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Fusion gene ID: 21513 |
FusionGeneSummary for MED1_NGFR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MED1_NGFR | Fusion gene ID: 21513 | Hgene | Tgene | Gene symbol | MED1 | NGFR | Gene ID | 8930 | 4804 |
| Gene name | methyl-CpG binding domain 4, DNA glycosylase | nerve growth factor receptor | |
| Synonyms | MED1 | CD271|Gp80-LNGFR|TNFRSF16|p75(NTR)|p75NTR | |
| Cytomap | 3q21.3 | 17q21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methyl-CpG-binding domain protein 43,N(4)-ethenocytosine glycosylaseG/5-fluorouracil mismatch glycosylase with biphasic kineticsG/T mismatch glycosylaseG/U mismatch glycosylasemethyl-CpG binding domain protein 4methyl-CpG-binding endonuclease 1meth | tumor necrosis factor receptor superfamily member 16NGF receptorTNFR superfamily, member 16low affinity neurotrophin receptor p75NTRlow-affinity nerve growth factor receptorp75 ICD | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q15648 | P08138 | |
| Ensembl transtripts involved in fusion gene | ENST00000394287, ENST00000300651, | ENST00000172229, ENST00000504201, | |
| Fusion gene scores | * DoF score | 25 X 11 X 9=2475 | 4 X 2 X 3=24 |
| # samples | 25 | 4 | |
| ** MAII score | log2(25/2475*10)=-3.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MED1 [Title/Abstract] AND NGFR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NGFR | GO:0007266 | Rho protein signal transduction | 16712417 |
| Tgene | NGFR | GO:1900182 | positive regulation of protein localization to nucleus | 26268439 |
| Tgene | NGFR | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 26268439 |
| Tgene | NGFR | GO:1904646 | cellular response to amyloid-beta | 11927634 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A132-01A | MED1 | chr17 | 37604051 | - | NGFR | chr17 | 47579425 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394287 | ENST00000172229 | MED1 | chr17 | 37604051 | - | NGFR | chr17 | 47579425 | + |
| 5CDS-5UTR | ENST00000394287 | ENST00000504201 | MED1 | chr17 | 37604051 | - | NGFR | chr17 | 47579425 | + |
| In-frame | ENST00000300651 | ENST00000172229 | MED1 | chr17 | 37604051 | - | NGFR | chr17 | 47579425 | + |
| 5CDS-5UTR | ENST00000300651 | ENST00000504201 | MED1 | chr17 | 37604051 | - | NGFR | chr17 | 47579425 | + |
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FusionProtFeatures for MED1_NGFR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MED1 | NGFR |
| Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors (PubMed:10406464, PubMed:11867769,PubMed:12037571, PubMed:12218053, PubMed:12556447,PubMed:14636573, PubMed:15340084, PubMed:15471764,PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as acoactivator for GATA1-mediated transcriptional activation duringerythroid differentiation of K562 erythroleukemia cells(PubMed:24245781). {ECO:0000269|PubMed:10406464,ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571,ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447,ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084,ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967,ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781,ECO:0000269|PubMed:9653119}. | Plays a role in the regulation of the translocation ofGLUT4 to the cell surface in adipocytes and skeletal muscle cellsin response to insulin, probably by regulating RAB31 activity, andthereby contributes to the regulation of insulin-dependent glucoseuptake (By similarity). Low affinity receptor which can bind toNGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well ascell death of neural cells. Necessary for the circadianoscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1in the suprachiasmatic nucleus (SCN) of the brain and in liver andof the genes involved in glucose and lipid metabolism in theliver. {ECO:0000250, ECO:0000269|PubMed:14966521,ECO:0000269|PubMed:23785138}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >NGFR | chr17:37604051 | chr17:47579425 | ENST00000172229 | + | 0 | 6 | 197_248 | 22 | 428 | Compositional bias | Note=Ser/Thr-rich |
| Tgene | >NGFR | chr17:37604051 | chr17:47579425 | ENST00000172229 | + | 0 | 6 | 344_421 | 22 | 428 | Domain | Death |
| Tgene | >NGFR | chr17:37604051 | chr17:47579425 | ENST00000172229 | + | 0 | 6 | 108_146 | 22 | 428 | Repeat | Note=TNFR-Cys 3 |
| Tgene | >NGFR | chr17:37604051 | chr17:47579425 | ENST00000172229 | + | 0 | 6 | 148_188 | 22 | 428 | Repeat | Note=TNFR-Cys 4 |
| Tgene | >NGFR | chr17:37604051 | chr17:47579425 | ENST00000172229 | + | 0 | 6 | 31_64 | 22 | 428 | Repeat | Note=TNFR-Cys 1 |
| Tgene | >NGFR | chr17:37604051 | chr17:47579425 | ENST00000172229 | + | 0 | 6 | 66_107 | 22 | 428 | Repeat | Note=TNFR-Cys 2 |
| Tgene | >NGFR | chr17:37604051 | chr17:47579425 | ENST00000172229 | + | 0 | 6 | 273_427 | 22 | 428 | Topological domain | Cytoplasmic |
| Tgene | >NGFR | chr17:37604051 | chr17:47579425 | ENST00000172229 | + | 0 | 6 | 29_250 | 22 | 428 | Topological domain | Extracellular |
| Tgene | >NGFR | chr17:37604051 | chr17:47579425 | ENST00000172229 | + | 0 | 6 | 251_272 | 22 | 428 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MED1 | chr17:37604051 | chr17:47579425 | ENST00000300651 | - | 2 | 17 | 1078_1482 | 44 | 1582 | Compositional bias | Note=Ser-rich |
| Hgene | >MED1 | chr17:37604051 | chr17:47579425 | ENST00000300651 | - | 2 | 17 | 1496_1529 | 44 | 1582 | Compositional bias | Note=Lys-rich |
| Hgene | >MED1 | chr17:37604051 | chr17:47579425 | ENST00000394287 | - | 2 | 18 | 1078_1482 | 44 | 557 | Compositional bias | Note=Ser-rich |
| Hgene | >MED1 | chr17:37604051 | chr17:47579425 | ENST00000394287 | - | 2 | 18 | 1496_1529 | 44 | 557 | Compositional bias | Note=Lys-rich |
| Hgene | >MED1 | chr17:37604051 | chr17:47579425 | ENST00000300651 | - | 2 | 17 | 604_608 | 44 | 1582 | Motif | Note=LXXLL motif 1 |
| Hgene | >MED1 | chr17:37604051 | chr17:47579425 | ENST00000300651 | - | 2 | 17 | 645_649 | 44 | 1582 | Motif | Note=LXXLL motif 2 |
| Hgene | >MED1 | chr17:37604051 | chr17:47579425 | ENST00000394287 | - | 2 | 18 | 604_608 | 44 | 557 | Motif | Note=LXXLL motif 1 |
| Hgene | >MED1 | chr17:37604051 | chr17:47579425 | ENST00000394287 | - | 2 | 18 | 645_649 | 44 | 557 | Motif | Note=LXXLL motif 2 |
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FusionGeneSequence for MED1_NGFR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MED1_ENST00000394287_chr17_37604051_-_NGFR_ENST00000172229_chr17_47579425_+_450aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCL DSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEA NHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTT DNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSS LPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSESTATSPVX >In-frame_MED1_ENST00000300651_chr17_37604051_-_NGFR_ENST00000172229_chr17_47579425_+_450aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCL DSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEA NHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTT DNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSS LPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSESTATSPVX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MED1_ENST00000394287_chr17_37604051_-_NGFR_ENST00000172229_chr17_47579425_+_1350nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGTGTCCCTTGGAGGTGCCAAGGAGGCATGCCCCACAGGCCTGTACACA CACAGCGGTGAGTGCTGCAAAGCCTGCAACCTGGGCGAGGGTGTGGCCCAGCCTTGTGGAGCCAACCAGACCGTGTGTGAGCCCTGCCTG GACAGCGTGACGTTCTCCGACGTGGTGAGCGCGACCGAGCCGTGCAAGCCGTGCACCGAGTGCGTGGGGCTCCAGAGCATGTCGGCGCCG TGCGTGGAGGCCGACGACGCCGTGTGCCGCTGCGCCTACGGCTACTACCAGGATGAGACGACTGGGCGCTGCGAGGCGTGCCGCGTGTGC GAGGCGGGCTCGGGCCTCGTGTTCTCCTGCCAGGACAAGCAGAACACCGTGTGCGAGGAGTGCCCCGACGGCACGTATTCCGACGAGGCC AACCACGTGGACCCGTGCCTGCCCTGCACCGTGTGCGAGGACACCGAGCGCCAGCTCCGCGAGTGCACACGCTGGGCCGACGCCGAGTGC GAGGAGATCCCTGGCCGTTGGATTACACGGTCCACACCCCCAGAGGGCTCGGACAGCACAGCCCCCAGCACCCAGGAGCCTGAGGCACCT CCAGAACAAGACCTCATAGCCAGCACGGTGGCAGGTGTGGTGACCACAGTGATGGGCAGCTCCCAGCCCGTGGTGACCCGAGGCACCACC GACAACCTCATCCCTGTCTATTGCTCCATCCTGGCTGCTGTGGTTGTGGGCCTTGTGGCCTACATAGCCTTCAAGAGGTGGAACAGCTGC AAGCAGAACAAGCAAGGAGCCAACAGCCGGCCAGTGAACCAGACGCCCCCACCAGAGGGAGAAAAACTCCACAGCGACAGTGGCATCTCC GTGGACAGCCAGAGCCTGCATGACCAGCAGCCCCACACGCAGACAGCCTCGGGCCAGGCCCTCAAGGGTGACGGAGGCCTCTACAGCAGC CTGCCCCCAGCCAAGCGGGAGGAGGTGGAGAAGCTTCTCAACGGCTCTGCGGGGGACACCTGGCGGCACCTGGCGGGCGAGCTGGGCTAC CAGCCCGAGCACATAGACTCCTTTACCCATGAGGCCTGCCCCGTTCGCGCCCTGCTTGCAAGCTGGGCCACCCAGGACAGCGCCACACTG GACGCCCTCCTGGCCGCCCTGCGCCGCATCCAGCGAGCCGACCTCGTGGAGAGTCTGTGCAGTGAGTCCACTGCCACATCCCCGGTGTGA >In-frame_MED1_ENST00000300651_chr17_37604051_-_NGFR_ENST00000172229_chr17_47579425_+_1350nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGTGTCCCTTGGAGGTGCCAAGGAGGCATGCCCCACAGGCCTGTACACA CACAGCGGTGAGTGCTGCAAAGCCTGCAACCTGGGCGAGGGTGTGGCCCAGCCTTGTGGAGCCAACCAGACCGTGTGTGAGCCCTGCCTG GACAGCGTGACGTTCTCCGACGTGGTGAGCGCGACCGAGCCGTGCAAGCCGTGCACCGAGTGCGTGGGGCTCCAGAGCATGTCGGCGCCG TGCGTGGAGGCCGACGACGCCGTGTGCCGCTGCGCCTACGGCTACTACCAGGATGAGACGACTGGGCGCTGCGAGGCGTGCCGCGTGTGC GAGGCGGGCTCGGGCCTCGTGTTCTCCTGCCAGGACAAGCAGAACACCGTGTGCGAGGAGTGCCCCGACGGCACGTATTCCGACGAGGCC AACCACGTGGACCCGTGCCTGCCCTGCACCGTGTGCGAGGACACCGAGCGCCAGCTCCGCGAGTGCACACGCTGGGCCGACGCCGAGTGC GAGGAGATCCCTGGCCGTTGGATTACACGGTCCACACCCCCAGAGGGCTCGGACAGCACAGCCCCCAGCACCCAGGAGCCTGAGGCACCT CCAGAACAAGACCTCATAGCCAGCACGGTGGCAGGTGTGGTGACCACAGTGATGGGCAGCTCCCAGCCCGTGGTGACCCGAGGCACCACC GACAACCTCATCCCTGTCTATTGCTCCATCCTGGCTGCTGTGGTTGTGGGCCTTGTGGCCTACATAGCCTTCAAGAGGTGGAACAGCTGC AAGCAGAACAAGCAAGGAGCCAACAGCCGGCCAGTGAACCAGACGCCCCCACCAGAGGGAGAAAAACTCCACAGCGACAGTGGCATCTCC GTGGACAGCCAGAGCCTGCATGACCAGCAGCCCCACACGCAGACAGCCTCGGGCCAGGCCCTCAAGGGTGACGGAGGCCTCTACAGCAGC CTGCCCCCAGCCAAGCGGGAGGAGGTGGAGAAGCTTCTCAACGGCTCTGCGGGGGACACCTGGCGGCACCTGGCGGGCGAGCTGGGCTAC CAGCCCGAGCACATAGACTCCTTTACCCATGAGGCCTGCCCCGTTCGCGCCCTGCTTGCAAGCTGGGCCACCCAGGACAGCGCCACACTG GACGCCCTCCTGGCCGCCCTGCGCCGCATCCAGCGAGCCGACCTCGTGGAGAGTCTGTGCAGTGAGTCCACTGCCACATCCCCGGTGTGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MED1_ENST00000394287_chr17_37604051_-_NGFR_ENST00000172229_chr17_47579425_+_3564nt TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGTGTCCCTTGGAGGTGCCAAGG AGGCATGCCCCACAGGCCTGTACACACACAGCGGTGAGTGCTGCAAAGCCTGCAACCTGGGCGAGGGTGTGGCCCAGCCTTGTGGAGCCA ACCAGACCGTGTGTGAGCCCTGCCTGGACAGCGTGACGTTCTCCGACGTGGTGAGCGCGACCGAGCCGTGCAAGCCGTGCACCGAGTGCG TGGGGCTCCAGAGCATGTCGGCGCCGTGCGTGGAGGCCGACGACGCCGTGTGCCGCTGCGCCTACGGCTACTACCAGGATGAGACGACTG GGCGCTGCGAGGCGTGCCGCGTGTGCGAGGCGGGCTCGGGCCTCGTGTTCTCCTGCCAGGACAAGCAGAACACCGTGTGCGAGGAGTGCC CCGACGGCACGTATTCCGACGAGGCCAACCACGTGGACCCGTGCCTGCCCTGCACCGTGTGCGAGGACACCGAGCGCCAGCTCCGCGAGT GCACACGCTGGGCCGACGCCGAGTGCGAGGAGATCCCTGGCCGTTGGATTACACGGTCCACACCCCCAGAGGGCTCGGACAGCACAGCCC CCAGCACCCAGGAGCCTGAGGCACCTCCAGAACAAGACCTCATAGCCAGCACGGTGGCAGGTGTGGTGACCACAGTGATGGGCAGCTCCC AGCCCGTGGTGACCCGAGGCACCACCGACAACCTCATCCCTGTCTATTGCTCCATCCTGGCTGCTGTGGTTGTGGGCCTTGTGGCCTACA TAGCCTTCAAGAGGTGGAACAGCTGCAAGCAGAACAAGCAAGGAGCCAACAGCCGGCCAGTGAACCAGACGCCCCCACCAGAGGGAGAAA AACTCCACAGCGACAGTGGCATCTCCGTGGACAGCCAGAGCCTGCATGACCAGCAGCCCCACACGCAGACAGCCTCGGGCCAGGCCCTCA AGGGTGACGGAGGCCTCTACAGCAGCCTGCCCCCAGCCAAGCGGGAGGAGGTGGAGAAGCTTCTCAACGGCTCTGCGGGGGACACCTGGC GGCACCTGGCGGGCGAGCTGGGCTACCAGCCCGAGCACATAGACTCCTTTACCCATGAGGCCTGCCCCGTTCGCGCCCTGCTTGCAAGCT GGGCCACCCAGGACAGCGCCACACTGGACGCCCTCCTGGCCGCCCTGCGCCGCATCCAGCGAGCCGACCTCGTGGAGAGTCTGTGCAGTG AGTCCACTGCCACATCCCCGGTGTGAGCCCAACCGGGGAGCCCCCGCCCCGCCCCACATTCCGACAACCGATGCTCCAGCCAACCCCTGT GGAGCCCGCACCCCCACCCTTTGGGGGGGGCCCGCCTGGCAGAACTGAGCTCCTCTGGGCAGGACCTCAGAGTCCAGGCCCCAAAACCAC AGCCCTGTCAGTGCAGCCCGTGTGGCCCCTTCACTTCTGACCACACTTCCTGTCCAGAGAGAGAAGTGCCCCTGCTGCCTCCCCAACCCT GCCCCTGCCCCGTCACCATCTCAGGCCACCTGCCCCCTTCTCCCACACTGCTAGGTGGGCCAGCCCCTCCCACCACAGCAGGTGTCATAT ATGGGGGGCCAACACCAGGGATGGTACTAGGGGGAAGTGACAAGGCCCCAGAGACTCAGAGGGAGGAATCGAGGAACCAGAGCCATGGAC TCTACACTGTGAACTTGGGGAACAAGGGTGGCATCCCAGTGGCCTCAACCCTCCCTCAGCCCCTCTTGCCCCCCACCCCAGCCTAAGATG AAGAGGATCGGAGGCTTGTCAGAGCTGGGAGGGGTTTTCGAAGCTCAGCCCACCCCCCTCATTTTGGATATAGGTCAGTGAGGCCCAGGG AGAGGCCATGATTCGCCCAAAGCCAGACAGCAACGGGGAGGCCAAGTGCAGGCTGGCACCGCCTTCTCTAAATGAGGGGCCTCAGGTTTG CCTGAGGGCGAGGGGAGGGTGGCAGGTGACCTTCTGGGAAATGGCTTGAAGCCAAGTCAGCTTTGCCTTCCACGCTGTCTCCAGACCCCC ACCCCTTCCCCACTGCCTGCCCACCCGTGGAGATGGGATGCTTGCCTAGGGCCTGGTCCATGATGGAGTCAGGTTTGGGGTTCGTGGAAA GGGTGCTGCTTCCCTCTGCCTGTCCCTCTCAGGCATGCCTGTGTGACATCAGTGGCATGGCTCCAGTCTGCTGCCCTCCATCCCGACATG GACCCGGAGCTAACACTGGCCCCTAGAATCAGCCTAGGGGTCAGGGACCAAGGACCCCTCACCTTGCAACACACAGACACACGCACACAC ACACACAGGAGGAGAAATCTCACTTTTCTCCATGAGTTTTTTCTCTTGGGCTGAGACTGGATACTGCCCGGGGCAGCTGCCAGAGAAGCA TCGGAGGGAATTGAGGTCTGCTCGGCCGTCTTCACTCGCCCCCGGGTTTGGCGGGCCAAGGACTGCCGACCGAGGCTGGAGCTGGCGTCT GTCTTCAAGGGCTTACACGTGGAGGAATGCTCCCCCATCCTCCCCTTCCCTGCAAACATGGGGTTGGCTGGGCCCAGAAGGTTGTGATGA AGAAAAGTGGGCCAGTGTGGGAATGCGGCAAGAAGGAATTGACTTCGACTGTGACCTGTGGGGATTTCTCCCAGCTCTAGACAACCCTGC AAAGGACTGTTTTTTCCTGAGCTTGGCCAGAAGGGGGCCATGAGGCCTCAGTGGACTTTCCACCCCCTCCCTGGCCTGTTCTGTTTTGCC TGAAGTTGGAGTGAGTGTGGCTCCCCTCTATTTAGCATGACAAGCCCCAGGCAGGCTGTGCGCTGACAACCACCGCTCCCCAGCCCAGGG TTCCCCCAGCCCTGTGGAAGGGACTAGGAGCACTGTAGTAAATGGCAATTCTTTGACCTCAACCTGTGATGAGGGGAGGAAACTCACCTG CTGGCCCCTCACCTGGGCACCTGGGGAGTGGGACAGAGTCTGGGTGTATTTATTTTCCTCCCCAGCAGGTGGGGAGGGGGTTTGGGGGCT TGCAAGTATGTTTTAGCATGTGTTTGGTTCTGGGGCCCCTTTTTACTCCCCTTGAGCTGAGATGGAACCCTTTTGGCCCCCGAGCTGGGG GCCATGAGCTCCAGACCCCCAGCAACCCTCCTATCACCTCCCCTCCTTGCCTCCTGTGTAATCATTTCTTGGGCCCTCCTGAAACTTACA >In-frame_MED1_ENST00000300651_chr17_37604051_-_NGFR_ENST00000172229_chr17_47579425_+_3582nt ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGTGT CCCTTGGAGGTGCCAAGGAGGCATGCCCCACAGGCCTGTACACACACAGCGGTGAGTGCTGCAAAGCCTGCAACCTGGGCGAGGGTGTGG CCCAGCCTTGTGGAGCCAACCAGACCGTGTGTGAGCCCTGCCTGGACAGCGTGACGTTCTCCGACGTGGTGAGCGCGACCGAGCCGTGCA AGCCGTGCACCGAGTGCGTGGGGCTCCAGAGCATGTCGGCGCCGTGCGTGGAGGCCGACGACGCCGTGTGCCGCTGCGCCTACGGCTACT ACCAGGATGAGACGACTGGGCGCTGCGAGGCGTGCCGCGTGTGCGAGGCGGGCTCGGGCCTCGTGTTCTCCTGCCAGGACAAGCAGAACA CCGTGTGCGAGGAGTGCCCCGACGGCACGTATTCCGACGAGGCCAACCACGTGGACCCGTGCCTGCCCTGCACCGTGTGCGAGGACACCG AGCGCCAGCTCCGCGAGTGCACACGCTGGGCCGACGCCGAGTGCGAGGAGATCCCTGGCCGTTGGATTACACGGTCCACACCCCCAGAGG GCTCGGACAGCACAGCCCCCAGCACCCAGGAGCCTGAGGCACCTCCAGAACAAGACCTCATAGCCAGCACGGTGGCAGGTGTGGTGACCA CAGTGATGGGCAGCTCCCAGCCCGTGGTGACCCGAGGCACCACCGACAACCTCATCCCTGTCTATTGCTCCATCCTGGCTGCTGTGGTTG TGGGCCTTGTGGCCTACATAGCCTTCAAGAGGTGGAACAGCTGCAAGCAGAACAAGCAAGGAGCCAACAGCCGGCCAGTGAACCAGACGC CCCCACCAGAGGGAGAAAAACTCCACAGCGACAGTGGCATCTCCGTGGACAGCCAGAGCCTGCATGACCAGCAGCCCCACACGCAGACAG CCTCGGGCCAGGCCCTCAAGGGTGACGGAGGCCTCTACAGCAGCCTGCCCCCAGCCAAGCGGGAGGAGGTGGAGAAGCTTCTCAACGGCT CTGCGGGGGACACCTGGCGGCACCTGGCGGGCGAGCTGGGCTACCAGCCCGAGCACATAGACTCCTTTACCCATGAGGCCTGCCCCGTTC GCGCCCTGCTTGCAAGCTGGGCCACCCAGGACAGCGCCACACTGGACGCCCTCCTGGCCGCCCTGCGCCGCATCCAGCGAGCCGACCTCG TGGAGAGTCTGTGCAGTGAGTCCACTGCCACATCCCCGGTGTGAGCCCAACCGGGGAGCCCCCGCCCCGCCCCACATTCCGACAACCGAT GCTCCAGCCAACCCCTGTGGAGCCCGCACCCCCACCCTTTGGGGGGGGCCCGCCTGGCAGAACTGAGCTCCTCTGGGCAGGACCTCAGAG TCCAGGCCCCAAAACCACAGCCCTGTCAGTGCAGCCCGTGTGGCCCCTTCACTTCTGACCACACTTCCTGTCCAGAGAGAGAAGTGCCCC TGCTGCCTCCCCAACCCTGCCCCTGCCCCGTCACCATCTCAGGCCACCTGCCCCCTTCTCCCACACTGCTAGGTGGGCCAGCCCCTCCCA CCACAGCAGGTGTCATATATGGGGGGCCAACACCAGGGATGGTACTAGGGGGAAGTGACAAGGCCCCAGAGACTCAGAGGGAGGAATCGA GGAACCAGAGCCATGGACTCTACACTGTGAACTTGGGGAACAAGGGTGGCATCCCAGTGGCCTCAACCCTCCCTCAGCCCCTCTTGCCCC CCACCCCAGCCTAAGATGAAGAGGATCGGAGGCTTGTCAGAGCTGGGAGGGGTTTTCGAAGCTCAGCCCACCCCCCTCATTTTGGATATA GGTCAGTGAGGCCCAGGGAGAGGCCATGATTCGCCCAAAGCCAGACAGCAACGGGGAGGCCAAGTGCAGGCTGGCACCGCCTTCTCTAAA TGAGGGGCCTCAGGTTTGCCTGAGGGCGAGGGGAGGGTGGCAGGTGACCTTCTGGGAAATGGCTTGAAGCCAAGTCAGCTTTGCCTTCCA CGCTGTCTCCAGACCCCCACCCCTTCCCCACTGCCTGCCCACCCGTGGAGATGGGATGCTTGCCTAGGGCCTGGTCCATGATGGAGTCAG GTTTGGGGTTCGTGGAAAGGGTGCTGCTTCCCTCTGCCTGTCCCTCTCAGGCATGCCTGTGTGACATCAGTGGCATGGCTCCAGTCTGCT GCCCTCCATCCCGACATGGACCCGGAGCTAACACTGGCCCCTAGAATCAGCCTAGGGGTCAGGGACCAAGGACCCCTCACCTTGCAACAC ACAGACACACGCACACACACACACAGGAGGAGAAATCTCACTTTTCTCCATGAGTTTTTTCTCTTGGGCTGAGACTGGATACTGCCCGGG GCAGCTGCCAGAGAAGCATCGGAGGGAATTGAGGTCTGCTCGGCCGTCTTCACTCGCCCCCGGGTTTGGCGGGCCAAGGACTGCCGACCG AGGCTGGAGCTGGCGTCTGTCTTCAAGGGCTTACACGTGGAGGAATGCTCCCCCATCCTCCCCTTCCCTGCAAACATGGGGTTGGCTGGG CCCAGAAGGTTGTGATGAAGAAAAGTGGGCCAGTGTGGGAATGCGGCAAGAAGGAATTGACTTCGACTGTGACCTGTGGGGATTTCTCCC AGCTCTAGACAACCCTGCAAAGGACTGTTTTTTCCTGAGCTTGGCCAGAAGGGGGCCATGAGGCCTCAGTGGACTTTCCACCCCCTCCCT GGCCTGTTCTGTTTTGCCTGAAGTTGGAGTGAGTGTGGCTCCCCTCTATTTAGCATGACAAGCCCCAGGCAGGCTGTGCGCTGACAACCA CCGCTCCCCAGCCCAGGGTTCCCCCAGCCCTGTGGAAGGGACTAGGAGCACTGTAGTAAATGGCAATTCTTTGACCTCAACCTGTGATGA GGGGAGGAAACTCACCTGCTGGCCCCTCACCTGGGCACCTGGGGAGTGGGACAGAGTCTGGGTGTATTTATTTTCCTCCCCAGCAGGTGG GGAGGGGGTTTGGGGGCTTGCAAGTATGTTTTAGCATGTGTTTGGTTCTGGGGCCCCTTTTTACTCCCCTTGAGCTGAGATGGAACCCTT TTGGCCCCCGAGCTGGGGGCCATGAGCTCCAGACCCCCAGCAACCCTCCTATCACCTCCCCTCCTTGCCTCCTGTGTAATCATTTCTTGG |
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FusionGenePPI for MED1_NGFR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MED1 | MED10, MED9, MED29, MED19, MED28, MED26, PPARGC1A, NR3C1, YWHAQ, TGS1, TP53, CDK8, VDR, MED1, HNF4A, THRA, THRAP3, MED24, AR, ESR1, ESR2, MED13, MED6, MED16, MED17, MED20, MED14, MED12, MED23, MED27, MED4, MED7, MED8, MED30, MED22, MED31, MED15, MED18, MED11, MED25, POLR2A, MED21, POLR2F, GABPA, GATA1, ATM, POU1F1, GATA2, PARP1, RXRA, TRRAP, PPARG, RARA, SREBF1, KAT2A, SUPT3H, SUPT7L, MYC, CCNC, CDK19, POLR2E, CDK9, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, TRA, NR1H2, KIF1A, BRD4, CTDP1, NCOA6, ELAVL1, MDM2, ZNF281, ZNF326, RALY, SETD7, FBXW7, MED13L, EPAS1, EZH2, BAG3, GJB5, PIN1, POLL, NR1I3, TCL1B, HNRNPC, NTRK1, POLR2G, EMC2, SMEK1, MED12L, RPAP2, POLR2D, BIRC5, PLK1, SPAG5 | NGFR | PRKACB, NGF, NDN, NDNL2, FSCN1, MAGED1, TRADD, MAGEH1, CAV1, NGFRAP1, TRAF1, TRAF3, TRAF4, TRAF5, TRAF6, TRAF2, SHC1, TRIM37, TCF19, UFD1L, H2AFX, TK1, CDKN1A, SMN1, STMN2, RCC1, RPN2, TTR, ANXA7, NGFR, BFAR, CD80, SQSTM1, IKBKB, NTRK1, MDM2, TP53 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000300651 | - | 2 | 17 | 16_590 | 44 | 1582 | ESR1 |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000300651 | - | 2 | 17 | 656_1066 | 44 | 1582 | ESR1 |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000394287 | - | 2 | 18 | 16_590 | 44 | 557 | ESR1 |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000394287 | - | 2 | 18 | 656_1066 | 44 | 557 | ESR1 |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000300651 | - | 2 | 17 | 681_715 | 44 | 1582 | GATA1 |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000394287 | - | 2 | 18 | 681_715 | 44 | 557 | GATA1 |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000300651 | - | 2 | 17 | 622_701 | 44 | 1582 | PPARGC1A and THRA |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000394287 | - | 2 | 18 | 622_701 | 44 | 557 | PPARGC1A and THRA |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000300651 | - | 2 | 17 | 108_212 | 44 | 1582 | the Mediator complex |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000300651 | - | 2 | 17 | 215_390 | 44 | 1582 | the Mediator complex |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000394287 | - | 2 | 18 | 108_212 | 44 | 557 | the Mediator complex |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000394287 | - | 2 | 18 | 215_390 | 44 | 557 | the Mediator complex |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000300651 | - | 2 | 17 | 1_670 | 44 | 1582 | the Mediator complex and THRA |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000394287 | - | 2 | 18 | 1_670 | 44 | 557 | the Mediator complex and THRA |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000300651 | - | 2 | 17 | 405_644 | 44 | 1582 | THRA |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000394287 | - | 2 | 18 | 405_644 | 44 | 557 | THRA |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000300651 | - | 2 | 17 | 1249_1421 | 44 | 1582 | TP53 |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000394287 | - | 2 | 18 | 1249_1421 | 44 | 557 | TP53 |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000300651 | - | 2 | 17 | 542_789 | 44 | 1582 | VDR |
| Hgene | MED1 | chr17:37604051 | chr17:47579425 | ENST00000394287 | - | 2 | 18 | 542_789 | 44 | 557 | VDR |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MED1_NGFR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MED1_NGFR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MED1 | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | MED1 | C2239176 | Liver carcinoma | 1 | CTD_human |
| Hgene | MED1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Tgene | NGFR | C0011581 | Depressive disorder | 2 | PSYGENET |
| Tgene | NGFR | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Tgene | NGFR | C0011570 | Mental Depression | 1 | PSYGENET |
| Tgene | NGFR | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Tgene | NGFR | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | NGFR | C0036572 | Seizures | 1 | CTD_human |
| Tgene | NGFR | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
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