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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 21398

FusionGeneSummary for MDM2_XPOT

check button Fusion gene summary
Fusion gene informationFusion gene name: MDM2_XPOT
Fusion gene ID: 21398
HgeneTgene
Gene symbol

MDM2

XPOT

Gene ID

4193

11260

Gene nameMDM2 proto-oncogeneexportin for tRNA
SynonymsACTFS|HDMX|hdm2XPO3
Cytomap

12q15

12q14.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, humexportin-Texportin(tRNA)exportin, tRNA (nuclear export receptor for tRNAs)tRNA exportin
Modification date2018052720180523
UniProtAcc

Q00987

O43592

Ensembl transtripts involved in fusion geneENST00000462284, ENST00000356290, 
ENST00000540827, ENST00000258149, 
ENST00000428863, ENST00000393412, 
ENST00000258148, ENST00000544561, 
ENST00000393410, ENST00000393413, 
ENST00000517852, ENST00000545204, 
ENST00000350057, ENST00000360430, 
ENST00000299252, ENST00000348801, 
ENST00000478070, ENST00000544125, 
ENST00000332707, 
Fusion gene scores* DoF score24 X 14 X 8=26886 X 6 X 4=144
# samples 256
** MAII scorelog2(25/2688*10)=-3.42653313811667
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MDM2 [Title/Abstract] AND XPOT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

HgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

HgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

HgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

HgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

HgeneMDM2

GO:0034504

protein localization to nucleus

10360174

HgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

HgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

HgeneMDM2

GO:0045184

establishment of protein localization

10360174

HgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

HgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

HgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

HgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

HgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

HgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922

TgeneXPOT

GO:0006409

tRNA export from nucleus

9660920


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0AM-01AMDM2chr12

69222710

+XPOTchr12

64833023

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000462284ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
intron-3CDSENST00000356290ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
intron-3CDSENST00000540827ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
In-frameENST00000258149ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
intron-3CDSENST00000428863ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
intron-3CDSENST00000393412ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
In-frameENST00000258148ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
intron-3CDSENST00000544561ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
intron-3CDSENST00000393410ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
intron-3CDSENST00000393413ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
intron-3CDSENST00000517852ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
intron-3CDSENST00000545204ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
In-frameENST00000350057ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
intron-3CDSENST00000360430ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
intron-3CDSENST00000299252ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
intron-3CDSENST00000348801ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
intron-3CDSENST00000478070ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+
intron-3CDSENST00000544125ENST00000332707MDM2chr12

69222710

+XPOTchr12

64833023

+

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FusionProtFeatures for MDM2_XPOT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MDM2

Q00987

XPOT

O43592

Mediates the nuclear export of aminoacylated tRNAs. Inthe nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear porecomplex (NPC) is mediated through binding to nucleoporins. Upontransit of a nuclear export complex into the cytoplasm,disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP(induced by RANBP1 and RANGAP1, respectively) cause release of thetRNA from the export receptor. XPOT then return to the nuclearcompartment and mediate another round of transport. Thedirectionality of nuclear export is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. {ECO:0000269|PubMed:12138183,ECO:0000269|PubMed:9512417, ECO:0000269|PubMed:9660920}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69222710chr12:64833023ENST00000462284+811210_215228498Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222710chr12:64833023ENST00000258149+6927_107167437DomainNote=SWIB
HgeneMDM2chr12:69222710chr12:64833023ENST00000462284+81127_107228498DomainNote=SWIB
HgeneMDM2chr12:69222710chr12:64833023ENST00000462284+811179_185228498MotifNuclear localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000462284+811190_202228498MotifNote=Nuclear export signal

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69222710chr12:64833023ENST00000258149+69210_215167437Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222710chr12:64833023ENST00000258149+69243_301167437Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222710chr12:64833023ENST00000299252+15210_2150322Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222710chr12:64833023ENST00000299252+15243_3010322Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222710chr12:64833023ENST00000348801+13210_2150266Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222710chr12:64833023ENST00000348801+13243_3010266Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222710chr12:64833023ENST00000356290+16210_215-102322Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222710chr12:64833023ENST00000356290+16243_301-102322Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222710chr12:64833023ENST00000360430+14210_2150297Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222710chr12:64833023ENST00000360430+14243_3010297Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222710chr12:64833023ENST00000393412+13210_215-92219Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222710chr12:64833023ENST00000393412+13243_301-92219Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222710chr12:64833023ENST00000393413+12210_2150219Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222710chr12:64833023ENST00000393413+12243_3010219Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222710chr12:64833023ENST00000428863+14210_215-102271Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222710chr12:64833023ENST00000428863+14243_301-102271Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222710chr12:64833023ENST00000462284+811243_301228498Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222710chr12:64833023ENST00000540827+15210_215-102297Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222710chr12:64833023ENST00000540827+15243_301-102297Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222710chr12:64833023ENST00000299252+1527_1070322DomainNote=SWIB
HgeneMDM2chr12:69222710chr12:64833023ENST00000348801+1327_1070266DomainNote=SWIB
HgeneMDM2chr12:69222710chr12:64833023ENST00000356290+1627_107-102322DomainNote=SWIB
HgeneMDM2chr12:69222710chr12:64833023ENST00000360430+1427_1070297DomainNote=SWIB
HgeneMDM2chr12:69222710chr12:64833023ENST00000393412+1327_107-92219DomainNote=SWIB
HgeneMDM2chr12:69222710chr12:64833023ENST00000393413+1227_1070219DomainNote=SWIB
HgeneMDM2chr12:69222710chr12:64833023ENST00000428863+1427_107-102271DomainNote=SWIB
HgeneMDM2chr12:69222710chr12:64833023ENST00000540827+1527_107-102297DomainNote=SWIB
HgeneMDM2chr12:69222710chr12:64833023ENST00000258149+69179_185167437MotifNuclear localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000258149+69190_202167437MotifNote=Nuclear export signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000258149+69466_473167437MotifNucleolar localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000299252+15179_1850322MotifNuclear localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000299252+15190_2020322MotifNote=Nuclear export signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000299252+15466_4730322MotifNucleolar localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000348801+13179_1850266MotifNuclear localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000348801+13190_2020266MotifNote=Nuclear export signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000348801+13466_4730266MotifNucleolar localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000356290+16179_185-102322MotifNuclear localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000356290+16190_202-102322MotifNote=Nuclear export signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000356290+16466_473-102322MotifNucleolar localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000360430+14179_1850297MotifNuclear localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000360430+14190_2020297MotifNote=Nuclear export signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000360430+14466_4730297MotifNucleolar localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000393412+13179_185-92219MotifNuclear localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000393412+13190_202-92219MotifNote=Nuclear export signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000393412+13466_473-92219MotifNucleolar localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000393413+12179_1850219MotifNuclear localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000393413+12190_2020219MotifNote=Nuclear export signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000393413+12466_4730219MotifNucleolar localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000428863+14179_185-102271MotifNuclear localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000428863+14190_202-102271MotifNote=Nuclear export signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000428863+14466_473-102271MotifNucleolar localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000462284+811466_473228498MotifNucleolar localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000540827+15179_185-102297MotifNuclear localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000540827+15190_202-102297MotifNote=Nuclear export signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000540827+15466_473-102297MotifNucleolar localization signal
HgeneMDM2chr12:69222710chr12:64833023ENST00000258149+69210_304167437RegionNote=ARF-binding
HgeneMDM2chr12:69222710chr12:64833023ENST00000258149+69242_331167437RegionNote=Region II
HgeneMDM2chr12:69222710chr12:64833023ENST00000299252+15210_3040322RegionNote=ARF-binding
HgeneMDM2chr12:69222710chr12:64833023ENST00000299252+15242_3310322RegionNote=Region II
HgeneMDM2chr12:69222710chr12:64833023ENST00000348801+13210_3040266RegionNote=ARF-binding
HgeneMDM2chr12:69222710chr12:64833023ENST00000348801+13242_3310266RegionNote=Region II
HgeneMDM2chr12:69222710chr12:64833023ENST00000356290+16210_304-102322RegionNote=ARF-binding
HgeneMDM2chr12:69222710chr12:64833023ENST00000356290+16242_331-102322RegionNote=Region II
HgeneMDM2chr12:69222710chr12:64833023ENST00000360430+14210_3040297RegionNote=ARF-binding
HgeneMDM2chr12:69222710chr12:64833023ENST00000360430+14242_3310297RegionNote=Region II
HgeneMDM2chr12:69222710chr12:64833023ENST00000393412+13210_304-92219RegionNote=ARF-binding
HgeneMDM2chr12:69222710chr12:64833023ENST00000393412+13242_331-92219RegionNote=Region II
HgeneMDM2chr12:69222710chr12:64833023ENST00000393413+12210_3040219RegionNote=ARF-binding
HgeneMDM2chr12:69222710chr12:64833023ENST00000393413+12242_3310219RegionNote=Region II
HgeneMDM2chr12:69222710chr12:64833023ENST00000428863+14210_304-102271RegionNote=ARF-binding
HgeneMDM2chr12:69222710chr12:64833023ENST00000428863+14242_331-102271RegionNote=Region II
HgeneMDM2chr12:69222710chr12:64833023ENST00000462284+811210_304228498RegionNote=ARF-binding
HgeneMDM2chr12:69222710chr12:64833023ENST00000462284+811242_331228498RegionNote=Region II
HgeneMDM2chr12:69222710chr12:64833023ENST00000540827+15210_304-102297RegionNote=ARF-binding
HgeneMDM2chr12:69222710chr12:64833023ENST00000540827+15242_331-102297RegionNote=Region II
HgeneMDM2chr12:69222710chr12:64833023ENST00000258149+69299_328167437Zinc fingerRanBP2-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000258149+69438_479167437Zinc fingerRING-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000299252+15299_3280322Zinc fingerRanBP2-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000299252+15438_4790322Zinc fingerRING-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000348801+13299_3280266Zinc fingerRanBP2-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000348801+13438_4790266Zinc fingerRING-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000356290+16299_328-102322Zinc fingerRanBP2-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000356290+16438_479-102322Zinc fingerRING-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000360430+14299_3280297Zinc fingerRanBP2-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000360430+14438_4790297Zinc fingerRING-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000393412+13299_328-92219Zinc fingerRanBP2-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000393412+13438_479-92219Zinc fingerRING-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000393413+12299_3280219Zinc fingerRanBP2-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000393413+12438_4790219Zinc fingerRING-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000428863+14299_328-102271Zinc fingerRanBP2-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000428863+14438_479-102271Zinc fingerRING-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000462284+811299_328228498Zinc fingerRanBP2-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000462284+811438_479228498Zinc fingerRING-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000540827+15299_328-102297Zinc fingerRanBP2-type
HgeneMDM2chr12:69222710chr12:64833023ENST00000540827+15438_479-102297Zinc fingerRING-type
TgeneXPOTchr12:69222710chr12:64833023ENST00000332707+2125443_962911963RegionNote=Necessary for tRNA-binding%2C cytoplasmic localization and nuclear export


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FusionGeneSequence for MDM2_XPOT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MDM2_ENST00000462284_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_280aa
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTTTMKEVLFTLGQTIMTKRLTDEKQQHIVTCSNDLLGD
LFGVPSFSVKEHRKITTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPGPECVQTLQQEYLPSLQVAPEIIQEFCQALQQPDAKVFKNYL

>In-frame_MDM2_ENST00000258149_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_219aa
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTTTMKEVLFTLGQTIMTKRLTDEKQQHIVTCSNDLLGDLFGVPS
FSVKEHRKITTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPGPECVQTLQQEYL

>In-frame_MDM2_ENST00000258148_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_225aa
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTTTMKEVLFTLGQTIMTKRLTDEKQQHIVTCSNDLLGD
LFGVPSFSVKEHRKITTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPGPECVQT

>In-frame_MDM2_ENST00000350057_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_249aa
MCNTNMSVPTDGAVTTSQIPASEQETLVLFTLGQTIMTKRLTDEKQQHIVTCSNDLLGDLFGVPSFSVKEHRKITTMIYRNLVVVNQQES
SDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MDM2_ENST00000462284_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_840nt
ATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAA
GAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTTCTT
TTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGAT
TTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAA
TCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAA
GAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAA
TTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAG
ATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCCCAGAATGTGTTCAGTATCTTCAACAAGAATAC
CTGCCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGCAGCCTGATGCTAAAGTTTTTAAAAATTACTTA

>In-frame_MDM2_ENST00000258149_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_657nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA
AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTAT
ATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGC
TTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAAGAAAATTCAGATGAATTA
TCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATA
TGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCCCAGAATGTGTTCAGTATCTTCAACAAGAATACCTG
CCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGCAGCCTGATGCTAAAGTTTTTAAAAATTACTTAAAG

>In-frame_MDM2_ENST00000258148_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_675nt
ATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAA
GAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTTCTT
TTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGAT
TTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAA
GAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTG
TGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCCCAGAATGTGTTCAGTAT
CTTCAACAAGAATACCTGCCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGCAGCCTGATGCTAAAGTT

>In-frame_MDM2_ENST00000350057_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_747nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAATTA
TCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATA
TGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCCCAGAATGTGTTCAGTATCTTCAACAAGAATACCTG
CCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGCAGCCTGATGCTAAAGTTTTTAAAAATTACTTAAAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_MDM2_ENST00000462284_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_4138nt
GGGGCGCGCACCGAGGCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGC
CCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGC
CCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGA
GGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTG
TAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCAC
AAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATA
TTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCT
ACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTG
ATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAG
CAATTAGTGAGACAGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTG
ATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCC
CAGAATGTGTTCAGTATCTTCAACAAGAATACCTGCCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGC
AGCCTGATGCTAAAGTTTTTAAAAATTACTTAAAGGTGTTCTTCCAGAGAGCAAAGCCCTGAGGACTGGATTTCCCTGTGCCTACTTCAT
GATCATGAATTCCAGTTAATTTATAAAGAGGCGATTTTTGTGTGCCATTCACACTGGTCTTTTTCACATTGTTTTGAGCTTATTGCAGTA
TATGTTTTGGGATTTTTCTGTAAAATGGGTGTAATTTTCCTAATACAGGTATGTAACAACAAAAGAAGTTGCCTGCATGCCGGTCCAAAT
TGTTCTGTATAAAGATGCTCTTAAAAGACACAAGAGTTATCCTAGAACCTTAATTCTTTTTTATTTGAAATTTTAAGTCAAGTCCTTTAT
AAAGACCATAGCAGTGGAAAACAGTGTACTTTTTAAAAAATTGCTGAATATAAAATCTTTGAAAATTTTCTTTATGTGTGAAGACACAAA
GTATGGGGGAAGACAGCAATCAAAACTAACTTTTTGTAGATAGCCATTTCATTTCTTTAAACTGTTTCAACGCCAATATGTATTCTACAA
AAGAGAATGGTTTTAGGCTCCAGTGTTATACTTTTTTTTATATATATATATAAAAATAAACTTTACGTAGTGAAATCTTCCAAGTCTTTT
CTGGAATTATTATAAATACTTTAGTTTTATTTTCTCATCTTAATCTCTCCATAATTTCCCATTTAAAGGTTTACAAATATGAGTGTGTGG
ATGCTTTAATTCATTTAACCTCACTCCTCAAAGGTAACATGCAACTTAGTTCTGTTATATGAGAGTCTTTTTCTTTAATGTACTGGAAAA
AGCCTATGTGAATCTGTTGATAGAATTTAAAATTCCAGGCCGGGCGTGGTGGCTCACGACTGTAATCCCAGAACTTTGGGAGGCCAAGGC
AGGTGGATCACTTGAGGTCAGGAGTTCGAGACTAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAACAGCCAGGTGTGA
TGGTGCACGCTCGTAATCCCGGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGAAGGCAGAGGTTGCAGTGAGCTGAGATT
GTGCCACTGCACGCCAGCCTGGGCAAGAGAGTAAGACTCTCTCTCAAAAAAAAAAAAAAAGAATTTAAAATCCCAATTTATTTTCTAACT
CTTTTATTGGATGTATTTAGAACACAGTATACCTATAGTATACCTATGTGTTTATTATGTTTGTAAATGGTAACTGACATTTAATTATTA
GAAGTACTTACCCCTGCCTTCCTCCATTTTTATTCATGGCTACTTGAGAAAGCAAAAGGAAAAAATAATAGTTATCAGTAGTGTCACTGG
AAAGAAGAGAGGAGGGACAAAACTGAGCAGCAGAATTCGTATAGACATTTACGTTTAAATTCTAAAAGCCCAATTGAGATGTTCAGGGAG
GGTTTGTTTTGCCCTTTGGCCTCATGAATGGGTTTCATGAATGGGCTTCAGTGGCTTATAAACTCTGTAAAATTCTATTCTAAATTTTGT
ACATTTATTTTGTTCCGGTTAATTCCAGAAGACATTTCAAACATTTTTCTTACACCATATAATAAAAATACTTAACTAAATTGACAGTTA
TAAAAATAAATCAGTGAAATGTACCTTATACTTTAATAAAAAATGTTTTCAGAAATAGATAAGTGAAAGCTGAGTGTTTCTTTGATAGGT
TCCCCTGTACTATAGGAGTGATAATTGCAGCTATTGCAATAGTAGTAATTGTTAAATGGATACTAATGAATAGCATAGCATAGTGGGTAA
GAGTTTATATAGCACAGGCTCTAGAATCAGATTAAGTAGGTTCAAATACCAGTTCTGCCAGTAACTGGTTTTAGAACCTTGGGCAAGTTA
AAGAATGTCTCCCAGCCTCAGTTTCCCTATTTGTAAAATGGAAATAATGGTAGCTACCTCAAACCTCATTACGAATTCAATGAGTTAAAC
TTGAAAAGACTTATTACAGTAGCTGGCACATAAAGACTTGATAGTAGTTTATATGGATGCTATCTCATATTAGCATATATGGAATTAATA
GTGTATCACTATACTTTTTTTTTCTTTTTTTTTTTTGAATAGAGATCAGTCTATCACCCAGGCTGGAGTGCAGTGGTGACATCATAGCTC
ACTGTAACTTCTCCCATACTCTACCAATCCTCCTGCCTCAGCATCCAGACTAGCTGTGATTACAGGTGTGCACCACCACACCCAGCTACA
TTTTTTTTTGGTAGAGACAGGGTCTCACTATGTTACCCAGTCTGGTCTCAAACTCCCGGCCTCAAGCAATCCTCCCACTGGCCTCACAAT
GTTGGGATTACAGGTATAAGCCACTGCACACGGCCTTACTATGCTATCAATTCCATATATGGAAAGGTGTTTTCCCTTTCAGAGCTCTTT
AAAGCTCTGCAGAAGATTTACATGTGTTTATAGAGCTAAGAGAAATCAGGGCATGGAAATTGAGTGTGTAATAAAAATTAAACTCTTCAT
GTTATATAATCATGCATAACTTCTATCTTCATTCTCTGAAGTTGCCTAGAGCACCATCACAGCTAGGAAGCTTCCATCATGAATTACCTT
ATTTCCAAAAGCAAGTACTCAAATAATTGTCTCAAGAGAGGAAGGACAAAACTGTTACAAGCTGAAATATTTGGGGATTTGTTTGACTTG
ACTAGGGAACCACAAGTTTTCATATAATGCCTGATTTAGCCCTGTGCCTAACAGTTTAAATCTTAATGCTAATGTTAATTGCTTCCCAGT
TGGTTGACCTTATAAGAAAACACTGTGTGGTATTTTAATGTGGTAAACATGTGAATGAAGGCCTGTGGCTCAGTTAATCACTCCCACAAC
TTTGAGCTGTGAGTTTTACTGGTGGAAGGAACTTTAACAGGTCTTCGCTCTTGTCATTAGATATCAAAGAACTGAAATTAGTTGGAATTG

>In-frame_MDM2_ENST00000258149_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_3958nt
GCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGC
GACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCC
GGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCC
AAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGA
TTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATA
CTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAA
ATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAG
TAGTCAATCAGCAGGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTG
ATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCC
CAGAATGTGTTCAGTATCTTCAACAAGAATACCTGCCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGC
AGCCTGATGCTAAAGTTTTTAAAAATTACTTAAAGGTGTTCTTCCAGAGAGCAAAGCCCTGAGGACTGGATTTCCCTGTGCCTACTTCAT
GATCATGAATTCCAGTTAATTTATAAAGAGGCGATTTTTGTGTGCCATTCACACTGGTCTTTTTCACATTGTTTTGAGCTTATTGCAGTA
TATGTTTTGGGATTTTTCTGTAAAATGGGTGTAATTTTCCTAATACAGGTATGTAACAACAAAAGAAGTTGCCTGCATGCCGGTCCAAAT
TGTTCTGTATAAAGATGCTCTTAAAAGACACAAGAGTTATCCTAGAACCTTAATTCTTTTTTATTTGAAATTTTAAGTCAAGTCCTTTAT
AAAGACCATAGCAGTGGAAAACAGTGTACTTTTTAAAAAATTGCTGAATATAAAATCTTTGAAAATTTTCTTTATGTGTGAAGACACAAA
GTATGGGGGAAGACAGCAATCAAAACTAACTTTTTGTAGATAGCCATTTCATTTCTTTAAACTGTTTCAACGCCAATATGTATTCTACAA
AAGAGAATGGTTTTAGGCTCCAGTGTTATACTTTTTTTTATATATATATATAAAAATAAACTTTACGTAGTGAAATCTTCCAAGTCTTTT
CTGGAATTATTATAAATACTTTAGTTTTATTTTCTCATCTTAATCTCTCCATAATTTCCCATTTAAAGGTTTACAAATATGAGTGTGTGG
ATGCTTTAATTCATTTAACCTCACTCCTCAAAGGTAACATGCAACTTAGTTCTGTTATATGAGAGTCTTTTTCTTTAATGTACTGGAAAA
AGCCTATGTGAATCTGTTGATAGAATTTAAAATTCCAGGCCGGGCGTGGTGGCTCACGACTGTAATCCCAGAACTTTGGGAGGCCAAGGC
AGGTGGATCACTTGAGGTCAGGAGTTCGAGACTAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAACAGCCAGGTGTGA
TGGTGCACGCTCGTAATCCCGGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGAAGGCAGAGGTTGCAGTGAGCTGAGATT
GTGCCACTGCACGCCAGCCTGGGCAAGAGAGTAAGACTCTCTCTCAAAAAAAAAAAAAAAGAATTTAAAATCCCAATTTATTTTCTAACT
CTTTTATTGGATGTATTTAGAACACAGTATACCTATAGTATACCTATGTGTTTATTATGTTTGTAAATGGTAACTGACATTTAATTATTA
GAAGTACTTACCCCTGCCTTCCTCCATTTTTATTCATGGCTACTTGAGAAAGCAAAAGGAAAAAATAATAGTTATCAGTAGTGTCACTGG
AAAGAAGAGAGGAGGGACAAAACTGAGCAGCAGAATTCGTATAGACATTTACGTTTAAATTCTAAAAGCCCAATTGAGATGTTCAGGGAG
GGTTTGTTTTGCCCTTTGGCCTCATGAATGGGTTTCATGAATGGGCTTCAGTGGCTTATAAACTCTGTAAAATTCTATTCTAAATTTTGT
ACATTTATTTTGTTCCGGTTAATTCCAGAAGACATTTCAAACATTTTTCTTACACCATATAATAAAAATACTTAACTAAATTGACAGTTA
TAAAAATAAATCAGTGAAATGTACCTTATACTTTAATAAAAAATGTTTTCAGAAATAGATAAGTGAAAGCTGAGTGTTTCTTTGATAGGT
TCCCCTGTACTATAGGAGTGATAATTGCAGCTATTGCAATAGTAGTAATTGTTAAATGGATACTAATGAATAGCATAGCATAGTGGGTAA
GAGTTTATATAGCACAGGCTCTAGAATCAGATTAAGTAGGTTCAAATACCAGTTCTGCCAGTAACTGGTTTTAGAACCTTGGGCAAGTTA
AAGAATGTCTCCCAGCCTCAGTTTCCCTATTTGTAAAATGGAAATAATGGTAGCTACCTCAAACCTCATTACGAATTCAATGAGTTAAAC
TTGAAAAGACTTATTACAGTAGCTGGCACATAAAGACTTGATAGTAGTTTATATGGATGCTATCTCATATTAGCATATATGGAATTAATA
GTGTATCACTATACTTTTTTTTTCTTTTTTTTTTTTGAATAGAGATCAGTCTATCACCCAGGCTGGAGTGCAGTGGTGACATCATAGCTC
ACTGTAACTTCTCCCATACTCTACCAATCCTCCTGCCTCAGCATCCAGACTAGCTGTGATTACAGGTGTGCACCACCACACCCAGCTACA
TTTTTTTTTGGTAGAGACAGGGTCTCACTATGTTACCCAGTCTGGTCTCAAACTCCCGGCCTCAAGCAATCCTCCCACTGGCCTCACAAT
GTTGGGATTACAGGTATAAGCCACTGCACACGGCCTTACTATGCTATCAATTCCATATATGGAAAGGTGTTTTCCCTTTCAGAGCTCTTT
AAAGCTCTGCAGAAGATTTACATGTGTTTATAGAGCTAAGAGAAATCAGGGCATGGAAATTGAGTGTGTAATAAAAATTAAACTCTTCAT
GTTATATAATCATGCATAACTTCTATCTTCATTCTCTGAAGTTGCCTAGAGCACCATCACAGCTAGGAAGCTTCCATCATGAATTACCTT
ATTTCCAAAAGCAAGTACTCAAATAATTGTCTCAAGAGAGGAAGGACAAAACTGTTACAAGCTGAAATATTTGGGGATTTGTTTGACTTG
ACTAGGGAACCACAAGTTTTCATATAATGCCTGATTTAGCCCTGTGCCTAACAGTTTAAATCTTAATGCTAATGTTAATTGCTTCCCAGT
TGGTTGACCTTATAAGAAAACACTGTGTGGTATTTTAATGTGGTAAACATGTGAATGAAGGCCTGTGGCTCAGTTAATCACTCCCACAAC
TTTGAGCTGTGAGTTTTACTGGTGGAAGGAACTTTAACAGGTCTTCGCTCTTGTCATTAGATATCAAAGAACTGAAATTAGTTGGAATTG

>In-frame_MDM2_ENST00000258148_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_3685nt
CGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTC
CAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTA
TGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATG
ATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAG
TCAATCAGCAGGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATG
AAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCCCAG
AATGTGTTCAGTATCTTCAACAAGAATACCTGCCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGCAGC
CTGATGCTAAAGTTTTTAAAAATTACTTAAAGGTGTTCTTCCAGAGAGCAAAGCCCTGAGGACTGGATTTCCCTGTGCCTACTTCATGAT
CATGAATTCCAGTTAATTTATAAAGAGGCGATTTTTGTGTGCCATTCACACTGGTCTTTTTCACATTGTTTTGAGCTTATTGCAGTATAT
GTTTTGGGATTTTTCTGTAAAATGGGTGTAATTTTCCTAATACAGGTATGTAACAACAAAAGAAGTTGCCTGCATGCCGGTCCAAATTGT
TCTGTATAAAGATGCTCTTAAAAGACACAAGAGTTATCCTAGAACCTTAATTCTTTTTTATTTGAAATTTTAAGTCAAGTCCTTTATAAA
GACCATAGCAGTGGAAAACAGTGTACTTTTTAAAAAATTGCTGAATATAAAATCTTTGAAAATTTTCTTTATGTGTGAAGACACAAAGTA
TGGGGGAAGACAGCAATCAAAACTAACTTTTTGTAGATAGCCATTTCATTTCTTTAAACTGTTTCAACGCCAATATGTATTCTACAAAAG
AGAATGGTTTTAGGCTCCAGTGTTATACTTTTTTTTATATATATATATAAAAATAAACTTTACGTAGTGAAATCTTCCAAGTCTTTTCTG
GAATTATTATAAATACTTTAGTTTTATTTTCTCATCTTAATCTCTCCATAATTTCCCATTTAAAGGTTTACAAATATGAGTGTGTGGATG
CTTTAATTCATTTAACCTCACTCCTCAAAGGTAACATGCAACTTAGTTCTGTTATATGAGAGTCTTTTTCTTTAATGTACTGGAAAAAGC
CTATGTGAATCTGTTGATAGAATTTAAAATTCCAGGCCGGGCGTGGTGGCTCACGACTGTAATCCCAGAACTTTGGGAGGCCAAGGCAGG
TGGATCACTTGAGGTCAGGAGTTCGAGACTAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAACAGCCAGGTGTGATGG
TGCACGCTCGTAATCCCGGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGAAGGCAGAGGTTGCAGTGAGCTGAGATTGTG
CCACTGCACGCCAGCCTGGGCAAGAGAGTAAGACTCTCTCTCAAAAAAAAAAAAAAAGAATTTAAAATCCCAATTTATTTTCTAACTCTT
TTATTGGATGTATTTAGAACACAGTATACCTATAGTATACCTATGTGTTTATTATGTTTGTAAATGGTAACTGACATTTAATTATTAGAA
GTACTTACCCCTGCCTTCCTCCATTTTTATTCATGGCTACTTGAGAAAGCAAAAGGAAAAAATAATAGTTATCAGTAGTGTCACTGGAAA
GAAGAGAGGAGGGACAAAACTGAGCAGCAGAATTCGTATAGACATTTACGTTTAAATTCTAAAAGCCCAATTGAGATGTTCAGGGAGGGT
TTGTTTTGCCCTTTGGCCTCATGAATGGGTTTCATGAATGGGCTTCAGTGGCTTATAAACTCTGTAAAATTCTATTCTAAATTTTGTACA
TTTATTTTGTTCCGGTTAATTCCAGAAGACATTTCAAACATTTTTCTTACACCATATAATAAAAATACTTAACTAAATTGACAGTTATAA
AAATAAATCAGTGAAATGTACCTTATACTTTAATAAAAAATGTTTTCAGAAATAGATAAGTGAAAGCTGAGTGTTTCTTTGATAGGTTCC
CCTGTACTATAGGAGTGATAATTGCAGCTATTGCAATAGTAGTAATTGTTAAATGGATACTAATGAATAGCATAGCATAGTGGGTAAGAG
TTTATATAGCACAGGCTCTAGAATCAGATTAAGTAGGTTCAAATACCAGTTCTGCCAGTAACTGGTTTTAGAACCTTGGGCAAGTTAAAG
AATGTCTCCCAGCCTCAGTTTCCCTATTTGTAAAATGGAAATAATGGTAGCTACCTCAAACCTCATTACGAATTCAATGAGTTAAACTTG
AAAAGACTTATTACAGTAGCTGGCACATAAAGACTTGATAGTAGTTTATATGGATGCTATCTCATATTAGCATATATGGAATTAATAGTG
TATCACTATACTTTTTTTTTCTTTTTTTTTTTTGAATAGAGATCAGTCTATCACCCAGGCTGGAGTGCAGTGGTGACATCATAGCTCACT
GTAACTTCTCCCATACTCTACCAATCCTCCTGCCTCAGCATCCAGACTAGCTGTGATTACAGGTGTGCACCACCACACCCAGCTACATTT
TTTTTTGGTAGAGACAGGGTCTCACTATGTTACCCAGTCTGGTCTCAAACTCCCGGCCTCAAGCAATCCTCCCACTGGCCTCACAATGTT
GGGATTACAGGTATAAGCCACTGCACACGGCCTTACTATGCTATCAATTCCATATATGGAAAGGTGTTTTCCCTTTCAGAGCTCTTTAAA
GCTCTGCAGAAGATTTACATGTGTTTATAGAGCTAAGAGAAATCAGGGCATGGAAATTGAGTGTGTAATAAAAATTAAACTCTTCATGTT
ATATAATCATGCATAACTTCTATCTTCATTCTCTGAAGTTGCCTAGAGCACCATCACAGCTAGGAAGCTTCCATCATGAATTACCTTATT
TCCAAAAGCAAGTACTCAAATAATTGTCTCAAGAGAGGAAGGACAAAACTGTTACAAGCTGAAATATTTGGGGATTTGTTTGACTTGACT
AGGGAACCACAAGTTTTCATATAATGCCTGATTTAGCCCTGTGCCTAACAGTTTAAATCTTAATGCTAATGTTAATTGCTTCCCAGTTGG
TTGACCTTATAAGAAAACACTGTGTGGTATTTTAATGTGGTAAACATGTGAATGAAGGCCTGTGGCTCAGTTAATCACTCCCACAACTTT
GAGCTGTGAGTTTTACTGGTGGAAGGAACTTTAACAGGTCTTCGCTCTTGTCATTAGATATCAAAGAACTGAAATTAGTTGGAATTGTAA

>In-frame_MDM2_ENST00000350057_chr12_69222710_+_XPOT_ENST00000332707_chr12_64833023_+_3743nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAATTA
TCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATA
TGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGGCCCAGAATGTGTTCAGTATCTTCAACAAGAATACCTG
CCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCGCTTCAGCAGCCTGATGCTAAAGTTTTTAAAAATTACTTAAAG
GTGTTCTTCCAGAGAGCAAAGCCCTGAGGACTGGATTTCCCTGTGCCTACTTCATGATCATGAATTCCAGTTAATTTATAAAGAGGCGAT
TTTTGTGTGCCATTCACACTGGTCTTTTTCACATTGTTTTGAGCTTATTGCAGTATATGTTTTGGGATTTTTCTGTAAAATGGGTGTAAT
TTTCCTAATACAGGTATGTAACAACAAAAGAAGTTGCCTGCATGCCGGTCCAAATTGTTCTGTATAAAGATGCTCTTAAAAGACACAAGA
GTTATCCTAGAACCTTAATTCTTTTTTATTTGAAATTTTAAGTCAAGTCCTTTATAAAGACCATAGCAGTGGAAAACAGTGTACTTTTTA
AAAAATTGCTGAATATAAAATCTTTGAAAATTTTCTTTATGTGTGAAGACACAAAGTATGGGGGAAGACAGCAATCAAAACTAACTTTTT
GTAGATAGCCATTTCATTTCTTTAAACTGTTTCAACGCCAATATGTATTCTACAAAAGAGAATGGTTTTAGGCTCCAGTGTTATACTTTT
TTTTATATATATATATAAAAATAAACTTTACGTAGTGAAATCTTCCAAGTCTTTTCTGGAATTATTATAAATACTTTAGTTTTATTTTCT
CATCTTAATCTCTCCATAATTTCCCATTTAAAGGTTTACAAATATGAGTGTGTGGATGCTTTAATTCATTTAACCTCACTCCTCAAAGGT
AACATGCAACTTAGTTCTGTTATATGAGAGTCTTTTTCTTTAATGTACTGGAAAAAGCCTATGTGAATCTGTTGATAGAATTTAAAATTC
CAGGCCGGGCGTGGTGGCTCACGACTGTAATCCCAGAACTTTGGGAGGCCAAGGCAGGTGGATCACTTGAGGTCAGGAGTTCGAGACTAG
CCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAACAGCCAGGTGTGATGGTGCACGCTCGTAATCCCGGCTACTCAGGAGGC
TGAGGCAGGAGAATCGCTTGAACCCGGAAGGCAGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACGCCAGCCTGGGCAAGAGAGTAAG
ACTCTCTCTCAAAAAAAAAAAAAAAGAATTTAAAATCCCAATTTATTTTCTAACTCTTTTATTGGATGTATTTAGAACACAGTATACCTA
TAGTATACCTATGTGTTTATTATGTTTGTAAATGGTAACTGACATTTAATTATTAGAAGTACTTACCCCTGCCTTCCTCCATTTTTATTC
ATGGCTACTTGAGAAAGCAAAAGGAAAAAATAATAGTTATCAGTAGTGTCACTGGAAAGAAGAGAGGAGGGACAAAACTGAGCAGCAGAA
TTCGTATAGACATTTACGTTTAAATTCTAAAAGCCCAATTGAGATGTTCAGGGAGGGTTTGTTTTGCCCTTTGGCCTCATGAATGGGTTT
CATGAATGGGCTTCAGTGGCTTATAAACTCTGTAAAATTCTATTCTAAATTTTGTACATTTATTTTGTTCCGGTTAATTCCAGAAGACAT
TTCAAACATTTTTCTTACACCATATAATAAAAATACTTAACTAAATTGACAGTTATAAAAATAAATCAGTGAAATGTACCTTATACTTTA
ATAAAAAATGTTTTCAGAAATAGATAAGTGAAAGCTGAGTGTTTCTTTGATAGGTTCCCCTGTACTATAGGAGTGATAATTGCAGCTATT
GCAATAGTAGTAATTGTTAAATGGATACTAATGAATAGCATAGCATAGTGGGTAAGAGTTTATATAGCACAGGCTCTAGAATCAGATTAA
GTAGGTTCAAATACCAGTTCTGCCAGTAACTGGTTTTAGAACCTTGGGCAAGTTAAAGAATGTCTCCCAGCCTCAGTTTCCCTATTTGTA
AAATGGAAATAATGGTAGCTACCTCAAACCTCATTACGAATTCAATGAGTTAAACTTGAAAAGACTTATTACAGTAGCTGGCACATAAAG
ACTTGATAGTAGTTTATATGGATGCTATCTCATATTAGCATATATGGAATTAATAGTGTATCACTATACTTTTTTTTTCTTTTTTTTTTT
TGAATAGAGATCAGTCTATCACCCAGGCTGGAGTGCAGTGGTGACATCATAGCTCACTGTAACTTCTCCCATACTCTACCAATCCTCCTG
CCTCAGCATCCAGACTAGCTGTGATTACAGGTGTGCACCACCACACCCAGCTACATTTTTTTTTGGTAGAGACAGGGTCTCACTATGTTA
CCCAGTCTGGTCTCAAACTCCCGGCCTCAAGCAATCCTCCCACTGGCCTCACAATGTTGGGATTACAGGTATAAGCCACTGCACACGGCC
TTACTATGCTATCAATTCCATATATGGAAAGGTGTTTTCCCTTTCAGAGCTCTTTAAAGCTCTGCAGAAGATTTACATGTGTTTATAGAG
CTAAGAGAAATCAGGGCATGGAAATTGAGTGTGTAATAAAAATTAAACTCTTCATGTTATATAATCATGCATAACTTCTATCTTCATTCT
CTGAAGTTGCCTAGAGCACCATCACAGCTAGGAAGCTTCCATCATGAATTACCTTATTTCCAAAAGCAAGTACTCAAATAATTGTCTCAA
GAGAGGAAGGACAAAACTGTTACAAGCTGAAATATTTGGGGATTTGTTTGACTTGACTAGGGAACCACAAGTTTTCATATAATGCCTGAT
TTAGCCCTGTGCCTAACAGTTTAAATCTTAATGCTAATGTTAATTGCTTCCCAGTTGGTTGACCTTATAAGAAAACACTGTGTGGTATTT
TAATGTGGTAAACATGTGAATGAAGGCCTGTGGCTCAGTTAATCACTCCCACAACTTTGAGCTGTGAGTTTTACTGGTGGAAGGAACTTT
AACAGGTCTTCGCTCTTGTCATTAGATATCAAAGAACTGAAATTAGTTGGAATTGTAAGCAGTGAATAGATGTGTTGTTAGAATGATTCC


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FusionGenePPI for MDM2_XPOT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MDM2TP53, MDC1, CTBP1, CTBP2, TP73, PML, RPL11, RPL5, CDKN2A, NUMB, UBE2A, HIF1A, KAT5, HDAC1, EID1, MDM4, KAT2B, EP300, TBP, TAF1, MDM2, ESR1, ARRB2, ABL1, CCNG1, ARRB1, TSG101, RB1, MTBP, FKBP3, RYBP, RRM2B, RPL26, GNAS, FOXO4, IGF1R, DAXX, DHFR, GNL3, CCAR1, PSMD10, PSME3, PTK2, AR, PPM1D, USP7, COPS5, SFN, RBBP6, CDH1, CHEK2, YWHAQ, NCL, UBE2G2, UBE2U, UBE2Z, PYHIN1, BANP, DDX17, E2F1, TRIM28, UBC, GATA3, ATF3, HIST2H2BE, RPL23, YY1, AKT1, RAD23A, CDKN1A, NR3C1, UBE2I, HIST3H3, EHMT1, SUV39H1, RPS27L, RPS27, ADRB2, SIVA1, MTA1, RCHY1, UBE2D1, CASP2, RPS27A, RPS7, G3BP2, PSMD2, PAK1IP1, RPS6KB1, ZNF668, TP63, PCNA, USP10, PSMC1, PSMD4, PSMC3, PSMC5, PSMC6, PSMA7, PSMD1, RUNX3, GNL3L, TERT, APEX1, UIMC1, CREBBP, SOX4, UBE4B, TBRG1, BAIAP2L1, RFWD3, ERBB3, PA2G4, HEXIM1, CDK9, DYRK2, HSP90AA1, HSPA4, HSPA8, LAMP2, RPS3, USP2, TRIM13, XRCC6, GORAB, FOXO1, FOXO3, UCHL1, S100A1, S100A2, S100A4, S100A6, S100B, USP42, CUL1, BTRC, FBXW11, CSNK1D, RFWD2, SMURF1, NOTCH4, CSNK1A1, PDLIM7, SENP3, RN5S1@, PDE4D, NOTCH1, SNAI1, RASSF1, TRIM27, RFFL, RPS14, PPP2R4, TTF1, PSMB6, PSMA8, RASSF3, NR0B2, UBE2B, PIAS1, RANBP1, LATS1, RAD50, NBN, MRE11A, CUL4A, DTL, PIM1, GSK3B, PSMA3, ESR2, ADRBK1, AATF, HNRNPK, BUB1B, SUMO1, RASSF5, UBE2D2, POLH, NPM1, TCAP, CDK5RAP3, ARIH2, IRF2, RPS25, TPT1, ANG, RHOA, PDCD5, CDKN2AIP, LATS2, WWOX, MED1, ERCC6, ERCC8, DDB1, CUL4B, HIPK2, DHRS2, CASP3, ITCH, EEF1A1, DCD, TUBB, TUBB2A, KRT14, RPS20, GAPDH, TUBA1C, GSN, ERBB4, XIAP, HNF4A, PLK1, NME2, NEDD4, DAPK1, DAPK3, ATM, PBX1, UBE2D3, UBE3A, UBE2L3, UBE2E2, UBE2E3, RNF2, EGR1, PAK6, DLG4, IRF1, VCP, STRA13, GADD45A, RABL6, RPS26, RPL37, RPS15, RNF8, TRIM4, TRIM23, TRAF5, TRIM9, MKRN3, PHF7, RNF10, RNF126, UBE2K, LMO7, HLA-DMB, SETDB1, YY1AP1, NACA, ATF4, MYD88, RELA, SDHC, WT1, SORBS2, HRSP12, DNAJB4, GCAT, SHPK, POT1, ANKRD17, GLTSCR2, SESN2, RASSF6, JUND, EZR, RYR2, JUN, CLSTN1, APP, CLU, SREK1, SET, HSP90B1, CWC25, ZNF133, PKM, TAB1, RPL6, AURKA, NOC2L, JAK1, XPC, PGAM1, PGAM2, DNAJB1, ANAPC2, NLK, SNAI2, RBM38, FHIT, AGPS, ALDH16A1, DDX5, DHX9, DLAT, EDC4, EIF2AK1, ESYT1, GTF2I, HMHA1, HNRNPM, HNRNPU, HRNR, HSP90AB1, IARS, IFI16, IGF2BP3, ILF3, KARS, CCAR2, NEK9, OGDH, OGDHL, RARS, RBBP8, RECQL, SF3B1, SFPQ, TOP1, ZNF318, PER2, SIRT6, TSC22D3, RPS6, UBE2M, RAD54B, SMARCA2, ACACA, PTBP1, IYD, ACTB, HNRNPD, U2AF2, FUBP1, TFRC, EEF2, XPO1, KRT2, EIF3B, SND1, DCAF8, USO1, EFTUD2, EXOSC6, IPO7, SF3B3, DET1, UBE2N, RPL10A, DIRAS3, SURF2, RFPL2, CMSS1, PPARD, RPL22L1, IER2, MAGEA2, ZNF420, ELF4, ABL2, SRC, HCK, GTF2E2, ATP2A2, BRINP1, C19orf10, CANX, MS4A1, PDIA3, PPIB, RAB8A, RPS23, RUVBL2, SMARCA4, SMARCE1, SRSF11, TPR, UBTF, PPARG, VDR, FBXO31, TFIP11, SETD7, PPP1CA, RARA, DDX24, NAT10, CCND1, RLIM, IER3, FHL2, RPL23A, SUZ12, EZH2, EED, RRM1, RPL4, NOLC1, DDX42, MAP2, NUCKS1, RRP1, PDS5A, RPL36A, TP53RK, RPL15, NPIPB3, HMGN1, MAP1LC3A, PRDM2, KIAA1551, PBXIP1, SP1, SHARPIN, MAPKAPK2, USP15, USP26, FKBP1A, NGFR, SMG7, RSL1D1, SIRT1, SIRT7, SIRT2, SIRT3, KPNA1, KPNA6, MSI2, PHLDB3, CLPB, XAGE1B, ZNF550, YAF2, PDGFB, ARNTL2, RPS11, TSPYL6, HIST1H2BJ, ZNF764, MAK16, ZNF274, PPAN, RPL37A, CRTC2, CRTC3, TRIM25, CSNK2A1, CSNK2B, CSNK2A2, HEY1, RANBP2XPOTHDLBP, RAN, AIRE, CAMKK2, CLN3, MYC, HDAC5, SIRT7, FBXO25, CUL5, USP7, TXNL1, ECT2, CA9, IQCB1, EGFR, FBXO6, APEX1, PAPSS1, MCMBP, NFRKB, RNF2, HTR6, GCSH, NAA40, PSMA3, PSMA4, WDR11, PSMB2, NTRK1, XRCC1, HDAC6, FBXO7, FAM46A, ARMC6, RNF126, DPF3, PTPRE, CDC14B, EPHA1, PTPRA, PTPRN, AAR2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneMDM2chr12:69222710chr12:64833023ENST00000462284+811150_230228498PYHIN1 and necessary for interaction with RFFL and RNF34


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMDM2chr12:69222710chr12:64833023ENST00000258149+69170_306167437MTBP
HgeneMDM2chr12:69222710chr12:64833023ENST00000299252+15170_3060322MTBP
HgeneMDM2chr12:69222710chr12:64833023ENST00000348801+13170_3060266MTBP
HgeneMDM2chr12:69222710chr12:64833023ENST00000356290+16170_306-102322MTBP
HgeneMDM2chr12:69222710chr12:64833023ENST00000360430+14170_3060297MTBP
HgeneMDM2chr12:69222710chr12:64833023ENST00000393412+13170_306-92219MTBP
HgeneMDM2chr12:69222710chr12:64833023ENST00000393413+12170_3060219MTBP
HgeneMDM2chr12:69222710chr12:64833023ENST00000428863+14170_306-102271MTBP
HgeneMDM2chr12:69222710chr12:64833023ENST00000462284+811170_306228498MTBP
HgeneMDM2chr12:69222710chr12:64833023ENST00000540827+15170_306-102297MTBP
HgeneMDM2chr12:69222710chr12:64833023ENST00000258149+69150_230167437PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222710chr12:64833023ENST00000299252+15150_2300322PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222710chr12:64833023ENST00000348801+13150_2300266PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222710chr12:64833023ENST00000356290+16150_230-102322PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222710chr12:64833023ENST00000360430+14150_2300297PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222710chr12:64833023ENST00000393412+13150_230-92219PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222710chr12:64833023ENST00000393413+12150_2300219PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222710chr12:64833023ENST00000428863+14150_230-102271PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222710chr12:64833023ENST00000540827+15150_230-102297PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222710chr12:64833023ENST00000258149+69223_232167437USP7
HgeneMDM2chr12:69222710chr12:64833023ENST00000299252+15223_2320322USP7
HgeneMDM2chr12:69222710chr12:64833023ENST00000348801+13223_2320266USP7
HgeneMDM2chr12:69222710chr12:64833023ENST00000356290+16223_232-102322USP7
HgeneMDM2chr12:69222710chr12:64833023ENST00000360430+14223_2320297USP7
HgeneMDM2chr12:69222710chr12:64833023ENST00000393412+13223_232-92219USP7
HgeneMDM2chr12:69222710chr12:64833023ENST00000393413+12223_2320219USP7
HgeneMDM2chr12:69222710chr12:64833023ENST00000428863+14223_232-102271USP7
HgeneMDM2chr12:69222710chr12:64833023ENST00000462284+811223_232228498USP7
HgeneMDM2chr12:69222710chr12:64833023ENST00000540827+15223_232-102297USP7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MDM2_XPOT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMDM2Q00987DB01593ZincE3 ubiquitin-protein ligase Mdm2small moleculeapproved|investigational

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RelatedDiseases for MDM2_XPOT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMDM2C0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneMDM2C0007621Neoplastic Cell Transformation1CTD_human
HgeneMDM2C0019693HIV Infections1CTD_human
HgeneMDM2C0021364Male infertility1CTD_human
HgeneMDM2C0025202melanoma1CTD_human
HgeneMDM2C0032927Precancerous Conditions1CTD_human
HgeneMDM2C0033578Prostatic Neoplasms1CTD_human
HgeneMDM2C1458155Mammary Neoplasms1CTD_human