGGTTAAAGACGACTACCAGGTATCTAACTTGTTTAACATTGAGTTTGTGTGTGTGTGTGTATGTTTGTGTGTTTTGTATATTG TTTACATTTTGAGAGGTAGCATTCTGTTTCAAATGCTTTTTGTTTTTCTGACAGTATTGTTGACTGGGTCATAACATTTTGAGCTGTGGT TTGGTGGATTTTCAATTTTTTTTTTTAAAGGTCATTCGCTGTGCTATCTTCAAAACCTTGAGTTTGGCCCCCAATTTTTGGCATTCAAAT GTTTAAAAGCTATTTATCTTGGTTTATACAAGTTTCCTTTCTCTTCTTTTTGTCATGGTATTCTATTTGGTCTGCAGTTTGAATGTAGAG AAAGTGGACTGATCCCCCAAGCGTTGTCTGCCCCCACTCTTTCCTCCTTGGGTCCCGCCATTCTTTTACTGGGCAGTCGAGGGCATTGGA GGGGAAGTGACTGCCCTCAGCCTCACTCCCTGGGGCCATGAAGAAAAGCTAAACAGTCTCATGGCATCTCAGAATAATGTTGGGTCTCCC AAGAAGAAAGGTGTAAGAATAACGACATGGCTGATTAGGCGAGGCCAGGATAGGGCTAAGGCCAGGATTCCTGGCTGGCATCCAGTCACC CCTTCTCCCATCCTTCCCCCTCTTCTTCCACAAGTCCGCAGCCGAGACACTGTAGTCTCCCAGCCACAGTGATGAGTGCCCTGGAGACTC CACTGACCTCTAGATGAAGGCCCCTGGCCCTGGTTCCTGTTAATTAACCTCTGGGTCTTTGAGTCCCCCAGCACAAACTTCTTTCCTGTA CCCTGCGGCTTGGGGTCACAGGGCATGCCGGGAAGCCACAGCTGAGGGGCGCAGACTGAAGCAGTGCTCCACCTCTCCTTCTTTAGCTCA GGGGTTGCTGGTCTGTGGCAGGCGCCACGAGTGGCCCCTGTGGCTGTTCTCAGTGGCAGTCTCTTAAGTTCCCACCACAGGCAGCTCTTT ATCCCCTCTCCCTACTTGACTCTTTCTCTTGCCTGTGCTTTTGGCCTCAAACAGGCCTGCTGGTAGCGCTCAGGGCGTGAGGCTACACTC CTGCCCTGCCTTTCCTGTCTTCATGGTCTGCCAGGGCATACCTTGGGGAGGTGGACCAAAGACCCAGGACTTTTTGCAGTAGCCAGTCCT ACCCCCCAGTTGTCTTTTTACCAATTCAGGGTGGGAGAGAAAACTGCAGCACCCCAGCATGTGAGTTACTCAGGTGTTGGGGGCTAGAAG GGACAGTGCGTTTAAACAACACTCAGAGCTCTGGCCTTAAACCTGTGGCCCCCCAAGTCTAGGAGCCTCATCTCTTCCTGGCAGTCATGC GGGCAGGAGGTCCTGAAAGGGAAAACCCATTCAGACAACTGTTCCCCAATCTACCAGCCATCTGCAGGGGTCAGTGACCGTGGCCCTCTC CCTCCTCTAGAATGTGCCACTTATGAAGAGTGCCCCATGGGGAAAAGGAGACTCAGCTGTCCCTTGGCAGCTTGTGCCAGTATCCCAGGG CAGAAGTTTCCACAGGAGCCTCTTGCCCTTGCGCAGAGCCACTGTGAGAGGCGGTGGGAGCCAACACCCTTGGGGGAGGGGGCAGTACTG CTCGGCACATCCCAGCATCAGGTCAGATCATTGAAATTAAAAAATGTGAATTAAGTTCATATCCACCTTTTGGGGAAGCAGGACAAACCA CCACCCCACCAAGTGTGTGACTTCTCCATATCCCACTGCAGTTTCCATTTTTTAAATGGGAATTTTCAATCCCCTGTGCTTGTCTAACGT CTGCTTTAAAAAGTTTGAGACCCTGTTACTGTTTGAAAATGCATGCATGTTACGATGAATCTCCAACCTGAGGAAAAAAATAAAACTCAA >In-frame_MED1_ENST00000300651_chr17_37607291_-_PIP4K2B_ENST00000269554_chr17_36943173_-_5343nt ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGATCAATGAGCTGAGCAATGTT CCTGTTCCTGTCATGCTAATGCCAGATGACTTCAAAGCCTACAGCAAGATCAAGGTGGACAATCATCTCTTCAATAAGGAGAACCTGCCC AGCCGCTTTAAGTTTAAGGAGTATTGCCCCATGGTGTTCCGAAACCTTCGGGAGAGGTTTGGAATTGATGATCAGGATTACCAGAATTCA GTGACGCGCAGCGCCCCCATCAACAGTGACAGCCAGGGTCGGTGTGGCACGCGTTTCCTCACCACCTACGACCGGCGCTTTGTCATCAAG ACTGTGTCCAGCGAGGACGTGGCGGAGATGCACAACATCTTAAAGAAATACCACCAGTTTATAGTGGAGTGTCATGGCAACACGCTTTTG CCACAGTTCCTGGGCATGTACCGCCTGACCGTGGATGGTGTGGAAACCTACATGGTGGTTACCAGGAACGTGTTCAGCCATCGGCTCACT GTGCATCGCAAGTATGACCTCAAGGGTTCTACGGTTGCCAGAGAAGCGAGCGACAAGGAGAAGGCCAAGGACTTGCCAACATTCAAAGAC AATGACTTCCTCAATGAAGGGCAGAAGCTGCATGTGGGAGAGGAGAGTAAAAAGAACTTCCTGGAGAAACTGAAGCGGGACGTTGAGTTC TTGGCACAGCTGAAGATCATGGACTACAGCCTGCTGGTGGGCATCCACGACGTGGACCGGGCAGAGCAGGAGGAGATGGAGGTGGAGGAG CGGGCAGAGGACGAGGAGTGTGAGAATGATGGGGTGGGTGGCAACCTACTCTGCTCCTATGGCACACCTCCGGACAGCCCTGGCAACCTC CTCAGCTTTCCTCGGTTCTTTGGTCCTGGGGAATTCGACCCCTCTGTTGACGTCTATGCCATGAAAAGCCATGAAAGTTCCCCCAAGAAG GAGGTGTATTTCATGGCCATCATTGATATCCTCACGCCATACGATACAAAGAAGAAAGCTGCACATGCTGCCAAAACGGTGAAACACGGG GCAGGGGCCGAGATCTCGACTGTGAACCCTGAGCAGTACTCCAAACGCTTCAACGAGTTTATGTCCAACATCCTGACGTAGTTCTCTTCT ACCTTCAGCCAGAGCCAGAGAGCTGGATATGGGGTCGGGGATCGGGAGTTAGGGAGAAGGGTGTATTTGGGCTAGATGGGAGGGTGGGAG CAGAGTCGGGTTTGGGAGGGCTTTAGCAATGAGACTGCAGCCTGTGACACCGAAAGAGACTTTAGCTGAAGAGGAGGGGGATGTGCTGTG TGTGCACCTGCTCACAGGATGTAACCCCACCTTCTGCTTACCCTTGATTTTTTCTCCCCATTTGACACCCAGGTTAAAAAGGGGTTCCCT TTTTGGTACCTTGTAACCTTTTAAGATACCTTGGGGCTAGAGATGACTTCGTGGGTTTATTTGGGTTTTGTTTCTGAAATTTCATTGCTC CAGGTTTGCTATTTATAATCATATTTCATCAGCCTACCCACCCTCCCCATCTTTGCTGAGCTCTCAGTTCCCTTCAATTAAAGAGATACC CGGTAGACCCAGCACAAGGGTCCTTCCAGAACCAAGTGCTATGGATGCCAGATTGGAGAGGTCAGACACCTCGCCCTGCTGCATTTGCTC TTGTCTGGATTAACTTTGTAATTTATGGAGTATTGTGCACAACTTCCTCCACCTTTCCCTTGGATTCAAGTGAAAACTGTTGCATTATTC CTCCATCCTGTCTGGAATACACCAGGTCAACACCAGAGATCTCAGATCAGAATCAGAGATCTCAGAGGGGAATAAGTTCATCCTCATGGG ATGGTGAGGGGCAGGAAAGCGGCTGGGCTCTTGGACACCTGGTTCTCAGAGAACCCTGTGATGATCACCCAAGCCCCAGGCTGTCTTAGC CCCTGGAGTTCAGAAGTCCTCTCTGTAAAGCCTGCCTCCCACTAGGTCAAGAGGAACTAGAGTACCTTTGGATTTATCAGGACCCTCATG TTTAAATGGTTATTTCCCTTTGGGAAAACTTCAGAAACTGATGTATCAAATGAGGCCCTGTGCCCTCGATCTATTTCCTTCTTCCTTCTG ACCTCCTCCCAGGCACTCTTACTTCTAGCCGAACTCTTAGCTCTGGGCAGATCTCCAAGCGCCTGGAGTGCTTTTTAGCAGAGACACCTC GTTAAGCTCCGGGATGACCTTGTAGGAGATCTGTCTCCCTGTGCCTGGAGAGTTACAGCCAGCAAGGTGCCCCCATCTTAGAGTGTGGTG TCCAAACGTGAGGTGGCTTCCTAGTTACATGAGGATGTGATCCAGGAAATCCAGTTTGGAGGCTTGATGTGGGTTTTGACCTGGCCTCAG CCTTGGGGCTGTTTTTCCTTGTTGCCCCGCTCTAGACTTTTAGCAGATCTGCAGCCCACAGGCTTTTTTGGAAGGAGTGGCTTCCTGCAG GTGTTCCACCTGCCTTCGGAGCCTGCCACCCAGGCCCTCAGAACTGAGCCACAGGCTGCTCTGGCCAGGAGAGAAACAGCTCTGTTGTTC TGCATTGGGGGAGGTACATTCCTGCATCTTCTCACCCCCTCAACCAGGAACTGGGGATTTGGGATGAGATATGGTCAGACTTGTAGATAA CCCCAAAGATGTGAAGATCGCTTGTGAAACCATTTTGAATGAATAGATTGGTTTCCTGTGGCTCCCTCCAAACCTGGCCAAGCCCAGCTT CCGAAGCAGGAACCAGCACTGTCTCTGTGCCTGACTCACAGCATATAGGTCAGGAAAGAATGGAGACGGCATTCTTGGACTTCACTGGGG CTGCTGGATTGGATGGGAAACCTTCTGGAAGAGGCAGATGGGGGTCAAACCACTGCCTTGGCCCCAGGAAGGGGCCATAGGTAGGTCTGA ACAACTGCCGCAAGACCACTACATGACTTAGGGAACTTGAAACCAACTGGCTCATGGAGAAAACAAATTTGACTTGGGAAAGGGATTATG TAGGAATAATGTTTGGACTTGATTTCCCCACGTCATAATGAAGAATGGAAGTTTGGATCTGCTCCTCGTCAGGCGCAGCATCTCTGAAGC TTGGAAAGCTGTCTTCCAGCAGCCTCCGTGGCCTCGGGTTCCTACCGGCTTCTCTGCATTTGGTCTGCTGATCATGTTGCCATAATGTGT ATGGAAAGTGTAACACATTCTTACTGGTTAAAGACGACTACCAGGTATCTAACTTGTTTAACATTGAGTTTGTGTGTGTGTGTGTATGTT TGTGTGTTTTGTATATTGTTTACATTTTGAGAGGTAGCATTCTGTTTCAAATGCTTTTTGTTTTTCTGACAGTATTGTTGACTGGGTCAT AACATTTTGAGCTGTGGTTTGGTGGATTTTCAATTTTTTTTTTTAAAGGTCATTCGCTGTGCTATCTTCAAAACCTTGAGTTTGGCCCCC AATTTTTGGCATTCAAATGTTTAAAAGCTATTTATCTTGGTTTATACAAGTTTCCTTTCTCTTCTTTTTGTCATGGTATTCTATTTGGTC TGCAGTTTGAATGTAGAGAAAGTGGACTGATCCCCCAAGCGTTGTCTGCCCCCACTCTTTCCTCCTTGGGTCCCGCCATTCTTTTACTGG GCAGTCGAGGGCATTGGAGGGGAAGTGACTGCCCTCAGCCTCACTCCCTGGGGCCATGAAGAAAAGCTAAACAGTCTCATGGCATCTCAG AATAATGTTGGGTCTCCCAAGAAGAAAGGTGTAAGAATAACGACATGGCTGATTAGGCGAGGCCAGGATAGGGCTAAGGCCAGGATTCCT GGCTGGCATCCAGTCACCCCTTCTCCCATCCTTCCCCCTCTTCTTCCACAAGTCCGCAGCCGAGACACTGTAGTCTCCCAGCCACAGTGA TGAGTGCCCTGGAGACTCCACTGACCTCTAGATGAAGGCCCCTGGCCCTGGTTCCTGTTAATTAACCTCTGGGTCTTTGAGTCCCCCAGC ACAAACTTCTTTCCTGTACCCTGCGGCTTGGGGTCACAGGGCATGCCGGGAAGCCACAGCTGAGGGGCGCAGACTGAAGCAGTGCTCCAC CTCTCCTTCTTTAGCTCAGGGGTTGCTGGTCTGTGGCAGGCGCCACGAGTGGCCCCTGTGGCTGTTCTCAGTGGCAGTCTCTTAAGTTCC CACCACAGGCAGCTCTTTATCCCCTCTCCCTACTTGACTCTTTCTCTTGCCTGTGCTTTTGGCCTCAAACAGGCCTGCTGGTAGCGCTCA GGGCGTGAGGCTACACTCCTGCCCTGCCTTTCCTGTCTTCATGGTCTGCCAGGGCATACCTTGGGGAGGTGGACCAAAGACCCAGGACTT TTTGCAGTAGCCAGTCCTACCCCCCAGTTGTCTTTTTACCAATTCAGGGTGGGAGAGAAAACTGCAGCACCCCAGCATGTGAGTTACTCA GGTGTTGGGGGCTAGAAGGGACAGTGCGTTTAAACAACACTCAGAGCTCTGGCCTTAAACCTGTGGCCCCCCAAGTCTAGGAGCCTCATC TCTTCCTGGCAGTCATGCGGGCAGGAGGTCCTGAAAGGGAAAACCCATTCAGACAACTGTTCCCCAATCTACCAGCCATCTGCAGGGGTC AGTGACCGTGGCCCTCTCCCTCCTCTAGAATGTGCCACTTATGAAGAGTGCCCCATGGGGAAAAGGAGACTCAGCTGTCCCTTGGCAGCT TGTGCCAGTATCCCAGGGCAGAAGTTTCCACAGGAGCCTCTTGCCCTTGCGCAGAGCCACTGTGAGAGGCGGTGGGAGCCAACACCCTTG GGGGAGGGGGCAGTACTGCTCGGCACATCCCAGCATCAGGTCAGATCATTGAAATTAAAAAATGTGAATTAAGTTCATATCCACCTTTTG GGGAAGCAGGACAAACCACCACCCCACCAAGTGTGTGACTTCTCCATATCCCACTGCAGTTTCCATTTTTTAAATGGGAATTTTCAATCC CCTGTGCTTGTCTAACGTCTGCTTTAAAAAGTTTGAGACCCTGTTACTGTTTGAAAATGCATGCATGTTACGATGAATCTCCAACCTGAG |
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FusionGenePPI for MED1_PIP4K2B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MED1 | MED10, MED9, MED29, MED19, MED28, MED26, PPARGC1A, NR3C1, YWHAQ, TGS1, TP53, CDK8, VDR, MED1, HNF4A, THRA, THRAP3, MED24, AR, ESR1, ESR2, MED13, MED6, MED16, MED17, MED20, MED14, MED12, MED23, MED27, MED4, MED7, MED8, MED30, MED22, MED31, MED15, MED18, MED11, MED25, POLR2A, MED21, POLR2F, GABPA, GATA1, ATM, POU1F1, GATA2, PARP1, RXRA, TRRAP, PPARG, RARA, SREBF1, KAT2A, SUPT3H, SUPT7L, MYC, CCNC, CDK19, POLR2E, CDK9, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, TRA, NR1H2, KIF1A, BRD4, CTDP1, NCOA6, ELAVL1, MDM2, ZNF281, ZNF326, RALY, SETD7, FBXW7, MED13L, EPAS1, EZH2, BAG3, GJB5, PIN1, POLL, NR1I3, TCL1B, HNRNPC, NTRK1, POLR2G, EMC2, SMEK1, MED12L, RPAP2, POLR2D, BIRC5, PLK1, SPAG5 | PIP4K2B | TNFRSF1A, PIP4K2B, SPOP, UBQLN4, MED18, CSNK2A2, HMBOX1, ARL6IP4, EAF1, ZRANB2, EPB41L3, LIN7A, DDX23, MYL9, PRPF8, SKP1, MED4, CLK1, CEP19, PIP4K2A, HIF1AN, LZTS2, ARHGAP22, AHCYL2, GPBP1L1, SPRY4, PRICKLE3, ZNF428, TULP3, TMEM194A, SUN2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000300651 | - | 1 | 17 | 16_590 | 8 | 1582 | ESR1 |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000300651 | - | 1 | 17 | 656_1066 | 8 | 1582 | ESR1 |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000394287 | - | 1 | 18 | 16_590 | 8 | 557 | ESR1 |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000394287 | - | 1 | 18 | 656_1066 | 8 | 557 | ESR1 |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000300651 | - | 1 | 17 | 681_715 | 8 | 1582 | GATA1 |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000394287 | - | 1 | 18 | 681_715 | 8 | 557 | GATA1 |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000300651 | - | 1 | 17 | 622_701 | 8 | 1582 | PPARGC1A and THRA |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000394287 | - | 1 | 18 | 622_701 | 8 | 557 | PPARGC1A and THRA |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000300651 | - | 1 | 17 | 108_212 | 8 | 1582 | the Mediator complex |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000300651 | - | 1 | 17 | 215_390 | 8 | 1582 | the Mediator complex |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000394287 | - | 1 | 18 | 108_212 | 8 | 557 | the Mediator complex |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000394287 | - | 1 | 18 | 215_390 | 8 | 557 | the Mediator complex |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000300651 | - | 1 | 17 | 1_670 | 8 | 1582 | the Mediator complex and THRA |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000394287 | - | 1 | 18 | 1_670 | 8 | 557 | the Mediator complex and THRA |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000300651 | - | 1 | 17 | 405_644 | 8 | 1582 | THRA |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000394287 | - | 1 | 18 | 405_644 | 8 | 557 | THRA |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000300651 | - | 1 | 17 | 1249_1421 | 8 | 1582 | TP53 |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000394287 | - | 1 | 18 | 1249_1421 | 8 | 557 | TP53 |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000300651 | - | 1 | 17 | 542_789 | 8 | 1582 | VDR |
| Hgene | MED1 | chr17:37607291 | chr17:36943173 | ENST00000394287 | - | 1 | 18 | 542_789 | 8 | 557 | VDR |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MED1_PIP4K2B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MED1_PIP4K2B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MED1 | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | MED1 | C2239176 | Liver carcinoma | 1 | CTD_human |
| Hgene | MED1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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