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Fusion gene ID: 21410 |
FusionGeneSummary for ME2_DCC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ME2_DCC | Fusion gene ID: 21410 | Hgene | Tgene | Gene symbol | ME2 | DCC | Gene ID | 9620 | 1630 |
| Gene name | cadherin EGF LAG seven-pass G-type receptor 1 | DCC netrin 1 receptor | |
| Synonyms | ADGRC1|CDHF9|FMI2|HFMI2|ME2 | CRC18|CRCR1|HGPPS2|IGDCC1|MRMV1|NTN1R1 | |
| Cytomap | 22q13.31 | 18q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cadherin EGF LAG seven-pass G-type receptor 1adhesion G protein-coupled receptor C1cadherin family member 9cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)flamingo homolog 2protocadherin flamingo 2 | netrin receptor DCCcolorectal cancer suppressordeleted in colorectal carcinomaimmunoglobulin superfamily DCC subclass member 1putative colorectal tumor suppressortumor suppressor protein DCC | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P23368 | P43146 | |
| Ensembl transtripts involved in fusion gene | ENST00000321341, ENST00000382927, ENST00000585680, | ENST00000442544, ENST00000412726, ENST00000581580, ENST00000580146, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 7 X 7 X 6=294 |
| # samples | 2 | 8 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(8/294*10)=-1.877744249949 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ME2 [Title/Abstract] AND DCC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | COAD | TCGA-A6-2674-01A | ME2 | chr18 | 48466756 | + | DCC | chr18 | 50831948 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000321341 | ENST00000442544 | ME2 | chr18 | 48466756 | + | DCC | chr18 | 50831948 | + |
| In-frame | ENST00000321341 | ENST00000412726 | ME2 | chr18 | 48466756 | + | DCC | chr18 | 50831948 | + |
| In-frame | ENST00000321341 | ENST00000581580 | ME2 | chr18 | 48466756 | + | DCC | chr18 | 50831948 | + |
| 5CDS-intron | ENST00000321341 | ENST00000580146 | ME2 | chr18 | 48466756 | + | DCC | chr18 | 50831948 | + |
| intron-3CDS | ENST00000382927 | ENST00000442544 | ME2 | chr18 | 48466756 | + | DCC | chr18 | 50831948 | + |
| intron-3CDS | ENST00000382927 | ENST00000412726 | ME2 | chr18 | 48466756 | + | DCC | chr18 | 50831948 | + |
| intron-3CDS | ENST00000382927 | ENST00000581580 | ME2 | chr18 | 48466756 | + | DCC | chr18 | 50831948 | + |
| intron-intron | ENST00000382927 | ENST00000580146 | ME2 | chr18 | 48466756 | + | DCC | chr18 | 50831948 | + |
| 3UTR-3CDS | ENST00000585680 | ENST00000442544 | ME2 | chr18 | 48466756 | + | DCC | chr18 | 50831948 | + |
| 3UTR-3CDS | ENST00000585680 | ENST00000412726 | ME2 | chr18 | 48466756 | + | DCC | chr18 | 50831948 | + |
| 3UTR-3CDS | ENST00000585680 | ENST00000581580 | ME2 | chr18 | 48466756 | + | DCC | chr18 | 50831948 | + |
| 3UTR-intron | ENST00000585680 | ENST00000580146 | ME2 | chr18 | 48466756 | + | DCC | chr18 | 50831948 | + |
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FusionProtFeatures for ME2_DCC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ME2 | DCC |
| Receptor for netrin required for axon guidance. Mediatesaxon attraction of neuronal growth cones in the developing nervoussystem upon ligand binding. Its association with UNC5 proteins maytrigger signaling for axon repulsion. It also acts as a dependencereceptor required for apoptosis induction when not associated withnetrin ligand. Implicated as a tumor suppressor gene.{ECO:0000269|PubMed:8187090, ECO:0000269|PubMed:8861902}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ME2 | chr18:48466756 | chr18:50831948 | ENST00000321341 | + | 15 | 16 | 165_173 | 529 | 585 | Nucleotide binding | NAD |
| Hgene | ME2 | chr18:48466756 | chr18:50831948 | ENST00000321341 | + | 15 | 16 | 311_328 | 529 | 585 | Nucleotide binding | NAD |
| Tgene | >DCC | chr18:48466756 | chr18:50831948 | ENST00000442544 | + | 11 | 29 | 728_821 | 637 | 1448 | Domain | Fibronectin type-III 4 |
| Tgene | >DCC | chr18:48466756 | chr18:50831948 | ENST00000442544 | + | 11 | 29 | 846_942 | 637 | 1448 | Domain | Fibronectin type-III 5 |
| Tgene | >DCC | chr18:48466756 | chr18:50831948 | ENST00000442544 | + | 11 | 29 | 947_1044 | 637 | 1448 | Domain | Fibronectin type-III 6 |
| Tgene | >DCC | chr18:48466756 | chr18:50831948 | ENST00000442544 | + | 11 | 29 | 1123_1447 | 637 | 1448 | Topological domain | Cytoplasmic |
| Tgene | >DCC | chr18:48466756 | chr18:50831948 | ENST00000442544 | + | 11 | 29 | 1098_1122 | 637 | 1448 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ME2 | chr18:48466756 | chr18:50831948 | ENST00000382927 | + | 1 | 14 | 165_173 | -67 | 480 | Nucleotide binding | NAD |
| Hgene | >ME2 | chr18:48466756 | chr18:50831948 | ENST00000382927 | + | 1 | 14 | 311_328 | -67 | 480 | Nucleotide binding | NAD |
| Tgene | DCC | chr18:48466756 | chr18:50831948 | ENST00000442544 | + | 11 | 29 | 139_229 | 637 | 1448 | Domain | Note=Ig-like C2-type 2 |
| Tgene | DCC | chr18:48466756 | chr18:50831948 | ENST00000442544 | + | 11 | 29 | 234_326 | 637 | 1448 | Domain | Note=Ig-like C2-type 3 |
| Tgene | DCC | chr18:48466756 | chr18:50831948 | ENST00000442544 | + | 11 | 29 | 26_135 | 637 | 1448 | Domain | Note=Ig-like C2-type 1 |
| Tgene | DCC | chr18:48466756 | chr18:50831948 | ENST00000442544 | + | 11 | 29 | 331_416 | 637 | 1448 | Domain | Note=Ig-like C2-type 4 |
| Tgene | DCC | chr18:48466756 | chr18:50831948 | ENST00000442544 | + | 11 | 29 | 431_524 | 637 | 1448 | Domain | Fibronectin type-III 1 |
| Tgene | DCC | chr18:48466756 | chr18:50831948 | ENST00000442544 | + | 11 | 29 | 530_620 | 637 | 1448 | Domain | Fibronectin type-III 2 |
| Tgene | DCC | chr18:48466756 | chr18:50831948 | ENST00000442544 | + | 11 | 29 | 625_718 | 637 | 1448 | Domain | Fibronectin type-III 3 |
| Tgene | DCC | chr18:48466756 | chr18:50831948 | ENST00000442544 | + | 11 | 29 | 26_1097 | 637 | 1448 | Topological domain | Extracellular |
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FusionGeneSequence for ME2_DCC |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ME2_ENST00000321341_chr18_48466756_+_DCC_ENST00000442544_chr18_50831948_+_1340aa MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQE RNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIP VGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYR EKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDS YQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFG PVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKSIKVSWLPPPS GTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQT NCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYP LLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEF SVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQ IMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNL LVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTP VSHSQSETQLGSKSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFT LRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLS >In-frame_ME2_ENST00000321341_chr18_48466756_+_DCC_ENST00000412726_chr18_50831948_+_942aa MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQE RNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIP VGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYR EKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDS YQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFG PVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKSIKVSWLPPPS GTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQT NCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDLSTPMLPPV GVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHAT TYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSK >In-frame_ME2_ENST00000321341_chr18_48466756_+_DCC_ENST00000581580_chr18_50831948_+_1314aa MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQE RNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIP VGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYR EKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDS YQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFG PVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKSIKVSWLPPPS GTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQT NCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDLSTPMLPPV GVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHAT TYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSK GVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVA VICTRRSSAQQRKKRATHSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQ DTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRT VSEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ME2_ENST00000321341_chr18_48466756_+_DCC_ENST00000442544_chr18_50831948_+_4020nt ATGTTGTCCCGGTTAAGAGTAGTTTCCACCACTTGTACTTTGGCATGTCGACATTTGCACATAAAAGAAAAAGGCAAGCCACTTATGCTG AACCCAAGAACAAACAAGGGAATGGCATTTACTTTACAAGAACGACAAATGCTTGGTCTTCAAGGACTTCTACCTCCCAAAATAGAGACA CAAGATATTCAAGCCTTACGATTTCATAGAAACTTGAAGAAAATGACTAGCCCTTTGGAAAAATATATCTACATAATGGGAATACAAGAA AGAAATGAGAAATTGTTTTATAGAATACTGCAAGATGACATTGAGAGTTTAATGCCAATTGTATATACACCGACGGTTGGTCTTGCCTGC TCCCAGTATGGACACATCTTTAGAAGACCTAAGGGATTATTTATTTCGATCTCAGACAGAGGTCATGTTAGATCAATTGTGGATAACTGG CCAGAAAATCATGTTAAGGCTGTTGTAGTGACTGATGGAGAGAGAATTCTGGGTCTTGGAGATCTGGGTGTCTATGGAATGGGAATTCCA GTAGGAAAACTTTGTTTGTATACAGCTTGTGCAGGAATACGGCCTGATAGATGCCTGCCAGTGTGTATTGATGTGGGAACTGATAATATC GCACTCTTAAAAGACCCATTTTACATGGGCTTGTACCAGAAACGAGATCGCACACAACAGTATGATGACCTGATTGATGAGTTTATGAAA GCTATTACTGACAGATATGGCCGGAACACACTCATTCAGTTCGAAGACTTTGGAAATCATAATGCATTCAGGTTCTTGAGAAAGTACCGA GAAAAATATTGTACTTTCAATGATGATATTCAAGGGACAGCTGCAGTAGCTCTAGCAGGTCTTCTTGCAGCACAAAAAGTTATTAGTAAA CCAATCTCCGAACACAAAATCTTATTCCTTGGAGCAGGAGAGGCTGCTCTTGGAATTGCAAATCTTATAGTTATGTCTATGGTAGAAAAT GGCCTGTCAGAACAAGAGGCACAAAAGAAAATCTGGATGTTTGACAAGTATGGTTTATTAGTTAAGGGACGGAAAGCAAAAATAGATAGT TATCAGGAACCATTTACTCACTCAGCCCCAGAGAGCATACCTGATACTTTTGAAGATGCAGTGAATATACTGAAGCCTTCAACTATAATT GGAGTTGCAGGTGCTGGCCGTCTTTTCACTCCTGATGTAATCAGAGCCATGGCCTCTATCAATGAAAGGCCTGTAATATTTGCATTAAGT AATCCTACAGCACAGGCAGAGTGCACGGCTGAAGAAGCATATACACTTACAGAGGGCAGGTGTTTGTTTGCCAGTGGCAGTCCATTTGGG CCAGTGAAACTTACAGATGGGCGAGTCTTTACACCAGGTCAAGGAAACAATGTTTATATTTTTCCAGGTGTGGCTTTAGCTGTTATTCTC TGTAACACCCGGCATATTAGTGACAGTGTTTTCCTAGAAGCTGCAAAGGCCCTGACAAGCCAATTGACAGATGAAGAGCTAGCCCAAGGG AGACTTTACCCACCGCTTGCTAATATTCAGGAAGTTTCTATTAACATTGCTATTAAAAGTATCAAAGTTAGCTGGCTGCCTCCTCCATCA GGAACACAAAATGGATTTATTACCGGCTATAAAATTCGACACAGAAAGACGACCCGCAGGGGTGAGATGGAAACACTGGAGCCAAACAAC CTCTGGTACCTATTCACAGGACTGGAGAAAGGAAGTCAGTACAGTTTCCAGGTGTCAGCCATGACAGTCAATGGTACTGGACCACCTTCC AACTGGTATACTGCAGAGACTCCAGAGAATGATCTAGATGAATCTCAAGTTCCTGATCAACCAAGCTCTCTTCATGTGAGGCCCCAGACT AACTGCATCATCATGAGTTGGACTCCTCCCTTGAACCCAAACATCGTGGTGCGAGGTTATATTATCGGTTATGGCGTTGGGAGCCCTTAC GCTGAGACAGTGCGTGTGGACAGCAAGCAGCGATATTATTCCATTGAGAGGTTAGAGTCAAGTTCCCATTATGTAATCTCCCTAAAAGCT TTTAACAATGCCGGAGAAGGAGTTCCTCTTTATGAAAGTGCCACCACCAGGTCTATAACCGATCCCACTGACCCAGTTGATTATTATCCT TTGCTTGATGATTTCCCCACCTCGGTCCCAGATCTCTCCACCCCCATGCTCCCACCAGTAGGTGTACAGGCTGTGGCTCTTACCCATGAT GCTGTGAGGGTCAGCTGGGCAGACAACTCTGTCCCTAAGAACCAAAAGACGTCTGAGGTGCGACTTTACACCGTCCGGTGGAGAACCAGC TTTTCTGCAAGTGCAAAATACAAGTCAGAAGACACAACATCTCTAAGTTACACAGCAACAGGCCTCAAACCAAACACAATGTATGAATTC TCGGTCATGGTAACAAAAAACAGAAGGTCCAGTACTTGGAGCATGACTGCACATGCCACCACGTATGAAGCAGCCCCCACCTCTGCTCCC AAGGACTTGACAGTCATTACTAGGGAAGGGAAGCCTCGTGCCGTCATTGTGAGTTGGCAGCCTCCCTTGGAAGCCAATGGGAAAATTACT GCTTACATCTTATTTTATACCTTGGACAAGAACATCCCAATTGATGACTGGATTATGGAAACAATCAGTGGTGATAGGCTTACTCATCAA ATCATGGATCTCAACCTTGATACTATGTATTACTTTCGAATTCAAGCACGAAATTCAAAAGGAGTGGGGCCACTCTCTGATCCTATCCTC TTCAGGACTCTGAAAGTGGAACACCCTGACAAAATGGCTAATGACCAAGGTCGTCATGGAGATGGAGGTTATTGGCCAGTTGATACTAAT TTGATTGATAGAAGCACCCTAAATGAGCCGCCAATTGGACAAATGCACCCCCCGCATGGCAGTGTCACTCCTCAGAAGAACAGCAACCTG CTTGTGATCATTGTGGTCACCGTTGGTGTCATCACAGTGCTGGTAGTGGTCATCGTGGCTGTGATTTGCACCCGACGCTCTTCAGCCCAG CAGAGAAAGAAACGGGCCACCCACAGTGCTGGCAAAAGGAAGGGCAGCCAGAAGGACCTCCGACCCCCTGATCTTTGGATCCATCATGAA GAAATGGAGATGAAAAATATTGAAAAGCCATCTGGCACTGACCCTGCAGGAAGGGACTCTCCCATCCAAAGTTGCCAAGACCTCACACCA GTCAGCCACAGCCAGTCAGAAACCCAACTGGGAAGCAAAAGCACCTCTCATTCAGGTCAAGACACTGAGGAAGCAGGGAGCTCTATGTCC ACTCTGGAGAGGTCGCTGGCTGCACGCCGAGCCCCCCGGGCCAAGCTCATGATTCCCATGGATGCCCAGTCCAACAATCCTGCTGTCGTG AGCGCCATCCCGGTGCCAACGCTAGAAAGTGCCCAGTACCCAGGAATCCTCCCGTCTCCCACCTGTGGATATCCCCACCCGCAGTTCACT CTCCGGCCTGTGCCATTCCCAACACTCTCAGTGGACCGAGGTTTCGGAGCAGGAAGAAGTCAGTCAGTGAGTGAAGGACCAACTACCCAA CAACCACCTATGCTGCCCCCATCTCAGCCTGAGCATTCTAGCAGCGAGGAGGCACCAAGCAGAACCATCCCCACAGCTTGTGTTCGACCA ACTCACCCACTCCGCAGCTTTGCTAATCCTTTGCTACCTCCACCAATGAGTGCAATAGAACCGAAAGTCCCTTACACACCACTTTTGTCT CAGCCAGGGCCCACTCTTCCTAAGACCCATGTGAAAACAGCCTCCCTTGGGTTGGCTGGAAAAGCAAGATCCCCTTTGCTTCCTGTGTCT GTGCCAACAGCCCCTGAAGTGTCTGAGGAGAGCCACAAACCAACAGAGGATTCAGCCAATGTGTATGAACAGGATGATCTGAGTGAACAA >In-frame_ME2_ENST00000321341_chr18_48466756_+_DCC_ENST00000412726_chr18_50831948_+_2826nt ATGTTGTCCCGGTTAAGAGTAGTTTCCACCACTTGTACTTTGGCATGTCGACATTTGCACATAAAAGAAAAAGGCAAGCCACTTATGCTG AACCCAAGAACAAACAAGGGAATGGCATTTACTTTACAAGAACGACAAATGCTTGGTCTTCAAGGACTTCTACCTCCCAAAATAGAGACA CAAGATATTCAAGCCTTACGATTTCATAGAAACTTGAAGAAAATGACTAGCCCTTTGGAAAAATATATCTACATAATGGGAATACAAGAA AGAAATGAGAAATTGTTTTATAGAATACTGCAAGATGACATTGAGAGTTTAATGCCAATTGTATATACACCGACGGTTGGTCTTGCCTGC TCCCAGTATGGACACATCTTTAGAAGACCTAAGGGATTATTTATTTCGATCTCAGACAGAGGTCATGTTAGATCAATTGTGGATAACTGG CCAGAAAATCATGTTAAGGCTGTTGTAGTGACTGATGGAGAGAGAATTCTGGGTCTTGGAGATCTGGGTGTCTATGGAATGGGAATTCCA GTAGGAAAACTTTGTTTGTATACAGCTTGTGCAGGAATACGGCCTGATAGATGCCTGCCAGTGTGTATTGATGTGGGAACTGATAATATC GCACTCTTAAAAGACCCATTTTACATGGGCTTGTACCAGAAACGAGATCGCACACAACAGTATGATGACCTGATTGATGAGTTTATGAAA GCTATTACTGACAGATATGGCCGGAACACACTCATTCAGTTCGAAGACTTTGGAAATCATAATGCATTCAGGTTCTTGAGAAAGTACCGA GAAAAATATTGTACTTTCAATGATGATATTCAAGGGACAGCTGCAGTAGCTCTAGCAGGTCTTCTTGCAGCACAAAAAGTTATTAGTAAA CCAATCTCCGAACACAAAATCTTATTCCTTGGAGCAGGAGAGGCTGCTCTTGGAATTGCAAATCTTATAGTTATGTCTATGGTAGAAAAT GGCCTGTCAGAACAAGAGGCACAAAAGAAAATCTGGATGTTTGACAAGTATGGTTTATTAGTTAAGGGACGGAAAGCAAAAATAGATAGT TATCAGGAACCATTTACTCACTCAGCCCCAGAGAGCATACCTGATACTTTTGAAGATGCAGTGAATATACTGAAGCCTTCAACTATAATT GGAGTTGCAGGTGCTGGCCGTCTTTTCACTCCTGATGTAATCAGAGCCATGGCCTCTATCAATGAAAGGCCTGTAATATTTGCATTAAGT AATCCTACAGCACAGGCAGAGTGCACGGCTGAAGAAGCATATACACTTACAGAGGGCAGGTGTTTGTTTGCCAGTGGCAGTCCATTTGGG CCAGTGAAACTTACAGATGGGCGAGTCTTTACACCAGGTCAAGGAAACAATGTTTATATTTTTCCAGGTGTGGCTTTAGCTGTTATTCTC TGTAACACCCGGCATATTAGTGACAGTGTTTTCCTAGAAGCTGCAAAGGCCCTGACAAGCCAATTGACAGATGAAGAGCTAGCCCAAGGG AGACTTTACCCACCGCTTGCTAATATTCAGGAAGTTTCTATTAACATTGCTATTAAAAGTATCAAAGTTAGCTGGCTGCCTCCTCCATCA GGAACACAAAATGGATTTATTACCGGCTATAAAATTCGACACAGAAAGACGACCCGCAGGGGTGAGATGGAAACACTGGAGCCAAACAAC CTCTGGTACCTATTCACAGGACTGGAGAAAGGAAGTCAGTACAGTTTCCAGGTGTCAGCCATGACAGTCAATGGTACTGGACCACCTTCC AACTGGTATACTGCAGAGACTCCAGAGAATGATCTAGATGAATCTCAAGTTCCTGATCAACCAAGCTCTCTTCATGTGAGGCCCCAGACT AACTGCATCATCATGAGTTGGACTCCTCCCTTGAACCCAAACATCGTGGTGCGAGGTTATATTATCGGTTATGGCGTTGGGAGCCCTTAC GCTGAGACAGTGCGTGTGGACAGCAAGCAGCGATATTATTCCATTGAGAGGTTAGAGTCAAGTTCCCATTATGTAATCTCCCTAAAAGCT TTTAACAATGCCGGAGAAGGAGTTCCTCTTTATGAAAGTGCCACCACCAGGTCTATAACCGATCTCTCCACCCCCATGCTCCCACCAGTA GGTGTACAGGCTGTGGCTCTTACCCATGATGCTGTGAGGGTCAGCTGGGCAGACAACTCTGTCCCTAAGAACCAAAAGACGTCTGAGGTG CGACTTTACACCGTCCGGTGGAGAACCAGCTTTTCTGCAAGTGCAAAATACAAGTCAGAAGACACAACATCTCTAAGTTACACAGCAACA GGCCTCAAACCAAACACAATGTATGAATTCTCGGTCATGGTAACAAAAAACAGAAGGTCCAGTACTTGGAGCATGACTGCACATGCCACC ACGTATGAAGCAGCCCCCACCTCTGCTCCCAAGGACTTGACAGTCATTACTAGGGAAGGGAAGCCTCGTGCCGTCATTGTGAGTTGGCAG CCTCCCTTGGAAGCCAATGGGAAAATTACTGCTTACATCTTATTTTATACCTTGGACAAGAACATCCCAATTGATGACTGGATTATGGAA ACAATCAGTGGTGATAGGCTTACTCATCAAATCATGGATCTCAACCTTGATACTATGTATTACTTTCGAATTCAAGCACGAAATTCAAAA GGAGTGGGGCCACTCTCTGATCCTATCCTCTTCAGGACTCTGAAAGTGGAACACCCTGACAAAATGGCTAATGACCAAGACACTGGCGTG >In-frame_ME2_ENST00000321341_chr18_48466756_+_DCC_ENST00000581580_chr18_50831948_+_3942nt ATGTTGTCCCGGTTAAGAGTAGTTTCCACCACTTGTACTTTGGCATGTCGACATTTGCACATAAAAGAAAAAGGCAAGCCACTTATGCTG AACCCAAGAACAAACAAGGGAATGGCATTTACTTTACAAGAACGACAAATGCTTGGTCTTCAAGGACTTCTACCTCCCAAAATAGAGACA CAAGATATTCAAGCCTTACGATTTCATAGAAACTTGAAGAAAATGACTAGCCCTTTGGAAAAATATATCTACATAATGGGAATACAAGAA AGAAATGAGAAATTGTTTTATAGAATACTGCAAGATGACATTGAGAGTTTAATGCCAATTGTATATACACCGACGGTTGGTCTTGCCTGC TCCCAGTATGGACACATCTTTAGAAGACCTAAGGGATTATTTATTTCGATCTCAGACAGAGGTCATGTTAGATCAATTGTGGATAACTGG CCAGAAAATCATGTTAAGGCTGTTGTAGTGACTGATGGAGAGAGAATTCTGGGTCTTGGAGATCTGGGTGTCTATGGAATGGGAATTCCA GTAGGAAAACTTTGTTTGTATACAGCTTGTGCAGGAATACGGCCTGATAGATGCCTGCCAGTGTGTATTGATGTGGGAACTGATAATATC GCACTCTTAAAAGACCCATTTTACATGGGCTTGTACCAGAAACGAGATCGCACACAACAGTATGATGACCTGATTGATGAGTTTATGAAA GCTATTACTGACAGATATGGCCGGAACACACTCATTCAGTTCGAAGACTTTGGAAATCATAATGCATTCAGGTTCTTGAGAAAGTACCGA GAAAAATATTGTACTTTCAATGATGATATTCAAGGGACAGCTGCAGTAGCTCTAGCAGGTCTTCTTGCAGCACAAAAAGTTATTAGTAAA CCAATCTCCGAACACAAAATCTTATTCCTTGGAGCAGGAGAGGCTGCTCTTGGAATTGCAAATCTTATAGTTATGTCTATGGTAGAAAAT GGCCTGTCAGAACAAGAGGCACAAAAGAAAATCTGGATGTTTGACAAGTATGGTTTATTAGTTAAGGGACGGAAAGCAAAAATAGATAGT TATCAGGAACCATTTACTCACTCAGCCCCAGAGAGCATACCTGATACTTTTGAAGATGCAGTGAATATACTGAAGCCTTCAACTATAATT GGAGTTGCAGGTGCTGGCCGTCTTTTCACTCCTGATGTAATCAGAGCCATGGCCTCTATCAATGAAAGGCCTGTAATATTTGCATTAAGT AATCCTACAGCACAGGCAGAGTGCACGGCTGAAGAAGCATATACACTTACAGAGGGCAGGTGTTTGTTTGCCAGTGGCAGTCCATTTGGG CCAGTGAAACTTACAGATGGGCGAGTCTTTACACCAGGTCAAGGAAACAATGTTTATATTTTTCCAGGTGTGGCTTTAGCTGTTATTCTC TGTAACACCCGGCATATTAGTGACAGTGTTTTCCTAGAAGCTGCAAAGGCCCTGACAAGCCAATTGACAGATGAAGAGCTAGCCCAAGGG AGACTTTACCCACCGCTTGCTAATATTCAGGAAGTTTCTATTAACATTGCTATTAAAAGTATCAAAGTTAGCTGGCTGCCTCCTCCATCA GGAACACAAAATGGATTTATTACCGGCTATAAAATTCGACACAGAAAGACGACCCGCAGGGGTGAGATGGAAACACTGGAGCCAAACAAC CTCTGGTACCTATTCACAGGACTGGAGAAAGGAAGTCAGTACAGTTTCCAGGTGTCAGCCATGACAGTCAATGGTACTGGACCACCTTCC AACTGGTATACTGCAGAGACTCCAGAGAATGATCTAGATGAATCTCAAGTTCCTGATCAACCAAGCTCTCTTCATGTGAGGCCCCAGACT AACTGCATCATCATGAGTTGGACTCCTCCCTTGAACCCAAACATCGTGGTGCGAGGTTATATTATCGGTTATGGCGTTGGGAGCCCTTAC GCTGAGACAGTGCGTGTGGACAGCAAGCAGCGATATTATTCCATTGAGAGGTTAGAGTCAAGTTCCCATTATGTAATCTCCCTAAAAGCT TTTAACAATGCCGGAGAAGGAGTTCCTCTTTATGAAAGTGCCACCACCAGGTCTATAACCGATCTCTCCACCCCCATGCTCCCACCAGTA GGTGTACAGGCTGTGGCTCTTACCCATGATGCTGTGAGGGTCAGCTGGGCAGACAACTCTGTCCCTAAGAACCAAAAGACGTCTGAGGTG CGACTTTACACCGTCCGGTGGAGAACCAGCTTTTCTGCAAGTGCAAAATACAAGTCAGAAGACACAACATCTCTAAGTTACACAGCAACA GGCCTCAAACCAAACACAATGTATGAATTCTCGGTCATGGTAACAAAAAACAGAAGGTCCAGTACTTGGAGCATGACTGCACATGCCACC ACGTATGAAGCAGCCCCCACCTCTGCTCCCAAGGACTTGACAGTCATTACTAGGGAAGGGAAGCCTCGTGCCGTCATTGTGAGTTGGCAG CCTCCCTTGGAAGCCAATGGGAAAATTACTGCTTACATCTTATTTTATACCTTGGACAAGAACATCCCAATTGATGACTGGATTATGGAA ACAATCAGTGGTGATAGGCTTACTCATCAAATCATGGATCTCAACCTTGATACTATGTATTACTTTCGAATTCAAGCACGAAATTCAAAA GGAGTGGGGCCACTCTCTGATCCTATCCTCTTCAGGACTCTGAAAGTGGAACACCCTGACAAAATGGCTAATGACCAAGGTCGTCATGGA GATGGAGGTTATTGGCCAGTTGATACTAATTTGATTGATAGAAGCACCCTAAATGAGCCGCCAATTGGACAAATGCACCCCCCGCATGGC AGTGTCACTCCTCAGAAGAACAGCAACCTGCTTGTGATCATTGTGGTCACCGTTGGTGTCATCACAGTGCTGGTAGTGGTCATCGTGGCT GTGATTTGCACCCGACGCTCTTCAGCCCAGCAGAGAAAGAAACGGGCCACCCACAGTGCTGGCAAAAGGAAGGGCAGCCAGAAGGACCTC CGACCCCCTGATCTTTGGATCCATCATGAAGAAATGGAGATGAAAAATATTGAAAAGCCATCTGGCACTGACCCTGCAGGAAGGGACTCT CCCATCCAAAGTTGCCAAGACCTCACACCAGTCAGCCACAGCCAGTCAGAAACCCAACTGGGAAGCAAAAGCACCTCTCATTCAGGTCAA GACACTGAGGAAGCAGGGAGCTCTATGTCCACTCTGGAGAGGTCGCTGGCTGCACGCCGAGCCCCCCGGGCCAAGCTCATGATTCCCATG GATGCCCAGTCCAACAATCCTGCTGTCGTGAGCGCCATCCCGGTGCCAACGCTAGAAAGTGCCCAGTACCCAGGAATCCTCCCGTCTCCC ACCTGTGGATATCCCCACCCGCAGTTCACTCTCCGGCCTGTGCCATTCCCAACACTCTCAGTGGACCGAGGTTTCGGAGCAGGAAGAACA GTGAGTGAAGGACCAACTACCCAACAACCACCTATGCTGCCCCCATCTCAGCCTGAGCATTCTAGCAGCGAGGAGGCACCAAGCAGAACC ATCCCCACAGCTTGTGTTCGACCAACTCACCCACTCCGCAGCTTTGCTAATCCTTTGCTACCTCCACCAATGAGTGCAATAGAACCGAAA GTCCCTTACACACCACTTTTGTCTCAGCCAGGGCCCACTCTTCCTAAGACCCATGTGAAAACAGCCTCCCTTGGGTTGGCTGGAAAAGCA AGATCCCCTTTGCTTCCTGTGTCTGTGCCAACAGCCCCTGAAGTGTCTGAGGAGAGCCACAAACCAACAGAGGATTCAGCCAATGTGGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ME2_ENST00000321341_chr18_48466756_+_DCC_ENST00000442544_chr18_50831948_+_5053nt CCCGTCCGTCTCCACCGTGGGCCACGCCTTCCGGGCCCCGCGGCTGGCCGGCTCCTCGCGCCCTCCCCTCTCTCGGCCGCTCTTCGGGCC GCCTCTGCGTGTGGGGCCGCCCGCGCCAGTGTGAGCCTGAGCTGACGGCGGCTCCGGGAGGCTCGCAGAAGGGGAGGGCCGGGCGGCGCG GGAGCTGAGCATCGCCAGGGCGGGCGGCAGGGCGCGGCCTCTCCGCCGGGTGTACCACCTGTCGCGGCGCGAGACCTCTGGTGAAAGAAA AGATGTTGTCCCGGTTAAGAGTAGTTTCCACCACTTGTACTTTGGCATGTCGACATTTGCACATAAAAGAAAAAGGCAAGCCACTTATGC TGAACCCAAGAACAAACAAGGGAATGGCATTTACTTTACAAGAACGACAAATGCTTGGTCTTCAAGGACTTCTACCTCCCAAAATAGAGA CACAAGATATTCAAGCCTTACGATTTCATAGAAACTTGAAGAAAATGACTAGCCCTTTGGAAAAATATATCTACATAATGGGAATACAAG AAAGAAATGAGAAATTGTTTTATAGAATACTGCAAGATGACATTGAGAGTTTAATGCCAATTGTATATACACCGACGGTTGGTCTTGCCT GCTCCCAGTATGGACACATCTTTAGAAGACCTAAGGGATTATTTATTTCGATCTCAGACAGAGGTCATGTTAGATCAATTGTGGATAACT GGCCAGAAAATCATGTTAAGGCTGTTGTAGTGACTGATGGAGAGAGAATTCTGGGTCTTGGAGATCTGGGTGTCTATGGAATGGGAATTC CAGTAGGAAAACTTTGTTTGTATACAGCTTGTGCAGGAATACGGCCTGATAGATGCCTGCCAGTGTGTATTGATGTGGGAACTGATAATA TCGCACTCTTAAAAGACCCATTTTACATGGGCTTGTACCAGAAACGAGATCGCACACAACAGTATGATGACCTGATTGATGAGTTTATGA AAGCTATTACTGACAGATATGGCCGGAACACACTCATTCAGTTCGAAGACTTTGGAAATCATAATGCATTCAGGTTCTTGAGAAAGTACC GAGAAAAATATTGTACTTTCAATGATGATATTCAAGGGACAGCTGCAGTAGCTCTAGCAGGTCTTCTTGCAGCACAAAAAGTTATTAGTA AACCAATCTCCGAACACAAAATCTTATTCCTTGGAGCAGGAGAGGCTGCTCTTGGAATTGCAAATCTTATAGTTATGTCTATGGTAGAAA ATGGCCTGTCAGAACAAGAGGCACAAAAGAAAATCTGGATGTTTGACAAGTATGGTTTATTAGTTAAGGGACGGAAAGCAAAAATAGATA GTTATCAGGAACCATTTACTCACTCAGCCCCAGAGAGCATACCTGATACTTTTGAAGATGCAGTGAATATACTGAAGCCTTCAACTATAA TTGGAGTTGCAGGTGCTGGCCGTCTTTTCACTCCTGATGTAATCAGAGCCATGGCCTCTATCAATGAAAGGCCTGTAATATTTGCATTAA GTAATCCTACAGCACAGGCAGAGTGCACGGCTGAAGAAGCATATACACTTACAGAGGGCAGGTGTTTGTTTGCCAGTGGCAGTCCATTTG GGCCAGTGAAACTTACAGATGGGCGAGTCTTTACACCAGGTCAAGGAAACAATGTTTATATTTTTCCAGGTGTGGCTTTAGCTGTTATTC TCTGTAACACCCGGCATATTAGTGACAGTGTTTTCCTAGAAGCTGCAAAGGCCCTGACAAGCCAATTGACAGATGAAGAGCTAGCCCAAG GGAGACTTTACCCACCGCTTGCTAATATTCAGGAAGTTTCTATTAACATTGCTATTAAAAGTATCAAAGTTAGCTGGCTGCCTCCTCCAT CAGGAACACAAAATGGATTTATTACCGGCTATAAAATTCGACACAGAAAGACGACCCGCAGGGGTGAGATGGAAACACTGGAGCCAAACA ACCTCTGGTACCTATTCACAGGACTGGAGAAAGGAAGTCAGTACAGTTTCCAGGTGTCAGCCATGACAGTCAATGGTACTGGACCACCTT CCAACTGGTATACTGCAGAGACTCCAGAGAATGATCTAGATGAATCTCAAGTTCCTGATCAACCAAGCTCTCTTCATGTGAGGCCCCAGA CTAACTGCATCATCATGAGTTGGACTCCTCCCTTGAACCCAAACATCGTGGTGCGAGGTTATATTATCGGTTATGGCGTTGGGAGCCCTT ACGCTGAGACAGTGCGTGTGGACAGCAAGCAGCGATATTATTCCATTGAGAGGTTAGAGTCAAGTTCCCATTATGTAATCTCCCTAAAAG CTTTTAACAATGCCGGAGAAGGAGTTCCTCTTTATGAAAGTGCCACCACCAGGTCTATAACCGATCCCACTGACCCAGTTGATTATTATC CTTTGCTTGATGATTTCCCCACCTCGGTCCCAGATCTCTCCACCCCCATGCTCCCACCAGTAGGTGTACAGGCTGTGGCTCTTACCCATG ATGCTGTGAGGGTCAGCTGGGCAGACAACTCTGTCCCTAAGAACCAAAAGACGTCTGAGGTGCGACTTTACACCGTCCGGTGGAGAACCA GCTTTTCTGCAAGTGCAAAATACAAGTCAGAAGACACAACATCTCTAAGTTACACAGCAACAGGCCTCAAACCAAACACAATGTATGAAT TCTCGGTCATGGTAACAAAAAACAGAAGGTCCAGTACTTGGAGCATGACTGCACATGCCACCACGTATGAAGCAGCCCCCACCTCTGCTC CCAAGGACTTGACAGTCATTACTAGGGAAGGGAAGCCTCGTGCCGTCATTGTGAGTTGGCAGCCTCCCTTGGAAGCCAATGGGAAAATTA CTGCTTACATCTTATTTTATACCTTGGACAAGAACATCCCAATTGATGACTGGATTATGGAAACAATCAGTGGTGATAGGCTTACTCATC AAATCATGGATCTCAACCTTGATACTATGTATTACTTTCGAATTCAAGCACGAAATTCAAAAGGAGTGGGGCCACTCTCTGATCCTATCC TCTTCAGGACTCTGAAAGTGGAACACCCTGACAAAATGGCTAATGACCAAGGTCGTCATGGAGATGGAGGTTATTGGCCAGTTGATACTA ATTTGATTGATAGAAGCACCCTAAATGAGCCGCCAATTGGACAAATGCACCCCCCGCATGGCAGTGTCACTCCTCAGAAGAACAGCAACC TGCTTGTGATCATTGTGGTCACCGTTGGTGTCATCACAGTGCTGGTAGTGGTCATCGTGGCTGTGATTTGCACCCGACGCTCTTCAGCCC AGCAGAGAAAGAAACGGGCCACCCACAGTGCTGGCAAAAGGAAGGGCAGCCAGAAGGACCTCCGACCCCCTGATCTTTGGATCCATCATG AAGAAATGGAGATGAAAAATATTGAAAAGCCATCTGGCACTGACCCTGCAGGAAGGGACTCTCCCATCCAAAGTTGCCAAGACCTCACAC CAGTCAGCCACAGCCAGTCAGAAACCCAACTGGGAAGCAAAAGCACCTCTCATTCAGGTCAAGACACTGAGGAAGCAGGGAGCTCTATGT CCACTCTGGAGAGGTCGCTGGCTGCACGCCGAGCCCCCCGGGCCAAGCTCATGATTCCCATGGATGCCCAGTCCAACAATCCTGCTGTCG TGAGCGCCATCCCGGTGCCAACGCTAGAAAGTGCCCAGTACCCAGGAATCCTCCCGTCTCCCACCTGTGGATATCCCCACCCGCAGTTCA CTCTCCGGCCTGTGCCATTCCCAACACTCTCAGTGGACCGAGGTTTCGGAGCAGGAAGAAGTCAGTCAGTGAGTGAAGGACCAACTACCC AACAACCACCTATGCTGCCCCCATCTCAGCCTGAGCATTCTAGCAGCGAGGAGGCACCAAGCAGAACCATCCCCACAGCTTGTGTTCGAC CAACTCACCCACTCCGCAGCTTTGCTAATCCTTTGCTACCTCCACCAATGAGTGCAATAGAACCGAAAGTCCCTTACACACCACTTTTGT CTCAGCCAGGGCCCACTCTTCCTAAGACCCATGTGAAAACAGCCTCCCTTGGGTTGGCTGGAAAAGCAAGATCCCCTTTGCTTCCTGTGT CTGTGCCAACAGCCCCTGAAGTGTCTGAGGAGAGCCACAAACCAACAGAGGATTCAGCCAATGTGTATGAACAGGATGATCTGAGTGAAC AAATGGCAAGTTTGGAAGGACTCATGAAGCAGCTTAATGCCATCACAGGCTCAGCCTTTTAACATGTATTTCTGAATGGATGAGGTGAAT TTTCCGGGAACTTTGCAGCATACCAATTACCCATAAACAGCACACCTGTGTCCAAGAACTCTAACCAGTGTACAGGTCACCCATCAGGAC CACTCAGTTAAGGAAGATCCTGAAGCAGTTCAGAAGGAATAAGCATTCCTTCTTTCACAGGCATCAGGAATTGTCAAATGATGATTATGA GTTCCCTAAACAAAAGCAAAGATGCATTTTCACTGCAATGTCAAAGTTTAAGCTGCTAGAATAGTCATGGGCCTTTGTCACTGCAGTGAC CACACTGTCATAACTAATACCTATGTTTTCCTTTGTCAAGGCCTGTTGTTTAATGTGTAGGTCTAGTCTTACAAAATGCAAGTGCATTAT TTAAGCCTGTACCATGCCATGGCAAACCAGTGCAAGCTCACTATTTTGTTTTCAACTTAAACATACAAAGCACCCATGGGAATCTCTCAT GCCATAGCACCAAAGGATTGGATGTTTTCCTTACAGCACAAAAAGTAAATAGTAAACAAACAAAAGGCAGAGAATGCTTATGTTTGTAAC TCAGTCATTCATCTTGCACAAGTGGTGGATATTAGTGAGTGGCTAAAAATTCACCTATTTTGGCAAGTATTTGTAAATCCACCCTTGGTT AATATGTATGTCTGGAGTCCAGGAATATAAAAATCTGCAACTAGTGGCATTCTGCCAGCAGCAGTACATTTCTGGAAAGAGGATATAATA >In-frame_ME2_ENST00000321341_chr18_48466756_+_DCC_ENST00000412726_chr18_50831948_+_3196nt CCCGTCCGTCTCCACCGTGGGCCACGCCTTCCGGGCCCCGCGGCTGGCCGGCTCCTCGCGCCCTCCCCTCTCTCGGCCGCTCTTCGGGCC GCCTCTGCGTGTGGGGCCGCCCGCGCCAGTGTGAGCCTGAGCTGACGGCGGCTCCGGGAGGCTCGCAGAAGGGGAGGGCCGGGCGGCGCG GGAGCTGAGCATCGCCAGGGCGGGCGGCAGGGCGCGGCCTCTCCGCCGGGTGTACCACCTGTCGCGGCGCGAGACCTCTGGTGAAAGAAA AGATGTTGTCCCGGTTAAGAGTAGTTTCCACCACTTGTACTTTGGCATGTCGACATTTGCACATAAAAGAAAAAGGCAAGCCACTTATGC TGAACCCAAGAACAAACAAGGGAATGGCATTTACTTTACAAGAACGACAAATGCTTGGTCTTCAAGGACTTCTACCTCCCAAAATAGAGA CACAAGATATTCAAGCCTTACGATTTCATAGAAACTTGAAGAAAATGACTAGCCCTTTGGAAAAATATATCTACATAATGGGAATACAAG AAAGAAATGAGAAATTGTTTTATAGAATACTGCAAGATGACATTGAGAGTTTAATGCCAATTGTATATACACCGACGGTTGGTCTTGCCT GCTCCCAGTATGGACACATCTTTAGAAGACCTAAGGGATTATTTATTTCGATCTCAGACAGAGGTCATGTTAGATCAATTGTGGATAACT GGCCAGAAAATCATGTTAAGGCTGTTGTAGTGACTGATGGAGAGAGAATTCTGGGTCTTGGAGATCTGGGTGTCTATGGAATGGGAATTC CAGTAGGAAAACTTTGTTTGTATACAGCTTGTGCAGGAATACGGCCTGATAGATGCCTGCCAGTGTGTATTGATGTGGGAACTGATAATA TCGCACTCTTAAAAGACCCATTTTACATGGGCTTGTACCAGAAACGAGATCGCACACAACAGTATGATGACCTGATTGATGAGTTTATGA AAGCTATTACTGACAGATATGGCCGGAACACACTCATTCAGTTCGAAGACTTTGGAAATCATAATGCATTCAGGTTCTTGAGAAAGTACC GAGAAAAATATTGTACTTTCAATGATGATATTCAAGGGACAGCTGCAGTAGCTCTAGCAGGTCTTCTTGCAGCACAAAAAGTTATTAGTA AACCAATCTCCGAACACAAAATCTTATTCCTTGGAGCAGGAGAGGCTGCTCTTGGAATTGCAAATCTTATAGTTATGTCTATGGTAGAAA ATGGCCTGTCAGAACAAGAGGCACAAAAGAAAATCTGGATGTTTGACAAGTATGGTTTATTAGTTAAGGGACGGAAAGCAAAAATAGATA GTTATCAGGAACCATTTACTCACTCAGCCCCAGAGAGCATACCTGATACTTTTGAAGATGCAGTGAATATACTGAAGCCTTCAACTATAA TTGGAGTTGCAGGTGCTGGCCGTCTTTTCACTCCTGATGTAATCAGAGCCATGGCCTCTATCAATGAAAGGCCTGTAATATTTGCATTAA GTAATCCTACAGCACAGGCAGAGTGCACGGCTGAAGAAGCATATACACTTACAGAGGGCAGGTGTTTGTTTGCCAGTGGCAGTCCATTTG GGCCAGTGAAACTTACAGATGGGCGAGTCTTTACACCAGGTCAAGGAAACAATGTTTATATTTTTCCAGGTGTGGCTTTAGCTGTTATTC TCTGTAACACCCGGCATATTAGTGACAGTGTTTTCCTAGAAGCTGCAAAGGCCCTGACAAGCCAATTGACAGATGAAGAGCTAGCCCAAG GGAGACTTTACCCACCGCTTGCTAATATTCAGGAAGTTTCTATTAACATTGCTATTAAAAGTATCAAAGTTAGCTGGCTGCCTCCTCCAT CAGGAACACAAAATGGATTTATTACCGGCTATAAAATTCGACACAGAAAGACGACCCGCAGGGGTGAGATGGAAACACTGGAGCCAAACA ACCTCTGGTACCTATTCACAGGACTGGAGAAAGGAAGTCAGTACAGTTTCCAGGTGTCAGCCATGACAGTCAATGGTACTGGACCACCTT CCAACTGGTATACTGCAGAGACTCCAGAGAATGATCTAGATGAATCTCAAGTTCCTGATCAACCAAGCTCTCTTCATGTGAGGCCCCAGA CTAACTGCATCATCATGAGTTGGACTCCTCCCTTGAACCCAAACATCGTGGTGCGAGGTTATATTATCGGTTATGGCGTTGGGAGCCCTT ACGCTGAGACAGTGCGTGTGGACAGCAAGCAGCGATATTATTCCATTGAGAGGTTAGAGTCAAGTTCCCATTATGTAATCTCCCTAAAAG CTTTTAACAATGCCGGAGAAGGAGTTCCTCTTTATGAAAGTGCCACCACCAGGTCTATAACCGATCTCTCCACCCCCATGCTCCCACCAG TAGGTGTACAGGCTGTGGCTCTTACCCATGATGCTGTGAGGGTCAGCTGGGCAGACAACTCTGTCCCTAAGAACCAAAAGACGTCTGAGG TGCGACTTTACACCGTCCGGTGGAGAACCAGCTTTTCTGCAAGTGCAAAATACAAGTCAGAAGACACAACATCTCTAAGTTACACAGCAA CAGGCCTCAAACCAAACACAATGTATGAATTCTCGGTCATGGTAACAAAAAACAGAAGGTCCAGTACTTGGAGCATGACTGCACATGCCA CCACGTATGAAGCAGCCCCCACCTCTGCTCCCAAGGACTTGACAGTCATTACTAGGGAAGGGAAGCCTCGTGCCGTCATTGTGAGTTGGC AGCCTCCCTTGGAAGCCAATGGGAAAATTACTGCTTACATCTTATTTTATACCTTGGACAAGAACATCCCAATTGATGACTGGATTATGG AAACAATCAGTGGTGATAGGCTTACTCATCAAATCATGGATCTCAACCTTGATACTATGTATTACTTTCGAATTCAAGCACGAAATTCAA AAGGAGTGGGGCCACTCTCTGATCCTATCCTCTTCAGGACTCTGAAAGTGGAACACCCTGACAAAATGGCTAATGACCAAGACACTGGCG TGACGATTAATCTTGTTAATGAAGTTCTGCTTGGCTGAGGCTGCGGCTCTGATAAGGAAGATGTAAATTTTCTTGAGAGGAAATTGTTTT >In-frame_ME2_ENST00000321341_chr18_48466756_+_DCC_ENST00000581580_chr18_50831948_+_4235nt CCCGTCCGTCTCCACCGTGGGCCACGCCTTCCGGGCCCCGCGGCTGGCCGGCTCCTCGCGCCCTCCCCTCTCTCGGCCGCTCTTCGGGCC GCCTCTGCGTGTGGGGCCGCCCGCGCCAGTGTGAGCCTGAGCTGACGGCGGCTCCGGGAGGCTCGCAGAAGGGGAGGGCCGGGCGGCGCG GGAGCTGAGCATCGCCAGGGCGGGCGGCAGGGCGCGGCCTCTCCGCCGGGTGTACCACCTGTCGCGGCGCGAGACCTCTGGTGAAAGAAA AGATGTTGTCCCGGTTAAGAGTAGTTTCCACCACTTGTACTTTGGCATGTCGACATTTGCACATAAAAGAAAAAGGCAAGCCACTTATGC TGAACCCAAGAACAAACAAGGGAATGGCATTTACTTTACAAGAACGACAAATGCTTGGTCTTCAAGGACTTCTACCTCCCAAAATAGAGA CACAAGATATTCAAGCCTTACGATTTCATAGAAACTTGAAGAAAATGACTAGCCCTTTGGAAAAATATATCTACATAATGGGAATACAAG AAAGAAATGAGAAATTGTTTTATAGAATACTGCAAGATGACATTGAGAGTTTAATGCCAATTGTATATACACCGACGGTTGGTCTTGCCT GCTCCCAGTATGGACACATCTTTAGAAGACCTAAGGGATTATTTATTTCGATCTCAGACAGAGGTCATGTTAGATCAATTGTGGATAACT GGCCAGAAAATCATGTTAAGGCTGTTGTAGTGACTGATGGAGAGAGAATTCTGGGTCTTGGAGATCTGGGTGTCTATGGAATGGGAATTC CAGTAGGAAAACTTTGTTTGTATACAGCTTGTGCAGGAATACGGCCTGATAGATGCCTGCCAGTGTGTATTGATGTGGGAACTGATAATA TCGCACTCTTAAAAGACCCATTTTACATGGGCTTGTACCAGAAACGAGATCGCACACAACAGTATGATGACCTGATTGATGAGTTTATGA AAGCTATTACTGACAGATATGGCCGGAACACACTCATTCAGTTCGAAGACTTTGGAAATCATAATGCATTCAGGTTCTTGAGAAAGTACC GAGAAAAATATTGTACTTTCAATGATGATATTCAAGGGACAGCTGCAGTAGCTCTAGCAGGTCTTCTTGCAGCACAAAAAGTTATTAGTA AACCAATCTCCGAACACAAAATCTTATTCCTTGGAGCAGGAGAGGCTGCTCTTGGAATTGCAAATCTTATAGTTATGTCTATGGTAGAAA ATGGCCTGTCAGAACAAGAGGCACAAAAGAAAATCTGGATGTTTGACAAGTATGGTTTATTAGTTAAGGGACGGAAAGCAAAAATAGATA GTTATCAGGAACCATTTACTCACTCAGCCCCAGAGAGCATACCTGATACTTTTGAAGATGCAGTGAATATACTGAAGCCTTCAACTATAA TTGGAGTTGCAGGTGCTGGCCGTCTTTTCACTCCTGATGTAATCAGAGCCATGGCCTCTATCAATGAAAGGCCTGTAATATTTGCATTAA GTAATCCTACAGCACAGGCAGAGTGCACGGCTGAAGAAGCATATACACTTACAGAGGGCAGGTGTTTGTTTGCCAGTGGCAGTCCATTTG GGCCAGTGAAACTTACAGATGGGCGAGTCTTTACACCAGGTCAAGGAAACAATGTTTATATTTTTCCAGGTGTGGCTTTAGCTGTTATTC TCTGTAACACCCGGCATATTAGTGACAGTGTTTTCCTAGAAGCTGCAAAGGCCCTGACAAGCCAATTGACAGATGAAGAGCTAGCCCAAG GGAGACTTTACCCACCGCTTGCTAATATTCAGGAAGTTTCTATTAACATTGCTATTAAAAGTATCAAAGTTAGCTGGCTGCCTCCTCCAT CAGGAACACAAAATGGATTTATTACCGGCTATAAAATTCGACACAGAAAGACGACCCGCAGGGGTGAGATGGAAACACTGGAGCCAAACA ACCTCTGGTACCTATTCACAGGACTGGAGAAAGGAAGTCAGTACAGTTTCCAGGTGTCAGCCATGACAGTCAATGGTACTGGACCACCTT CCAACTGGTATACTGCAGAGACTCCAGAGAATGATCTAGATGAATCTCAAGTTCCTGATCAACCAAGCTCTCTTCATGTGAGGCCCCAGA CTAACTGCATCATCATGAGTTGGACTCCTCCCTTGAACCCAAACATCGTGGTGCGAGGTTATATTATCGGTTATGGCGTTGGGAGCCCTT ACGCTGAGACAGTGCGTGTGGACAGCAAGCAGCGATATTATTCCATTGAGAGGTTAGAGTCAAGTTCCCATTATGTAATCTCCCTAAAAG CTTTTAACAATGCCGGAGAAGGAGTTCCTCTTTATGAAAGTGCCACCACCAGGTCTATAACCGATCTCTCCACCCCCATGCTCCCACCAG TAGGTGTACAGGCTGTGGCTCTTACCCATGATGCTGTGAGGGTCAGCTGGGCAGACAACTCTGTCCCTAAGAACCAAAAGACGTCTGAGG TGCGACTTTACACCGTCCGGTGGAGAACCAGCTTTTCTGCAAGTGCAAAATACAAGTCAGAAGACACAACATCTCTAAGTTACACAGCAA CAGGCCTCAAACCAAACACAATGTATGAATTCTCGGTCATGGTAACAAAAAACAGAAGGTCCAGTACTTGGAGCATGACTGCACATGCCA CCACGTATGAAGCAGCCCCCACCTCTGCTCCCAAGGACTTGACAGTCATTACTAGGGAAGGGAAGCCTCGTGCCGTCATTGTGAGTTGGC AGCCTCCCTTGGAAGCCAATGGGAAAATTACTGCTTACATCTTATTTTATACCTTGGACAAGAACATCCCAATTGATGACTGGATTATGG AAACAATCAGTGGTGATAGGCTTACTCATCAAATCATGGATCTCAACCTTGATACTATGTATTACTTTCGAATTCAAGCACGAAATTCAA AAGGAGTGGGGCCACTCTCTGATCCTATCCTCTTCAGGACTCTGAAAGTGGAACACCCTGACAAAATGGCTAATGACCAAGGTCGTCATG GAGATGGAGGTTATTGGCCAGTTGATACTAATTTGATTGATAGAAGCACCCTAAATGAGCCGCCAATTGGACAAATGCACCCCCCGCATG GCAGTGTCACTCCTCAGAAGAACAGCAACCTGCTTGTGATCATTGTGGTCACCGTTGGTGTCATCACAGTGCTGGTAGTGGTCATCGTGG CTGTGATTTGCACCCGACGCTCTTCAGCCCAGCAGAGAAAGAAACGGGCCACCCACAGTGCTGGCAAAAGGAAGGGCAGCCAGAAGGACC TCCGACCCCCTGATCTTTGGATCCATCATGAAGAAATGGAGATGAAAAATATTGAAAAGCCATCTGGCACTGACCCTGCAGGAAGGGACT CTCCCATCCAAAGTTGCCAAGACCTCACACCAGTCAGCCACAGCCAGTCAGAAACCCAACTGGGAAGCAAAAGCACCTCTCATTCAGGTC AAGACACTGAGGAAGCAGGGAGCTCTATGTCCACTCTGGAGAGGTCGCTGGCTGCACGCCGAGCCCCCCGGGCCAAGCTCATGATTCCCA TGGATGCCCAGTCCAACAATCCTGCTGTCGTGAGCGCCATCCCGGTGCCAACGCTAGAAAGTGCCCAGTACCCAGGAATCCTCCCGTCTC CCACCTGTGGATATCCCCACCCGCAGTTCACTCTCCGGCCTGTGCCATTCCCAACACTCTCAGTGGACCGAGGTTTCGGAGCAGGAAGAA CAGTGAGTGAAGGACCAACTACCCAACAACCACCTATGCTGCCCCCATCTCAGCCTGAGCATTCTAGCAGCGAGGAGGCACCAAGCAGAA CCATCCCCACAGCTTGTGTTCGACCAACTCACCCACTCCGCAGCTTTGCTAATCCTTTGCTACCTCCACCAATGAGTGCAATAGAACCGA AAGTCCCTTACACACCACTTTTGTCTCAGCCAGGGCCCACTCTTCCTAAGACCCATGTGAAAACAGCCTCCCTTGGGTTGGCTGGAAAAG CAAGATCCCCTTTGCTTCCTGTGTCTGTGCCAACAGCCCCTGAAGTGTCTGAGGAGAGCCACAAACCAACAGAGGATTCAGCCAATGTGG AGATGGAGTGGGTGAAACAATATGCAATCTCTTATTATCCCCTTTTATTACCAGCATCTTCATTCAGTGTATGAACAGGATGATCTGAGT |
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FusionGenePPI for ME2_DCC |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ME2 | ICT1, SIRT7, NTRK1, MCM2, TMEM184A | DCC | AR, NTN1, CASP3, CASP9, MAPK3, NCK1, MAZ, SIAH1, APPL1, PTK2, RPL5, EIF2B2, RPL10A, RPL23, RPL13, EIF2S3, EIF2B4, RPL38, RPS24, EIF1AX, RPS10, RPL28, RPS13, EIF5A2, MAPK1, EIF2S2, EIF3E, EZR, EIF2B1, EIF4E3, RPS6, EIF4E, EIF2A, RPS4X, SIAH2, BARD1, ALB |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | DCC | chr18:48466756 | chr18:50831948 | ENST00000442544 | + | 11 | 29 | 1432_1439 | 637 | 1448 | MYO10 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ME2_DCC |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ME2_DCC |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ME2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | ME2 | C0024713 | Manic Disorder | 1 | PSYGENET |
| Hgene | ME2 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | ME2 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | ME2 | C0338831 | Manic | 1 | PSYGENET |
| Hgene | ME2 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| Tgene | DCC | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Tgene | DCC | C0025202 | melanoma | 1 | CTD_human |
| Tgene | DCC | C0036341 | Schizophrenia | 1 | PSYGENET |
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