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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 21387

FusionGeneSummary for MDM2_IL22

check button Fusion gene summary
Fusion gene informationFusion gene name: MDM2_IL22
Fusion gene ID: 21387
HgeneTgene
Gene symbol

MDM2

IL22

Gene ID

4193

50616

Gene nameMDM2 proto-oncogeneinterleukin 22
SynonymsACTFS|HDMX|hdm2IL-21|IL-22|IL-D110|IL-TIF|ILTIF|TIFIL-23|TIFa|zcyto18
Cytomap

12q15

12q15

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, huminterleukin-22IL-10-related T-cell-derived inducible factorcytokine Zcyto18
Modification date2018052720180527
UniProtAcc

Q00987

Q9GZX6

Ensembl transtripts involved in fusion geneENST00000462284, ENST00000356290, 
ENST00000540827, ENST00000258149, 
ENST00000428863, ENST00000393412, 
ENST00000258148, ENST00000544561, 
ENST00000393410, ENST00000393413, 
ENST00000517852, ENST00000545204, 
ENST00000350057, ENST00000360430, 
ENST00000299252, ENST00000348801, 
ENST00000478070, ENST00000544125, 
ENST00000538666, ENST00000328087, 
Fusion gene scores* DoF score24 X 14 X 8=26883 X 2 X 2=12
# samples 253
** MAII scorelog2(25/2688*10)=-3.42653313811667
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MDM2 [Title/Abstract] AND IL22 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

HgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

HgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

HgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

HgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

HgeneMDM2

GO:0034504

protein localization to nucleus

10360174

HgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

HgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

HgeneMDM2

GO:0045184

establishment of protein localization

10360174

HgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

HgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

HgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

HgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

HgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

HgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-WK-A8XO-01AMDM2chr12

69222711

+IL22chr12

68642656

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000462284ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
Frame-shitENST00000462284ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000356290ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000356290ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000540827ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000540827ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
In-frameENST00000258149ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
Frame-shitENST00000258149ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000428863ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000428863ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000393412ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000393412ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
In-frameENST00000258148ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
Frame-shitENST00000258148ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000544561ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000544561ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000393410ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000393410ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000393413ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000393413ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000517852ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000517852ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000545204ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000545204ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
In-frameENST00000350057ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
Frame-shitENST00000350057ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000360430ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000360430ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000299252ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000299252ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000348801ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000348801ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000478070ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000478070ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000544125ENST00000538666MDM2chr12

69222711

+IL22chr12

68642656

-
intron-3CDSENST00000544125ENST00000328087MDM2chr12

69222711

+IL22chr12

68642656

-

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FusionProtFeatures for MDM2_IL22


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MDM2

Q00987

IL22

Q9GZX6

Cytokine that contributes to the inflammatory responsein vivo.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69222711chr12:68642656ENST00000462284+811210_215228498Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222711chr12:68642656ENST00000258149+6927_107167437DomainNote=SWIB
HgeneMDM2chr12:69222711chr12:68642656ENST00000462284+81127_107228498DomainNote=SWIB
HgeneMDM2chr12:69222711chr12:68642656ENST00000462284+811179_185228498MotifNuclear localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000462284+811190_202228498MotifNote=Nuclear export signal

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69222711chr12:68642656ENST00000258149+69210_215167437Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222711chr12:68642656ENST00000258149+69243_301167437Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222711chr12:68642656ENST00000299252+15210_2150322Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222711chr12:68642656ENST00000299252+15243_3010322Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222711chr12:68642656ENST00000348801+13210_2150266Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222711chr12:68642656ENST00000348801+13243_3010266Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222711chr12:68642656ENST00000356290+16210_215-102322Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222711chr12:68642656ENST00000356290+16243_301-102322Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222711chr12:68642656ENST00000360430+14210_2150297Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222711chr12:68642656ENST00000360430+14243_3010297Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222711chr12:68642656ENST00000393412+13210_215-92219Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222711chr12:68642656ENST00000393412+13243_301-92219Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222711chr12:68642656ENST00000393413+12210_2150219Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222711chr12:68642656ENST00000393413+12243_3010219Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222711chr12:68642656ENST00000428863+14210_215-102271Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222711chr12:68642656ENST00000428863+14243_301-102271Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222711chr12:68642656ENST00000462284+811243_301228498Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222711chr12:68642656ENST00000540827+15210_215-102297Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69222711chr12:68642656ENST00000540827+15243_301-102297Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69222711chr12:68642656ENST00000299252+1527_1070322DomainNote=SWIB
HgeneMDM2chr12:69222711chr12:68642656ENST00000348801+1327_1070266DomainNote=SWIB
HgeneMDM2chr12:69222711chr12:68642656ENST00000356290+1627_107-102322DomainNote=SWIB
HgeneMDM2chr12:69222711chr12:68642656ENST00000360430+1427_1070297DomainNote=SWIB
HgeneMDM2chr12:69222711chr12:68642656ENST00000393412+1327_107-92219DomainNote=SWIB
HgeneMDM2chr12:69222711chr12:68642656ENST00000393413+1227_1070219DomainNote=SWIB
HgeneMDM2chr12:69222711chr12:68642656ENST00000428863+1427_107-102271DomainNote=SWIB
HgeneMDM2chr12:69222711chr12:68642656ENST00000540827+1527_107-102297DomainNote=SWIB
HgeneMDM2chr12:69222711chr12:68642656ENST00000258149+69179_185167437MotifNuclear localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000258149+69190_202167437MotifNote=Nuclear export signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000258149+69466_473167437MotifNucleolar localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000299252+15179_1850322MotifNuclear localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000299252+15190_2020322MotifNote=Nuclear export signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000299252+15466_4730322MotifNucleolar localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000348801+13179_1850266MotifNuclear localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000348801+13190_2020266MotifNote=Nuclear export signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000348801+13466_4730266MotifNucleolar localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000356290+16179_185-102322MotifNuclear localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000356290+16190_202-102322MotifNote=Nuclear export signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000356290+16466_473-102322MotifNucleolar localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000360430+14179_1850297MotifNuclear localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000360430+14190_2020297MotifNote=Nuclear export signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000360430+14466_4730297MotifNucleolar localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000393412+13179_185-92219MotifNuclear localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000393412+13190_202-92219MotifNote=Nuclear export signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000393412+13466_473-92219MotifNucleolar localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000393413+12179_1850219MotifNuclear localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000393413+12190_2020219MotifNote=Nuclear export signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000393413+12466_4730219MotifNucleolar localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000428863+14179_185-102271MotifNuclear localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000428863+14190_202-102271MotifNote=Nuclear export signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000428863+14466_473-102271MotifNucleolar localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000462284+811466_473228498MotifNucleolar localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000540827+15179_185-102297MotifNuclear localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000540827+15190_202-102297MotifNote=Nuclear export signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000540827+15466_473-102297MotifNucleolar localization signal
HgeneMDM2chr12:69222711chr12:68642656ENST00000258149+69210_304167437RegionNote=ARF-binding
HgeneMDM2chr12:69222711chr12:68642656ENST00000258149+69242_331167437RegionNote=Region II
HgeneMDM2chr12:69222711chr12:68642656ENST00000299252+15210_3040322RegionNote=ARF-binding
HgeneMDM2chr12:69222711chr12:68642656ENST00000299252+15242_3310322RegionNote=Region II
HgeneMDM2chr12:69222711chr12:68642656ENST00000348801+13210_3040266RegionNote=ARF-binding
HgeneMDM2chr12:69222711chr12:68642656ENST00000348801+13242_3310266RegionNote=Region II
HgeneMDM2chr12:69222711chr12:68642656ENST00000356290+16210_304-102322RegionNote=ARF-binding
HgeneMDM2chr12:69222711chr12:68642656ENST00000356290+16242_331-102322RegionNote=Region II
HgeneMDM2chr12:69222711chr12:68642656ENST00000360430+14210_3040297RegionNote=ARF-binding
HgeneMDM2chr12:69222711chr12:68642656ENST00000360430+14242_3310297RegionNote=Region II
HgeneMDM2chr12:69222711chr12:68642656ENST00000393412+13210_304-92219RegionNote=ARF-binding
HgeneMDM2chr12:69222711chr12:68642656ENST00000393412+13242_331-92219RegionNote=Region II
HgeneMDM2chr12:69222711chr12:68642656ENST00000393413+12210_3040219RegionNote=ARF-binding
HgeneMDM2chr12:69222711chr12:68642656ENST00000393413+12242_3310219RegionNote=Region II
HgeneMDM2chr12:69222711chr12:68642656ENST00000428863+14210_304-102271RegionNote=ARF-binding
HgeneMDM2chr12:69222711chr12:68642656ENST00000428863+14242_331-102271RegionNote=Region II
HgeneMDM2chr12:69222711chr12:68642656ENST00000462284+811210_304228498RegionNote=ARF-binding
HgeneMDM2chr12:69222711chr12:68642656ENST00000462284+811242_331228498RegionNote=Region II
HgeneMDM2chr12:69222711chr12:68642656ENST00000540827+15210_304-102297RegionNote=ARF-binding
HgeneMDM2chr12:69222711chr12:68642656ENST00000540827+15242_331-102297RegionNote=Region II
HgeneMDM2chr12:69222711chr12:68642656ENST00000258149+69299_328167437Zinc fingerRanBP2-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000258149+69438_479167437Zinc fingerRING-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000299252+15299_3280322Zinc fingerRanBP2-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000299252+15438_4790322Zinc fingerRING-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000348801+13299_3280266Zinc fingerRanBP2-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000348801+13438_4790266Zinc fingerRING-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000356290+16299_328-102322Zinc fingerRanBP2-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000356290+16438_479-102322Zinc fingerRING-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000360430+14299_3280297Zinc fingerRanBP2-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000360430+14438_4790297Zinc fingerRING-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000393412+13299_328-92219Zinc fingerRanBP2-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000393412+13438_479-92219Zinc fingerRING-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000393413+12299_3280219Zinc fingerRanBP2-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000393413+12438_4790219Zinc fingerRING-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000428863+14299_328-102271Zinc fingerRanBP2-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000428863+14438_479-102271Zinc fingerRING-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000462284+811299_328228498Zinc fingerRanBP2-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000462284+811438_479228498Zinc fingerRING-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000540827+15299_328-102297Zinc fingerRanBP2-type
HgeneMDM2chr12:69222711chr12:68642656ENST00000540827+15438_479-102297Zinc fingerRING-type


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FusionGeneSequence for MDM2_IL22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MDM2_ENST00000462284_chr12_69222711_+_IL22_ENST00000538666_chr12_68642656_-_254aa
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTTTMKEVLFTLGQTIMTKRLTDEKQQHIVTCSNDLLGD
LFGVPSFSVKEHRKITTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE

>In-frame_MDM2_ENST00000258149_chr12_69222711_+_IL22_ENST00000538666_chr12_68642656_-_193aa
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTTTMKEVLFTLGQTIMTKRLTDEKQQHIVTCSNDLLGDLFGVPS
FSVKEHRKITTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPLGESGEIKAIGEL

>In-frame_MDM2_ENST00000258148_chr12_69222711_+_IL22_ENST00000538666_chr12_68642656_-_199aa
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTTTMKEVLFTLGQTIMTKRLTDEKQQHIVTCSNDLLGD
LFGVPSFSVKEHRKITTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPLGESGEI

>In-frame_MDM2_ENST00000350057_chr12_69222711_+_IL22_ENST00000538666_chr12_68642656_-_223aa
MCNTNMSVPTDGAVTTSQIPASEQETLVLFTLGQTIMTKRLTDEKQQHIVTCSNDLLGDLFGVPSFSVKEHRKITTMIYRNLVVVNQQES
SDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MDM2_ENST00000462284_chr12_69222711_+_IL22_ENST00000538666_chr12_68642656_-_762nt
ATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAA
GAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTTCTT
TTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGAT
TTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAA
TCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAA
GAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAA
TTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAG
ATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGCTTGGAGAGAGTGGAGAGATCAAAGCAATTGGAGAA

>In-frame_MDM2_ENST00000258149_chr12_69222711_+_IL22_ENST00000538666_chr12_68642656_-_579nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA
AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTAT
ATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGC
TTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAAGAAAATTCAGATGAATTA
TCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATA
TGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGCTTGGAGAGAGTGGAGAGATCAAAGCAATTGGAGAACTG

>In-frame_MDM2_ENST00000258148_chr12_69222711_+_IL22_ENST00000538666_chr12_68642656_-_597nt
ATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAA
GAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTTCTT
TTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGAT
TTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAA
GAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTG
TGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGCTTGGAGAGAGTGGAGAGATC

>In-frame_MDM2_ENST00000350057_chr12_69222711_+_IL22_ENST00000538666_chr12_68642656_-_669nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAATTA
TCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATA
TGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGCTTGGAGAGAGTGGAGAGATCAAAGCAATTGGAGAACTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_MDM2_ENST00000462284_chr12_69222711_+_IL22_ENST00000538666_chr12_68642656_-_1621nt
GGGGCGCGCACCGAGGCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGC
CCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGC
CCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGA
GGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTG
TAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCAC
AAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATA
TTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCT
ACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTG
ATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAG
CAATTAGTGAGACAGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTG
ATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGCTTG
GAGAGAGTGGAGAGATCAAAGCAATTGGAGAACTGGATTTGCTGTTTATGTCTCTGAGAAATGCCTGCATTTGACCAGAGCAAAGCTGAA
AAATGAATAACTAACCCCCTTTCCCTGCTAGAAATAACAATTAGATGCCCCAAAGCGATTTTTTTTAACCAAAAGGAAGATGGGAAGCCA
AACTCCATCATGATGGGTGGATTCCAAATGAACCCCTGCGTTAGTTACAAAGGAAACCAATGCCACTTTTGTTTATAAGACCAGAAGGTA
GACTTTCTAAGCATAGATATTTATTGATAACATTTCATTGTAACTGGTGTTCTATACACAGAAAACAATTTATTTTTTAAATAATTGTCT
TTTTCCATAAAAAAGATTACTTTCCATTCCTTTAGGGGAAAAAACCCCTAAATAGCTTCATGTTTCCATAATCAGTACTTTATATTTATA
AATGTATTTATTATTATTATAAGACTGCATTTTATTTATATCATTTTATTAATATGGATTTATTTATAGAAACATCATTCGATATTGCTA
CTTGAGTGTAAGGCTAATATTGATATTTATGACAATAATTATAGAGCTATAACATGTTTATTTGACCTCAATAAACACTTGGATATCCTA

>In-frame_MDM2_ENST00000258149_chr12_69222711_+_IL22_ENST00000538666_chr12_68642656_-_1441nt
GCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGC
GACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCC
GGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCC
AAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGA
TTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATA
CTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAA
ATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAG
TAGTCAATCAGCAGGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTG
ATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGCTTG
GAGAGAGTGGAGAGATCAAAGCAATTGGAGAACTGGATTTGCTGTTTATGTCTCTGAGAAATGCCTGCATTTGACCAGAGCAAAGCTGAA
AAATGAATAACTAACCCCCTTTCCCTGCTAGAAATAACAATTAGATGCCCCAAAGCGATTTTTTTTAACCAAAAGGAAGATGGGAAGCCA
AACTCCATCATGATGGGTGGATTCCAAATGAACCCCTGCGTTAGTTACAAAGGAAACCAATGCCACTTTTGTTTATAAGACCAGAAGGTA
GACTTTCTAAGCATAGATATTTATTGATAACATTTCATTGTAACTGGTGTTCTATACACAGAAAACAATTTATTTTTTAAATAATTGTCT
TTTTCCATAAAAAAGATTACTTTCCATTCCTTTAGGGGAAAAAACCCCTAAATAGCTTCATGTTTCCATAATCAGTACTTTATATTTATA
AATGTATTTATTATTATTATAAGACTGCATTTTATTTATATCATTTTATTAATATGGATTTATTTATAGAAACATCATTCGATATTGCTA
CTTGAGTGTAAGGCTAATATTGATATTTATGACAATAATTATAGAGCTATAACATGTTTATTTGACCTCAATAAACACTTGGATATCCTA

>In-frame_MDM2_ENST00000258148_chr12_69222711_+_IL22_ENST00000538666_chr12_68642656_-_1168nt
CGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTC
CAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTA
TGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATG
ATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAG
TCAATCAGCAGGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATG
AAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGCTTGGAG
AGAGTGGAGAGATCAAAGCAATTGGAGAACTGGATTTGCTGTTTATGTCTCTGAGAAATGCCTGCATTTGACCAGAGCAAAGCTGAAAAA
TGAATAACTAACCCCCTTTCCCTGCTAGAAATAACAATTAGATGCCCCAAAGCGATTTTTTTTAACCAAAAGGAAGATGGGAAGCCAAAC
TCCATCATGATGGGTGGATTCCAAATGAACCCCTGCGTTAGTTACAAAGGAAACCAATGCCACTTTTGTTTATAAGACCAGAAGGTAGAC
TTTCTAAGCATAGATATTTATTGATAACATTTCATTGTAACTGGTGTTCTATACACAGAAAACAATTTATTTTTTAAATAATTGTCTTTT
TCCATAAAAAAGATTACTTTCCATTCCTTTAGGGGAAAAAACCCCTAAATAGCTTCATGTTTCCATAATCAGTACTTTATATTTATAAAT
GTATTTATTATTATTATAAGACTGCATTTTATTTATATCATTTTATTAATATGGATTTATTTATAGAAACATCATTCGATATTGCTACTT

>In-frame_MDM2_ENST00000350057_chr12_69222711_+_IL22_ENST00000538666_chr12_68642656_-_1226nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAATTA
TCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATA
TGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGCTTGGAGAGAGTGGAGAGATCAAAGCAATTGGAGAACTG
GATTTGCTGTTTATGTCTCTGAGAAATGCCTGCATTTGACCAGAGCAAAGCTGAAAAATGAATAACTAACCCCCTTTCCCTGCTAGAAAT
AACAATTAGATGCCCCAAAGCGATTTTTTTTAACCAAAAGGAAGATGGGAAGCCAAACTCCATCATGATGGGTGGATTCCAAATGAACCC
CTGCGTTAGTTACAAAGGAAACCAATGCCACTTTTGTTTATAAGACCAGAAGGTAGACTTTCTAAGCATAGATATTTATTGATAACATTT
CATTGTAACTGGTGTTCTATACACAGAAAACAATTTATTTTTTAAATAATTGTCTTTTTCCATAAAAAAGATTACTTTCCATTCCTTTAG
GGGAAAAAACCCCTAAATAGCTTCATGTTTCCATAATCAGTACTTTATATTTATAAATGTATTTATTATTATTATAAGACTGCATTTTAT
TTATATCATTTTATTAATATGGATTTATTTATAGAAACATCATTCGATATTGCTACTTGAGTGTAAGGCTAATATTGATATTTATGACAA


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FusionGenePPI for MDM2_IL22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MDM2TP53, MDC1, CTBP1, CTBP2, TP73, PML, RPL11, RPL5, CDKN2A, NUMB, UBE2A, HIF1A, KAT5, HDAC1, EID1, MDM4, KAT2B, EP300, TBP, TAF1, MDM2, ESR1, ARRB2, ABL1, CCNG1, ARRB1, TSG101, RB1, MTBP, FKBP3, RYBP, RRM2B, RPL26, GNAS, FOXO4, IGF1R, DAXX, DHFR, GNL3, CCAR1, PSMD10, PSME3, PTK2, AR, PPM1D, USP7, COPS5, SFN, RBBP6, CDH1, CHEK2, YWHAQ, NCL, UBE2G2, UBE2U, UBE2Z, PYHIN1, BANP, DDX17, E2F1, TRIM28, UBC, GATA3, ATF3, HIST2H2BE, RPL23, YY1, AKT1, RAD23A, CDKN1A, NR3C1, UBE2I, HIST3H3, EHMT1, SUV39H1, RPS27L, RPS27, ADRB2, SIVA1, MTA1, RCHY1, UBE2D1, CASP2, RPS27A, RPS7, G3BP2, PSMD2, PAK1IP1, RPS6KB1, ZNF668, TP63, PCNA, USP10, PSMC1, PSMD4, PSMC3, PSMC5, PSMC6, PSMA7, PSMD1, RUNX3, GNL3L, TERT, APEX1, UIMC1, CREBBP, SOX4, UBE4B, TBRG1, BAIAP2L1, RFWD3, ERBB3, PA2G4, HEXIM1, CDK9, DYRK2, HSP90AA1, HSPA4, HSPA8, LAMP2, RPS3, USP2, TRIM13, XRCC6, GORAB, FOXO1, FOXO3, UCHL1, S100A1, S100A2, S100A4, S100A6, S100B, USP42, CUL1, BTRC, FBXW11, CSNK1D, RFWD2, SMURF1, NOTCH4, CSNK1A1, PDLIM7, SENP3, RN5S1@, PDE4D, NOTCH1, SNAI1, RASSF1, TRIM27, RFFL, RPS14, PPP2R4, TTF1, PSMB6, PSMA8, RASSF3, NR0B2, UBE2B, PIAS1, RANBP1, LATS1, RAD50, NBN, MRE11A, CUL4A, DTL, PIM1, GSK3B, PSMA3, ESR2, ADRBK1, AATF, HNRNPK, BUB1B, SUMO1, RASSF5, UBE2D2, POLH, NPM1, TCAP, CDK5RAP3, ARIH2, IRF2, RPS25, TPT1, ANG, RHOA, PDCD5, CDKN2AIP, LATS2, WWOX, MED1, ERCC6, ERCC8, DDB1, CUL4B, HIPK2, DHRS2, CASP3, ITCH, EEF1A1, DCD, TUBB, TUBB2A, KRT14, RPS20, GAPDH, TUBA1C, GSN, ERBB4, XIAP, HNF4A, PLK1, NME2, NEDD4, DAPK1, DAPK3, ATM, PBX1, UBE2D3, UBE3A, UBE2L3, UBE2E2, UBE2E3, RNF2, EGR1, PAK6, DLG4, IRF1, VCP, STRA13, GADD45A, RABL6, RPS26, RPL37, RPS15, RNF8, TRIM4, TRIM23, TRAF5, TRIM9, MKRN3, PHF7, RNF10, RNF126, UBE2K, LMO7, HLA-DMB, SETDB1, YY1AP1, NACA, ATF4, MYD88, RELA, SDHC, WT1, SORBS2, HRSP12, DNAJB4, GCAT, SHPK, POT1, ANKRD17, GLTSCR2, SESN2, RASSF6, JUND, EZR, RYR2, JUN, CLSTN1, APP, CLU, SREK1, SET, HSP90B1, CWC25, ZNF133, PKM, TAB1, RPL6, AURKA, NOC2L, JAK1, XPC, PGAM1, PGAM2, DNAJB1, ANAPC2, NLK, SNAI2, RBM38, FHIT, AGPS, ALDH16A1, DDX5, DHX9, DLAT, EDC4, EIF2AK1, ESYT1, GTF2I, HMHA1, HNRNPM, HNRNPU, HRNR, HSP90AB1, IARS, IFI16, IGF2BP3, ILF3, KARS, CCAR2, NEK9, OGDH, OGDHL, RARS, RBBP8, RECQL, SF3B1, SFPQ, TOP1, ZNF318, PER2, SIRT6, TSC22D3, RPS6, UBE2M, RAD54B, SMARCA2, ACACA, PTBP1, IYD, ACTB, HNRNPD, U2AF2, FUBP1, TFRC, EEF2, XPO1, KRT2, EIF3B, SND1, DCAF8, USO1, EFTUD2, EXOSC6, IPO7, SF3B3, DET1, UBE2N, RPL10A, DIRAS3, SURF2, RFPL2, CMSS1, PPARD, RPL22L1, IER2, MAGEA2, ZNF420, ELF4, ABL2, SRC, HCK, GTF2E2, ATP2A2, BRINP1, C19orf10, CANX, MS4A1, PDIA3, PPIB, RAB8A, RPS23, RUVBL2, SMARCA4, SMARCE1, SRSF11, TPR, UBTF, PPARG, VDR, FBXO31, TFIP11, SETD7, PPP1CA, RARA, DDX24, NAT10, CCND1, RLIM, IER3, FHL2, RPL23A, SUZ12, EZH2, EED, RRM1, RPL4, NOLC1, DDX42, MAP2, NUCKS1, RRP1, PDS5A, RPL36A, TP53RK, RPL15, NPIPB3, HMGN1, MAP1LC3A, PRDM2, KIAA1551, PBXIP1, SP1, SHARPIN, MAPKAPK2, USP15, USP26, FKBP1A, NGFR, SMG7, RSL1D1, SIRT1, SIRT7, SIRT2, SIRT3, KPNA1, KPNA6, MSI2, PHLDB3, CLPB, XAGE1B, ZNF550, YAF2, PDGFB, ARNTL2, RPS11, TSPYL6, HIST1H2BJ, ZNF764, MAK16, ZNF274, PPAN, RPL37A, CRTC2, CRTC3, TRIM25, CSNK2A1, CSNK2B, CSNK2A2, HEY1, RANBP2IL22IL22RA2, IL10RB, IL22RA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneMDM2chr12:69222711chr12:68642656ENST00000462284+811150_230228498PYHIN1 and necessary for interaction with RFFL and RNF34


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMDM2chr12:69222711chr12:68642656ENST00000258149+69170_306167437MTBP
HgeneMDM2chr12:69222711chr12:68642656ENST00000299252+15170_3060322MTBP
HgeneMDM2chr12:69222711chr12:68642656ENST00000348801+13170_3060266MTBP
HgeneMDM2chr12:69222711chr12:68642656ENST00000356290+16170_306-102322MTBP
HgeneMDM2chr12:69222711chr12:68642656ENST00000360430+14170_3060297MTBP
HgeneMDM2chr12:69222711chr12:68642656ENST00000393412+13170_306-92219MTBP
HgeneMDM2chr12:69222711chr12:68642656ENST00000393413+12170_3060219MTBP
HgeneMDM2chr12:69222711chr12:68642656ENST00000428863+14170_306-102271MTBP
HgeneMDM2chr12:69222711chr12:68642656ENST00000462284+811170_306228498MTBP
HgeneMDM2chr12:69222711chr12:68642656ENST00000540827+15170_306-102297MTBP
HgeneMDM2chr12:69222711chr12:68642656ENST00000258149+69150_230167437PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222711chr12:68642656ENST00000299252+15150_2300322PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222711chr12:68642656ENST00000348801+13150_2300266PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222711chr12:68642656ENST00000356290+16150_230-102322PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222711chr12:68642656ENST00000360430+14150_2300297PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222711chr12:68642656ENST00000393412+13150_230-92219PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222711chr12:68642656ENST00000393413+12150_2300219PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222711chr12:68642656ENST00000428863+14150_230-102271PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222711chr12:68642656ENST00000540827+15150_230-102297PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69222711chr12:68642656ENST00000258149+69223_232167437USP7
HgeneMDM2chr12:69222711chr12:68642656ENST00000299252+15223_2320322USP7
HgeneMDM2chr12:69222711chr12:68642656ENST00000348801+13223_2320266USP7
HgeneMDM2chr12:69222711chr12:68642656ENST00000356290+16223_232-102322USP7
HgeneMDM2chr12:69222711chr12:68642656ENST00000360430+14223_2320297USP7
HgeneMDM2chr12:69222711chr12:68642656ENST00000393412+13223_232-92219USP7
HgeneMDM2chr12:69222711chr12:68642656ENST00000393413+12223_2320219USP7
HgeneMDM2chr12:69222711chr12:68642656ENST00000428863+14223_232-102271USP7
HgeneMDM2chr12:69222711chr12:68642656ENST00000462284+811223_232228498USP7
HgeneMDM2chr12:69222711chr12:68642656ENST00000540827+15223_232-102297USP7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MDM2_IL22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMDM2Q00987DB01593ZincE3 ubiquitin-protein ligase Mdm2small moleculeapproved|investigational

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RelatedDiseases for MDM2_IL22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMDM2C0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneMDM2C0007621Neoplastic Cell Transformation1CTD_human
HgeneMDM2C0019693HIV Infections1CTD_human
HgeneMDM2C0021364Male infertility1CTD_human
HgeneMDM2C0025202melanoma1CTD_human
HgeneMDM2C0032927Precancerous Conditions1CTD_human
HgeneMDM2C0033578Prostatic Neoplasms1CTD_human
HgeneMDM2C1458155Mammary Neoplasms1CTD_human
TgeneIL22C4277682Chemical and Drug Induced Liver Injury3CTD_human
TgeneIL22C0241910Hepatitis, Autoimmune1CTD_human
TgeneIL22C0740392Infarction, Middle Cerebral Artery1CTD_human