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Fusion gene ID: 21409 |
FusionGeneSummary for ME1_UBE3D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ME1_UBE3D | Fusion gene ID: 21409 | Hgene | Tgene | Gene symbol | ME1 | UBE3D | Gene ID | 4199 | 90025 |
| Gene name | malic enzyme 1 | ubiquitin protein ligase E3D | |
| Synonyms | HUMNDME|MES | C6orf157|H10BH|UBE2CBP|YJR141W | |
| Cytomap | 6q14.2 | 6q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NADP-dependent malic enzymeMalic enzyme, cytoplasmicNADP-MEmalate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))malic enzyme 1, NADP(+)-dependent, cytosolicmalic enzyme 1, solublepyruvic-malic carboxylase | E3 ubiquitin-protein ligase E3DHECT-type E3 ubiquitin transferase E3DUBCH10 binding protein with a hect-like domainubcH10-binding protein with a HECT-like domainubiquitin-conjugating enzyme E2C-binding protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P48163 | Q7Z6J8 | |
| Ensembl transtripts involved in fusion gene | ENST00000369705, ENST00000541327, ENST00000543031, | ENST00000369747, ENST00000503942, ENST00000369745, | |
| Fusion gene scores | * DoF score | 3 X 5 X 4=60 | 1 X 2 X 2=4 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/60*10)=0 | log2(3/4*10)=2.90689059560852 | |
| Context | PubMed: ME1 [Title/Abstract] AND UBE3D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ME1 | GO:0006108 | malate metabolic process | 7622060|8187880 |
| Tgene | UBE3D | GO:0000209 | protein polyubiquitination | 15749827 |
| Tgene | UBE3D | GO:0006513 | protein monoubiquitination | 15749827 |
| Tgene | UBE3D | GO:0051865 | protein autoubiquitination | 15749827 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-LN-A4A9-01A | ME1 | chr6 | 84025029 | - | UBE3D | chr6 | 83667169 | - |
| TCGA | LD | ESCA | TCGA-VR-A8EO-01A | ME1 | chr6 | 84108086 | - | UBE3D | chr6 | 83667169 | - |
| TCGA | LD | LUSC | TCGA-60-2710-01A | ME1 | chr6 | 84055892 | - | UBE3D | chr6 | 83602761 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000369705 | ENST00000369747 | ME1 | chr6 | 84025029 | - | UBE3D | chr6 | 83667169 | - |
| 5CDS-intron | ENST00000369705 | ENST00000503942 | ME1 | chr6 | 84025029 | - | UBE3D | chr6 | 83667169 | - |
| 5CDS-intron | ENST00000369705 | ENST00000369745 | ME1 | chr6 | 84025029 | - | UBE3D | chr6 | 83667169 | - |
| Frame-shift | ENST00000541327 | ENST00000369747 | ME1 | chr6 | 84025029 | - | UBE3D | chr6 | 83667169 | - |
| 5CDS-intron | ENST00000541327 | ENST00000503942 | ME1 | chr6 | 84025029 | - | UBE3D | chr6 | 83667169 | - |
| 5CDS-intron | ENST00000541327 | ENST00000369745 | ME1 | chr6 | 84025029 | - | UBE3D | chr6 | 83667169 | - |
| Frame-shift | ENST00000543031 | ENST00000369747 | ME1 | chr6 | 84025029 | - | UBE3D | chr6 | 83667169 | - |
| 5CDS-intron | ENST00000543031 | ENST00000503942 | ME1 | chr6 | 84025029 | - | UBE3D | chr6 | 83667169 | - |
| 5CDS-intron | ENST00000543031 | ENST00000369745 | ME1 | chr6 | 84025029 | - | UBE3D | chr6 | 83667169 | - |
| In-frame | ENST00000369705 | ENST00000369747 | ME1 | chr6 | 84108086 | - | UBE3D | chr6 | 83667169 | - |
| 5CDS-intron | ENST00000369705 | ENST00000503942 | ME1 | chr6 | 84108086 | - | UBE3D | chr6 | 83667169 | - |
| 5CDS-intron | ENST00000369705 | ENST00000369745 | ME1 | chr6 | 84108086 | - | UBE3D | chr6 | 83667169 | - |
| intron-3CDS | ENST00000541327 | ENST00000369747 | ME1 | chr6 | 84108086 | - | UBE3D | chr6 | 83667169 | - |
| intron-intron | ENST00000541327 | ENST00000503942 | ME1 | chr6 | 84108086 | - | UBE3D | chr6 | 83667169 | - |
| intron-intron | ENST00000541327 | ENST00000369745 | ME1 | chr6 | 84108086 | - | UBE3D | chr6 | 83667169 | - |
| Frame-shift | ENST00000543031 | ENST00000369747 | ME1 | chr6 | 84108086 | - | UBE3D | chr6 | 83667169 | - |
| 5CDS-intron | ENST00000543031 | ENST00000503942 | ME1 | chr6 | 84108086 | - | UBE3D | chr6 | 83667169 | - |
| 5CDS-intron | ENST00000543031 | ENST00000369745 | ME1 | chr6 | 84108086 | - | UBE3D | chr6 | 83667169 | - |
| Frame-shift | ENST00000369705 | ENST00000369747 | ME1 | chr6 | 84055892 | - | UBE3D | chr6 | 83602761 | - |
| 5CDS-5UTR | ENST00000369705 | ENST00000503942 | ME1 | chr6 | 84055892 | - | UBE3D | chr6 | 83602761 | - |
| 5CDS-intron | ENST00000369705 | ENST00000369745 | ME1 | chr6 | 84055892 | - | UBE3D | chr6 | 83602761 | - |
| Frame-shift | ENST00000541327 | ENST00000369747 | ME1 | chr6 | 84055892 | - | UBE3D | chr6 | 83602761 | - |
| 5CDS-5UTR | ENST00000541327 | ENST00000503942 | ME1 | chr6 | 84055892 | - | UBE3D | chr6 | 83602761 | - |
| 5CDS-intron | ENST00000541327 | ENST00000369745 | ME1 | chr6 | 84055892 | - | UBE3D | chr6 | 83602761 | - |
| In-frame | ENST00000543031 | ENST00000369747 | ME1 | chr6 | 84055892 | - | UBE3D | chr6 | 83602761 | - |
| 5CDS-5UTR | ENST00000543031 | ENST00000503942 | ME1 | chr6 | 84055892 | - | UBE3D | chr6 | 83602761 | - |
| 5CDS-intron | ENST00000543031 | ENST00000369745 | ME1 | chr6 | 84055892 | - | UBE3D | chr6 | 83602761 | - |
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FusionProtFeatures for ME1_UBE3D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ME1 | UBE3D |
| E3 ubiquitin-protein ligase which accepts ubiquitin fromspecific E2 ubiquitin-conjugating enzymes, and transfers it tosubstrates, generally promoting their degradation by theproteasome. {ECO:0000269|PubMed:15749827}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >UBE3D | chr6:84025029 | chr6:83667169 | ENST00000369747 | - | 7 | 10 | 353_389 | 336 | 390 | Region | Note=HECT-like |
| Tgene | >UBE3D | chr6:84108086 | chr6:83667169 | ENST00000369747 | - | 7 | 10 | 353_389 | 336 | 390 | Region | Note=HECT-like |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ME1 | chr6:84025029 | chr6:83667169 | ENST00000369705 | - | 6 | 14 | 301_318 | 234 | 573 | Nucleotide binding | NADP |
| Hgene | >ME1 | chr6:84108086 | chr6:83667169 | ENST00000369705 | - | 3 | 14 | 301_318 | 120 | 573 | Nucleotide binding | NADP |
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FusionGeneSequence for ME1_UBE3D |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ME1_ENST00000369705_chr6_84025029_-_UBE3D_ENST00000369747_chr6_83667169_-_288aa MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVL TSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTAC GGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKLVSLWESDISVHPLTLPSATCLELLLILSKSNANL >In-frame_ME1_ENST00000369705_chr6_84108086_-_UBE3D_ENST00000369747_chr6_83667169_-_174aa MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVL >In-frame_ME1_ENST00000543031_chr6_84055892_-_UBE3D_ENST00000369747_chr6_83602761_-_132aa MDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ME1_ENST00000369705_chr6_84025029_-_UBE3D_ENST00000369747_chr6_83667169_-_864nt ATGGAGCCCGAAGCCCCCCGTCGCCGCCACACCCATCAGCGCGGCTACCTGCTGACACGGAACCCTCACCTCAACAAGGACTTGGCCTTT ACCCTGGAAGAGAGACAGCAATTGAACATTCATGGATTGTTGCCACCTTCCTTCAACAGTCAGGAGATCCAGGTTCTTAGAGTAGTAAAA AATTTCGAGCATCTGAACTCTGACTTTGACAGGTATCTTCTCTTAATGGATCTCCAAGATAGAAATGAAAAACTCTTTTATAGAGTGCTG ACATCTGACATTGAGAAATTCATGCCTATTGTTTATACTCCCACTGTGGGTCTGGCTTGCCAACAATATAGTTTGGTGTTTCGGAAGCCA AGAGGTCTCTTTATTACTATCCACGATCGAGGGCATATTGCTTCAGTTCTCAATGCATGGCCAGAAGATGTCATCAAGGCCATTGTGGTG ACTGATGGAGAGCGTATTCTTGGCTTGGGAGACCTTGGCTGTAATGGAATGGGCATCCCTGTGGGTAAATTGGCTCTATATACAGCTTGC GGAGGGATGAATCCTCAAGAATGTCTGCCTGTCATTCTGGATGTGGGAACCGAAAATGAGGAGTTACTTAAAGATCCACTCTACATTGGA CTACGGCAGAGAAGAGTAAGAGGTTCTGAATATGATGATTTTTTGGACGAATTCATGGAGGCAGTTTCTTCCAAACTTGTCAGCTTGTGG GAAAGTGACATCAGCGTCCACCCGCTAACCCTGCCCTCTGCAACCTGCTTGGAGCTGCTGTTGATATTGTCAAAGAGTAATGCCAATCTG >In-frame_ME1_ENST00000369705_chr6_84108086_-_UBE3D_ENST00000369747_chr6_83667169_-_522nt ATGGAGCCCGAAGCCCCCCGTCGCCGCCACACCCATCAGCGCGGCTACCTGCTGACACGGAACCCTCACCTCAACAAGGACTTGGCCTTT ACCCTGGAAGAGAGACAGCAATTGAACATTCATGGATTGTTGCCACCTTCCTTCAACAGTCAGGAGATCCAGGTTCTTAGAGTAGTAAAA AATTTCGAGCATCTGAACTCTGACTTTGACAGGTATCTTCTCTTAATGGATCTCCAAGATAGAAATGAAAAACTCTTTTATAGAGTGCTG ACATCTGACATTGAGAAATTCATGCCTATTGTTTATACTCCCACTGTGGGTCTGGCTTGCCAACAATATAGTTTGGTGTTTCGGAAGCCA AGACTTGTCAGCTTGTGGGAAAGTGACATCAGCGTCCACCCGCTAACCCTGCCCTCTGCAACCTGCTTGGAGCTGCTGTTGATATTGTCA >In-frame_ME1_ENST00000543031_chr6_84055892_-_UBE3D_ENST00000369747_chr6_83602761_-_396nt ATGGATCTCCAAGATAGAAATGAAAAACTCTTTTATAGAGTGCTGACATCTGACATTGAGAAATTCATGCCTATTGTTTATACTCCCACT GTGGGTCTGGCTTGCCAACAATATAGTTTGGTGTTTCGGAAGCCAAGAGGTCTCTTTATTACTATCCACGATCGAGGGCATATTGCTTCA GTTCTCAATGCATGGCCAGAAGATGTCATCAAGGCCATTGTGGTGACTGATGGAGAGCGTATTCTTGGCTTGGGAGACCTTGGCTGTAAT GGAATGGGCATCCCTGTGGGTAAATTGGCTCTATATACAGCTTGCGGAGGGATGAATCCTCAAGAATGTCTGCCTGTCATTCTGGATGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ME1_ENST00000369705_chr6_84025029_-_UBE3D_ENST00000369747_chr6_83667169_-_1605nt AGTGCGGCCGCCGCCGCCACAGCTGCAGTCAGCACCGTCACCCCAGCAGCATCCGCCGCCTGCACCGCGCGTGCGGCCCGCCCCGGCCTG ACCCCGCCGCCGAACCCGGCGCCAGCCATGGAGCCCGAAGCCCCCCGTCGCCGCCACACCCATCAGCGCGGCTACCTGCTGACACGGAAC CCTCACCTCAACAAGGACTTGGCCTTTACCCTGGAAGAGAGACAGCAATTGAACATTCATGGATTGTTGCCACCTTCCTTCAACAGTCAG GAGATCCAGGTTCTTAGAGTAGTAAAAAATTTCGAGCATCTGAACTCTGACTTTGACAGGTATCTTCTCTTAATGGATCTCCAAGATAGA AATGAAAAACTCTTTTATAGAGTGCTGACATCTGACATTGAGAAATTCATGCCTATTGTTTATACTCCCACTGTGGGTCTGGCTTGCCAA CAATATAGTTTGGTGTTTCGGAAGCCAAGAGGTCTCTTTATTACTATCCACGATCGAGGGCATATTGCTTCAGTTCTCAATGCATGGCCA GAAGATGTCATCAAGGCCATTGTGGTGACTGATGGAGAGCGTATTCTTGGCTTGGGAGACCTTGGCTGTAATGGAATGGGCATCCCTGTG GGTAAATTGGCTCTATATACAGCTTGCGGAGGGATGAATCCTCAAGAATGTCTGCCTGTCATTCTGGATGTGGGAACCGAAAATGAGGAG TTACTTAAAGATCCACTCTACATTGGACTACGGCAGAGAAGAGTAAGAGGTTCTGAATATGATGATTTTTTGGACGAATTCATGGAGGCA GTTTCTTCCAAACTTGTCAGCTTGTGGGAAAGTGACATCAGCGTCCACCCGCTAACCCTGCCCTCTGCAACCTGCTTGGAGCTGCTGTTG ATATTGTCAAAGAGTAATGCCAATCTGCCTTCATCCCTTCGCCGTGTGAATTCCTTTCAGGTGGCCTTTTTGAAGATGTAACTATTAGAG CTGGGCATTCTCCTCCCCCGGCAGACAGCTCTCAAGCAGGAGCACACCGAGGCCAGCAGTCAGCTCAGGAGGCATCAATTACAAAGACAA GAACCAGAGCTATGGGATAAGAGCATTGCATTGAAGTTTTAAGTTTACTTGTTTGCATGTATTCTCTAAGAGAAGAGTTAACTTTAGATC TTTGAAAACCCAGGACTGTGAAGAAAGTCATAGTAGCAGGTTGAGGCAAGTGTAGAAGTTACATCTCTATTTCCCACAGAGAGGAATATT CACATATGTGCAGTGTCAGCACCACCTGGAAGGTTATTACCTAATGGAGATCCATCTGTCCTGTGTGGAATCCAGTGAGGAATTTTATTG GTGGAACTGAATGTTAACTGCTGTAAATCCTAGGAAATAAACTTTTAAAGAGTTTCTCAGGATGATTTAAAACAAATTTTAAAAAAGAAA AGTAGAAAACATTTTATACTTTATTCAGAGGAGATGCTCAATAGATGTTTGTTGAATGAATGATTATCAAATTAAAGGATTTCCTATTTA >In-frame_ME1_ENST00000369705_chr6_84108086_-_UBE3D_ENST00000369747_chr6_83667169_-_1263nt AGTGCGGCCGCCGCCGCCACAGCTGCAGTCAGCACCGTCACCCCAGCAGCATCCGCCGCCTGCACCGCGCGTGCGGCCCGCCCCGGCCTG ACCCCGCCGCCGAACCCGGCGCCAGCCATGGAGCCCGAAGCCCCCCGTCGCCGCCACACCCATCAGCGCGGCTACCTGCTGACACGGAAC CCTCACCTCAACAAGGACTTGGCCTTTACCCTGGAAGAGAGACAGCAATTGAACATTCATGGATTGTTGCCACCTTCCTTCAACAGTCAG GAGATCCAGGTTCTTAGAGTAGTAAAAAATTTCGAGCATCTGAACTCTGACTTTGACAGGTATCTTCTCTTAATGGATCTCCAAGATAGA AATGAAAAACTCTTTTATAGAGTGCTGACATCTGACATTGAGAAATTCATGCCTATTGTTTATACTCCCACTGTGGGTCTGGCTTGCCAA CAATATAGTTTGGTGTTTCGGAAGCCAAGACTTGTCAGCTTGTGGGAAAGTGACATCAGCGTCCACCCGCTAACCCTGCCCTCTGCAACC TGCTTGGAGCTGCTGTTGATATTGTCAAAGAGTAATGCCAATCTGCCTTCATCCCTTCGCCGTGTGAATTCCTTTCAGGTGGCCTTTTTG AAGATGTAACTATTAGAGCTGGGCATTCTCCTCCCCCGGCAGACAGCTCTCAAGCAGGAGCACACCGAGGCCAGCAGTCAGCTCAGGAGG CATCAATTACAAAGACAAGAACCAGAGCTATGGGATAAGAGCATTGCATTGAAGTTTTAAGTTTACTTGTTTGCATGTATTCTCTAAGAG AAGAGTTAACTTTAGATCTTTGAAAACCCAGGACTGTGAAGAAAGTCATAGTAGCAGGTTGAGGCAAGTGTAGAAGTTACATCTCTATTT CCCACAGAGAGGAATATTCACATATGTGCAGTGTCAGCACCACCTGGAAGGTTATTACCTAATGGAGATCCATCTGTCCTGTGTGGAATC CAGTGAGGAATTTTATTGGTGGAACTGAATGTTAACTGCTGTAAATCCTAGGAAATAAACTTTTAAAGAGTTTCTCAGGATGATTTAAAA CAAATTTTAAAAAAGAAAAGTAGAAAACATTTTATACTTTATTCAGAGGAGATGCTCAATAGATGTTTGTTGAATGAATGATTATCAAAT TAAAGGATTTCCTATTTATGCAAATCTGCATGTTTCTTTTGTTATTTCCTTTACCATACATTATTGCAAATTAATAAATATACCTCACTA >In-frame_ME1_ENST00000543031_chr6_84055892_-_UBE3D_ENST00000369747_chr6_83602761_-_1235nt CTTTCCCAGTGCGGCCGCCGCCGCCACAGCTGCAGTCAGCACCGTCACCCCAGCAGCATCCGCCGCCTGCACCGCGCGTGCGGCCCGCCC CGGCCTGACCCCGCCGCCGAACCCGGCGCCAGCCATGGAGCCCGAAGCCCCCCGTCGCCGCCACACCCATCAGCGCGGCTACCTGCTGAC ACGGAACCCTCACCTCAACAAGGTATCTTCTCTTAATGGATCTCCAAGATAGAAATGAAAAACTCTTTTATAGAGTGCTGACATCTGACA TTGAGAAATTCATGCCTATTGTTTATACTCCCACTGTGGGTCTGGCTTGCCAACAATATAGTTTGGTGTTTCGGAAGCCAAGAGGTCTCT TTATTACTATCCACGATCGAGGGCATATTGCTTCAGTTCTCAATGCATGGCCAGAAGATGTCATCAAGGCCATTGTGGTGACTGATGGAG AGCGTATTCTTGGCTTGGGAGACCTTGGCTGTAATGGAATGGGCATCCCTGTGGGTAAATTGGCTCTATATACAGCTTGCGGAGGGATGA ATCCTCAAGAATGTCTGCCTGTCATTCTGGATGTGGGAACCGAAAATGAGGTGGCCTTTTTGAAGATGTAACTATTAGAGCTGGGCATTC TCCTCCCCCGGCAGACAGCTCTCAAGCAGGAGCACACCGAGGCCAGCAGTCAGCTCAGGAGGCATCAATTACAAAGACAAGAACCAGAGC TATGGGATAAGAGCATTGCATTGAAGTTTTAAGTTTACTTGTTTGCATGTATTCTCTAAGAGAAGAGTTAACTTTAGATCTTTGAAAACC CAGGACTGTGAAGAAAGTCATAGTAGCAGGTTGAGGCAAGTGTAGAAGTTACATCTCTATTTCCCACAGAGAGGAATATTCACATATGTG CAGTGTCAGCACCACCTGGAAGGTTATTACCTAATGGAGATCCATCTGTCCTGTGTGGAATCCAGTGAGGAATTTTATTGGTGGAACTGA ATGTTAACTGCTGTAAATCCTAGGAAATAAACTTTTAAAGAGTTTCTCAGGATGATTTAAAACAAATTTTAAAAAAGAAAAGTAGAAAAC ATTTTATACTTTATTCAGAGGAGATGCTCAATAGATGTTTGTTGAATGAATGATTATCAAATTAAAGGATTTCCTATTTATGCAAATCTG |
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FusionGenePPI for ME1_UBE3D |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ME1 | CTTN, BOP1, CUL3, GARS, GORASP2, GTF2A1, RPUSD2, TOM1, UGDH, VTA1, NMI, TBCD, EFNB2, NFYA, GSTK1, GPX4, PKM, STIP1, MSN, PREP, PTPN7, FCF1, VAC14, ZSCAN12, CDK15, FTH1, OAZ3, NPPA, LYPD4, FCRL5 | UBE3D | UBE2C, UBE3D, CCNB1, MEMO1, FKBP6, CPSF3, DNAAF2, GTPBP2, SUFU, DEFA1, HSP90AB4P, KLHDC2, CCM2, STIP1, BORA, TUBA4A, PPM1A, TSC22D3, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | UBE3D | chr6:84025029 | chr6:83667169 | ENST00000369747 | - | 7 | 10 | 235_257 | 336 | 390 | UBE2C |
| Tgene | UBE3D | chr6:84108086 | chr6:83667169 | ENST00000369747 | - | 7 | 10 | 235_257 | 336 | 390 | UBE2C |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ME1_UBE3D |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ME1_UBE3D |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ME1 | C0028754 | Obesity | 1 | CTD_human |
| Hgene | ME1 | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | ME1 | C2239176 | Liver carcinoma | 1 | CTD_human |
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