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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21420

FusionGeneSummary for MECOM_CD86

check button Fusion gene summary
Fusion gene informationFusion gene name: MECOM_CD86
Fusion gene ID: 21420
HgeneTgene
Gene symbol

MECOM

CD86

Gene ID

2122

942

Gene nameMDS1 and EVI1 complex locusCD86 molecule
SynonymsAML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2B7-2|B7.2|B70|CD28LG2|LAB72
Cytomap

3q26.2

3q13.33

Type of geneprotein-codingprotein-coding
DescriptionMDS1 and EVI1 complex locus proteinMDS1 and EVI1 complex locus protein EVI1AML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein 1oncT-lymphocyte activation antigen CD86B-lymphocyte activation antigen B7-2BU63CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)CTLA-4 counter-receptor B7.2FUN-1
Modification date2018052220180523
UniProtAcc

Q03112

P42081

Ensembl transtripts involved in fusion geneENST00000264674, ENST00000392736, 
ENST00000464456, ENST00000472280, 
ENST00000494292, ENST00000468789, 
ENST00000460814, ENST00000433243, 
ENST00000485957, 		ENST00000469710, 
ENST00000493101, ENST00000264468, 
ENST00000330540, ENST00000483949, 
ENST00000393627, 
Fusion gene scores* DoF score15 X 7 X 10=10504 X 2 X 4=32
# samples 214
** MAII scorelog2(21/1050*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MECOM [Title/Abstract] AND CD86 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMECOM

GO:0045892

negative regulation of transcription, DNA-templated

10856240|11568182

HgeneMECOM

GO:0045893

positive regulation of transcription, DNA-templated

11568182|19767769

HgeneMECOM

GO:0051726

regulation of cell cycle

11568182


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A3UA-01AMECOMchr3

169381124

-CD86chr3

121810448

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000264674ENST00000469710MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000264674ENST00000493101MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000264674ENST00000264468MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000264674ENST00000330540MECOMchr3

169381124

-CD86chr3

121810448

+
intron-3UTRENST00000264674ENST00000483949MECOMchr3

169381124

-CD86chr3

121810448

+
intron-5UTRENST00000264674ENST00000393627MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000392736ENST00000469710MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000392736ENST00000493101MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000392736ENST00000264468MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000392736ENST00000330540MECOMchr3

169381124

-CD86chr3

121810448

+
intron-3UTRENST00000392736ENST00000483949MECOMchr3

169381124

-CD86chr3

121810448

+
intron-5UTRENST00000392736ENST00000393627MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000464456ENST00000469710MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000464456ENST00000493101MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000464456ENST00000264468MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000464456ENST00000330540MECOMchr3

169381124

-CD86chr3

121810448

+
intron-3UTRENST00000464456ENST00000483949MECOMchr3

169381124

-CD86chr3

121810448

+
intron-5UTRENST00000464456ENST00000393627MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000472280ENST00000469710MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000472280ENST00000493101MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000472280ENST00000264468MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000472280ENST00000330540MECOMchr3

169381124

-CD86chr3

121810448

+
intron-3UTRENST00000472280ENST00000483949MECOMchr3

169381124

-CD86chr3

121810448

+
intron-5UTRENST00000472280ENST00000393627MECOMchr3

169381124

-CD86chr3

121810448

+
5CDS-intronENST00000494292ENST00000469710MECOMchr3

169381124

-CD86chr3

121810448

+
5CDS-intronENST00000494292ENST00000493101MECOMchr3

169381124

-CD86chr3

121810448

+
5CDS-intronENST00000494292ENST00000264468MECOMchr3

169381124

-CD86chr3

121810448

+
5CDS-intronENST00000494292ENST00000330540MECOMchr3

169381124

-CD86chr3

121810448

+
5CDS-3UTRENST00000494292ENST00000483949MECOMchr3

169381124

-CD86chr3

121810448

+
5CDS-5UTRENST00000494292ENST00000393627MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000468789ENST00000469710MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000468789ENST00000493101MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000468789ENST00000264468MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000468789ENST00000330540MECOMchr3

169381124

-CD86chr3

121810448

+
intron-3UTRENST00000468789ENST00000483949MECOMchr3

169381124

-CD86chr3

121810448

+
intron-5UTRENST00000468789ENST00000393627MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000460814ENST00000469710MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000460814ENST00000493101MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000460814ENST00000264468MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000460814ENST00000330540MECOMchr3

169381124

-CD86chr3

121810448

+
intron-3UTRENST00000460814ENST00000483949MECOMchr3

169381124

-CD86chr3

121810448

+
intron-5UTRENST00000460814ENST00000393627MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000433243ENST00000469710MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000433243ENST00000493101MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000433243ENST00000264468MECOMchr3

169381124

-CD86chr3

121810448

+
intron-intronENST00000433243ENST00000330540MECOMchr3

169381124

-CD86chr3

121810448

+
intron-3UTRENST00000433243ENST00000483949MECOMchr3

169381124

-CD86chr3

121810448

+
intron-5UTRENST00000433243ENST00000393627MECOMchr3

169381124

-CD86chr3

121810448

+
5UTR-intronENST00000485957ENST00000469710MECOMchr3

169381124

-CD86chr3

121810448

+
5UTR-intronENST00000485957ENST00000493101MECOMchr3

169381124

-CD86chr3

121810448

+
5UTR-intronENST00000485957ENST00000264468MECOMchr3

169381124

-CD86chr3

121810448

+
5UTR-intronENST00000485957ENST00000330540MECOMchr3

169381124

-CD86chr3

121810448

+
5UTR-3UTRENST00000485957ENST00000483949MECOMchr3

169381124

-CD86chr3

121810448

+
5UTR-5UTRENST00000485957ENST00000393627MECOMchr3

169381124

-CD86chr3

121810448

+

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FusionProtFeatures for MECOM_CD86


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MECOM

Q03112

CD86

P42081


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MECOM_CD86


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MECOM_CD86


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MECOMHDAC1, CTBP1, HDAC4, CREBBP, KAT2B, SMAD3, MBD3, SUV39H1, EHMT2, SMAD1, SMAD2, SMAD4, SIRT1, ELAVL1, SOX2, PIAS4, PRMT1, UBE2I, SPDEF, NLRP14, PIK3R3, RABGAP1L, MED23, HIC1, FOXJ2, ERMAP, L3MBTL1CD86CTLA4, MARCH8, MARCH1, PARP1, ECE2, CD80


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MECOM_CD86


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCD86P42081DB00098Antithymocyte immunoglobulin (rabbit)T-lymphocyte activation antigen CD86biotechapproved
TgeneCD86P42081DB01281AbataceptT-lymphocyte activation antigen CD86biotechapproved
TgeneCD86P42081DB06681BelataceptT-lymphocyte activation antigen CD86biotechapproved|investigational

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RelatedDiseases for MECOM_CD86


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMECOMC0009375Colonic Neoplasms1CTD_human
HgeneMECOMC0023448Lymphoid leukemia1CTD_human
HgeneMECOMC0023470Myeloid Leukemia1CTD_human
HgeneMECOMC0027439Nasopharyngeal Neoplasms1CTD_human
HgeneMECOMC0919267ovarian neoplasm1CTD_human
HgeneMECOMC1458155Mammary Neoplasms1CTD_human
HgeneMECOMC4225221RADIOULNAR SYNOSTOSIS WITH AMEGAKARYOCYTIC THROMBOCYTOPENIA 21UNIPROT
TgeneCD86C0011616Contact Dermatitis1CTD_human
TgeneCD86C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCD86C0023895Liver diseases1CTD_human
TgeneCD86C0026764Multiple Myeloma1CTD_human