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Fusion gene ID: 21511 |
FusionGeneSummary for MED1_KRT222 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MED1_KRT222 | Fusion gene ID: 21511 | Hgene | Tgene | Gene symbol | MED1 | KRT222 | Gene ID | 8930 | 125113 |
| Gene name | methyl-CpG binding domain 4, DNA glycosylase | keratin 222 | |
| Synonyms | MED1 | KA21|KRT222P | |
| Cytomap | 3q21.3 | 17q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methyl-CpG-binding domain protein 43,N(4)-ethenocytosine glycosylaseG/5-fluorouracil mismatch glycosylase with biphasic kineticsG/T mismatch glycosylaseG/U mismatch glycosylasemethyl-CpG binding domain protein 4methyl-CpG-binding endonuclease 1meth | keratin-like protein KRT222keratin 222, type IIkeratin-222 pseudogene | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q15648 | Q8N1A0 | |
| Ensembl transtripts involved in fusion gene | ENST00000394287, ENST00000300651, | ENST00000476049, ENST00000394052, | |
| Fusion gene scores | * DoF score | 25 X 11 X 9=2475 | 5 X 5 X 5=125 |
| # samples | 25 | 6 | |
| ** MAII score | log2(25/2475*10)=-3.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MED1 [Title/Abstract] AND KRT222 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-ER-A2NF-01A | MED1 | chr17 | 37604051 | - | KRT222 | chr17 | 38818296 | - |
| TCGA | RV | SKCM | TCGA-ER-A2NF-06A | MED1 | chr17 | 37604051 | - | KRT222 | chr17 | 38818296 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394287 | ENST00000476049 | MED1 | chr17 | 37604051 | - | KRT222 | chr17 | 38818296 | - |
| In-frame | ENST00000394287 | ENST00000394052 | MED1 | chr17 | 37604051 | - | KRT222 | chr17 | 38818296 | - |
| In-frame | ENST00000300651 | ENST00000476049 | MED1 | chr17 | 37604051 | - | KRT222 | chr17 | 38818296 | - |
| In-frame | ENST00000300651 | ENST00000394052 | MED1 | chr17 | 37604051 | - | KRT222 | chr17 | 38818296 | - |
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FusionProtFeatures for MED1_KRT222 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MED1 | KRT222 |
| Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors (PubMed:10406464, PubMed:11867769,PubMed:12037571, PubMed:12218053, PubMed:12556447,PubMed:14636573, PubMed:15340084, PubMed:15471764,PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as acoactivator for GATA1-mediated transcriptional activation duringerythroid differentiation of K562 erythroleukemia cells(PubMed:24245781). {ECO:0000269|PubMed:10406464,ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571,ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447,ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084,ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967,ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781,ECO:0000269|PubMed:9653119}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MED1 | chr17:37604051 | chr17:38818296 | ENST00000300651 | - | 2 | 17 | 1078_1482 | 44 | 1582 | Compositional bias | Note=Ser-rich |
| Hgene | >MED1 | chr17:37604051 | chr17:38818296 | ENST00000300651 | - | 2 | 17 | 1496_1529 | 44 | 1582 | Compositional bias | Note=Lys-rich |
| Hgene | >MED1 | chr17:37604051 | chr17:38818296 | ENST00000394287 | - | 2 | 18 | 1078_1482 | 44 | 557 | Compositional bias | Note=Ser-rich |
| Hgene | >MED1 | chr17:37604051 | chr17:38818296 | ENST00000394287 | - | 2 | 18 | 1496_1529 | 44 | 557 | Compositional bias | Note=Lys-rich |
| Hgene | >MED1 | chr17:37604051 | chr17:38818296 | ENST00000300651 | - | 2 | 17 | 604_608 | 44 | 1582 | Motif | Note=LXXLL motif 1 |
| Hgene | >MED1 | chr17:37604051 | chr17:38818296 | ENST00000300651 | - | 2 | 17 | 645_649 | 44 | 1582 | Motif | Note=LXXLL motif 2 |
| Hgene | >MED1 | chr17:37604051 | chr17:38818296 | ENST00000394287 | - | 2 | 18 | 604_608 | 44 | 557 | Motif | Note=LXXLL motif 1 |
| Hgene | >MED1 | chr17:37604051 | chr17:38818296 | ENST00000394287 | - | 2 | 18 | 645_649 | 44 | 557 | Motif | Note=LXXLL motif 2 |
| Tgene | KRT222 | chr17:37604051 | chr17:38818296 | ENST00000394052 | - | 0 | 6 | 2_150 | 32 | 296 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KRT222 | chr17:37604051 | chr17:38818296 | ENST00000394052 | - | 0 | 6 | 1_150 | 32 | 296 | Domain | IF rod |
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FusionGeneSequence for MED1_KRT222 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MED1_ENST00000394287_chr17_37604051_-_KRT222_ENST00000476049_chr17_38818296_-_44aa >In-frame_MED1_ENST00000394287_chr17_37604051_-_KRT222_ENST00000394052_chr17_38818296_-_308aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMLEEDISKKMDKDEEALKAAQAELKEARRQWHHLQVEIESLHAVERG LENSLHASEQHYQMQLQDLETVIEGLEKELQEVRRGIEKQLQEHEMLLNTKMRLEQEIATYRHLLEKEEIRYYGCIQGGKKDKKPTTSRV GFVLPSAIINEISFTTKVPQKYENENVETVTKQAILNGSIVKESTEAHGTIQTEKVDEVIKEWEGSFFKDNPRLRKKSVSLRFDLHLAAT >In-frame_MED1_ENST00000300651_chr17_37604051_-_KRT222_ENST00000476049_chr17_38818296_-_44aa >In-frame_MED1_ENST00000300651_chr17_37604051_-_KRT222_ENST00000394052_chr17_38818296_-_308aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMLEEDISKKMDKDEEALKAAQAELKEARRQWHHLQVEIESLHAVERG LENSLHASEQHYQMQLQDLETVIEGLEKELQEVRRGIEKQLQEHEMLLNTKMRLEQEIATYRHLLEKEEIRYYGCIQGGKKDKKPTTSRV GFVLPSAIINEISFTTKVPQKYENENVETVTKQAILNGSIVKESTEAHGTIQTEKVDEVIKEWEGSFFKDNPRLRKKSVSLRFDLHLAAT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MED1_ENST00000394287_chr17_37604051_-_KRT222_ENST00000476049_chr17_38818296_-_132nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT >In-frame_MED1_ENST00000394287_chr17_37604051_-_KRT222_ENST00000394052_chr17_38818296_-_924nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGCTAGAAGAAGACATAAGCAAAAAAATGGACAAAGATGAAGAGGCTTTG AAGGCAGCTCAAGCAGAACTCAAGGAGGCCCGACGCCAGTGGCACCACCTGCAAGTGGAAATTGAATCTCTCCATGCTGTGGAAAGGGGC CTTGAAAACTCCCTACATGCCAGCGAGCAGCATTACCAGATGCAGCTGCAAGACCTAGAGACTGTGATTGAAGGACTAGAAAAAGAGCTA CAGGAAGTAAGGCGCGGCATCGAAAAGCAGCTTCAAGAGCACGAGATGCTTCTCAACACGAAGATGAGGCTGGAACAAGAAATAGCAACT TATCGCCACCTCCTAGAAAAAGAAGAAATCAGATATTATGGTTGTATCCAAGGTGGGAAAAAAGACAAAAAGCCTACCACAAGTAGAGTT GGTTTTGTTTTACCATCAGCCATTATAAATGAAATATCTTTTACTACAAAAGTCCCACAAAAGTATGAGAATGAAAATGTAGAAACAGTA ACCAAACAGGCAATCTTAAATGGGAGTATCGTTAAGGAGAGCACTGAAGCTCATGGCACTATTCAGACAGAGAAAGTGGATGAAGTTATT AAAGAATGGGAAGGTTCTTTCTTTAAAGATAACCCTCGATTGAGGAAAAAGTCTGTTTCTCTTCGATTTGATCTTCATTTAGCAGCCACT GATGAAGGGTGTTTAGAGACTAAGCAGGATAATCTACCAGATATAGAAGTCAGGCTTATCATGAGAAGATCATGCAGTATTCCCTCTATC >In-frame_MED1_ENST00000300651_chr17_37604051_-_KRT222_ENST00000476049_chr17_38818296_-_132nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT >In-frame_MED1_ENST00000300651_chr17_37604051_-_KRT222_ENST00000394052_chr17_38818296_-_924nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGCTAGAAGAAGACATAAGCAAAAAAATGGACAAAGATGAAGAGGCTTTG AAGGCAGCTCAAGCAGAACTCAAGGAGGCCCGACGCCAGTGGCACCACCTGCAAGTGGAAATTGAATCTCTCCATGCTGTGGAAAGGGGC CTTGAAAACTCCCTACATGCCAGCGAGCAGCATTACCAGATGCAGCTGCAAGACCTAGAGACTGTGATTGAAGGACTAGAAAAAGAGCTA CAGGAAGTAAGGCGCGGCATCGAAAAGCAGCTTCAAGAGCACGAGATGCTTCTCAACACGAAGATGAGGCTGGAACAAGAAATAGCAACT TATCGCCACCTCCTAGAAAAAGAAGAAATCAGATATTATGGTTGTATCCAAGGTGGGAAAAAAGACAAAAAGCCTACCACAAGTAGAGTT GGTTTTGTTTTACCATCAGCCATTATAAATGAAATATCTTTTACTACAAAAGTCCCACAAAAGTATGAGAATGAAAATGTAGAAACAGTA ACCAAACAGGCAATCTTAAATGGGAGTATCGTTAAGGAGAGCACTGAAGCTCATGGCACTATTCAGACAGAGAAAGTGGATGAAGTTATT AAAGAATGGGAAGGTTCTTTCTTTAAAGATAACCCTCGATTGAGGAAAAAGTCTGTTTCTCTTCGATTTGATCTTCATTTAGCAGCCACT GATGAAGGGTGTTTAGAGACTAAGCAGGATAATCTACCAGATATAGAAGTCAGGCTTATCATGAGAAGATCATGCAGTATTCCCTCTATC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MED1_ENST00000394287_chr17_37604051_-_KRT222_ENST00000476049_chr17_38818296_-_2702nt TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGCTAGAAGAAGACATAAGCAAAA AAATGGACAAAGATGAAGAGGCTTTGAAGGCAGCTCAAGCAGAACTCAAGGAGGCCCGACGCCAGTGGCACCACCTGCAAGTGGAAATTG AATCTCTCCATGCTGTGGAAAGGGGCCTTGAAAACTCCCTACATGCCAGCGAGCAGCATTACCAGATGCAGCTGCAAGACCTAGAGACTG TGATTGAAGGACTAGAAAAAGAGCTACAGGAAGTAAGGCGCGGCATCGAAAAGCAGCTTCAAGAGCACGAGATGCTTCTCAACACGAAGA TGAGGCTGGAACAAGAAATAGCAACTTATCGCCACCTCCTAGAAAAAGAAGAAATCAGATATTATGGTTGTATCCAAGGTGGGAAAAAAG ACAAAAAGCCTACCACAAGTAGAGTTGGTTTTGTTTTACCATCAGCCATTATAAATGAAATATCTTTTACTACAAAAGTCCCACAAAAGT ATGAGAATGAAAATGTAGAAACAGTAACCAAACAGGCAATCTTAAATGGGAGTATCGTTAAGGAGAGCACTGAAGCTCATGGCACTATTC AGACAGAGAAAGTGGATGAAGTTATTAAAGAATGGGAAGGTTCTTTCTTTAAAGATAACCCTCGATTGAGGAAAAAGTCTGTTTCTCTTC GATTTGATCTTCATTTAGCAGCCACTGATGAAGGGTGTTTAGAGACTAAGCAGGATAATCTACCAGATATAGAAGTCAGGCTTATCATGA GAAGATCATGCAGTATTCCCTCTATCAAACCTCCATCAACAGCTAATTAATCCAAAGATAGTATTTGACTTGATTGGAAAATGTTAGGAT GGACCAAGGTGGGCCATACCAACTCCCTCTGTCCCAAAATTAACCACAGGTCAGGGATCCCATACGTTCATTCTCCCTCCACAGTGACCC ACAATATCCATCGGGTGTTTATGTATCCAAAGAAGAGGCTACTCATTCCATCTGGTAAACCAACATACTCATGATTTAGTGGAAAGAGCC CTGGAGTGGCACAGAGGGCTGCCTCAATACACACTTACTGAGCGTCTAACAATGAATGGGTCAAGCCCTTCGTAGGCACTGGCAATGGGA AGATGACCAATACAGACGGCTGAACCTTGCTTTCAAGGCCTTCATAAAGCACTGGAGATGACAAACACGGTCCGATACAAAGGGTCGGGT TCAGGACTCCAACCATTATTATCAAAGAGCCACGGGAATACAAAGGAAGGATTACTAGGGGGGAAGTTCCAGGAGGGCATCACAAAGAGA CCTCTGAGCTGGATCCAGAAGGACAGATGAGTTTAAGCTGAAAGTGGGGACGGTCGTTCCCGCTGGTGGGAACCGAAGGAGCCGAGGCAG CGCTGAGGCGGAGACCAGTAAAGGCTTCCAACCCTGACCTAAAGTTGTGGGAGATTGGCAAGATTATTGGTGGCATGTGGCGAGATCTCA CTGATGAAGAAAAACAAGAATATTTAAACGAATACGAAGCAGAAAAGATAGAGTACAATGAATCTATGAAGGCCTATCATAATTCCCCCG CGTACCTTGCTTACATAAATGCAAAAAGTCGTGCAGAAGCTGCTTTAGAGGAAGAAAGTCGACAGAGACAATCTCGCATGGAGAAAGGAG AACCGTACATGAGCATTCAGCCTGCTGAAGATCCAGATGATTATGATGATGGCTTTTCAATGAAGCATACAGCCACCGCCCGTTTCCAGA GAAACCACCGCCTCATCAGTGAAATTCTTAGTGAGAGTGTGGTGCCAGACGTTCGGTCAGTTGTCACAACAGCTAGAATGCAGGTCCTCA AACGGCAGGTCCAGTCCTTAATGGTTCATCAGCGAAAACTAGAAGCTGAACTTCTTCAAATAGAGGAACGACACCAGGAGAAGAAGAGGA AATTCCTGGAAAGCACAGATTCATTTAACAATGAACTTAAAAGGTTGTGCGGTCTGAAAGTAGAAGTGGATATGGAGAAAATTGCAGCTG AGATTGCACAGGCAGAGGAACAGGCCCGCAAAAGGCAGGAGGAAAGGGAGAAGGAGGCCGCAGAGCAAGCTGAGCGCAGTCAGAGCAGCA TCGTTCCTGAGGAAGAACAAGCAGCTAACAAAGGCGAGGAGAAGAAAGACGACGAGAACATTCCGATGGAGACAGAGGAGACACACCTTG AAGAAACAACAGAGAGCCAACAGAATGGTGAAGAAGGCACGTCTACTCCTGAGGACAAGGAGAGTGGGCAGGAGGGGGTCGACAGTATGG CAGAGGAAGGAACCAGTGATAGTAACACTGGCTCGGAGAGCAACAGTGCAACAGTGGAGGAGCCACCAACAGATCCCATACCAGAAGATG >In-frame_MED1_ENST00000394287_chr17_37604051_-_KRT222_ENST00000394052_chr17_38818296_-_1302nt TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGCTAGAAGAAGACATAAGCAAAA AAATGGACAAAGATGAAGAGGCTTTGAAGGCAGCTCAAGCAGAACTCAAGGAGGCCCGACGCCAGTGGCACCACCTGCAAGTGGAAATTG AATCTCTCCATGCTGTGGAAAGGGGCCTTGAAAACTCCCTACATGCCAGCGAGCAGCATTACCAGATGCAGCTGCAAGACCTAGAGACTG TGATTGAAGGACTAGAAAAAGAGCTACAGGAAGTAAGGCGCGGCATCGAAAAGCAGCTTCAAGAGCACGAGATGCTTCTCAACACGAAGA TGAGGCTGGAACAAGAAATAGCAACTTATCGCCACCTCCTAGAAAAAGAAGAAATCAGATATTATGGTTGTATCCAAGGTGGGAAAAAAG ACAAAAAGCCTACCACAAGTAGAGTTGGTTTTGTTTTACCATCAGCCATTATAAATGAAATATCTTTTACTACAAAAGTCCCACAAAAGT ATGAGAATGAAAATGTAGAAACAGTAACCAAACAGGCAATCTTAAATGGGAGTATCGTTAAGGAGAGCACTGAAGCTCATGGCACTATTC AGACAGAGAAAGTGGATGAAGTTATTAAAGAATGGGAAGGTTCTTTCTTTAAAGATAACCCTCGATTGAGGAAAAAGTCTGTTTCTCTTC GATTTGATCTTCATTTAGCAGCCACTGATGAAGGGTGTTTAGAGACTAAGCAGGATAATCTACCAGATATAGAAGTCAGGCTTATCATGA GAAGATCATGCAGTATTCCCTCTATCAAACCTCCATCAACAGCTAATTAATCCAAAGATAGTATTTGACTTGATTGGAAAATGTTAGGAT GGACCAAGGTGGGCCATACCAACTCCCTCTGTCCCAAAATGTAAGTTATTACGTATGTATGGAAAATGTTATGATCAATATGTGGTTCTC >In-frame_MED1_ENST00000300651_chr17_37604051_-_KRT222_ENST00000476049_chr17_38818296_-_2720nt ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGCTAG AAGAAGACATAAGCAAAAAAATGGACAAAGATGAAGAGGCTTTGAAGGCAGCTCAAGCAGAACTCAAGGAGGCCCGACGCCAGTGGCACC ACCTGCAAGTGGAAATTGAATCTCTCCATGCTGTGGAAAGGGGCCTTGAAAACTCCCTACATGCCAGCGAGCAGCATTACCAGATGCAGC TGCAAGACCTAGAGACTGTGATTGAAGGACTAGAAAAAGAGCTACAGGAAGTAAGGCGCGGCATCGAAAAGCAGCTTCAAGAGCACGAGA TGCTTCTCAACACGAAGATGAGGCTGGAACAAGAAATAGCAACTTATCGCCACCTCCTAGAAAAAGAAGAAATCAGATATTATGGTTGTA TCCAAGGTGGGAAAAAAGACAAAAAGCCTACCACAAGTAGAGTTGGTTTTGTTTTACCATCAGCCATTATAAATGAAATATCTTTTACTA CAAAAGTCCCACAAAAGTATGAGAATGAAAATGTAGAAACAGTAACCAAACAGGCAATCTTAAATGGGAGTATCGTTAAGGAGAGCACTG AAGCTCATGGCACTATTCAGACAGAGAAAGTGGATGAAGTTATTAAAGAATGGGAAGGTTCTTTCTTTAAAGATAACCCTCGATTGAGGA AAAAGTCTGTTTCTCTTCGATTTGATCTTCATTTAGCAGCCACTGATGAAGGGTGTTTAGAGACTAAGCAGGATAATCTACCAGATATAG AAGTCAGGCTTATCATGAGAAGATCATGCAGTATTCCCTCTATCAAACCTCCATCAACAGCTAATTAATCCAAAGATAGTATTTGACTTG ATTGGAAAATGTTAGGATGGACCAAGGTGGGCCATACCAACTCCCTCTGTCCCAAAATTAACCACAGGTCAGGGATCCCATACGTTCATT CTCCCTCCACAGTGACCCACAATATCCATCGGGTGTTTATGTATCCAAAGAAGAGGCTACTCATTCCATCTGGTAAACCAACATACTCAT GATTTAGTGGAAAGAGCCCTGGAGTGGCACAGAGGGCTGCCTCAATACACACTTACTGAGCGTCTAACAATGAATGGGTCAAGCCCTTCG TAGGCACTGGCAATGGGAAGATGACCAATACAGACGGCTGAACCTTGCTTTCAAGGCCTTCATAAAGCACTGGAGATGACAAACACGGTC CGATACAAAGGGTCGGGTTCAGGACTCCAACCATTATTATCAAAGAGCCACGGGAATACAAAGGAAGGATTACTAGGGGGGAAGTTCCAG GAGGGCATCACAAAGAGACCTCTGAGCTGGATCCAGAAGGACAGATGAGTTTAAGCTGAAAGTGGGGACGGTCGTTCCCGCTGGTGGGAA CCGAAGGAGCCGAGGCAGCGCTGAGGCGGAGACCAGTAAAGGCTTCCAACCCTGACCTAAAGTTGTGGGAGATTGGCAAGATTATTGGTG GCATGTGGCGAGATCTCACTGATGAAGAAAAACAAGAATATTTAAACGAATACGAAGCAGAAAAGATAGAGTACAATGAATCTATGAAGG CCTATCATAATTCCCCCGCGTACCTTGCTTACATAAATGCAAAAAGTCGTGCAGAAGCTGCTTTAGAGGAAGAAAGTCGACAGAGACAAT CTCGCATGGAGAAAGGAGAACCGTACATGAGCATTCAGCCTGCTGAAGATCCAGATGATTATGATGATGGCTTTTCAATGAAGCATACAG CCACCGCCCGTTTCCAGAGAAACCACCGCCTCATCAGTGAAATTCTTAGTGAGAGTGTGGTGCCAGACGTTCGGTCAGTTGTCACAACAG CTAGAATGCAGGTCCTCAAACGGCAGGTCCAGTCCTTAATGGTTCATCAGCGAAAACTAGAAGCTGAACTTCTTCAAATAGAGGAACGAC ACCAGGAGAAGAAGAGGAAATTCCTGGAAAGCACAGATTCATTTAACAATGAACTTAAAAGGTTGTGCGGTCTGAAAGTAGAAGTGGATA TGGAGAAAATTGCAGCTGAGATTGCACAGGCAGAGGAACAGGCCCGCAAAAGGCAGGAGGAAAGGGAGAAGGAGGCCGCAGAGCAAGCTG AGCGCAGTCAGAGCAGCATCGTTCCTGAGGAAGAACAAGCAGCTAACAAAGGCGAGGAGAAGAAAGACGACGAGAACATTCCGATGGAGA CAGAGGAGACACACCTTGAAGAAACAACAGAGAGCCAACAGAATGGTGAAGAAGGCACGTCTACTCCTGAGGACAAGGAGAGTGGGCAGG AGGGGGTCGACAGTATGGCAGAGGAAGGAACCAGTGATAGTAACACTGGCTCGGAGAGCAACAGTGCAACAGTGGAGGAGCCACCAACAG >In-frame_MED1_ENST00000300651_chr17_37604051_-_KRT222_ENST00000394052_chr17_38818296_-_1320nt ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGCTAG AAGAAGACATAAGCAAAAAAATGGACAAAGATGAAGAGGCTTTGAAGGCAGCTCAAGCAGAACTCAAGGAGGCCCGACGCCAGTGGCACC ACCTGCAAGTGGAAATTGAATCTCTCCATGCTGTGGAAAGGGGCCTTGAAAACTCCCTACATGCCAGCGAGCAGCATTACCAGATGCAGC TGCAAGACCTAGAGACTGTGATTGAAGGACTAGAAAAAGAGCTACAGGAAGTAAGGCGCGGCATCGAAAAGCAGCTTCAAGAGCACGAGA TGCTTCTCAACACGAAGATGAGGCTGGAACAAGAAATAGCAACTTATCGCCACCTCCTAGAAAAAGAAGAAATCAGATATTATGGTTGTA TCCAAGGTGGGAAAAAAGACAAAAAGCCTACCACAAGTAGAGTTGGTTTTGTTTTACCATCAGCCATTATAAATGAAATATCTTTTACTA CAAAAGTCCCACAAAAGTATGAGAATGAAAATGTAGAAACAGTAACCAAACAGGCAATCTTAAATGGGAGTATCGTTAAGGAGAGCACTG AAGCTCATGGCACTATTCAGACAGAGAAAGTGGATGAAGTTATTAAAGAATGGGAAGGTTCTTTCTTTAAAGATAACCCTCGATTGAGGA AAAAGTCTGTTTCTCTTCGATTTGATCTTCATTTAGCAGCCACTGATGAAGGGTGTTTAGAGACTAAGCAGGATAATCTACCAGATATAG AAGTCAGGCTTATCATGAGAAGATCATGCAGTATTCCCTCTATCAAACCTCCATCAACAGCTAATTAATCCAAAGATAGTATTTGACTTG ATTGGAAAATGTTAGGATGGACCAAGGTGGGCCATACCAACTCCCTCTGTCCCAAAATGTAAGTTATTACGTATGTATGGAAAATGTTAT |
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FusionGenePPI for MED1_KRT222 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MED1 | MED10, MED9, MED29, MED19, MED28, MED26, PPARGC1A, NR3C1, YWHAQ, TGS1, TP53, CDK8, VDR, MED1, HNF4A, THRA, THRAP3, MED24, AR, ESR1, ESR2, MED13, MED6, MED16, MED17, MED20, MED14, MED12, MED23, MED27, MED4, MED7, MED8, MED30, MED22, MED31, MED15, MED18, MED11, MED25, POLR2A, MED21, POLR2F, GABPA, GATA1, ATM, POU1F1, GATA2, PARP1, RXRA, TRRAP, PPARG, RARA, SREBF1, KAT2A, SUPT3H, SUPT7L, MYC, CCNC, CDK19, POLR2E, CDK9, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, TRA, NR1H2, KIF1A, BRD4, CTDP1, NCOA6, ELAVL1, MDM2, ZNF281, ZNF326, RALY, SETD7, FBXW7, MED13L, EPAS1, EZH2, BAG3, GJB5, PIN1, POLL, NR1I3, TCL1B, HNRNPC, NTRK1, POLR2G, EMC2, SMEK1, MED12L, RPAP2, POLR2D, BIRC5, PLK1, SPAG5 | KRT222 | KDM1A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000300651 | - | 2 | 17 | 16_590 | 44 | 1582 | ESR1 |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000300651 | - | 2 | 17 | 656_1066 | 44 | 1582 | ESR1 |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000394287 | - | 2 | 18 | 16_590 | 44 | 557 | ESR1 |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000394287 | - | 2 | 18 | 656_1066 | 44 | 557 | ESR1 |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000300651 | - | 2 | 17 | 681_715 | 44 | 1582 | GATA1 |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000394287 | - | 2 | 18 | 681_715 | 44 | 557 | GATA1 |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000300651 | - | 2 | 17 | 622_701 | 44 | 1582 | PPARGC1A and THRA |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000394287 | - | 2 | 18 | 622_701 | 44 | 557 | PPARGC1A and THRA |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000300651 | - | 2 | 17 | 108_212 | 44 | 1582 | the Mediator complex |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000300651 | - | 2 | 17 | 215_390 | 44 | 1582 | the Mediator complex |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000394287 | - | 2 | 18 | 108_212 | 44 | 557 | the Mediator complex |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000394287 | - | 2 | 18 | 215_390 | 44 | 557 | the Mediator complex |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000300651 | - | 2 | 17 | 1_670 | 44 | 1582 | the Mediator complex and THRA |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000394287 | - | 2 | 18 | 1_670 | 44 | 557 | the Mediator complex and THRA |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000300651 | - | 2 | 17 | 405_644 | 44 | 1582 | THRA |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000394287 | - | 2 | 18 | 405_644 | 44 | 557 | THRA |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000300651 | - | 2 | 17 | 1249_1421 | 44 | 1582 | TP53 |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000394287 | - | 2 | 18 | 1249_1421 | 44 | 557 | TP53 |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000300651 | - | 2 | 17 | 542_789 | 44 | 1582 | VDR |
| Hgene | MED1 | chr17:37604051 | chr17:38818296 | ENST00000394287 | - | 2 | 18 | 542_789 | 44 | 557 | VDR |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MED1_KRT222 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MED1_KRT222 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MED1 | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | MED1 | C2239176 | Liver carcinoma | 1 | CTD_human |
| Hgene | MED1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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