|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 21398 |
FusionGeneSummary for MDM2_XPOT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MDM2_XPOT | Fusion gene ID: 21398 | Hgene | Tgene | Gene symbol | MDM2 | XPOT | Gene ID | 4193 | 11260 |
| Gene name | MDM2 proto-oncogene | exportin for tRNA | |
| Synonyms | ACTFS|HDMX|hdm2 | XPO3 | |
| Cytomap | 12q15 | 12q14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hum | exportin-Texportin(tRNA)exportin, tRNA (nuclear export receptor for tRNAs)tRNA exportin | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q00987 | O43592 | |
| Ensembl transtripts involved in fusion gene | ENST00000462284, ENST00000356290, ENST00000540827, ENST00000258149, ENST00000428863, ENST00000393412, ENST00000258148, ENST00000544561, ENST00000393410, ENST00000393413, ENST00000517852, ENST00000545204, ENST00000350057, ENST00000360430, ENST00000299252, ENST00000348801, ENST00000478070, ENST00000544125, | ENST00000332707, | |
| Fusion gene scores | * DoF score | 24 X 14 X 8=2688 | 6 X 6 X 4=144 |
| # samples | 25 | 6 | |
| ** MAII score | log2(25/2688*10)=-3.42653313811667 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MDM2 [Title/Abstract] AND XPOT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MDM2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 9271120|17310983 |
| Hgene | MDM2 | GO:0006511 | ubiquitin-dependent protein catabolic process | 11278372|15314173|16173922|17310983 |
| Hgene | MDM2 | GO:0016567 | protein ubiquitination | 9450543|15878855|19656744|20153724 |
| Hgene | MDM2 | GO:0031648 | protein destabilization | 9529249|10360174|15314173 |
| Hgene | MDM2 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 11278372 |
| Hgene | MDM2 | GO:0034504 | protein localization to nucleus | 10360174 |
| Hgene | MDM2 | GO:0042176 | regulation of protein catabolic process | 9153395 |
| Hgene | MDM2 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 9529249|10360174 |
| Hgene | MDM2 | GO:0045184 | establishment of protein localization | 10360174 |
| Hgene | MDM2 | GO:0045892 | negative regulation of transcription, DNA-templated | 9271120 |
| Hgene | MDM2 | GO:0065003 | protein-containing complex assembly | 10608892|12915590 |
| Hgene | MDM2 | GO:0071157 | negative regulation of cell cycle arrest | 9529249 |
| Hgene | MDM2 | GO:0071480 | cellular response to gamma radiation | 16213212 |
| Hgene | MDM2 | GO:0072717 | cellular response to actinomycin D | 15314173 |
| Hgene | MDM2 | GO:1901797 | negative regulation of signal transduction by p53 class mediator | 16173922 |
| Tgene | XPOT | GO:0006409 | tRNA export from nucleus | 9660920 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AN-A0AM-01A | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000462284 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| intron-3CDS | ENST00000356290 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| intron-3CDS | ENST00000540827 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| In-frame | ENST00000258149 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| intron-3CDS | ENST00000428863 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| intron-3CDS | ENST00000393412 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| In-frame | ENST00000258148 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| intron-3CDS | ENST00000544561 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| intron-3CDS | ENST00000393410 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| intron-3CDS | ENST00000393413 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| intron-3CDS | ENST00000517852 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| intron-3CDS | ENST00000545204 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| In-frame | ENST00000350057 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| intron-3CDS | ENST00000360430 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| intron-3CDS | ENST00000299252 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| intron-3CDS | ENST00000348801 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| intron-3CDS | ENST00000478070 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
| intron-3CDS | ENST00000544125 | ENST00000332707 | MDM2 | chr12 | 69222710 | + | XPOT | chr12 | 64833023 | + |
Top |
FusionProtFeatures for MDM2_XPOT |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MDM2 | XPOT |
| Mediates the nuclear export of aminoacylated tRNAs. Inthe nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear porecomplex (NPC) is mediated through binding to nucleoporins. Upontransit of a nuclear export complex into the cytoplasm,disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP(induced by RANBP1 and RANGAP1, respectively) cause release of thetRNA from the export receptor. XPOT then return to the nuclearcompartment and mediate another round of transport. Thedirectionality of nuclear export is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. {ECO:0000269|PubMed:12138183,ECO:0000269|PubMed:9512417, ECO:0000269|PubMed:9660920}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000462284 | + | 8 | 11 | 210_215 | 228 | 498 | Compositional bias | Note=Poly-Ser |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000258149 | + | 6 | 9 | 27_107 | 167 | 437 | Domain | Note=SWIB |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000462284 | + | 8 | 11 | 27_107 | 228 | 498 | Domain | Note=SWIB |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000462284 | + | 8 | 11 | 179_185 | 228 | 498 | Motif | Nuclear localization signal |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000462284 | + | 8 | 11 | 190_202 | 228 | 498 | Motif | Note=Nuclear export signal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000258149 | + | 6 | 9 | 210_215 | 167 | 437 | Compositional bias | Note=Poly-Ser |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000258149 | + | 6 | 9 | 243_301 | 167 | 437 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000299252 | + | 1 | 5 | 210_215 | 0 | 322 | Compositional bias | Note=Poly-Ser |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000299252 | + | 1 | 5 | 243_301 | 0 | 322 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000348801 | + | 1 | 3 | 210_215 | 0 | 266 | Compositional bias | Note=Poly-Ser |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000348801 | + | 1 | 3 | 243_301 | 0 | 266 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000356290 | + | 1 | 6 | 210_215 | -102 | 322 | Compositional bias | Note=Poly-Ser |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000356290 | + | 1 | 6 | 243_301 | -102 | 322 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000360430 | + | 1 | 4 | 210_215 | 0 | 297 | Compositional bias | Note=Poly-Ser |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000360430 | + | 1 | 4 | 243_301 | 0 | 297 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393412 | + | 1 | 3 | 210_215 | -92 | 219 | Compositional bias | Note=Poly-Ser |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393412 | + | 1 | 3 | 243_301 | -92 | 219 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393413 | + | 1 | 2 | 210_215 | 0 | 219 | Compositional bias | Note=Poly-Ser |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393413 | + | 1 | 2 | 243_301 | 0 | 219 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000428863 | + | 1 | 4 | 210_215 | -102 | 271 | Compositional bias | Note=Poly-Ser |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000428863 | + | 1 | 4 | 243_301 | -102 | 271 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000462284 | + | 8 | 11 | 243_301 | 228 | 498 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000540827 | + | 1 | 5 | 210_215 | -102 | 297 | Compositional bias | Note=Poly-Ser |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000540827 | + | 1 | 5 | 243_301 | -102 | 297 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000299252 | + | 1 | 5 | 27_107 | 0 | 322 | Domain | Note=SWIB |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000348801 | + | 1 | 3 | 27_107 | 0 | 266 | Domain | Note=SWIB |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000356290 | + | 1 | 6 | 27_107 | -102 | 322 | Domain | Note=SWIB |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000360430 | + | 1 | 4 | 27_107 | 0 | 297 | Domain | Note=SWIB |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393412 | + | 1 | 3 | 27_107 | -92 | 219 | Domain | Note=SWIB |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393413 | + | 1 | 2 | 27_107 | 0 | 219 | Domain | Note=SWIB |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000428863 | + | 1 | 4 | 27_107 | -102 | 271 | Domain | Note=SWIB |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000540827 | + | 1 | 5 | 27_107 | -102 | 297 | Domain | Note=SWIB |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000258149 | + | 6 | 9 | 179_185 | 167 | 437 | Motif | Nuclear localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000258149 | + | 6 | 9 | 190_202 | 167 | 437 | Motif | Note=Nuclear export signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000258149 | + | 6 | 9 | 466_473 | 167 | 437 | Motif | Nucleolar localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000299252 | + | 1 | 5 | 179_185 | 0 | 322 | Motif | Nuclear localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000299252 | + | 1 | 5 | 190_202 | 0 | 322 | Motif | Note=Nuclear export signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000299252 | + | 1 | 5 | 466_473 | 0 | 322 | Motif | Nucleolar localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000348801 | + | 1 | 3 | 179_185 | 0 | 266 | Motif | Nuclear localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000348801 | + | 1 | 3 | 190_202 | 0 | 266 | Motif | Note=Nuclear export signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000348801 | + | 1 | 3 | 466_473 | 0 | 266 | Motif | Nucleolar localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000356290 | + | 1 | 6 | 179_185 | -102 | 322 | Motif | Nuclear localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000356290 | + | 1 | 6 | 190_202 | -102 | 322 | Motif | Note=Nuclear export signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000356290 | + | 1 | 6 | 466_473 | -102 | 322 | Motif | Nucleolar localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000360430 | + | 1 | 4 | 179_185 | 0 | 297 | Motif | Nuclear localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000360430 | + | 1 | 4 | 190_202 | 0 | 297 | Motif | Note=Nuclear export signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000360430 | + | 1 | 4 | 466_473 | 0 | 297 | Motif | Nucleolar localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393412 | + | 1 | 3 | 179_185 | -92 | 219 | Motif | Nuclear localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393412 | + | 1 | 3 | 190_202 | -92 | 219 | Motif | Note=Nuclear export signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393412 | + | 1 | 3 | 466_473 | -92 | 219 | Motif | Nucleolar localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393413 | + | 1 | 2 | 179_185 | 0 | 219 | Motif | Nuclear localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393413 | + | 1 | 2 | 190_202 | 0 | 219 | Motif | Note=Nuclear export signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393413 | + | 1 | 2 | 466_473 | 0 | 219 | Motif | Nucleolar localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000428863 | + | 1 | 4 | 179_185 | -102 | 271 | Motif | Nuclear localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000428863 | + | 1 | 4 | 190_202 | -102 | 271 | Motif | Note=Nuclear export signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000428863 | + | 1 | 4 | 466_473 | -102 | 271 | Motif | Nucleolar localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000462284 | + | 8 | 11 | 466_473 | 228 | 498 | Motif | Nucleolar localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000540827 | + | 1 | 5 | 179_185 | -102 | 297 | Motif | Nuclear localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000540827 | + | 1 | 5 | 190_202 | -102 | 297 | Motif | Note=Nuclear export signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000540827 | + | 1 | 5 | 466_473 | -102 | 297 | Motif | Nucleolar localization signal |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000258149 | + | 6 | 9 | 210_304 | 167 | 437 | Region | Note=ARF-binding |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000258149 | + | 6 | 9 | 242_331 | 167 | 437 | Region | Note=Region II |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000299252 | + | 1 | 5 | 210_304 | 0 | 322 | Region | Note=ARF-binding |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000299252 | + | 1 | 5 | 242_331 | 0 | 322 | Region | Note=Region II |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000348801 | + | 1 | 3 | 210_304 | 0 | 266 | Region | Note=ARF-binding |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000348801 | + | 1 | 3 | 242_331 | 0 | 266 | Region | Note=Region II |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000356290 | + | 1 | 6 | 210_304 | -102 | 322 | Region | Note=ARF-binding |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000356290 | + | 1 | 6 | 242_331 | -102 | 322 | Region | Note=Region II |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000360430 | + | 1 | 4 | 210_304 | 0 | 297 | Region | Note=ARF-binding |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000360430 | + | 1 | 4 | 242_331 | 0 | 297 | Region | Note=Region II |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393412 | + | 1 | 3 | 210_304 | -92 | 219 | Region | Note=ARF-binding |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393412 | + | 1 | 3 | 242_331 | -92 | 219 | Region | Note=Region II |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393413 | + | 1 | 2 | 210_304 | 0 | 219 | Region | Note=ARF-binding |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393413 | + | 1 | 2 | 242_331 | 0 | 219 | Region | Note=Region II |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000428863 | + | 1 | 4 | 210_304 | -102 | 271 | Region | Note=ARF-binding |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000428863 | + | 1 | 4 | 242_331 | -102 | 271 | Region | Note=Region II |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000462284 | + | 8 | 11 | 210_304 | 228 | 498 | Region | Note=ARF-binding |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000462284 | + | 8 | 11 | 242_331 | 228 | 498 | Region | Note=Region II |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000540827 | + | 1 | 5 | 210_304 | -102 | 297 | Region | Note=ARF-binding |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000540827 | + | 1 | 5 | 242_331 | -102 | 297 | Region | Note=Region II |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000258149 | + | 6 | 9 | 299_328 | 167 | 437 | Zinc finger | RanBP2-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000258149 | + | 6 | 9 | 438_479 | 167 | 437 | Zinc finger | RING-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000299252 | + | 1 | 5 | 299_328 | 0 | 322 | Zinc finger | RanBP2-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000299252 | + | 1 | 5 | 438_479 | 0 | 322 | Zinc finger | RING-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000348801 | + | 1 | 3 | 299_328 | 0 | 266 | Zinc finger | RanBP2-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000348801 | + | 1 | 3 | 438_479 | 0 | 266 | Zinc finger | RING-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000356290 | + | 1 | 6 | 299_328 | -102 | 322 | Zinc finger | RanBP2-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000356290 | + | 1 | 6 | 438_479 | -102 | 322 | Zinc finger | RING-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000360430 | + | 1 | 4 | 299_328 | 0 | 297 | Zinc finger | RanBP2-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000360430 | + | 1 | 4 | 438_479 | 0 | 297 | Zinc finger | RING-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393412 | + | 1 | 3 | 299_328 | -92 | 219 | Zinc finger | RanBP2-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393412 | + | 1 | 3 | 438_479 | -92 | 219 | Zinc finger | RING-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393413 | + | 1 | 2 | 299_328 | 0 | 219 | Zinc finger | RanBP2-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393413 | + | 1 | 2 | 438_479 | 0 | 219 | Zinc finger | RING-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000428863 | + | 1 | 4 | 299_328 | -102 | 271 | Zinc finger | RanBP2-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000428863 | + | 1 | 4 | 438_479 | -102 | 271 | Zinc finger | RING-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000462284 | + | 8 | 11 | 299_328 | 228 | 498 | Zinc finger | RanBP2-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000462284 | + | 8 | 11 | 438_479 | 228 | 498 | Zinc finger | RING-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000540827 | + | 1 | 5 | 299_328 | -102 | 297 | Zinc finger | RanBP2-type |
| Hgene | >MDM2 | chr12:69222710 | chr12:64833023 | ENST00000540827 | + | 1 | 5 | 438_479 | -102 | 297 | Zinc finger | RING-type |
| Tgene | XPOT | chr12:69222710 | chr12:64833023 | ENST00000332707 | + | 21 | 25 | 443_962 | 911 | 963 | Region | Note=Necessary for tRNA-binding%2C cytoplasmic localization and nuclear export |
Top |
FusionGeneSequence for MDM2_XPOT |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MDM2_ENST00000462284_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_280aa MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGD LFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPGPECVQYLQQEYLPSLQVAPEIIQEFCQALQQPDAKVFKNYL >In-frame_MDM2_ENST00000258149_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_219aa MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPS FSVKEHRKIYTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPGPECVQYLQQEYL >In-frame_MDM2_ENST00000258148_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_225aa MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGD LFGVPSFSVKEHRKIYTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPGPECVQY >In-frame_MDM2_ENST00000350057_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_249aa MCNTNMSVPTDGAVTTSQIPASEQETLVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQES SDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MDM2_ENST00000462284_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_840nt ATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAA GAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTTCTT TTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGAT TTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAA TCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAA GAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAA TTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAG ATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCCCAGAATGTGTTCAGTATCTTCAACAAGAATAC CTGCCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGCAGCCTGATGCTAAAGTTTTTAAAAATTACTTA >In-frame_MDM2_ENST00000258149_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_657nt ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTAT ATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGC TTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAAGAAAATTCAGATGAATTA TCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATA TGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCCCAGAATGTGTTCAGTATCTTCAACAAGAATACCTG CCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGCAGCCTGATGCTAAAGTTTTTAAAAATTACTTAAAG >In-frame_MDM2_ENST00000258148_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_675nt ATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAA GAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTTCTT TTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGAT TTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAA GAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTG TGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCCCAGAATGTGTTCAGTAT CTTCAACAAGAATACCTGCCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGCAGCCTGATGCTAAAGTT >In-frame_MDM2_ENST00000350057_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_747nt ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAATTA TCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATA TGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCCCAGAATGTGTTCAGTATCTTCAACAAGAATACCTG CCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGCAGCCTGATGCTAAAGTTTTTAAAAATTACTTAAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MDM2_ENST00000462284_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_4138nt GGGGCGCGCACCGAGGCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGC CCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGC CCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGA GGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTG TAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCAC AAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATA TTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCT ACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTG ATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAG CAATTAGTGAGACAGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTG ATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCC CAGAATGTGTTCAGTATCTTCAACAAGAATACCTGCCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGC AGCCTGATGCTAAAGTTTTTAAAAATTACTTAAAGGTGTTCTTCCAGAGAGCAAAGCCCTGAGGACTGGATTTCCCTGTGCCTACTTCAT GATCATGAATTCCAGTTAATTTATAAAGAGGCGATTTTTGTGTGCCATTCACACTGGTCTTTTTCACATTGTTTTGAGCTTATTGCAGTA TATGTTTTGGGATTTTTCTGTAAAATGGGTGTAATTTTCCTAATACAGGTATGTAACAACAAAAGAAGTTGCCTGCATGCCGGTCCAAAT TGTTCTGTATAAAGATGCTCTTAAAAGACACAAGAGTTATCCTAGAACCTTAATTCTTTTTTATTTGAAATTTTAAGTCAAGTCCTTTAT AAAGACCATAGCAGTGGAAAACAGTGTACTTTTTAAAAAATTGCTGAATATAAAATCTTTGAAAATTTTCTTTATGTGTGAAGACACAAA GTATGGGGGAAGACAGCAATCAAAACTAACTTTTTGTAGATAGCCATTTCATTTCTTTAAACTGTTTCAACGCCAATATGTATTCTACAA AAGAGAATGGTTTTAGGCTCCAGTGTTATACTTTTTTTTATATATATATATAAAAATAAACTTTACGTAGTGAAATCTTCCAAGTCTTTT CTGGAATTATTATAAATACTTTAGTTTTATTTTCTCATCTTAATCTCTCCATAATTTCCCATTTAAAGGTTTACAAATATGAGTGTGTGG ATGCTTTAATTCATTTAACCTCACTCCTCAAAGGTAACATGCAACTTAGTTCTGTTATATGAGAGTCTTTTTCTTTAATGTACTGGAAAA AGCCTATGTGAATCTGTTGATAGAATTTAAAATTCCAGGCCGGGCGTGGTGGCTCACGACTGTAATCCCAGAACTTTGGGAGGCCAAGGC AGGTGGATCACTTGAGGTCAGGAGTTCGAGACTAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAACAGCCAGGTGTGA TGGTGCACGCTCGTAATCCCGGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGAAGGCAGAGGTTGCAGTGAGCTGAGATT GTGCCACTGCACGCCAGCCTGGGCAAGAGAGTAAGACTCTCTCTCAAAAAAAAAAAAAAAGAATTTAAAATCCCAATTTATTTTCTAACT CTTTTATTGGATGTATTTAGAACACAGTATACCTATAGTATACCTATGTGTTTATTATGTTTGTAAATGGTAACTGACATTTAATTATTA GAAGTACTTACCCCTGCCTTCCTCCATTTTTATTCATGGCTACTTGAGAAAGCAAAAGGAAAAAATAATAGTTATCAGTAGTGTCACTGG AAAGAAGAGAGGAGGGACAAAACTGAGCAGCAGAATTCGTATAGACATTTACGTTTAAATTCTAAAAGCCCAATTGAGATGTTCAGGGAG GGTTTGTTTTGCCCTTTGGCCTCATGAATGGGTTTCATGAATGGGCTTCAGTGGCTTATAAACTCTGTAAAATTCTATTCTAAATTTTGT ACATTTATTTTGTTCCGGTTAATTCCAGAAGACATTTCAAACATTTTTCTTACACCATATAATAAAAATACTTAACTAAATTGACAGTTA TAAAAATAAATCAGTGAAATGTACCTTATACTTTAATAAAAAATGTTTTCAGAAATAGATAAGTGAAAGCTGAGTGTTTCTTTGATAGGT TCCCCTGTACTATAGGAGTGATAATTGCAGCTATTGCAATAGTAGTAATTGTTAAATGGATACTAATGAATAGCATAGCATAGTGGGTAA GAGTTTATATAGCACAGGCTCTAGAATCAGATTAAGTAGGTTCAAATACCAGTTCTGCCAGTAACTGGTTTTAGAACCTTGGGCAAGTTA AAGAATGTCTCCCAGCCTCAGTTTCCCTATTTGTAAAATGGAAATAATGGTAGCTACCTCAAACCTCATTACGAATTCAATGAGTTAAAC TTGAAAAGACTTATTACAGTAGCTGGCACATAAAGACTTGATAGTAGTTTATATGGATGCTATCTCATATTAGCATATATGGAATTAATA GTGTATCACTATACTTTTTTTTTCTTTTTTTTTTTTGAATAGAGATCAGTCTATCACCCAGGCTGGAGTGCAGTGGTGACATCATAGCTC ACTGTAACTTCTCCCATACTCTACCAATCCTCCTGCCTCAGCATCCAGACTAGCTGTGATTACAGGTGTGCACCACCACACCCAGCTACA TTTTTTTTTGGTAGAGACAGGGTCTCACTATGTTACCCAGTCTGGTCTCAAACTCCCGGCCTCAAGCAATCCTCCCACTGGCCTCACAAT GTTGGGATTACAGGTATAAGCCACTGCACACGGCCTTACTATGCTATCAATTCCATATATGGAAAGGTGTTTTCCCTTTCAGAGCTCTTT AAAGCTCTGCAGAAGATTTACATGTGTTTATAGAGCTAAGAGAAATCAGGGCATGGAAATTGAGTGTGTAATAAAAATTAAACTCTTCAT GTTATATAATCATGCATAACTTCTATCTTCATTCTCTGAAGTTGCCTAGAGCACCATCACAGCTAGGAAGCTTCCATCATGAATTACCTT ATTTCCAAAAGCAAGTACTCAAATAATTGTCTCAAGAGAGGAAGGACAAAACTGTTACAAGCTGAAATATTTGGGGATTTGTTTGACTTG ACTAGGGAACCACAAGTTTTCATATAATGCCTGATTTAGCCCTGTGCCTAACAGTTTAAATCTTAATGCTAATGTTAATTGCTTCCCAGT TGGTTGACCTTATAAGAAAACACTGTGTGGTATTTTAATGTGGTAAACATGTGAATGAAGGCCTGTGGCTCAGTTAATCACTCCCACAAC TTTGAGCTGTGAGTTTTACTGGTGGAAGGAACTTTAACAGGTCTTCGCTCTTGTCATTAGATATCAAAGAACTGAAATTAGTTGGAATTG >In-frame_MDM2_ENST00000258149_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_3958nt GCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGC GACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCC GGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCC AAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGA TTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATA CTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAA ATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAG TAGTCAATCAGCAGGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTG ATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCC CAGAATGTGTTCAGTATCTTCAACAAGAATACCTGCCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGC AGCCTGATGCTAAAGTTTTTAAAAATTACTTAAAGGTGTTCTTCCAGAGAGCAAAGCCCTGAGGACTGGATTTCCCTGTGCCTACTTCAT GATCATGAATTCCAGTTAATTTATAAAGAGGCGATTTTTGTGTGCCATTCACACTGGTCTTTTTCACATTGTTTTGAGCTTATTGCAGTA TATGTTTTGGGATTTTTCTGTAAAATGGGTGTAATTTTCCTAATACAGGTATGTAACAACAAAAGAAGTTGCCTGCATGCCGGTCCAAAT TGTTCTGTATAAAGATGCTCTTAAAAGACACAAGAGTTATCCTAGAACCTTAATTCTTTTTTATTTGAAATTTTAAGTCAAGTCCTTTAT AAAGACCATAGCAGTGGAAAACAGTGTACTTTTTAAAAAATTGCTGAATATAAAATCTTTGAAAATTTTCTTTATGTGTGAAGACACAAA GTATGGGGGAAGACAGCAATCAAAACTAACTTTTTGTAGATAGCCATTTCATTTCTTTAAACTGTTTCAACGCCAATATGTATTCTACAA AAGAGAATGGTTTTAGGCTCCAGTGTTATACTTTTTTTTATATATATATATAAAAATAAACTTTACGTAGTGAAATCTTCCAAGTCTTTT CTGGAATTATTATAAATACTTTAGTTTTATTTTCTCATCTTAATCTCTCCATAATTTCCCATTTAAAGGTTTACAAATATGAGTGTGTGG ATGCTTTAATTCATTTAACCTCACTCCTCAAAGGTAACATGCAACTTAGTTCTGTTATATGAGAGTCTTTTTCTTTAATGTACTGGAAAA AGCCTATGTGAATCTGTTGATAGAATTTAAAATTCCAGGCCGGGCGTGGTGGCTCACGACTGTAATCCCAGAACTTTGGGAGGCCAAGGC AGGTGGATCACTTGAGGTCAGGAGTTCGAGACTAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAACAGCCAGGTGTGA TGGTGCACGCTCGTAATCCCGGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGAAGGCAGAGGTTGCAGTGAGCTGAGATT GTGCCACTGCACGCCAGCCTGGGCAAGAGAGTAAGACTCTCTCTCAAAAAAAAAAAAAAAGAATTTAAAATCCCAATTTATTTTCTAACT CTTTTATTGGATGTATTTAGAACACAGTATACCTATAGTATACCTATGTGTTTATTATGTTTGTAAATGGTAACTGACATTTAATTATTA GAAGTACTTACCCCTGCCTTCCTCCATTTTTATTCATGGCTACTTGAGAAAGCAAAAGGAAAAAATAATAGTTATCAGTAGTGTCACTGG AAAGAAGAGAGGAGGGACAAAACTGAGCAGCAGAATTCGTATAGACATTTACGTTTAAATTCTAAAAGCCCAATTGAGATGTTCAGGGAG GGTTTGTTTTGCCCTTTGGCCTCATGAATGGGTTTCATGAATGGGCTTCAGTGGCTTATAAACTCTGTAAAATTCTATTCTAAATTTTGT ACATTTATTTTGTTCCGGTTAATTCCAGAAGACATTTCAAACATTTTTCTTACACCATATAATAAAAATACTTAACTAAATTGACAGTTA TAAAAATAAATCAGTGAAATGTACCTTATACTTTAATAAAAAATGTTTTCAGAAATAGATAAGTGAAAGCTGAGTGTTTCTTTGATAGGT TCCCCTGTACTATAGGAGTGATAATTGCAGCTATTGCAATAGTAGTAATTGTTAAATGGATACTAATGAATAGCATAGCATAGTGGGTAA GAGTTTATATAGCACAGGCTCTAGAATCAGATTAAGTAGGTTCAAATACCAGTTCTGCCAGTAACTGGTTTTAGAACCTTGGGCAAGTTA AAGAATGTCTCCCAGCCTCAGTTTCCCTATTTGTAAAATGGAAATAATGGTAGCTACCTCAAACCTCATTACGAATTCAATGAGTTAAAC TTGAAAAGACTTATTACAGTAGCTGGCACATAAAGACTTGATAGTAGTTTATATGGATGCTATCTCATATTAGCATATATGGAATTAATA GTGTATCACTATACTTTTTTTTTCTTTTTTTTTTTTGAATAGAGATCAGTCTATCACCCAGGCTGGAGTGCAGTGGTGACATCATAGCTC ACTGTAACTTCTCCCATACTCTACCAATCCTCCTGCCTCAGCATCCAGACTAGCTGTGATTACAGGTGTGCACCACCACACCCAGCTACA TTTTTTTTTGGTAGAGACAGGGTCTCACTATGTTACCCAGTCTGGTCTCAAACTCCCGGCCTCAAGCAATCCTCCCACTGGCCTCACAAT GTTGGGATTACAGGTATAAGCCACTGCACACGGCCTTACTATGCTATCAATTCCATATATGGAAAGGTGTTTTCCCTTTCAGAGCTCTTT AAAGCTCTGCAGAAGATTTACATGTGTTTATAGAGCTAAGAGAAATCAGGGCATGGAAATTGAGTGTGTAATAAAAATTAAACTCTTCAT GTTATATAATCATGCATAACTTCTATCTTCATTCTCTGAAGTTGCCTAGAGCACCATCACAGCTAGGAAGCTTCCATCATGAATTACCTT ATTTCCAAAAGCAAGTACTCAAATAATTGTCTCAAGAGAGGAAGGACAAAACTGTTACAAGCTGAAATATTTGGGGATTTGTTTGACTTG ACTAGGGAACCACAAGTTTTCATATAATGCCTGATTTAGCCCTGTGCCTAACAGTTTAAATCTTAATGCTAATGTTAATTGCTTCCCAGT TGGTTGACCTTATAAGAAAACACTGTGTGGTATTTTAATGTGGTAAACATGTGAATGAAGGCCTGTGGCTCAGTTAATCACTCCCACAAC TTTGAGCTGTGAGTTTTACTGGTGGAAGGAACTTTAACAGGTCTTCGCTCTTGTCATTAGATATCAAAGAACTGAAATTAGTTGGAATTG >In-frame_MDM2_ENST00000258148_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_3685nt CGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTC CAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTA TGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATG ATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAG TCAATCAGCAGGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATG AAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCCCAG AATGTGTTCAGTATCTTCAACAAGAATACCTGCCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGCAGC CTGATGCTAAAGTTTTTAAAAATTACTTAAAGGTGTTCTTCCAGAGAGCAAAGCCCTGAGGACTGGATTTCCCTGTGCCTACTTCATGAT CATGAATTCCAGTTAATTTATAAAGAGGCGATTTTTGTGTGCCATTCACACTGGTCTTTTTCACATTGTTTTGAGCTTATTGCAGTATAT GTTTTGGGATTTTTCTGTAAAATGGGTGTAATTTTCCTAATACAGGTATGTAACAACAAAAGAAGTTGCCTGCATGCCGGTCCAAATTGT TCTGTATAAAGATGCTCTTAAAAGACACAAGAGTTATCCTAGAACCTTAATTCTTTTTTATTTGAAATTTTAAGTCAAGTCCTTTATAAA GACCATAGCAGTGGAAAACAGTGTACTTTTTAAAAAATTGCTGAATATAAAATCTTTGAAAATTTTCTTTATGTGTGAAGACACAAAGTA TGGGGGAAGACAGCAATCAAAACTAACTTTTTGTAGATAGCCATTTCATTTCTTTAAACTGTTTCAACGCCAATATGTATTCTACAAAAG AGAATGGTTTTAGGCTCCAGTGTTATACTTTTTTTTATATATATATATAAAAATAAACTTTACGTAGTGAAATCTTCCAAGTCTTTTCTG GAATTATTATAAATACTTTAGTTTTATTTTCTCATCTTAATCTCTCCATAATTTCCCATTTAAAGGTTTACAAATATGAGTGTGTGGATG CTTTAATTCATTTAACCTCACTCCTCAAAGGTAACATGCAACTTAGTTCTGTTATATGAGAGTCTTTTTCTTTAATGTACTGGAAAAAGC CTATGTGAATCTGTTGATAGAATTTAAAATTCCAGGCCGGGCGTGGTGGCTCACGACTGTAATCCCAGAACTTTGGGAGGCCAAGGCAGG TGGATCACTTGAGGTCAGGAGTTCGAGACTAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAACAGCCAGGTGTGATGG TGCACGCTCGTAATCCCGGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGAAGGCAGAGGTTGCAGTGAGCTGAGATTGTG CCACTGCACGCCAGCCTGGGCAAGAGAGTAAGACTCTCTCTCAAAAAAAAAAAAAAAGAATTTAAAATCCCAATTTATTTTCTAACTCTT TTATTGGATGTATTTAGAACACAGTATACCTATAGTATACCTATGTGTTTATTATGTTTGTAAATGGTAACTGACATTTAATTATTAGAA GTACTTACCCCTGCCTTCCTCCATTTTTATTCATGGCTACTTGAGAAAGCAAAAGGAAAAAATAATAGTTATCAGTAGTGTCACTGGAAA GAAGAGAGGAGGGACAAAACTGAGCAGCAGAATTCGTATAGACATTTACGTTTAAATTCTAAAAGCCCAATTGAGATGTTCAGGGAGGGT TTGTTTTGCCCTTTGGCCTCATGAATGGGTTTCATGAATGGGCTTCAGTGGCTTATAAACTCTGTAAAATTCTATTCTAAATTTTGTACA TTTATTTTGTTCCGGTTAATTCCAGAAGACATTTCAAACATTTTTCTTACACCATATAATAAAAATACTTAACTAAATTGACAGTTATAA AAATAAATCAGTGAAATGTACCTTATACTTTAATAAAAAATGTTTTCAGAAATAGATAAGTGAAAGCTGAGTGTTTCTTTGATAGGTTCC CCTGTACTATAGGAGTGATAATTGCAGCTATTGCAATAGTAGTAATTGTTAAATGGATACTAATGAATAGCATAGCATAGTGGGTAAGAG TTTATATAGCACAGGCTCTAGAATCAGATTAAGTAGGTTCAAATACCAGTTCTGCCAGTAACTGGTTTTAGAACCTTGGGCAAGTTAAAG AATGTCTCCCAGCCTCAGTTTCCCTATTTGTAAAATGGAAATAATGGTAGCTACCTCAAACCTCATTACGAATTCAATGAGTTAAACTTG AAAAGACTTATTACAGTAGCTGGCACATAAAGACTTGATAGTAGTTTATATGGATGCTATCTCATATTAGCATATATGGAATTAATAGTG TATCACTATACTTTTTTTTTCTTTTTTTTTTTTGAATAGAGATCAGTCTATCACCCAGGCTGGAGTGCAGTGGTGACATCATAGCTCACT GTAACTTCTCCCATACTCTACCAATCCTCCTGCCTCAGCATCCAGACTAGCTGTGATTACAGGTGTGCACCACCACACCCAGCTACATTT TTTTTTGGTAGAGACAGGGTCTCACTATGTTACCCAGTCTGGTCTCAAACTCCCGGCCTCAAGCAATCCTCCCACTGGCCTCACAATGTT GGGATTACAGGTATAAGCCACTGCACACGGCCTTACTATGCTATCAATTCCATATATGGAAAGGTGTTTTCCCTTTCAGAGCTCTTTAAA GCTCTGCAGAAGATTTACATGTGTTTATAGAGCTAAGAGAAATCAGGGCATGGAAATTGAGTGTGTAATAAAAATTAAACTCTTCATGTT ATATAATCATGCATAACTTCTATCTTCATTCTCTGAAGTTGCCTAGAGCACCATCACAGCTAGGAAGCTTCCATCATGAATTACCTTATT TCCAAAAGCAAGTACTCAAATAATTGTCTCAAGAGAGGAAGGACAAAACTGTTACAAGCTGAAATATTTGGGGATTTGTTTGACTTGACT AGGGAACCACAAGTTTTCATATAATGCCTGATTTAGCCCTGTGCCTAACAGTTTAAATCTTAATGCTAATGTTAATTGCTTCCCAGTTGG TTGACCTTATAAGAAAACACTGTGTGGTATTTTAATGTGGTAAACATGTGAATGAAGGCCTGTGGCTCAGTTAATCACTCCCACAACTTT GAGCTGTGAGTTTTACTGGTGGAAGGAACTTTAACAGGTCTTCGCTCTTGTCATTAGATATCAAAGAACTGAAATTAGTTGGAATTGTAA >In-frame_MDM2_ENST00000350057_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_3743nt ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAATTA TCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATA TGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCCCAGAATGTGTTCAGTATCTTCAACAAGAATACCTG CCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGCAGCCTGATGCTAAAGTTTTTAAAAATTACTTAAAG GTGTTCTTCCAGAGAGCAAAGCCCTGAGGACTGGATTTCCCTGTGCCTACTTCATGATCATGAATTCCAGTTAATTTATAAAGAGGCGAT TTTTGTGTGCCATTCACACTGGTCTTTTTCACATTGTTTTGAGCTTATTGCAGTATATGTTTTGGGATTTTTCTGTAAAATGGGTGTAAT TTTCCTAATACAGGTATGTAACAACAAAAGAAGTTGCCTGCATGCCGGTCCAAATTGTTCTGTATAAAGATGCTCTTAAAAGACACAAGA GTTATCCTAGAACCTTAATTCTTTTTTATTTGAAATTTTAAGTCAAGTCCTTTATAAAGACCATAGCAGTGGAAAACAGTGTACTTTTTA AAAAATTGCTGAATATAAAATCTTTGAAAATTTTCTTTATGTGTGAAGACACAAAGTATGGGGGAAGACAGCAATCAAAACTAACTTTTT GTAGATAGCCATTTCATTTCTTTAAACTGTTTCAACGCCAATATGTATTCTACAAAAGAGAATGGTTTTAGGCTCCAGTGTTATACTTTT TTTTATATATATATATAAAAATAAACTTTACGTAGTGAAATCTTCCAAGTCTTTTCTGGAATTATTATAAATACTTTAGTTTTATTTTCT CATCTTAATCTCTCCATAATTTCCCATTTAAAGGTTTACAAATATGAGTGTGTGGATGCTTTAATTCATTTAACCTCACTCCTCAAAGGT AACATGCAACTTAGTTCTGTTATATGAGAGTCTTTTTCTTTAATGTACTGGAAAAAGCCTATGTGAATCTGTTGATAGAATTTAAAATTC CAGGCCGGGCGTGGTGGCTCACGACTGTAATCCCAGAACTTTGGGAGGCCAAGGCAGGTGGATCACTTGAGGTCAGGAGTTCGAGACTAG CCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAACAGCCAGGTGTGATGGTGCACGCTCGTAATCCCGGCTACTCAGGAGGC TGAGGCAGGAGAATCGCTTGAACCCGGAAGGCAGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACGCCAGCCTGGGCAAGAGAGTAAG ACTCTCTCTCAAAAAAAAAAAAAAAGAATTTAAAATCCCAATTTATTTTCTAACTCTTTTATTGGATGTATTTAGAACACAGTATACCTA TAGTATACCTATGTGTTTATTATGTTTGTAAATGGTAACTGACATTTAATTATTAGAAGTACTTACCCCTGCCTTCCTCCATTTTTATTC ATGGCTACTTGAGAAAGCAAAAGGAAAAAATAATAGTTATCAGTAGTGTCACTGGAAAGAAGAGAGGAGGGACAAAACTGAGCAGCAGAA TTCGTATAGACATTTACGTTTAAATTCTAAAAGCCCAATTGAGATGTTCAGGGAGGGTTTGTTTTGCCCTTTGGCCTCATGAATGGGTTT CATGAATGGGCTTCAGTGGCTTATAAACTCTGTAAAATTCTATTCTAAATTTTGTACATTTATTTTGTTCCGGTTAATTCCAGAAGACAT TTCAAACATTTTTCTTACACCATATAATAAAAATACTTAACTAAATTGACAGTTATAAAAATAAATCAGTGAAATGTACCTTATACTTTA ATAAAAAATGTTTTCAGAAATAGATAAGTGAAAGCTGAGTGTTTCTTTGATAGGTTCCCCTGTACTATAGGAGTGATAATTGCAGCTATT GCAATAGTAGTAATTGTTAAATGGATACTAATGAATAGCATAGCATAGTGGGTAAGAGTTTATATAGCACAGGCTCTAGAATCAGATTAA GTAGGTTCAAATACCAGTTCTGCCAGTAACTGGTTTTAGAACCTTGGGCAAGTTAAAGAATGTCTCCCAGCCTCAGTTTCCCTATTTGTA AAATGGAAATAATGGTAGCTACCTCAAACCTCATTACGAATTCAATGAGTTAAACTTGAAAAGACTTATTACAGTAGCTGGCACATAAAG ACTTGATAGTAGTTTATATGGATGCTATCTCATATTAGCATATATGGAATTAATAGTGTATCACTATACTTTTTTTTTCTTTTTTTTTTT TGAATAGAGATCAGTCTATCACCCAGGCTGGAGTGCAGTGGTGACATCATAGCTCACTGTAACTTCTCCCATACTCTACCAATCCTCCTG CCTCAGCATCCAGACTAGCTGTGATTACAGGTGTGCACCACCACACCCAGCTACATTTTTTTTTGGTAGAGACAGGGTCTCACTATGTTA CCCAGTCTGGTCTCAAACTCCCGGCCTCAAGCAATCCTCCCACTGGCCTCACAATGTTGGGATTACAGGTATAAGCCACTGCACACGGCC TTACTATGCTATCAATTCCATATATGGAAAGGTGTTTTCCCTTTCAGAGCTCTTTAAAGCTCTGCAGAAGATTTACATGTGTTTATAGAG CTAAGAGAAATCAGGGCATGGAAATTGAGTGTGTAATAAAAATTAAACTCTTCATGTTATATAATCATGCATAACTTCTATCTTCATTCT CTGAAGTTGCCTAGAGCACCATCACAGCTAGGAAGCTTCCATCATGAATTACCTTATTTCCAAAAGCAAGTACTCAAATAATTGTCTCAA GAGAGGAAGGACAAAACTGTTACAAGCTGAAATATTTGGGGATTTGTTTGACTTGACTAGGGAACCACAAGTTTTCATATAATGCCTGAT TTAGCCCTGTGCCTAACAGTTTAAATCTTAATGCTAATGTTAATTGCTTCCCAGTTGGTTGACCTTATAAGAAAACACTGTGTGGTATTT TAATGTGGTAAACATGTGAATGAAGGCCTGTGGCTCAGTTAATCACTCCCACAACTTTGAGCTGTGAGTTTTACTGGTGGAAGGAACTTT AACAGGTCTTCGCTCTTGTCATTAGATATCAAAGAACTGAAATTAGTTGGAATTGTAAGCAGTGAATAGATGTGTTGTTAGAATGATTCC |
Top |
FusionGenePPI for MDM2_XPOT |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MDM2 | TP53, MDC1, CTBP1, CTBP2, TP73, PML, RPL11, RPL5, CDKN2A, NUMB, UBE2A, HIF1A, KAT5, HDAC1, EID1, MDM4, KAT2B, EP300, TBP, TAF1, MDM2, ESR1, ARRB2, ABL1, CCNG1, ARRB1, TSG101, RB1, MTBP, FKBP3, RYBP, RRM2B, RPL26, GNAS, FOXO4, IGF1R, DAXX, DHFR, GNL3, CCAR1, PSMD10, PSME3, PTK2, AR, PPM1D, USP7, COPS5, SFN, RBBP6, CDH1, CHEK2, YWHAQ, NCL, UBE2G2, UBE2U, UBE2Z, PYHIN1, BANP, DDX17, E2F1, TRIM28, UBC, GATA3, ATF3, HIST2H2BE, RPL23, YY1, AKT1, RAD23A, CDKN1A, NR3C1, UBE2I, HIST3H3, EHMT1, SUV39H1, RPS27L, RPS27, ADRB2, SIVA1, MTA1, RCHY1, UBE2D1, CASP2, RPS27A, RPS7, G3BP2, PSMD2, PAK1IP1, RPS6KB1, ZNF668, TP63, PCNA, USP10, PSMC1, PSMD4, PSMC3, PSMC5, PSMC6, PSMA7, PSMD1, RUNX3, GNL3L, TERT, APEX1, UIMC1, CREBBP, SOX4, UBE4B, TBRG1, BAIAP2L1, RFWD3, ERBB3, PA2G4, HEXIM1, CDK9, DYRK2, HSP90AA1, HSPA4, HSPA8, LAMP2, RPS3, USP2, TRIM13, XRCC6, GORAB, FOXO1, FOXO3, UCHL1, S100A1, S100A2, S100A4, S100A6, S100B, USP42, CUL1, BTRC, FBXW11, CSNK1D, RFWD2, SMURF1, NOTCH4, CSNK1A1, PDLIM7, SENP3, RN5S1@, PDE4D, NOTCH1, SNAI1, RASSF1, TRIM27, RFFL, RPS14, PPP2R4, TTF1, PSMB6, PSMA8, RASSF3, NR0B2, UBE2B, PIAS1, RANBP1, LATS1, RAD50, NBN, MRE11A, CUL4A, DTL, PIM1, GSK3B, PSMA3, ESR2, ADRBK1, AATF, HNRNPK, BUB1B, SUMO1, RASSF5, UBE2D2, POLH, NPM1, TCAP, CDK5RAP3, ARIH2, IRF2, RPS25, TPT1, ANG, RHOA, PDCD5, CDKN2AIP, LATS2, WWOX, MED1, ERCC6, ERCC8, DDB1, CUL4B, HIPK2, DHRS2, CASP3, ITCH, EEF1A1, DCD, TUBB, TUBB2A, KRT14, RPS20, GAPDH, TUBA1C, GSN, ERBB4, XIAP, HNF4A, PLK1, NME2, NEDD4, DAPK1, DAPK3, ATM, PBX1, UBE2D3, UBE3A, UBE2L3, UBE2E2, UBE2E3, RNF2, EGR1, PAK6, DLG4, IRF1, VCP, STRA13, GADD45A, RABL6, RPS26, RPL37, RPS15, RNF8, TRIM4, TRIM23, TRAF5, TRIM9, MKRN3, PHF7, RNF10, RNF126, UBE2K, LMO7, HLA-DMB, SETDB1, YY1AP1, NACA, ATF4, MYD88, RELA, SDHC, WT1, SORBS2, HRSP12, DNAJB4, GCAT, SHPK, POT1, ANKRD17, GLTSCR2, SESN2, RASSF6, JUND, EZR, RYR2, JUN, CLSTN1, APP, CLU, SREK1, SET, HSP90B1, CWC25, ZNF133, PKM, TAB1, RPL6, AURKA, NOC2L, JAK1, XPC, PGAM1, PGAM2, DNAJB1, ANAPC2, NLK, SNAI2, RBM38, FHIT, AGPS, ALDH16A1, DDX5, DHX9, DLAT, EDC4, EIF2AK1, ESYT1, GTF2I, HMHA1, HNRNPM, HNRNPU, HRNR, HSP90AB1, IARS, IFI16, IGF2BP3, ILF3, KARS, CCAR2, NEK9, OGDH, OGDHL, RARS, RBBP8, RECQL, SF3B1, SFPQ, TOP1, ZNF318, PER2, SIRT6, TSC22D3, RPS6, UBE2M, RAD54B, SMARCA2, ACACA, PTBP1, IYD, ACTB, HNRNPD, U2AF2, FUBP1, TFRC, EEF2, XPO1, KRT2, EIF3B, SND1, DCAF8, USO1, EFTUD2, EXOSC6, IPO7, SF3B3, DET1, UBE2N, RPL10A, DIRAS3, SURF2, RFPL2, CMSS1, PPARD, RPL22L1, IER2, MAGEA2, ZNF420, ELF4, ABL2, SRC, HCK, GTF2E2, ATP2A2, BRINP1, C19orf10, CANX, MS4A1, PDIA3, PPIB, RAB8A, RPS23, RUVBL2, SMARCA4, SMARCE1, SRSF11, TPR, UBTF, PPARG, VDR, FBXO31, TFIP11, SETD7, PPP1CA, RARA, DDX24, NAT10, CCND1, RLIM, IER3, FHL2, RPL23A, SUZ12, EZH2, EED, RRM1, RPL4, NOLC1, DDX42, MAP2, NUCKS1, RRP1, PDS5A, RPL36A, TP53RK, RPL15, NPIPB3, HMGN1, MAP1LC3A, PRDM2, KIAA1551, PBXIP1, SP1, SHARPIN, MAPKAPK2, USP15, USP26, FKBP1A, NGFR, SMG7, RSL1D1, SIRT1, SIRT7, SIRT2, SIRT3, KPNA1, KPNA6, MSI2, PHLDB3, CLPB, XAGE1B, ZNF550, YAF2, PDGFB, ARNTL2, RPS11, TSPYL6, HIST1H2BJ, ZNF764, MAK16, ZNF274, PPAN, RPL37A, CRTC2, CRTC3, TRIM25, CSNK2A1, CSNK2B, CSNK2A2, HEY1, RANBP2 | XPOT | HDLBP, RAN, AIRE, CAMKK2, CLN3, MYC, HDAC5, SIRT7, FBXO25, CUL5, USP7, TXNL1, ECT2, CA9, IQCB1, EGFR, FBXO6, APEX1, PAPSS1, MCMBP, NFRKB, RNF2, HTR6, GCSH, NAA40, PSMA3, PSMA4, WDR11, PSMB2, NTRK1, XRCC1, HDAC6, FBXO7, FAM46A, ARMC6, RNF126, DPF3, PTPRE, CDC14B, EPHA1, PTPRA, PTPRN, AAR2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000462284 | + | 8 | 11 | 150_230 | 228 | 498 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000258149 | + | 6 | 9 | 170_306 | 167 | 437 | MTBP |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000299252 | + | 1 | 5 | 170_306 | 0 | 322 | MTBP |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000348801 | + | 1 | 3 | 170_306 | 0 | 266 | MTBP |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000356290 | + | 1 | 6 | 170_306 | -102 | 322 | MTBP |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000360430 | + | 1 | 4 | 170_306 | 0 | 297 | MTBP |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393412 | + | 1 | 3 | 170_306 | -92 | 219 | MTBP |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393413 | + | 1 | 2 | 170_306 | 0 | 219 | MTBP |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000428863 | + | 1 | 4 | 170_306 | -102 | 271 | MTBP |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000462284 | + | 8 | 11 | 170_306 | 228 | 498 | MTBP |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000540827 | + | 1 | 5 | 170_306 | -102 | 297 | MTBP |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000258149 | + | 6 | 9 | 150_230 | 167 | 437 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000299252 | + | 1 | 5 | 150_230 | 0 | 322 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000348801 | + | 1 | 3 | 150_230 | 0 | 266 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000356290 | + | 1 | 6 | 150_230 | -102 | 322 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000360430 | + | 1 | 4 | 150_230 | 0 | 297 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393412 | + | 1 | 3 | 150_230 | -92 | 219 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393413 | + | 1 | 2 | 150_230 | 0 | 219 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000428863 | + | 1 | 4 | 150_230 | -102 | 271 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000540827 | + | 1 | 5 | 150_230 | -102 | 297 | PYHIN1 and necessary for interaction with RFFL and RNF34 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000258149 | + | 6 | 9 | 223_232 | 167 | 437 | USP7 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000299252 | + | 1 | 5 | 223_232 | 0 | 322 | USP7 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000348801 | + | 1 | 3 | 223_232 | 0 | 266 | USP7 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000356290 | + | 1 | 6 | 223_232 | -102 | 322 | USP7 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000360430 | + | 1 | 4 | 223_232 | 0 | 297 | USP7 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393412 | + | 1 | 3 | 223_232 | -92 | 219 | USP7 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000393413 | + | 1 | 2 | 223_232 | 0 | 219 | USP7 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000428863 | + | 1 | 4 | 223_232 | -102 | 271 | USP7 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000462284 | + | 8 | 11 | 223_232 | 228 | 498 | USP7 |
| Hgene | MDM2 | chr12:69222710 | chr12:64833023 | ENST00000540827 | + | 1 | 5 | 223_232 | -102 | 297 | USP7 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MDM2_XPOT |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | MDM2 | Q00987 | DB01593 | Zinc | E3 ubiquitin-protein ligase Mdm2 | small molecule | approved|investigational |
Top |
RelatedDiseases for MDM2_XPOT |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MDM2 | C0007131 | Non-Small Cell Lung Carcinoma | 2 | CTD_human |
| Hgene | MDM2 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Hgene | MDM2 | C0019693 | HIV Infections | 1 | CTD_human |
| Hgene | MDM2 | C0021364 | Male infertility | 1 | CTD_human |
| Hgene | MDM2 | C0025202 | melanoma | 1 | CTD_human |
| Hgene | MDM2 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Hgene | MDM2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | MDM2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|