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Fusion gene ID: 21506 |
FusionGeneSummary for MED1_GDPD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MED1_GDPD1 | Fusion gene ID: 21506 | Hgene | Tgene | Gene symbol | MED1 | GDPD1 | Gene ID | 8930 | 284161 |
| Gene name | methyl-CpG binding domain 4, DNA glycosylase | glycerophosphodiester phosphodiesterase domain containing 1 | |
| Synonyms | MED1 | GDE4 | |
| Cytomap | 3q21.3 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methyl-CpG-binding domain protein 43,N(4)-ethenocytosine glycosylaseG/5-fluorouracil mismatch glycosylase with biphasic kineticsG/T mismatch glycosylaseG/U mismatch glycosylasemethyl-CpG binding domain protein 4methyl-CpG-binding endonuclease 1meth | lysophospholipase D GDPD1glycerophosphodiester phosphodiesterase 4glycerophosphodiester phosphodiesterase domain-containing protein 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q15648 | Q8N9F7 | |
| Ensembl transtripts involved in fusion gene | ENST00000394287, ENST00000300651, | ENST00000284116, ENST00000581140, ENST00000581276, | |
| Fusion gene scores | * DoF score | 25 X 11 X 9=2475 | 4 X 3 X 3=36 |
| # samples | 25 | 4 | |
| ** MAII score | log2(25/2475*10)=-3.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MED1 [Title/Abstract] AND GDPD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A09I-01A | MED1 | chr17 | 37579580 | - | GDPD1 | chr17 | 57335112 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394287 | ENST00000284116 | MED1 | chr17 | 37579580 | - | GDPD1 | chr17 | 57335112 | + |
| In-frame | ENST00000394287 | ENST00000581140 | MED1 | chr17 | 37579580 | - | GDPD1 | chr17 | 57335112 | + |
| In-frame | ENST00000394287 | ENST00000581276 | MED1 | chr17 | 37579580 | - | GDPD1 | chr17 | 57335112 | + |
| In-frame | ENST00000300651 | ENST00000284116 | MED1 | chr17 | 37579580 | - | GDPD1 | chr17 | 57335112 | + |
| In-frame | ENST00000300651 | ENST00000581140 | MED1 | chr17 | 37579580 | - | GDPD1 | chr17 | 57335112 | + |
| In-frame | ENST00000300651 | ENST00000581276 | MED1 | chr17 | 37579580 | - | GDPD1 | chr17 | 57335112 | + |
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FusionProtFeatures for MED1_GDPD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MED1 | GDPD1 |
| Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors (PubMed:10406464, PubMed:11867769,PubMed:12037571, PubMed:12218053, PubMed:12556447,PubMed:14636573, PubMed:15340084, PubMed:15471764,PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as acoactivator for GATA1-mediated transcriptional activation duringerythroid differentiation of K562 erythroleukemia cells(PubMed:24245781). {ECO:0000269|PubMed:10406464,ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571,ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447,ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084,ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967,ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781,ECO:0000269|PubMed:9653119}. | Hydrolyzes lysoglycerophospholipids to producelysophosphatidic acid (LPA) and the corresponding amines. Shows apreference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF),lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine(lyso-PC). May be involved in bioactive N-acylethanolaminebiosynthesis. Does not display glycerophosphodiesterphosphodiesterase activity, since it cannot hydrolyze eitherglycerophosphoinositol or glycerophosphocholine.{ECO:0000250|UniProtKB:Q9CRY7}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000284116 | + | 4 | 10 | 217_314 | 162 | 315 | Topological domain | Extracellular |
| Tgene | >GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000581140 | + | 4 | 10 | 217_314 | 162 | 290 | Topological domain | Extracellular |
| Tgene | >GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000581276 | + | 4 | 9 | 217_314 | 162 | 291 | Topological domain | Extracellular |
| Tgene | >GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000284116 | + | 4 | 10 | 196_216 | 162 | 315 | Transmembrane | Helical |
| Tgene | >GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000581140 | + | 4 | 10 | 196_216 | 162 | 290 | Transmembrane | Helical |
| Tgene | >GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000581276 | + | 4 | 9 | 196_216 | 162 | 291 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MED1 | chr17:37579580 | chr17:57335112 | ENST00000300651 | - | 13 | 17 | 1078_1482 | 365 | 1582 | Compositional bias | Note=Ser-rich |
| Hgene | >MED1 | chr17:37579580 | chr17:57335112 | ENST00000300651 | - | 13 | 17 | 1496_1529 | 365 | 1582 | Compositional bias | Note=Lys-rich |
| Hgene | >MED1 | chr17:37579580 | chr17:57335112 | ENST00000394287 | - | 13 | 18 | 1078_1482 | 365 | 557 | Compositional bias | Note=Ser-rich |
| Hgene | >MED1 | chr17:37579580 | chr17:57335112 | ENST00000394287 | - | 13 | 18 | 1496_1529 | 365 | 557 | Compositional bias | Note=Lys-rich |
| Hgene | >MED1 | chr17:37579580 | chr17:57335112 | ENST00000300651 | - | 13 | 17 | 604_608 | 365 | 1582 | Motif | Note=LXXLL motif 1 |
| Hgene | >MED1 | chr17:37579580 | chr17:57335112 | ENST00000300651 | - | 13 | 17 | 645_649 | 365 | 1582 | Motif | Note=LXXLL motif 2 |
| Hgene | >MED1 | chr17:37579580 | chr17:57335112 | ENST00000394287 | - | 13 | 18 | 604_608 | 365 | 557 | Motif | Note=LXXLL motif 1 |
| Hgene | >MED1 | chr17:37579580 | chr17:57335112 | ENST00000394287 | - | 13 | 18 | 645_649 | 365 | 557 | Motif | Note=LXXLL motif 2 |
| Tgene | GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000284116 | + | 4 | 10 | 40_309 | 162 | 315 | Domain | Note=GP-PDE |
| Tgene | GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000581140 | + | 4 | 10 | 40_309 | 162 | 290 | Domain | Note=GP-PDE |
| Tgene | GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000581276 | + | 4 | 9 | 40_309 | 162 | 291 | Domain | Note=GP-PDE |
| Tgene | GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000284116 | + | 4 | 10 | 1_3 | 162 | 315 | Topological domain | Extracellular |
| Tgene | GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000284116 | + | 4 | 10 | 25_195 | 162 | 315 | Topological domain | Cytoplasmic |
| Tgene | GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000581140 | + | 4 | 10 | 1_3 | 162 | 290 | Topological domain | Extracellular |
| Tgene | GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000581140 | + | 4 | 10 | 25_195 | 162 | 290 | Topological domain | Cytoplasmic |
| Tgene | GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000581276 | + | 4 | 9 | 1_3 | 162 | 291 | Topological domain | Extracellular |
| Tgene | GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000581276 | + | 4 | 9 | 25_195 | 162 | 291 | Topological domain | Cytoplasmic |
| Tgene | GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000284116 | + | 4 | 10 | 4_24 | 162 | 315 | Transmembrane | Helical |
| Tgene | GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000581140 | + | 4 | 10 | 4_24 | 162 | 290 | Transmembrane | Helical |
| Tgene | GDPD1 | chr17:37579580 | chr17:57335112 | ENST00000581276 | + | 4 | 9 | 4_24 | 162 | 291 | Transmembrane | Helical |
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FusionGeneSequence for MED1_GDPD1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MED1_ENST00000394287_chr17_37579580_-_GDPD1_ENST00000284116_chr17_57335112_+_518aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAVSELVKRYNREHLTVWGNANYEIVEKCYKENSDIPILFSLQRVLLILGLFFTGLLPFVPIREQFFEIPMPSIILKLKEPHTMSRS >In-frame_MED1_ENST00000394287_chr17_37579580_-_GDPD1_ENST00000581140_chr17_57335112_+_493aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAVSELVKRYNREHLTVWGNANYEIVEKCYKENSDIPILFSLQRVLLILGLFFTGLLPFVPIREQFFEIPMPSIILKLKEPHTMSRS >In-frame_MED1_ENST00000394287_chr17_37579580_-_GDPD1_ENST00000581276_chr17_57335112_+_494aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAVSELVKRYNREHLTVWGNANYEIVEKCYKENSDIPILFSLQRVLLILGLFFTGLLPFVPIREQFFEIPMPSIILKLKEPHTMSRS >In-frame_MED1_ENST00000300651_chr17_37579580_-_GDPD1_ENST00000284116_chr17_57335112_+_518aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAVSELVKRYNREHLTVWGNANYEIVEKCYKENSDIPILFSLQRVLLILGLFFTGLLPFVPIREQFFEIPMPSIILKLKEPHTMSRS >In-frame_MED1_ENST00000300651_chr17_37579580_-_GDPD1_ENST00000581140_chr17_57335112_+_493aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAVSELVKRYNREHLTVWGNANYEIVEKCYKENSDIPILFSLQRVLLILGLFFTGLLPFVPIREQFFEIPMPSIILKLKEPHTMSRS >In-frame_MED1_ENST00000300651_chr17_37579580_-_GDPD1_ENST00000581276_chr17_57335112_+_494aa MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN MRFYAVSELVKRYNREHLTVWGNANYEIVEKCYKENSDIPILFSLQRVLLILGLFFTGLLPFVPIREQFFEIPMPSIILKLKEPHTMSRS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MED1_ENST00000394287_chr17_37579580_-_GDPD1_ENST00000284116_chr17_57335112_+_1554nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGTTTCAGAGTTGGTGAAGCGGTATAATCGAGAACACTTAACAGTGTGGGGTAATGCCAATTATGAAATTGTAGAA AAGTGCTACAAAGAGAATTCAGATATTCCTATACTCTTCAGTCTACAACGTGTCCTGCTCATTCTTGGCCTTTTCTTCACTGGCCTCTTG CCCTTTGTGCCCATTCGAGAACAGTTTTTTGAAATCCCAATGCCTTCTATTATACTGAAGCTAAAAGAACCACACACCATGTCCAGAAGT CAAAAGTTTCTCATCTGGCTTTCTGATCTCTTACTAATGAGGAAAGCTTTGTTTGACCACCTAACTGCTCGAGGCATTCAAGTGTATATT TGGGTATTAAATGAAGAACAAGAATACAAAAGAGCTTTTGATTTGGGAGCAACTGGGGTGATGACAGACTATCCAACAAAGCTTAGGGAT >In-frame_MED1_ENST00000394287_chr17_37579580_-_GDPD1_ENST00000581140_chr17_57335112_+_1479nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGTTTCAGAGTTGGTGAAGCGGTATAATCGAGAACACTTAACAGTGTGGGGTAATGCCAATTATGAAATTGTAGAA AAGTGCTACAAAGAGAATTCAGATATTCCTATACTCTTCAGTCTACAACGTGTCCTGCTCATTCTTGGCCTTTTCTTCACTGGCCTCTTG CCCTTTGTGCCCATTCGAGAACAGTTTTTTGAAATCCCAATGCCTTCTATTATACTGAAGCTAAAAGAACCACACACCATGTCCAGAAGT CAAAAGTTTCTCATCTGGCTTTCTGATCTCTTACTAATGAGGAAAGCTTTGTTTGAACCACTGCACCCGGCCAGTAAAAGAAATTTTGAA >In-frame_MED1_ENST00000394287_chr17_37579580_-_GDPD1_ENST00000581276_chr17_57335112_+_1482nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGTTTCAGAGTTGGTGAAGCGGTATAATCGAGAACACTTAACAGTGTGGGGTAATGCCAATTATGAAATTGTAGAA AAGTGCTACAAAGAGAATTCAGATATTCCTATACTCTTCAGTCTACAACGTGTCCTGCTCATTCTTGGCCTTTTCTTCACTGGCCTCTTG CCCTTTGTGCCCATTCGAGAACAGTTTTTTGAAATCCCAATGCCTTCTATTATACTGAAGCTAAAAGAACCACACACCATGTCCAGAAGT CAAAAGTTTCTCATCTGGCTTTCTGATCTCTTACTAATGAGGAAAGCTTTGTTTGACCACCTAACTGCTCGAGGCATTCAAGTAAGTTTC >In-frame_MED1_ENST00000300651_chr17_37579580_-_GDPD1_ENST00000284116_chr17_57335112_+_1554nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGTTTCAGAGTTGGTGAAGCGGTATAATCGAGAACACTTAACAGTGTGGGGTAATGCCAATTATGAAATTGTAGAA AAGTGCTACAAAGAGAATTCAGATATTCCTATACTCTTCAGTCTACAACGTGTCCTGCTCATTCTTGGCCTTTTCTTCACTGGCCTCTTG CCCTTTGTGCCCATTCGAGAACAGTTTTTTGAAATCCCAATGCCTTCTATTATACTGAAGCTAAAAGAACCACACACCATGTCCAGAAGT CAAAAGTTTCTCATCTGGCTTTCTGATCTCTTACTAATGAGGAAAGCTTTGTTTGACCACCTAACTGCTCGAGGCATTCAAGTGTATATT TGGGTATTAAATGAAGAACAAGAATACAAAAGAGCTTTTGATTTGGGAGCAACTGGGGTGATGACAGACTATCCAACAAAGCTTAGGGAT >In-frame_MED1_ENST00000300651_chr17_37579580_-_GDPD1_ENST00000581140_chr17_57335112_+_1479nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGTTTCAGAGTTGGTGAAGCGGTATAATCGAGAACACTTAACAGTGTGGGGTAATGCCAATTATGAAATTGTAGAA AAGTGCTACAAAGAGAATTCAGATATTCCTATACTCTTCAGTCTACAACGTGTCCTGCTCATTCTTGGCCTTTTCTTCACTGGCCTCTTG CCCTTTGTGCCCATTCGAGAACAGTTTTTTGAAATCCCAATGCCTTCTATTATACTGAAGCTAAAAGAACCACACACCATGTCCAGAAGT CAAAAGTTTCTCATCTGGCTTTCTGATCTCTTACTAATGAGGAAAGCTTTGTTTGAACCACTGCACCCGGCCAGTAAAAGAAATTTTGAA >In-frame_MED1_ENST00000300651_chr17_37579580_-_GDPD1_ENST00000581276_chr17_57335112_+_1482nt ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAAT AGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTG GGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTT TCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTAT CTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATT GCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTT GAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC ATGAGATTTTATGCTGTTTCAGAGTTGGTGAAGCGGTATAATCGAGAACACTTAACAGTGTGGGGTAATGCCAATTATGAAATTGTAGAA AAGTGCTACAAAGAGAATTCAGATATTCCTATACTCTTCAGTCTACAACGTGTCCTGCTCATTCTTGGCCTTTTCTTCACTGGCCTCTTG CCCTTTGTGCCCATTCGAGAACAGTTTTTTGAAATCCCAATGCCTTCTATTATACTGAAGCTAAAAGAACCACACACCATGTCCAGAAGT CAAAAGTTTCTCATCTGGCTTTCTGATCTCTTACTAATGAGGAAAGCTTTGTTTGACCACCTAACTGCTCGAGGCATTCAAGTAAGTTTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MED1_ENST00000394287_chr17_37579580_-_GDPD1_ENST00000284116_chr17_57335112_+_2499nt TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGTTTCAGAGTTGGTGAAGCGGTATAATCGAGAACACTTAACAGTGTGGG GTAATGCCAATTATGAAATTGTAGAAAAGTGCTACAAAGAGAATTCAGATATTCCTATACTCTTCAGTCTACAACGTGTCCTGCTCATTC TTGGCCTTTTCTTCACTGGCCTCTTGCCCTTTGTGCCCATTCGAGAACAGTTTTTTGAAATCCCAATGCCTTCTATTATACTGAAGCTAA AAGAACCACACACCATGTCCAGAAGTCAAAAGTTTCTCATCTGGCTTTCTGATCTCTTACTAATGAGGAAAGCTTTGTTTGACCACCTAA CTGCTCGAGGCATTCAAGTGTATATTTGGGTATTAAATGAAGAACAAGAATACAAAAGAGCTTTTGATTTGGGAGCAACTGGGGTGATGA CAGACTATCCAACAAAGCTTAGGGATTTTTTACATAACTTTTCAGCATAGAAAAAGAGGTACTTAGAAGTATTGAAGGAAAAAATGAAGA CCTAAGAAAAAAATATTTCATGATCATTTCCCTAAGCCATTTCCAGAATGGTAAAAGGTTTAATCAGTTTTTATTACCTCATTTTTAAGC CTGTATGAGAATGTAGAAACTATATATTATATGTATATTTATTTTAAATAATATTGTATATTTTATGTTTGTAAATTGTTTAGAAAGATA ATTGGTTATGAGATGTAAGTTTTAATTTCTTAATGTGCATTTTTGTTTCTAGATCTTATACAGAAATCTTGATTAATAACATACACAGAA ATGTACATACTACATCATCTACAGAAATCTTGATCAATAACCTAGAAACTAGGTTATCTAGGTTATTGATCAAGATTTCTGTAGATGATG CAGTGTTCTATCATAAGTAATTCTGGAATCAAAGACTATTGGATACATTTGGCATTGGGCTGAGTGTGGTGGCTCATGCCTGTAATCCCA GCACTTTGGGAGGCTGAGACAGGCGGATCATCTGAAGTCAGGAGTTAAAGACCAGCCTGGCCAACATGGCAAAACCCCATCTCTACCAAA AATACAAAAATTAACCATGCGTGGTGGTACACGTCTGTCATCCCAGCAGCTCTTAAGGCTGAGGCACAAGAATTGCTTGAACCCGGGAGG >In-frame_MED1_ENST00000394287_chr17_37579580_-_GDPD1_ENST00000581140_chr17_57335112_+_1992nt TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGTTTCAGAGTTGGTGAAGCGGTATAATCGAGAACACTTAACAGTGTGGG GTAATGCCAATTATGAAATTGTAGAAAAGTGCTACAAAGAGAATTCAGATATTCCTATACTCTTCAGTCTACAACGTGTCCTGCTCATTC TTGGCCTTTTCTTCACTGGCCTCTTGCCCTTTGTGCCCATTCGAGAACAGTTTTTTGAAATCCCAATGCCTTCTATTATACTGAAGCTAA AAGAACCACACACCATGTCCAGAAGTCAAAAGTTTCTCATCTGGCTTTCTGATCTCTTACTAATGAGGAAAGCTTTGTTTGAACCACTGC ACCCGGCCAGTAAAAGAAATTTTGAAGGCCATTGCAGCTATTTGGTAGTGTCTTGTTATTTCTAGGTGTACCTTAGTTAAAGAGGAAAAA TAAAACGGAAAAAAGCTTGGAAATCAGTGATGTGTAGTTATTTGGCAAGTTATACATAATCAGCAGCAGCCAGGCTCAAGAAAATAAAAG TTGATTAGTTGATCAGAAATAAAATCTGTAGAGTGAATTAGATTTCTGAGTTGTTGTTGTTAATGGAACATTCTATTTGAGACCTTTTTC AGGTGTGTAGCAATTCTACCATGTCCATTTTTTTAAGCATTAAAAAGGAACTTACCAGTTGTAAATTAAGACAAGATCCAAATAGTCATA >In-frame_MED1_ENST00000394287_chr17_37579580_-_GDPD1_ENST00000581276_chr17_57335112_+_1822nt TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGTTTCAGAGTTGGTGAAGCGGTATAATCGAGAACACTTAACAGTGTGGG GTAATGCCAATTATGAAATTGTAGAAAAGTGCTACAAAGAGAATTCAGATATTCCTATACTCTTCAGTCTACAACGTGTCCTGCTCATTC TTGGCCTTTTCTTCACTGGCCTCTTGCCCTTTGTGCCCATTCGAGAACAGTTTTTTGAAATCCCAATGCCTTCTATTATACTGAAGCTAA AAGAACCACACACCATGTCCAGAAGTCAAAAGTTTCTCATCTGGCTTTCTGATCTCTTACTAATGAGGAAAGCTTTGTTTGACCACCTAA CTGCTCGAGGCATTCAAGTAAGTTTCTGGAATGATGCATTTTGGAAGCAGCATAGCTCACCAGTTTAACACAAATATAAAGGGCAAGAAC TTTTAACTGACTTAGTTTGGCCCTTGACTCTGATGCTGCTGCTTTACTGATCCACAAATGAGGACCTTAAGCTCTTCCTTACACTTAGCA >In-frame_MED1_ENST00000300651_chr17_37579580_-_GDPD1_ENST00000284116_chr17_57335112_+_2517nt ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGTTTCAGAGTTGGTGAAGCGGTATAATCGAG AACACTTAACAGTGTGGGGTAATGCCAATTATGAAATTGTAGAAAAGTGCTACAAAGAGAATTCAGATATTCCTATACTCTTCAGTCTAC AACGTGTCCTGCTCATTCTTGGCCTTTTCTTCACTGGCCTCTTGCCCTTTGTGCCCATTCGAGAACAGTTTTTTGAAATCCCAATGCCTT CTATTATACTGAAGCTAAAAGAACCACACACCATGTCCAGAAGTCAAAAGTTTCTCATCTGGCTTTCTGATCTCTTACTAATGAGGAAAG CTTTGTTTGACCACCTAACTGCTCGAGGCATTCAAGTGTATATTTGGGTATTAAATGAAGAACAAGAATACAAAAGAGCTTTTGATTTGG GAGCAACTGGGGTGATGACAGACTATCCAACAAAGCTTAGGGATTTTTTACATAACTTTTCAGCATAGAAAAAGAGGTACTTAGAAGTAT TGAAGGAAAAAATGAAGACCTAAGAAAAAAATATTTCATGATCATTTCCCTAAGCCATTTCCAGAATGGTAAAAGGTTTAATCAGTTTTT ATTACCTCATTTTTAAGCCTGTATGAGAATGTAGAAACTATATATTATATGTATATTTATTTTAAATAATATTGTATATTTTATGTTTGT AAATTGTTTAGAAAGATAATTGGTTATGAGATGTAAGTTTTAATTTCTTAATGTGCATTTTTGTTTCTAGATCTTATACAGAAATCTTGA TTAATAACATACACAGAAATGTACATACTACATCATCTACAGAAATCTTGATCAATAACCTAGAAACTAGGTTATCTAGGTTATTGATCA AGATTTCTGTAGATGATGCAGTGTTCTATCATAAGTAATTCTGGAATCAAAGACTATTGGATACATTTGGCATTGGGCTGAGTGTGGTGG CTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGACAGGCGGATCATCTGAAGTCAGGAGTTAAAGACCAGCCTGGCCAACATGGCAA AACCCCATCTCTACCAAAAATACAAAAATTAACCATGCGTGGTGGTACACGTCTGTCATCCCAGCAGCTCTTAAGGCTGAGGCACAAGAA >In-frame_MED1_ENST00000300651_chr17_37579580_-_GDPD1_ENST00000581140_chr17_57335112_+_2010nt ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGTTTCAGAGTTGGTGAAGCGGTATAATCGAG AACACTTAACAGTGTGGGGTAATGCCAATTATGAAATTGTAGAAAAGTGCTACAAAGAGAATTCAGATATTCCTATACTCTTCAGTCTAC AACGTGTCCTGCTCATTCTTGGCCTTTTCTTCACTGGCCTCTTGCCCTTTGTGCCCATTCGAGAACAGTTTTTTGAAATCCCAATGCCTT CTATTATACTGAAGCTAAAAGAACCACACACCATGTCCAGAAGTCAAAAGTTTCTCATCTGGCTTTCTGATCTCTTACTAATGAGGAAAG CTTTGTTTGAACCACTGCACCCGGCCAGTAAAAGAAATTTTGAAGGCCATTGCAGCTATTTGGTAGTGTCTTGTTATTTCTAGGTGTACC TTAGTTAAAGAGGAAAAATAAAACGGAAAAAAGCTTGGAAATCAGTGATGTGTAGTTATTTGGCAAGTTATACATAATCAGCAGCAGCCA GGCTCAAGAAAATAAAAGTTGATTAGTTGATCAGAAATAAAATCTGTAGAGTGAATTAGATTTCTGAGTTGTTGTTGTTAATGGAACATT CTATTTGAGACCTTTTTCAGGTGTGTAGCAATTCTACCATGTCCATTTTTTTAAGCATTAAAAAGGAACTTACCAGTTGTAAATTAAGAC >In-frame_MED1_ENST00000300651_chr17_37579580_-_GDPD1_ENST00000581276_chr17_57335112_+_1840nt ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGTTTCAGAGTTGGTGAAGCGGTATAATCGAG AACACTTAACAGTGTGGGGTAATGCCAATTATGAAATTGTAGAAAAGTGCTACAAAGAGAATTCAGATATTCCTATACTCTTCAGTCTAC AACGTGTCCTGCTCATTCTTGGCCTTTTCTTCACTGGCCTCTTGCCCTTTGTGCCCATTCGAGAACAGTTTTTTGAAATCCCAATGCCTT CTATTATACTGAAGCTAAAAGAACCACACACCATGTCCAGAAGTCAAAAGTTTCTCATCTGGCTTTCTGATCTCTTACTAATGAGGAAAG CTTTGTTTGACCACCTAACTGCTCGAGGCATTCAAGTAAGTTTCTGGAATGATGCATTTTGGAAGCAGCATAGCTCACCAGTTTAACACA AATATAAAGGGCAAGAACTTTTAACTGACTTAGTTTGGCCCTTGACTCTGATGCTGCTGCTTTACTGATCCACAAATGAGGACCTTAAGC |
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FusionGenePPI for MED1_GDPD1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MED1 | MED10, MED9, MED29, MED19, MED28, MED26, PPARGC1A, NR3C1, YWHAQ, TGS1, TP53, CDK8, VDR, MED1, HNF4A, THRA, THRAP3, MED24, AR, ESR1, ESR2, MED13, MED6, MED16, MED17, MED20, MED14, MED12, MED23, MED27, MED4, MED7, MED8, MED30, MED22, MED31, MED15, MED18, MED11, MED25, POLR2A, MED21, POLR2F, GABPA, GATA1, ATM, POU1F1, GATA2, PARP1, RXRA, TRRAP, PPARG, RARA, SREBF1, KAT2A, SUPT3H, SUPT7L, MYC, CCNC, CDK19, POLR2E, CDK9, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, TRA, NR1H2, KIF1A, BRD4, CTDP1, NCOA6, ELAVL1, MDM2, ZNF281, ZNF326, RALY, SETD7, FBXW7, MED13L, EPAS1, EZH2, BAG3, GJB5, PIN1, POLL, NR1I3, TCL1B, HNRNPC, NTRK1, POLR2G, EMC2, SMEK1, MED12L, RPAP2, POLR2D, BIRC5, PLK1, SPAG5 | GDPD1 | TSPAN5, TF, C3, ALB, SERPINA3, ITIH2, APOA1, A2M, IGHG2, IGHG1, APOA4, CP, HP, SERPINA1, CFB, HBD, HBB, APOA2, HBA2, AHSG, HPX, A1BG, C4A, ORM2, ORM1, IGHA1, KNG1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000300651 | - | 13 | 17 | 108_212 | 365 | 1582 | the Mediator complex |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000394287 | - | 13 | 18 | 108_212 | 365 | 557 | the Mediator complex |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000300651 | - | 13 | 17 | 16_590 | 365 | 1582 | ESR1 |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000300651 | - | 13 | 17 | 656_1066 | 365 | 1582 | ESR1 |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000394287 | - | 13 | 18 | 16_590 | 365 | 557 | ESR1 |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000394287 | - | 13 | 18 | 656_1066 | 365 | 557 | ESR1 |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000300651 | - | 13 | 17 | 681_715 | 365 | 1582 | GATA1 |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000394287 | - | 13 | 18 | 681_715 | 365 | 557 | GATA1 |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000300651 | - | 13 | 17 | 622_701 | 365 | 1582 | PPARGC1A and THRA |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000394287 | - | 13 | 18 | 622_701 | 365 | 557 | PPARGC1A and THRA |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000300651 | - | 13 | 17 | 215_390 | 365 | 1582 | the Mediator complex |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000394287 | - | 13 | 18 | 215_390 | 365 | 557 | the Mediator complex |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000300651 | - | 13 | 17 | 1_670 | 365 | 1582 | the Mediator complex and THRA |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000394287 | - | 13 | 18 | 1_670 | 365 | 557 | the Mediator complex and THRA |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000300651 | - | 13 | 17 | 405_644 | 365 | 1582 | THRA |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000394287 | - | 13 | 18 | 405_644 | 365 | 557 | THRA |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000300651 | - | 13 | 17 | 1249_1421 | 365 | 1582 | TP53 |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000394287 | - | 13 | 18 | 1249_1421 | 365 | 557 | TP53 |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000300651 | - | 13 | 17 | 542_789 | 365 | 1582 | VDR |
| Hgene | MED1 | chr17:37579580 | chr17:57335112 | ENST00000394287 | - | 13 | 18 | 542_789 | 365 | 557 | VDR |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MED1_GDPD1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MED1_GDPD1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MED1 | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | MED1 | C2239176 | Liver carcinoma | 1 | CTD_human |
| Hgene | MED1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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