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Fusion gene ID: 21508 |
FusionGeneSummary for MED1_GSDMB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MED1_GSDMB | Fusion gene ID: 21508 | Hgene | Tgene | Gene symbol | MED1 | GSDMB | Gene ID | 8930 | 55876 |
| Gene name | methyl-CpG binding domain 4, DNA glycosylase | gasdermin B | |
| Synonyms | MED1 | GSDML|PP4052|PRO2521 | |
| Cytomap | 3q21.3 | 17q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methyl-CpG-binding domain protein 43,N(4)-ethenocytosine glycosylaseG/5-fluorouracil mismatch glycosylase with biphasic kineticsG/T mismatch glycosylaseG/U mismatch glycosylasemethyl-CpG binding domain protein 4methyl-CpG-binding endonuclease 1meth | gasdermin-Bgasdermin-like protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q15648 | Q8TAX9 | |
| Ensembl transtripts involved in fusion gene | ENST00000394287, ENST00000300651, | ENST00000360317, ENST00000394175, ENST00000309481, ENST00000520542, ENST00000418519, ENST00000394179, | |
| Fusion gene scores | * DoF score | 25 X 11 X 9=2475 | 7 X 5 X 6=210 |
| # samples | 25 | 8 | |
| ** MAII score | log2(25/2475*10)=-3.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MED1 [Title/Abstract] AND GSDMB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-5B-A90C-01A | MED1 | chr17 | 37575970 | - | GSDMB | chr17 | 38062524 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394287 | ENST00000360317 | MED1 | chr17 | 37575970 | - | GSDMB | chr17 | 38062524 | - |
| In-frame | ENST00000394287 | ENST00000394175 | MED1 | chr17 | 37575970 | - | GSDMB | chr17 | 38062524 | - |
| In-frame | ENST00000394287 | ENST00000309481 | MED1 | chr17 | 37575970 | - | GSDMB | chr17 | 38062524 | - |
| In-frame | ENST00000394287 | ENST00000520542 | MED1 | chr17 | 37575970 | - | GSDMB | chr17 | 38062524 | - |
| In-frame | ENST00000394287 | ENST00000418519 | MED1 | chr17 | 37575970 | - | GSDMB | chr17 | 38062524 | - |
| In-frame | ENST00000394287 | ENST00000394179 | MED1 | chr17 | 37575970 | - | GSDMB | chr17 | 38062524 | - |
| In-frame | ENST00000300651 | ENST00000360317 | MED1 | chr17 | 37575970 | - | GSDMB | chr17 | 38062524 | - |
| In-frame | ENST00000300651 | ENST00000394175 | MED1 | chr17 | 37575970 | - | GSDMB | chr17 | 38062524 | - |
| In-frame | ENST00000300651 | ENST00000309481 | MED1 | chr17 | 37575970 | - | GSDMB | chr17 | 38062524 | - |
| In-frame | ENST00000300651 | ENST00000520542 | MED1 | chr17 | 37575970 | - | GSDMB | chr17 | 38062524 | - |
| In-frame | ENST00000300651 | ENST00000418519 | MED1 | chr17 | 37575970 | - | GSDMB | chr17 | 38062524 | - |
| In-frame | ENST00000300651 | ENST00000394179 | MED1 | chr17 | 37575970 | - | GSDMB | chr17 | 38062524 | - |
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FusionProtFeatures for MED1_GSDMB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MED1 | GSDMB |
| Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors (PubMed:10406464, PubMed:11867769,PubMed:12037571, PubMed:12218053, PubMed:12556447,PubMed:14636573, PubMed:15340084, PubMed:15471764,PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as acoactivator for GATA1-mediated transcriptional activation duringerythroid differentiation of K562 erythroleukemia cells(PubMed:24245781). {ECO:0000269|PubMed:10406464,ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571,ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447,ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084,ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967,ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781,ECO:0000269|PubMed:9653119}. | The N-terminal moiety promotes pyroptosis. May be actingby homooligomerizing within the membrane and forming pores(PubMed:27281216). The physiological relevance of this observationis unknown (Probable). {ECO:0000269|PubMed:27281216, ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >GSDMB | chr17:37575970 | chr17:38062524 | ENST00000309481 | - | 5 | 10 | 243_271 | 229 | 404 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >GSDMB | chr17:37575970 | chr17:38062524 | ENST00000360317 | - | 5 | 10 | 243_271 | 242 | 417 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >GSDMB | chr17:37575970 | chr17:38062524 | ENST00000394175 | - | 3 | 8 | 243_271 | 220 | 395 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >GSDMB | chr17:37575970 | chr17:38062524 | ENST00000394179 | - | 5 | 10 | 243_271 | 237 | 412 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >GSDMB | chr17:37575970 | chr17:38062524 | ENST00000418519 | - | 6 | 11 | 243_271 | 242 | 417 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >GSDMB | chr17:37575970 | chr17:38062524 | ENST00000520542 | - | 5 | 10 | 243_271 | 233 | 408 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MED1 | chr17:37575970 | chr17:38062524 | ENST00000300651 | - | 14 | 17 | 1078_1482 | 432 | 1582 | Compositional bias | Note=Ser-rich |
| Hgene | >MED1 | chr17:37575970 | chr17:38062524 | ENST00000300651 | - | 14 | 17 | 1496_1529 | 432 | 1582 | Compositional bias | Note=Lys-rich |
| Hgene | >MED1 | chr17:37575970 | chr17:38062524 | ENST00000394287 | - | 14 | 18 | 1078_1482 | 432 | 557 | Compositional bias | Note=Ser-rich |
| Hgene | >MED1 | chr17:37575970 | chr17:38062524 | ENST00000394287 | - | 14 | 18 | 1496_1529 | 432 | 557 | Compositional bias | Note=Lys-rich |
| Hgene | >MED1 | chr17:37575970 | chr17:38062524 | ENST00000300651 | - | 14 | 17 | 604_608 | 432 | 1582 | Motif | Note=LXXLL motif 1 |
| Hgene | >MED1 | chr17:37575970 | chr17:38062524 | ENST00000300651 | - | 14 | 17 | 645_649 | 432 | 1582 | Motif | Note=LXXLL motif 2 |
| Hgene | >MED1 | chr17:37575970 | chr17:38062524 | ENST00000394287 | - | 14 | 18 | 604_608 | 432 | 557 | Motif | Note=LXXLL motif 1 |
| Hgene | >MED1 | chr17:37575970 | chr17:38062524 | ENST00000394287 | - | 14 | 18 | 645_649 | 432 | 557 | Motif | Note=LXXLL motif 2 |
| Tgene | GSDMB | chr17:37575970 | chr17:38062524 | ENST00000309481 | - | 5 | 10 | 1_275 | 229 | 404 | Region | Triggers pyroptosis |
| Tgene | GSDMB | chr17:37575970 | chr17:38062524 | ENST00000360317 | - | 5 | 10 | 1_275 | 242 | 417 | Region | Triggers pyroptosis |
| Tgene | GSDMB | chr17:37575970 | chr17:38062524 | ENST00000394175 | - | 3 | 8 | 1_275 | 220 | 395 | Region | Triggers pyroptosis |
| Tgene | GSDMB | chr17:37575970 | chr17:38062524 | ENST00000394179 | - | 5 | 10 | 1_275 | 237 | 412 | Region | Triggers pyroptosis |
| Tgene | GSDMB | chr17:37575970 | chr17:38062524 | ENST00000418519 | - | 6 | 11 | 1_275 | 242 | 417 | Region | Triggers pyroptosis |
| Tgene | GSDMB | chr17:37575970 | chr17:38062524 | ENST00000520542 | - | 5 | 10 | 1_275 | 233 | 408 | Region | Triggers pyroptosis |
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FusionGeneSequence for MED1_GSDMB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000360317_chr17_38062524_-_607aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000394175_chr17_38062524_-_607aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000309481_chr17_38062524_-_607aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000520542_chr17_38062524_-_607aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000418519_chr17_38062524_-_607aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000394179_chr17_38062524_-_607aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000360317_chr17_38062524_-_607aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000394175_chr17_38062524_-_607aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000309481_chr17_38062524_-_607aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000520542_chr17_38062524_-_607aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000418519_chr17_38062524_-_607aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000394179_chr17_38062524_-_607aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000360317_chr17_38062524_-_1821nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGA ACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTC ATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGAC ATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGG CAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTT AATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTT GTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGC AGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGG >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000394175_chr17_38062524_-_1821nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGA ACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTC ATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGAC ATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGG CAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTT AATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTT GTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGC AGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGG >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000309481_chr17_38062524_-_1821nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGA ACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTC ATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGAC ATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGG CAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTT AATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTT GTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGC AGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGG >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000520542_chr17_38062524_-_1821nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGA ACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTC ATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGAC ATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGG CAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTT AATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTT GTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGC AGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGG >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000418519_chr17_38062524_-_1821nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGA ACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTC ATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGAC ATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGG CAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTT AATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTT GTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGC AGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGG >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000394179_chr17_38062524_-_1821nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGA ACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTC ATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGAC ATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGG CAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTT AATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTT GTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGC AGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGG >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000360317_chr17_38062524_-_1821nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGA ACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTC ATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGAC ATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGG CAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTT AATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTT GTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGC AGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGG >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000394175_chr17_38062524_-_1821nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGA ACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTC ATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGAC ATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGG CAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTT AATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTT GTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGC AGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGG >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000309481_chr17_38062524_-_1821nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGA ACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTC ATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGAC ATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGG CAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTT AATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTT GTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGC AGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGG >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000520542_chr17_38062524_-_1821nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGA ACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTC ATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGAC ATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGG CAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTT AATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTT GTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGC AGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGG >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000418519_chr17_38062524_-_1821nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGA ACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTC ATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGAC ATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGG CAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTT AATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTT GTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGC AGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGG >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000394179_chr17_38062524_-_1821nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGA ACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTC ATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGAC ATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGG CAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTT AATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTT GTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGC AGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000360317_chr17_38062524_-_2244nt TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000394175_chr17_38062524_-_2244nt TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000309481_chr17_38062524_-_2244nt TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000520542_chr17_38062524_-_2242nt TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000418519_chr17_38062524_-_2242nt TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC >In-frame_MED1_ENST00000394287_chr17_37575970_-_GSDMB_ENST00000394179_chr17_38062524_-_2242nt TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000360317_chr17_38062524_-_2262nt ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000394175_chr17_38062524_-_2262nt ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000309481_chr17_38062524_-_2262nt ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000520542_chr17_38062524_-_2260nt ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000418519_chr17_38062524_-_2260nt ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT >In-frame_MED1_ENST00000300651_chr17_37575970_-_GSDMB_ENST00000394179_chr17_38062524_-_2260nt ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT |
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FusionGenePPI for MED1_GSDMB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MED1 | MED10, MED9, MED29, MED19, MED28, MED26, PPARGC1A, NR3C1, YWHAQ, TGS1, TP53, CDK8, VDR, MED1, HNF4A, THRA, THRAP3, MED24, AR, ESR1, ESR2, MED13, MED6, MED16, MED17, MED20, MED14, MED12, MED23, MED27, MED4, MED7, MED8, MED30, MED22, MED31, MED15, MED18, MED11, MED25, POLR2A, MED21, POLR2F, GABPA, GATA1, ATM, POU1F1, GATA2, PARP1, RXRA, TRRAP, PPARG, RARA, SREBF1, KAT2A, SUPT3H, SUPT7L, MYC, CCNC, CDK19, POLR2E, CDK9, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, TRA, NR1H2, KIF1A, BRD4, CTDP1, NCOA6, ELAVL1, MDM2, ZNF281, ZNF326, RALY, SETD7, FBXW7, MED13L, EPAS1, EZH2, BAG3, GJB5, PIN1, POLL, NR1I3, TCL1B, HNRNPC, NTRK1, POLR2G, EMC2, SMEK1, MED12L, RPAP2, POLR2D, BIRC5, PLK1, SPAG5 | GSDMB | APP, HIVEP1, ORM1, SERPINA1, IGFBP2, PEBP1, AGT, CLK1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000300651 | - | 14 | 17 | 108_212 | 432 | 1582 | the Mediator complex |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000300651 | - | 14 | 17 | 215_390 | 432 | 1582 | the Mediator complex |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000394287 | - | 14 | 18 | 108_212 | 432 | 557 | the Mediator complex |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000394287 | - | 14 | 18 | 215_390 | 432 | 557 | the Mediator complex |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000300651 | - | 14 | 17 | 16_590 | 432 | 1582 | ESR1 |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000300651 | - | 14 | 17 | 656_1066 | 432 | 1582 | ESR1 |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000394287 | - | 14 | 18 | 16_590 | 432 | 557 | ESR1 |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000394287 | - | 14 | 18 | 656_1066 | 432 | 557 | ESR1 |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000300651 | - | 14 | 17 | 681_715 | 432 | 1582 | GATA1 |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000394287 | - | 14 | 18 | 681_715 | 432 | 557 | GATA1 |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000300651 | - | 14 | 17 | 622_701 | 432 | 1582 | PPARGC1A and THRA |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000394287 | - | 14 | 18 | 622_701 | 432 | 557 | PPARGC1A and THRA |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000300651 | - | 14 | 17 | 1_670 | 432 | 1582 | the Mediator complex and THRA |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000394287 | - | 14 | 18 | 1_670 | 432 | 557 | the Mediator complex and THRA |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000300651 | - | 14 | 17 | 405_644 | 432 | 1582 | THRA |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000394287 | - | 14 | 18 | 405_644 | 432 | 557 | THRA |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000300651 | - | 14 | 17 | 1249_1421 | 432 | 1582 | TP53 |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000394287 | - | 14 | 18 | 1249_1421 | 432 | 557 | TP53 |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000300651 | - | 14 | 17 | 542_789 | 432 | 1582 | VDR |
| Hgene | MED1 | chr17:37575970 | chr17:38062524 | ENST00000394287 | - | 14 | 18 | 542_789 | 432 | 557 | VDR |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MED1_GSDMB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MED1_GSDMB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MED1 | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | MED1 | C2239176 | Liver carcinoma | 1 | CTD_human |
| Hgene | MED1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Tgene | GSDMB | C0004096 | Asthma | 1 | CTD_human |
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