FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 21376

FusionGeneSummary for MDM2_BRI3BP

check button Fusion gene summary
Fusion gene informationFusion gene name: MDM2_BRI3BP
Fusion gene ID: 21376
HgeneTgene
Gene symbol

MDM2

BRI3BP

Gene ID

4193

140707

Gene nameMDM2 proto-oncogeneBRI3 binding protein
SynonymsACTFS|HDMX|hdm2BNAS1|HCCR-1|HCCR-2|HCCRBP-1|HCCRBP-3|KG19
Cytomap

12q15

12q24.31

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, humBRI3-binding proteinI3-binding proteincervical cancer 1 proto-oncogene-binding protein KG19cervical cancer oncogene binding protein
Modification date2018052720180523
UniProtAcc

Q00987

Q8WY22

Ensembl transtripts involved in fusion geneENST00000462284, ENST00000356290, 
ENST00000540827, ENST00000258149, 
ENST00000428863, ENST00000393412, 
ENST00000258148, ENST00000544561, 
ENST00000393410, ENST00000393413, 
ENST00000517852, ENST00000545204, 
ENST00000350057, ENST00000360430, 
ENST00000299252, ENST00000348801, 
ENST00000478070, ENST00000544125, 
ENST00000341446, 
Fusion gene scores* DoF score24 X 14 X 8=26883 X 3 X 3=27
# samples 253
** MAII scorelog2(25/2688*10)=-3.42653313811667
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MDM2 [Title/Abstract] AND BRI3BP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

HgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

HgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

HgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

HgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

HgeneMDM2

GO:0034504

protein localization to nucleus

10360174

HgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

HgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

HgeneMDM2

GO:0045184

establishment of protein localization

10360174

HgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

HgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

HgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

HgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

HgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

HgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-KK-A7B2-01AMDM2chr12

69214154

+BRI3BPchr12

125509890

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000462284ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000356290ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000540827ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
In-frameENST00000258149ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000428863ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000393412ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
In-frameENST00000258148ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000544561ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000393410ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000393413ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000517852ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000545204ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
In-frameENST00000350057ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000360430ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000299252ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000348801ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
Frame-shitENST00000478070ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+
intron-3CDSENST00000544125ENST00000341446MDM2chr12

69214154

+BRI3BPchr12

125509890

+

Top

FusionProtFeatures for MDM2_BRI3BP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MDM2

Q00987

BRI3BP

Q8WY22

Involved in tumorigenesis and may function bystabilizing p53/TP53. {ECO:0000269|PubMed:17943721}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+5927_107113437DomainNote=SWIB
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+51127_107119498DomainNote=SWIB
TgeneBRI3BPchr12:69214154chr12:125509890ENST00000341446+03217_247-31252Coiled coilOntology_term=ECO:0000255
TgeneBRI3BPchr12:69214154chr12:125509890ENST00000341446+03125_145-31252TransmembraneHelical
TgeneBRI3BPchr12:69214154chr12:125509890ENST00000341446+0313_33-31252TransmembraneHelical
TgeneBRI3BPchr12:69214154chr12:125509890ENST00000341446+03146_166-31252TransmembraneHelical
TgeneBRI3BPchr12:69214154chr12:125509890ENST00000341446+03185_205-31252TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59210_215113437Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59243_301113437Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15210_2150322Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15243_3010322Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13210_2150266Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13243_3010266Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16210_215-102322Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16243_301-102322Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14210_2150297Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14243_3010297Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13210_215-92219Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13243_301-92219Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12210_2150219Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12243_3010219Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14210_215-102271Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14243_301-102271Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511210_215119498Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511243_301119498Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15210_215-102297Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15243_301-102297Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+1527_1070322DomainNote=SWIB
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+1327_1070266DomainNote=SWIB
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+1627_107-102322DomainNote=SWIB
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+1427_1070297DomainNote=SWIB
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+1327_107-92219DomainNote=SWIB
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+1227_1070219DomainNote=SWIB
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+1427_107-102271DomainNote=SWIB
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+1527_107-102297DomainNote=SWIB
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59179_185113437MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59190_202113437MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59466_473113437MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15179_1850322MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15190_2020322MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15466_4730322MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13179_1850266MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13190_2020266MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13466_4730266MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16179_185-102322MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16190_202-102322MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16466_473-102322MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14179_1850297MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14190_2020297MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14466_4730297MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13179_185-92219MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13190_202-92219MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13466_473-92219MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12179_1850219MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12190_2020219MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12466_4730219MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14179_185-102271MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14190_202-102271MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14466_473-102271MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511179_185119498MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511190_202119498MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511466_473119498MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15179_185-102297MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15190_202-102297MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15466_473-102297MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59210_304113437RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59242_331113437RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15210_3040322RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15242_3310322RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13210_3040266RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13242_3310266RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16210_304-102322RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16242_331-102322RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14210_3040297RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14242_3310297RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13210_304-92219RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13242_331-92219RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12210_3040219RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12242_3310219RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14210_304-102271RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14242_331-102271RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511210_304119498RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511242_331119498RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15210_304-102297RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15242_331-102297RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59299_328113437Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59438_479113437Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15299_3280322Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15438_4790322Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13299_3280266Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13438_4790266Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16299_328-102322Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16438_479-102322Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14299_3280297Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14438_4790297Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13299_328-92219Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13438_479-92219Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12299_3280219Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12438_4790219Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14299_328-102271Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14438_479-102271Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511299_328119498Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511438_479119498Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15299_328-102297Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15438_479-102297Zinc fingerRING-type


Top

FusionGeneSequence for MDM2_BRI3BP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MDM2_ENST00000462284_chr12_69214154_+_BRI3BP_ENST00000341446_chr12_125509890_+_2053aa
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTTTMKEVLFTLGQTIMTKRLTDEKQQHIVTCSNDLLGD
LFGVPSFSVKEHRKITTMIYRNLVVVNQQEVSRPGGSTVTSTLSQKTKTEEKNPKPQTILINTTEQESGAV_GTFHPPGSS_DTFPEERK
DH_RGTTHEV_LVGEKIFFKQRI_PTLVVQ_EKFICA_SIKLIFSSI_IHLL_GFLIKAD_VKFIKTLHGGEETANLTFEKSLNASVCFH
SLGIGG_GLCALFSCSQTVSFISCTFWWMLT_FMNVVTSKCGQLGCRMQLNLFWILETPAKPPSVLFLNEDIAISRRPEIFFPLCFDVF_
PQHFETENARRGQEMSWGFDARKYLVRIGDCSRIYCMSQFAVCSLGLTTKAIPLRVFFFFF_FPQDLRGKTNSSS_TSQVTCCLERSSGT
ISSNKQAFEKI_ILFPEIFTIHRCFLSEICCVLLLGSLCGQRVGLARWTAVGILGKGVSEGVAQGLVETPFC_DLFFKKESPRPGAVADA
CNPSALGGRGVWIT_GQEFKTSLANMVKPPSLLKIQKLVRHGGGCL_SSYSGG_GRRIA_TWEVEVAVSRDHATALQPRQQSKTSS_KKK
KKPSILQL_SCWGSRLSLWPLPGHRCTLATRSQCPACRFIDNPCQTCYNQDLMVQVSVWRRFSCLPLLV_CSCEVLFLVASIWKTDADVF
VDVVETFETSVSKVHMMGPKLSWRVPFTS_NVHLFQVHVTSVCMDI_DLLEQAGQGGSPL_SQHFGRPRQVDHLRSGV_DQPGQQSETPS
LLKIQKLARPGGGRL_SQLLGRLRLENRLNMGGGGCSQLRSYHHTLASATE_DSVSKKIICWIESFFF_DGVSLSTRLECSGTISAHCKL
RLLGSRHSPTSASQVAGTTGAHHHARLIFTIFSRDGVSPC_PGWSRSPDLVIRPPRPPKVLGLQA_ATALGLDQIFIHAHWNTGLLG_NH
SSFVI_ILVDESILAQGINNSGGHLTLLSFCAFGTTTFRY_NSFATVGQGKTWHSVRKANDRQPCLGPSLVTGHCKMPAC_GLSCHWAGC
NTRFIPPPTLLPET_RALCSIEISIRSSF_LVFN_GR_HDIWVLVD_DLKHQFKIAVENMHTFFFPLWLSVGSEASFIA_YILVKDVFIF
NERTYS__VSPQGRNSDRNSDTLKL__KS_MLDLKKTWVLLHRFHLFWGTSYPKIIGDFFVPSPFHGTL_GVGIGPPLATRHMSLFFSLF
CMWKNVFLYHISYLERNLFSIFRAVETISVTLH_M_RKSILMKTGSVIIKTQCLKTLNQC_FPSVSVSQ_ILVLLRTENNPEKEKDQPSL
DCWNCMDVLGLV__SLP_HPSKDAFVECKPFINILSRLGAVAQACNPSTLGGQGGWITCGREFETSLANIVKSRLYQKIQKKKKKKK_PG
VVVGSCSPSYSGG_GGRIV_TWEAEVAVN_DHTTVLQLRRQSETQSQKKKKVCVCVTICITIYTHTHFPIPVGITRPLVSFALDFSPHII
SGNRAQQ_NFWEADLVNRACVLIHKG_VNAVERCFIHLPQK_EPVSCRSREAAMSGNWDTVFMTVMVVTKWGGPLWGAE_ERKGLGQ_LG
RL_TDFVHAREGCLVERM_AA_SLIWPCDSGLWSVKNNSCQMA_TWLMQFVASGNPELLPFCDHCYFLRCF__MSSALQVDT__LLPDGF
PNWLT_PKSQLLPSILH_KEFLRLLRGQLPHS_LFTF_WSIPSATFLFMAI_IVGL_LLTCE__ETILQNLT_YP_NSYWTTISVMTSIW
CKQILFSILNTSVFCFSLICRRCTSTSFSLVVA_NADCHLHCLLKSCGSEWTT_PCVLMSFCRFKGFIVVSI_TLHVCLISEYHVIKLIN
L_W_W_LAHTKNPMKQLSPSS_LEITLVRTGIHTQQWIHD_LHILCIWL_ILTSI_FGT_TKSI_FE_CVCVHGVCVCVHFSFVSLGKLI

>In-frame_MDM2_ENST00000258149_chr12_69214154_+_BRI3BP_ENST00000341446_chr12_125509890_+_2047aa
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTTTMKEVLFTLGQTIMTKRLTDEKQQHIVTCSNDLLGDLFGVPS
FSVKEHRKITTMIYRNLVVVNQQEVSRPGGSTVTSTLSQKTKTEEKNPKPQTILINTTEQESGAV_GTFHPPGSS_DTFPEERKDH_RGT
THEV_LVGEKIFFKQRI_PTLVVQ_EKFICA_SIKLIFSSI_IHLL_GFLIKAD_VKFIKTLHGGEETANLTFEKSLNASVCFHSLGIGG
_GLCALFSCSQTVSFISCTFWWMLT_FMNVVTSKCGQLGCRMQLNLFWILETPAKPPSVLFLNEDIAISRRPEIFFPLCFDVF_PQHFET
ENARRGQEMSWGFDARKYLVRIGDCSRIYCMSQFAVCSLGLTTKAIPLRVFFFFF_FPQDLRGKTNSSS_TSQVTCCLERSSGTISSNKQ
AFEKI_ILFPEIFTIHRCFLSEICCVLLLGSLCGQRVGLARWTAVGILGKGVSEGVAQGLVETPFC_DLFFKKESPRPGAVADACNPSAL
GGRGVWIT_GQEFKTSLANMVKPPSLLKIQKLVRHGGGCL_SSYSGG_GRRIA_TWEVEVAVSRDHATALQPRQQSKTSS_KKKKKPSIL
QL_SCWGSRLSLWPLPGHRCTLATRSQCPACRFIDNPCQTCYNQDLMVQVSVWRRFSCLPLLV_CSCEVLFLVASIWKTDADVFVDVVET
FETSVSKVHMMGPKLSWRVPFTS_NVHLFQVHVTSVCMDI_DLLEQAGQGGSPL_SQHFGRPRQVDHLRSGV_DQPGQQSETPSLLKIQK
LARPGGGRL_SQLLGRLRLENRLNMGGGGCSQLRSYHHTLASATE_DSVSKKIICWIESFFF_DGVSLSTRLECSGTISAHCKLRLLGSR
HSPTSASQVAGTTGAHHHARLIFTIFSRDGVSPC_PGWSRSPDLVIRPPRPPKVLGLQA_ATALGLDQIFIHAHWNTGLLG_NHSSFVI_
ILVDESILAQGINNSGGHLTLLSFCAFGTTTFRY_NSFATVGQGKTWHSVRKANDRQPCLGPSLVTGHCKMPAC_GLSCHWAGCNTRFIP
PPTLLPET_RALCSIEISIRSSF_LVFN_GR_HDIWVLVD_DLKHQFKIAVENMHTFFFPLWLSVGSEASFIA_YILVKDVFIFNERTYS
__VSPQGRNSDRNSDTLKL__KS_MLDLKKTWVLLHRFHLFWGTSYPKIIGDFFVPSPFHGTL_GVGIGPPLATRHMSLFFSLFCMWKNV
FLYHISYLERNLFSIFRAVETISVTLH_M_RKSILMKTGSVIIKTQCLKTLNQC_FPSVSVSQ_ILVLLRTENNPEKEKDQPSLDCWNCM
DVLGLV__SLP_HPSKDAFVECKPFINILSRLGAVAQACNPSTLGGQGGWITCGREFETSLANIVKSRLYQKIQKKKKKKK_PGVVVGSC
SPSYSGG_GGRIV_TWEAEVAVN_DHTTVLQLRRQSETQSQKKKKVCVCVTICITIYTHTHFPIPVGITRPLVSFALDFSPHIISGNRAQ
Q_NFWEADLVNRACVLIHKG_VNAVERCFIHLPQK_EPVSCRSREAAMSGNWDTVFMTVMVVTKWGGPLWGAE_ERKGLGQ_LGRL_TDF
VHAREGCLVERM_AA_SLIWPCDSGLWSVKNNSCQMA_TWLMQFVASGNPELLPFCDHCYFLRCF__MSSALQVDT__LLPDGFPNWLT_
PKSQLLPSILH_KEFLRLLRGQLPHS_LFTF_WSIPSATFLFMAI_IVGL_LLTCE__ETILQNLT_YP_NSYWTTISVMTSIWCKQILF
SILNTSVFCFSLICRRCTSTSFSLVVA_NADCHLHCLLKSCGSEWTT_PCVLMSFCRFKGFIVVSI_TLHVCLISEYHVIKLINL_W_W_
LAHTKNPMKQLSPSS_LEITLVRTGIHTQQWIHD_LHILCIWL_ILTSI_FGT_TKSI_FE_CVCVHGVCVCVHFSFVSLGKLILQISTI

>In-frame_MDM2_ENST00000258148_chr12_69214154_+_BRI3BP_ENST00000341446_chr12_125509890_+_2053aa
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTTTMKEVLFTLGQTIMTKRLTDEKQQHIVTCSNDLLGD
LFGVPSFSVKEHRKITTMIYRNLVVVNQQEVSRPGGSTVTSTLSQKTKTEEKNPKPQTILINTTEQESGAV_GTFHPPGSS_DTFPEERK
DH_RGTTHEV_LVGEKIFFKQRI_PTLVVQ_EKFICA_SIKLIFSSI_IHLL_GFLIKAD_VKFIKTLHGGEETANLTFEKSLNASVCFH
SLGIGG_GLCALFSCSQTVSFISCTFWWMLT_FMNVVTSKCGQLGCRMQLNLFWILETPAKPPSVLFLNEDIAISRRPEIFFPLCFDVF_
PQHFETENARRGQEMSWGFDARKYLVRIGDCSRIYCMSQFAVCSLGLTTKAIPLRVFFFFF_FPQDLRGKTNSSS_TSQVTCCLERSSGT
ISSNKQAFEKI_ILFPEIFTIHRCFLSEICCVLLLGSLCGQRVGLARWTAVGILGKGVSEGVAQGLVETPFC_DLFFKKESPRPGAVADA
CNPSALGGRGVWIT_GQEFKTSLANMVKPPSLLKIQKLVRHGGGCL_SSYSGG_GRRIA_TWEVEVAVSRDHATALQPRQQSKTSS_KKK
KKPSILQL_SCWGSRLSLWPLPGHRCTLATRSQCPACRFIDNPCQTCYNQDLMVQVSVWRRFSCLPLLV_CSCEVLFLVASIWKTDADVF
VDVVETFETSVSKVHMMGPKLSWRVPFTS_NVHLFQVHVTSVCMDI_DLLEQAGQGGSPL_SQHFGRPRQVDHLRSGV_DQPGQQSETPS
LLKIQKLARPGGGRL_SQLLGRLRLENRLNMGGGGCSQLRSYHHTLASATE_DSVSKKIICWIESFFF_DGVSLSTRLECSGTISAHCKL
RLLGSRHSPTSASQVAGTTGAHHHARLIFTIFSRDGVSPC_PGWSRSPDLVIRPPRPPKVLGLQA_ATALGLDQIFIHAHWNTGLLG_NH
SSFVI_ILVDESILAQGINNSGGHLTLLSFCAFGTTTFRY_NSFATVGQGKTWHSVRKANDRQPCLGPSLVTGHCKMPAC_GLSCHWAGC
NTRFIPPPTLLPET_RALCSIEISIRSSF_LVFN_GR_HDIWVLVD_DLKHQFKIAVENMHTFFFPLWLSVGSEASFIA_YILVKDVFIF
NERTYS__VSPQGRNSDRNSDTLKL__KS_MLDLKKTWVLLHRFHLFWGTSYPKIIGDFFVPSPFHGTL_GVGIGPPLATRHMSLFFSLF
CMWKNVFLYHISYLERNLFSIFRAVETISVTLH_M_RKSILMKTGSVIIKTQCLKTLNQC_FPSVSVSQ_ILVLLRTENNPEKEKDQPSL
DCWNCMDVLGLV__SLP_HPSKDAFVECKPFINILSRLGAVAQACNPSTLGGQGGWITCGREFETSLANIVKSRLYQKIQKKKKKKK_PG
VVVGSCSPSYSGG_GGRIV_TWEAEVAVN_DHTTVLQLRRQSETQSQKKKKVCVCVTICITIYTHTHFPIPVGITRPLVSFALDFSPHII
SGNRAQQ_NFWEADLVNRACVLIHKG_VNAVERCFIHLPQK_EPVSCRSREAAMSGNWDTVFMTVMVVTKWGGPLWGAE_ERKGLGQ_LG
RL_TDFVHAREGCLVERM_AA_SLIWPCDSGLWSVKNNSCQMA_TWLMQFVASGNPELLPFCDHCYFLRCF__MSSALQVDT__LLPDGF
PNWLT_PKSQLLPSILH_KEFLRLLRGQLPHS_LFTF_WSIPSATFLFMAI_IVGL_LLTCE__ETILQNLT_YP_NSYWTTISVMTSIW
CKQILFSILNTSVFCFSLICRRCTSTSFSLVVA_NADCHLHCLLKSCGSEWTT_PCVLMSFCRFKGFIVVSI_TLHVCLISEYHVIKLIN
L_W_W_LAHTKNPMKQLSPSS_LEITLVRTGIHTQQWIHD_LHILCIWL_ILTSI_FGT_TKSI_FE_CVCVHGVCVCVHFSFVSLGKLI

>In-frame_MDM2_ENST00000350057_chr12_69214154_+_BRI3BP_ENST00000341446_chr12_125509890_+_2022aa
MCNTNMSVPTDGAVTTSQIPASEQETLVLFTLGQTIMTKRLTDEKQQHIVTCSNDLLGDLFGVPSFSVKEHRKITTMIYRNLVVVNQQEV
SRPGGSTVTSTLSQKTKTEEKNPKPQTILINTTEQESGAV_GTFHPPGSS_DTFPEERKDH_RGTTHEV_LVGEKIFFKQRI_PTLVVQ_
EKFICA_SIKLIFSSI_IHLL_GFLIKAD_VKFIKTLHGGEETANLTFEKSLNASVCFHSLGIGG_GLCALFSCSQTVSFISCTFWWMLT
_FMNVVTSKCGQLGCRMQLNLFWILETPAKPPSVLFLNEDIAISRRPEIFFPLCFDVF_PQHFETENARRGQEMSWGFDARKYLVRIGDC
SRIYCMSQFAVCSLGLTTKAIPLRVFFFFF_FPQDLRGKTNSSS_TSQVTCCLERSSGTISSNKQAFEKI_ILFPEIFTIHRCFLSEICC
VLLLGSLCGQRVGLARWTAVGILGKGVSEGVAQGLVETPFC_DLFFKKESPRPGAVADACNPSALGGRGVWIT_GQEFKTSLANMVKPPS
LLKIQKLVRHGGGCL_SSYSGG_GRRIA_TWEVEVAVSRDHATALQPRQQSKTSS_KKKKKPSILQL_SCWGSRLSLWPLPGHRCTLATR
SQCPACRFIDNPCQTCYNQDLMVQVSVWRRFSCLPLLV_CSCEVLFLVASIWKTDADVFVDVVETFETSVSKVHMMGPKLSWRVPFTS_N
VHLFQVHVTSVCMDI_DLLEQAGQGGSPL_SQHFGRPRQVDHLRSGV_DQPGQQSETPSLLKIQKLARPGGGRL_SQLLGRLRLENRLNM
GGGGCSQLRSYHHTLASATE_DSVSKKIICWIESFFF_DGVSLSTRLECSGTISAHCKLRLLGSRHSPTSASQVAGTTGAHHHARLIFTI
FSRDGVSPC_PGWSRSPDLVIRPPRPPKVLGLQA_ATALGLDQIFIHAHWNTGLLG_NHSSFVI_ILVDESILAQGINNSGGHLTLLSFC
AFGTTTFRY_NSFATVGQGKTWHSVRKANDRQPCLGPSLVTGHCKMPAC_GLSCHWAGCNTRFIPPPTLLPET_RALCSIEISIRSSF_L
VFN_GR_HDIWVLVD_DLKHQFKIAVENMHTFFFPLWLSVGSEASFIA_YILVKDVFIFNERTYS__VSPQGRNSDRNSDTLKL__KS_M
LDLKKTWVLLHRFHLFWGTSYPKIIGDFFVPSPFHGTL_GVGIGPPLATRHMSLFFSLFCMWKNVFLYHISYLERNLFSIFRAVETISVT
LH_M_RKSILMKTGSVIIKTQCLKTLNQC_FPSVSVSQ_ILVLLRTENNPEKEKDQPSLDCWNCMDVLGLV__SLP_HPSKDAFVECKPF
INILSRLGAVAQACNPSTLGGQGGWITCGREFETSLANIVKSRLYQKIQKKKKKKK_PGVVVGSCSPSYSGG_GGRIV_TWEAEVAVN_D
HTTVLQLRRQSETQSQKKKKVCVCVTICITIYTHTHFPIPVGITRPLVSFALDFSPHIISGNRAQQ_NFWEADLVNRACVLIHKG_VNAV
ERCFIHLPQK_EPVSCRSREAAMSGNWDTVFMTVMVVTKWGGPLWGAE_ERKGLGQ_LGRL_TDFVHAREGCLVERM_AA_SLIWPCDSG
LWSVKNNSCQMA_TWLMQFVASGNPELLPFCDHCYFLRCF__MSSALQVDT__LLPDGFPNWLT_PKSQLLPSILH_KEFLRLLRGQLPH
S_LFTF_WSIPSATFLFMAI_IVGL_LLTCE__ETILQNLT_YP_NSYWTTISVMTSIWCKQILFSILNTSVFCFSLICRRCTSTSFSLV
VA_NADCHLHCLLKSCGSEWTT_PCVLMSFCRFKGFIVVSI_TLHVCLISEYHVIKLINL_W_W_LAHTKNPMKQLSPSS_LEITLVRTG
IHTQQWIHD_LHILCIWL_ILTSI_FGT_TKSI_FE_CVCVHGVCVCVHFSFVSLGKLILQISTIEINVSGIFLQSDIYIPLIT_ITGFG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MDM2_ENST00000462284_chr12_69214154_+_BRI3BP_ENST00000341446_chr12_125509890_+_6159nt
ATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAA
GAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTTCTT
TTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGAT
TTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAG
GTCAGCCGGCCGGGCGGGTCCACAGTTACCAGCACGCTGTCTCAGAAAACGAAAACGGAGGAAAAAAACCCCAAACCCCAAACAATCTTA
ATAAACACGACTGAGCAAGAAAGTGGCGCTGTGTAGGGCTATTTCCACCCACCCGGCAGCTCTTAGGACACATTCCCAGAAGAGCGGAAA
GATCATTGACGTGGAACTACACACGAAGTGTAATTAGTGGGGGAAAAAATATTTTTTAAACAAAGGATATAACCATATTTAGTTGTACAG
TAAGAGAAATTTATCTGTGCATAGAGCATAAAGTTAATTTTTTCAAGCATTTAAATACATCTTTTGTAAGGTTTTTTAATAAAGGCAGAT
TGAGTCAAGTTTATTAAAACTTTACATGGAGGGGAAGAATATGCTAATTTGACATTTGAGAAAAGTTTAAATGCGAGCGTTTGTTTTCAC
AGCTTAGGGATTGGTGGGTGAGGTCTGTGTGCGTTATTTTCATGTTCCCAAACTGTGAGCTTTATTTCATGTTATTTTTGGTGGATGTTG
ACTTAGTTCATGAATGTTGTCACTTCTAAATGTGGACAGTTGGGCTGCAGGATGCAACTCAACCTCTTTTGGATCCTAGAGACCCCTGCC
AAGCCCCCATCAGTCCTATTTTTAAATGAAGACATCGCCATTTCTAGAAGACCTGAGATTTTCTTCCCTCTGTGCTTCGATGTATTTTAA
CCTCAACATTTTGAAACGGAAAATGCAAGGAGGGGCCAAGAAATGTCCTGGGGATTTGATGCCAGGAAGTACCTGGTAAGGATTGGAGAT
TGCTCCAGAATCTACTGCATGTCCCAATTTGCAGTTTGCTCACTAGGGCTATATACAAAAGCTATACCCTTGAGGGTTTTTTTTTTTTTC
TTTTGATTTCCTCAGGACCTTAGAGGGAAAACAAACAGTAGCAGCTAATATTCTCAAGTATATTGCTGCTTAGAAAGATCCTCAGGAACA
ATTAGCAGCAATAAGCAAGCCTTTGAAAAGATCTGAATTCTTTTTCCTGAAATATTTACGATACACAGGTGCTTTTTATCTGAAATCTGT
TGTGTCCTCCTTTTAGGCAGTCTCTGTGGGCAGAGAGTGGGACTTGCGAGGTGGACAGCTGTGGGGATCCTGGGCAAGGGAGTTTCAGAA
GGTGTGGCTCAGGGGCTGGTAGAAACCCCCTTTTGTTAGGACTTGTTTTTTAAAAAAGAAAGCCCTAGGCCAGGCGCAGTGGCTGATGCC
TGTAATCCCAGCGCTTTGGGAGGCCGAGGAGTATGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCCG
TCTCTACTAAAAATACAAAAATTAGTCAGGCATGGTGGTGGGTGCCTGTAGTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGA
ACCTGGGAGGTGGAGGTTGCGGTGAGCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACAGAGCAAGACTTCATCTTAAAAAAAAAAA
AAAAAGCCCAGCATTTTGCAGCTTTGAAGCTGCTGGGGATCACGACTGTCTCTGTGGCCCTTACCTGGCCACAGATGTACCCTGGCAACC
CGCTCACAGTGCCCTGCGTGCAGGTTTATAGATAACCCCTGCCAGACCTGCTACAACCAAGACCTTATGGTCCAGGTCTCAGTTTGGAGA
AGATTTAGCTGTCTACCACTTCTTGTGTAGTGTTCCTGTGAAGTTTTATTTTTGGTTGCAAGTATCTGGAAAACAGATGCAGATGTTTTT
GTGGATGTTGTTGAGACTTTTGAGACTTCTGTTTCTAAGGTACACATGATGGGACCCAAACTCTCCTGGAGAGTTCCATTCACTTCCTGA
AACGTGCACCTGTTTCAGGTGCATGTTTATTCAGTGTGCATGGATATTTAAGATTTGCTGGAGCAGGCTGGGCAGGGTGGCTCACCCCTA
TAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCCGGCCAACAGAGTGAAACCCCGTCT
CTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGTGGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCTGGAGAATCGCTTGAAC
ATGGGAGGCGGAGGTTGCAGTCAGCTGAGATCATACCACCACACTCTAGCCTCAGCAACAGAGTGAGACTCCGTCTCAAAAAAAATTATT
TGCTGGATCGAATCTTTTTTTTTTTGAGATGGAGTCTCACTGTCAACCAGGCTGGAGTGCAGTGGCACCATCTCGGCTCACTGCAAGCTC
CGCCTCCTGGGTTCACGCCATTCTCCTACCTCAGCCTCCCAAGTAGCCGGGACTACAGGCGCCCACCATCATGCCCGGCTAATTTTTTAT
ATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTG
CTGGGATTACAGGCGTGAGCCACCGCGCTGGGCCTAGATCAAATCTTTATCCATGCACATTGGAACACAGGATTACTGGGTTGAAATCAT
TCTAGTTTTGTCATTTAGATACTTGTAGATGAATCTATTTTAGCACAAGGTATAAATAACTCGGGAGGTCATCTCTATCTTCTTTCCTTT
TGTGCATTTGGCTATACCACGTTTAGGTACTAAAACAGCTTTGCTTATGTTGGCCAGGGGAAAACATGGCATTCTGTGCGCAAAGCTAAT
GATCGCCAGCCCTGCCTTGGCCCCTCCCTTGTTTATGGTCATTGTAAGATGCCCGCATGTTAAGGCTTAAGCTGTCACTGGGCTGGGTGT
AATACCCGCTTCATTCCTCCTCCCACCCTCTTACCCGAAACATGAAGGGCACTGTGCTCTATTGAGATCTCGATAAGATCATCATTTTAA
CTTGTATTCAACTGAGGGAGGTAACATGATATCTGGGTGCTGGTGGATTGAGACCTCAAGCATCAATTCAAAATTGCTGTCGAAAATATG
CACTATTTTTTTTTTCCACTCTGGCTAAGTGTAGGCTCTGAAGCCAGTTTTATAGCTTGATACATTCTGGTGAAAGATGTCTTCATTTTT
AATGAAAGAACCTACAGTTAGTAGGTGTCACCTCAGGGTAGAAATTCTGATAGAAATTCTGATTATTTGAAACTCTGATAGAAATCCTAG
ATGCTAGATTTGAAGAAAACCTGGGTTTTATTGCATAGATTTCACCTTTTCTGGGGCACATCTTACCCCAAAATAATTGGGGATTTTTTT
GTTCCTTCTCCATTCCATGGAACCTTGTAGGGTGTTGGGATTGGGCCTCCCCTCGCCACCCGCCACATGTCTTTGTTTTTTTCTCTCTTT
TGTATGTGGAAAAATGTATTTTTGTACCATATCTCATACCTGGAGAGAAACCTTTTTTCTATCTTCAGGGCTGTAGAATATATTAGCGTA
ACACTTCACTGAATGTGACGTAAAAGCATTCTGATGAAAACTGGTTCTGTTATAATTAAGACTCAGTGTTTAAAATATCTTAATCAGTGT
TAATTTCCCAGTGTTTCAGTATCACAGTAAATACTTGTTTTACTGAGAACAGAAAATAATCCAGAAAAGGAAAAGGACCAGCCCTCTCTA
GATTGCTGGAATTGTATGGATGTGTTGGGGTTGGTTTAGTGATCTCTTCCTTGACACCCTAGCAAAGATGCTTTTGTGGAGTGCAAACCT
TTCATAAATATACTTTCCAGGCTGGGTGCAGTGGCTCAAGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACTTGCGGT
CGGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAATCCCGTCTCTACCAAAAAATACAAAAAAAAAAAAAAAAAAAAAAATAGCCAGGT
GTGGTGGTGGGTTCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGAATTGTATGAACCTGGGAGGCAGAGGTTGCAGTGAACTGA
GATCACACCACTGTACTCCAGTTGAGGCGACAGAGTGAGACCCAGTCTCAAAAAAAAAAAAAAGTGTGTGTGTGTGTATATATATGTATA
TATATATACACACACACACACTTTCCAATACCAGTCGGCATTACCCGCCCTTTGGTTTCTTTTGCTTTGGATTTCAGCCCCCATATCATT
TCTGGTAACAGAGCACAGCAATAGAATTTCTGGGAAGCAGACCTTGTGAATCGTGCCTGTGTCTTAATTCACAAAGGGTAAGTGAATGCC
GTTGAAAGGTGTTTCATACACTTACCCCAGAAATGAGAGCCTGTCTCATGCAGGAGTCGGGAGGCAGCGATGTCAGGGAACTGGGACTAT
GTCTTTATGACTGTGATGGTGGTAACCAAGTGGGGTGGTCCCCTCTGGGGAGCTGAGTAAGAACGCAAAGGTTTGGGTCAGTGATTAGGA
AGACTATAATATGACTTTGTGCATGCCCGGGAGGGCTGCCTTGTAGAGAGGATGTGAGCAGCTTAGTCGCTCATCTGGCCCTGTGATTCA
GGCTTATGGAGCGTTAAGAATAACAGCTGTCAAATGGCCTAGACATGGTTAATGCAATTTGTTGCTAGTGGAAATCCTGAATTGCTTCCT
TTCTGTGATCACTGCTACTTCTTAAGATGCTTTTGATGAATGTCATCTGCCTTACAAGTTGACACCTGATAACTTCTCCCTGATGGGTTT
CCGAACTGGCTGACTTAACCAAAAAGCCAGCTCTTGCCATCTATCTTGCATTAAAAGGAATTCCTGAGGCTCCTAAGGGGTCAGCTGCCC
CACTCCTGACTTTTTTATTTTTAATGGTCTATACCTTCTGCAACATTTTTGTTTATGGCCATTTGAATAGTTGGACTTTGACTCCTCACT
TGTGAATAATAGGAATATATTTTGCAGAATCTAACATAATACCCTTAAAATTCATACTGGACAACCATCAGTGTGATGTATAGTATCTGG
TGTAAACAAATTTTATTCAGCATATTAAATTATTCTGTGTTTTGCTTTTCCTTGATATGTAGGAGGTGCACCAGTACCAGTTTTTCTCTT
GTGGTGGCTTAAAACGCTGATTGCCATTTGCATTGTCTACTGAAAAGCTGTGGCAGCGAGTGGTATTATTGACCATGTGTTCTCATGTCT
TTTTGCAGATTTAAAGGTTTTATTGTAGTGTCCATTTAATATCTGCATGTGTGTTTAATCTCTGAATACCATGTAATTAAACTGATTAAC
TTGTGATGGTGATGGTGATTAGCACACACTAAAAACCCAATGAAGCAATTGTCTCCCTCTTCTTAACTGGAAATCACACTTGTGAGGTAT
GGTATCCATTATCAACAGTGGATTCATGATTGACTTCATATTTTGTGTATCTGGTTATAAATTTTGTATAGCATTTAATTTGGCACTTAA
TATAAATCCATTTGATTTGAATAGTGTGTGTGTGTACATGGTGTGTGTGTGTGTGTGCACTTTAGTTTCGTGAGCCTTGGGAAACTGATT
CTACAAATATCTTATATAGAGATAAATGTATCAGGCATTTTTTTGCAAAGCGATATATACATTCCTCTTATTTATTAAATCACTGGCTTT
GGTGTTATGTAGAGATATTTGTAGATCTCAGAACAGAATTAAAATATTGTGAAAATTACAGCTTAATAAATGTTTATTGTAATTTTGTTG

>In-frame_MDM2_ENST00000258149_chr12_69214154_+_BRI3BP_ENST00000341446_chr12_125509890_+_6141nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA
AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTAT
ATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGC
TTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAGGTCAGCCGGCCGGGCGGG
TCCACAGTTACCAGCACGCTGTCTCAGAAAACGAAAACGGAGGAAAAAAACCCCAAACCCCAAACAATCTTAATAAACACGACTGAGCAA
GAAAGTGGCGCTGTGTAGGGCTATTTCCACCCACCCGGCAGCTCTTAGGACACATTCCCAGAAGAGCGGAAAGATCATTGACGTGGAACT
ACACACGAAGTGTAATTAGTGGGGGAAAAAATATTTTTTAAACAAAGGATATAACCATATTTAGTTGTACAGTAAGAGAAATTTATCTGT
GCATAGAGCATAAAGTTAATTTTTTCAAGCATTTAAATACATCTTTTGTAAGGTTTTTTAATAAAGGCAGATTGAGTCAAGTTTATTAAA
ACTTTACATGGAGGGGAAGAATATGCTAATTTGACATTTGAGAAAAGTTTAAATGCGAGCGTTTGTTTTCACAGCTTAGGGATTGGTGGG
TGAGGTCTGTGTGCGTTATTTTCATGTTCCCAAACTGTGAGCTTTATTTCATGTTATTTTTGGTGGATGTTGACTTAGTTCATGAATGTT
GTCACTTCTAAATGTGGACAGTTGGGCTGCAGGATGCAACTCAACCTCTTTTGGATCCTAGAGACCCCTGCCAAGCCCCCATCAGTCCTA
TTTTTAAATGAAGACATCGCCATTTCTAGAAGACCTGAGATTTTCTTCCCTCTGTGCTTCGATGTATTTTAACCTCAACATTTTGAAACG
GAAAATGCAAGGAGGGGCCAAGAAATGTCCTGGGGATTTGATGCCAGGAAGTACCTGGTAAGGATTGGAGATTGCTCCAGAATCTACTGC
ATGTCCCAATTTGCAGTTTGCTCACTAGGGCTATATACAAAAGCTATACCCTTGAGGGTTTTTTTTTTTTTCTTTTGATTTCCTCAGGAC
CTTAGAGGGAAAACAAACAGTAGCAGCTAATATTCTCAAGTATATTGCTGCTTAGAAAGATCCTCAGGAACAATTAGCAGCAATAAGCAA
GCCTTTGAAAAGATCTGAATTCTTTTTCCTGAAATATTTACGATACACAGGTGCTTTTTATCTGAAATCTGTTGTGTCCTCCTTTTAGGC
AGTCTCTGTGGGCAGAGAGTGGGACTTGCGAGGTGGACAGCTGTGGGGATCCTGGGCAAGGGAGTTTCAGAAGGTGTGGCTCAGGGGCTG
GTAGAAACCCCCTTTTGTTAGGACTTGTTTTTTAAAAAAGAAAGCCCTAGGCCAGGCGCAGTGGCTGATGCCTGTAATCCCAGCGCTTTG
GGAGGCCGAGGAGTATGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCCGTCTCTACTAAAAATACAA
AAATTAGTCAGGCATGGTGGTGGGTGCCTGTAGTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGTT
GCGGTGAGCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACAGAGCAAGACTTCATCTTAAAAAAAAAAAAAAAAGCCCAGCATTTTG
CAGCTTTGAAGCTGCTGGGGATCACGACTGTCTCTGTGGCCCTTACCTGGCCACAGATGTACCCTGGCAACCCGCTCACAGTGCCCTGCG
TGCAGGTTTATAGATAACCCCTGCCAGACCTGCTACAACCAAGACCTTATGGTCCAGGTCTCAGTTTGGAGAAGATTTAGCTGTCTACCA
CTTCTTGTGTAGTGTTCCTGTGAAGTTTTATTTTTGGTTGCAAGTATCTGGAAAACAGATGCAGATGTTTTTGTGGATGTTGTTGAGACT
TTTGAGACTTCTGTTTCTAAGGTACACATGATGGGACCCAAACTCTCCTGGAGAGTTCCATTCACTTCCTGAAACGTGCACCTGTTTCAG
GTGCATGTTTATTCAGTGTGCATGGATATTTAAGATTTGCTGGAGCAGGCTGGGCAGGGTGGCTCACCCCTATAATCCCAACACTTTGGG
AGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCCGGCCAACAGAGTGAAACCCCGTCTCTACTAAAAATACAAAAA
TTAGCCAGGCCTGGTGGTGGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCTGGAGAATCGCTTGAACATGGGAGGCGGAGGTTGC
AGTCAGCTGAGATCATACCACCACACTCTAGCCTCAGCAACAGAGTGAGACTCCGTCTCAAAAAAAATTATTTGCTGGATCGAATCTTTT
TTTTTTTGAGATGGAGTCTCACTGTCAACCAGGCTGGAGTGCAGTGGCACCATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGC
CATTCTCCTACCTCAGCCTCCCAAGTAGCCGGGACTACAGGCGCCCACCATCATGCCCGGCTAATTTTTTATATTTTTAGTAGAGACGGG
GTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGA
GCCACCGCGCTGGGCCTAGATCAAATCTTTATCCATGCACATTGGAACACAGGATTACTGGGTTGAAATCATTCTAGTTTTGTCATTTAG
ATACTTGTAGATGAATCTATTTTAGCACAAGGTATAAATAACTCGGGAGGTCATCTCTATCTTCTTTCCTTTTGTGCATTTGGCTATACC
ACGTTTAGGTACTAAAACAGCTTTGCTTATGTTGGCCAGGGGAAAACATGGCATTCTGTGCGCAAAGCTAATGATCGCCAGCCCTGCCTT
GGCCCCTCCCTTGTTTATGGTCATTGTAAGATGCCCGCATGTTAAGGCTTAAGCTGTCACTGGGCTGGGTGTAATACCCGCTTCATTCCT
CCTCCCACCCTCTTACCCGAAACATGAAGGGCACTGTGCTCTATTGAGATCTCGATAAGATCATCATTTTAACTTGTATTCAACTGAGGG
AGGTAACATGATATCTGGGTGCTGGTGGATTGAGACCTCAAGCATCAATTCAAAATTGCTGTCGAAAATATGCACTATTTTTTTTTTCCA
CTCTGGCTAAGTGTAGGCTCTGAAGCCAGTTTTATAGCTTGATACATTCTGGTGAAAGATGTCTTCATTTTTAATGAAAGAACCTACAGT
TAGTAGGTGTCACCTCAGGGTAGAAATTCTGATAGAAATTCTGATTATTTGAAACTCTGATAGAAATCCTAGATGCTAGATTTGAAGAAA
ACCTGGGTTTTATTGCATAGATTTCACCTTTTCTGGGGCACATCTTACCCCAAAATAATTGGGGATTTTTTTGTTCCTTCTCCATTCCAT
GGAACCTTGTAGGGTGTTGGGATTGGGCCTCCCCTCGCCACCCGCCACATGTCTTTGTTTTTTTCTCTCTTTTGTATGTGGAAAAATGTA
TTTTTGTACCATATCTCATACCTGGAGAGAAACCTTTTTTCTATCTTCAGGGCTGTAGAATATATTAGCGTAACACTTCACTGAATGTGA
CGTAAAAGCATTCTGATGAAAACTGGTTCTGTTATAATTAAGACTCAGTGTTTAAAATATCTTAATCAGTGTTAATTTCCCAGTGTTTCA
GTATCACAGTAAATACTTGTTTTACTGAGAACAGAAAATAATCCAGAAAAGGAAAAGGACCAGCCCTCTCTAGATTGCTGGAATTGTATG
GATGTGTTGGGGTTGGTTTAGTGATCTCTTCCTTGACACCCTAGCAAAGATGCTTTTGTGGAGTGCAAACCTTTCATAAATATACTTTCC
AGGCTGGGTGCAGTGGCTCAAGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACTTGCGGTCGGGAGTTCGAGACCAGC
CTGGCCAACATAGTGAAATCCCGTCTCTACCAAAAAATACAAAAAAAAAAAAAAAAAAAAAAATAGCCAGGTGTGGTGGTGGGTTCCTGT
AGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGAATTGTATGAACCTGGGAGGCAGAGGTTGCAGTGAACTGAGATCACACCACTGTACTC
CAGTTGAGGCGACAGAGTGAGACCCAGTCTCAAAAAAAAAAAAAAGTGTGTGTGTGTGTATATATATGTATATATATATACACACACACA
CACTTTCCAATACCAGTCGGCATTACCCGCCCTTTGGTTTCTTTTGCTTTGGATTTCAGCCCCCATATCATTTCTGGTAACAGAGCACAG
CAATAGAATTTCTGGGAAGCAGACCTTGTGAATCGTGCCTGTGTCTTAATTCACAAAGGGTAAGTGAATGCCGTTGAAAGGTGTTTCATA
CACTTACCCCAGAAATGAGAGCCTGTCTCATGCAGGAGTCGGGAGGCAGCGATGTCAGGGAACTGGGACTATGTCTTTATGACTGTGATG
GTGGTAACCAAGTGGGGTGGTCCCCTCTGGGGAGCTGAGTAAGAACGCAAAGGTTTGGGTCAGTGATTAGGAAGACTATAATATGACTTT
GTGCATGCCCGGGAGGGCTGCCTTGTAGAGAGGATGTGAGCAGCTTAGTCGCTCATCTGGCCCTGTGATTCAGGCTTATGGAGCGTTAAG
AATAACAGCTGTCAAATGGCCTAGACATGGTTAATGCAATTTGTTGCTAGTGGAAATCCTGAATTGCTTCCTTTCTGTGATCACTGCTAC
TTCTTAAGATGCTTTTGATGAATGTCATCTGCCTTACAAGTTGACACCTGATAACTTCTCCCTGATGGGTTTCCGAACTGGCTGACTTAA
CCAAAAAGCCAGCTCTTGCCATCTATCTTGCATTAAAAGGAATTCCTGAGGCTCCTAAGGGGTCAGCTGCCCCACTCCTGACTTTTTTAT
TTTTAATGGTCTATACCTTCTGCAACATTTTTGTTTATGGCCATTTGAATAGTTGGACTTTGACTCCTCACTTGTGAATAATAGGAATAT
ATTTTGCAGAATCTAACATAATACCCTTAAAATTCATACTGGACAACCATCAGTGTGATGTATAGTATCTGGTGTAAACAAATTTTATTC
AGCATATTAAATTATTCTGTGTTTTGCTTTTCCTTGATATGTAGGAGGTGCACCAGTACCAGTTTTTCTCTTGTGGTGGCTTAAAACGCT
GATTGCCATTTGCATTGTCTACTGAAAAGCTGTGGCAGCGAGTGGTATTATTGACCATGTGTTCTCATGTCTTTTTGCAGATTTAAAGGT
TTTATTGTAGTGTCCATTTAATATCTGCATGTGTGTTTAATCTCTGAATACCATGTAATTAAACTGATTAACTTGTGATGGTGATGGTGA
TTAGCACACACTAAAAACCCAATGAAGCAATTGTCTCCCTCTTCTTAACTGGAAATCACACTTGTGAGGTATGGTATCCATTATCAACAG
TGGATTCATGATTGACTTCATATTTTGTGTATCTGGTTATAAATTTTGTATAGCATTTAATTTGGCACTTAATATAAATCCATTTGATTT
GAATAGTGTGTGTGTGTACATGGTGTGTGTGTGTGTGTGCACTTTAGTTTCGTGAGCCTTGGGAAACTGATTCTACAAATATCTTATATA
GAGATAAATGTATCAGGCATTTTTTTGCAAAGCGATATATACATTCCTCTTATTTATTAAATCACTGGCTTTGGTGTTATGTAGAGATAT
TTGTAGATCTCAGAACAGAATTAAAATATTGTGAAAATTACAGCTTAATAAATGTTTATTGTAATTTTGTTGTATGGACTTTTAAAATAT

>In-frame_MDM2_ENST00000258148_chr12_69214154_+_BRI3BP_ENST00000341446_chr12_125509890_+_6159nt
ATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAA
GAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTTCTT
TTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGAT
TTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAG
GTCAGCCGGCCGGGCGGGTCCACAGTTACCAGCACGCTGTCTCAGAAAACGAAAACGGAGGAAAAAAACCCCAAACCCCAAACAATCTTA
ATAAACACGACTGAGCAAGAAAGTGGCGCTGTGTAGGGCTATTTCCACCCACCCGGCAGCTCTTAGGACACATTCCCAGAAGAGCGGAAA
GATCATTGACGTGGAACTACACACGAAGTGTAATTAGTGGGGGAAAAAATATTTTTTAAACAAAGGATATAACCATATTTAGTTGTACAG
TAAGAGAAATTTATCTGTGCATAGAGCATAAAGTTAATTTTTTCAAGCATTTAAATACATCTTTTGTAAGGTTTTTTAATAAAGGCAGAT
TGAGTCAAGTTTATTAAAACTTTACATGGAGGGGAAGAATATGCTAATTTGACATTTGAGAAAAGTTTAAATGCGAGCGTTTGTTTTCAC
AGCTTAGGGATTGGTGGGTGAGGTCTGTGTGCGTTATTTTCATGTTCCCAAACTGTGAGCTTTATTTCATGTTATTTTTGGTGGATGTTG
ACTTAGTTCATGAATGTTGTCACTTCTAAATGTGGACAGTTGGGCTGCAGGATGCAACTCAACCTCTTTTGGATCCTAGAGACCCCTGCC
AAGCCCCCATCAGTCCTATTTTTAAATGAAGACATCGCCATTTCTAGAAGACCTGAGATTTTCTTCCCTCTGTGCTTCGATGTATTTTAA
CCTCAACATTTTGAAACGGAAAATGCAAGGAGGGGCCAAGAAATGTCCTGGGGATTTGATGCCAGGAAGTACCTGGTAAGGATTGGAGAT
TGCTCCAGAATCTACTGCATGTCCCAATTTGCAGTTTGCTCACTAGGGCTATATACAAAAGCTATACCCTTGAGGGTTTTTTTTTTTTTC
TTTTGATTTCCTCAGGACCTTAGAGGGAAAACAAACAGTAGCAGCTAATATTCTCAAGTATATTGCTGCTTAGAAAGATCCTCAGGAACA
ATTAGCAGCAATAAGCAAGCCTTTGAAAAGATCTGAATTCTTTTTCCTGAAATATTTACGATACACAGGTGCTTTTTATCTGAAATCTGT
TGTGTCCTCCTTTTAGGCAGTCTCTGTGGGCAGAGAGTGGGACTTGCGAGGTGGACAGCTGTGGGGATCCTGGGCAAGGGAGTTTCAGAA
GGTGTGGCTCAGGGGCTGGTAGAAACCCCCTTTTGTTAGGACTTGTTTTTTAAAAAAGAAAGCCCTAGGCCAGGCGCAGTGGCTGATGCC
TGTAATCCCAGCGCTTTGGGAGGCCGAGGAGTATGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCCG
TCTCTACTAAAAATACAAAAATTAGTCAGGCATGGTGGTGGGTGCCTGTAGTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGA
ACCTGGGAGGTGGAGGTTGCGGTGAGCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACAGAGCAAGACTTCATCTTAAAAAAAAAAA
AAAAAGCCCAGCATTTTGCAGCTTTGAAGCTGCTGGGGATCACGACTGTCTCTGTGGCCCTTACCTGGCCACAGATGTACCCTGGCAACC
CGCTCACAGTGCCCTGCGTGCAGGTTTATAGATAACCCCTGCCAGACCTGCTACAACCAAGACCTTATGGTCCAGGTCTCAGTTTGGAGA
AGATTTAGCTGTCTACCACTTCTTGTGTAGTGTTCCTGTGAAGTTTTATTTTTGGTTGCAAGTATCTGGAAAACAGATGCAGATGTTTTT
GTGGATGTTGTTGAGACTTTTGAGACTTCTGTTTCTAAGGTACACATGATGGGACCCAAACTCTCCTGGAGAGTTCCATTCACTTCCTGA
AACGTGCACCTGTTTCAGGTGCATGTTTATTCAGTGTGCATGGATATTTAAGATTTGCTGGAGCAGGCTGGGCAGGGTGGCTCACCCCTA
TAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCCGGCCAACAGAGTGAAACCCCGTCT
CTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGTGGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCTGGAGAATCGCTTGAAC
ATGGGAGGCGGAGGTTGCAGTCAGCTGAGATCATACCACCACACTCTAGCCTCAGCAACAGAGTGAGACTCCGTCTCAAAAAAAATTATT
TGCTGGATCGAATCTTTTTTTTTTTGAGATGGAGTCTCACTGTCAACCAGGCTGGAGTGCAGTGGCACCATCTCGGCTCACTGCAAGCTC
CGCCTCCTGGGTTCACGCCATTCTCCTACCTCAGCCTCCCAAGTAGCCGGGACTACAGGCGCCCACCATCATGCCCGGCTAATTTTTTAT
ATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTG
CTGGGATTACAGGCGTGAGCCACCGCGCTGGGCCTAGATCAAATCTTTATCCATGCACATTGGAACACAGGATTACTGGGTTGAAATCAT
TCTAGTTTTGTCATTTAGATACTTGTAGATGAATCTATTTTAGCACAAGGTATAAATAACTCGGGAGGTCATCTCTATCTTCTTTCCTTT
TGTGCATTTGGCTATACCACGTTTAGGTACTAAAACAGCTTTGCTTATGTTGGCCAGGGGAAAACATGGCATTCTGTGCGCAAAGCTAAT
GATCGCCAGCCCTGCCTTGGCCCCTCCCTTGTTTATGGTCATTGTAAGATGCCCGCATGTTAAGGCTTAAGCTGTCACTGGGCTGGGTGT
AATACCCGCTTCATTCCTCCTCCCACCCTCTTACCCGAAACATGAAGGGCACTGTGCTCTATTGAGATCTCGATAAGATCATCATTTTAA
CTTGTATTCAACTGAGGGAGGTAACATGATATCTGGGTGCTGGTGGATTGAGACCTCAAGCATCAATTCAAAATTGCTGTCGAAAATATG
CACTATTTTTTTTTTCCACTCTGGCTAAGTGTAGGCTCTGAAGCCAGTTTTATAGCTTGATACATTCTGGTGAAAGATGTCTTCATTTTT
AATGAAAGAACCTACAGTTAGTAGGTGTCACCTCAGGGTAGAAATTCTGATAGAAATTCTGATTATTTGAAACTCTGATAGAAATCCTAG
ATGCTAGATTTGAAGAAAACCTGGGTTTTATTGCATAGATTTCACCTTTTCTGGGGCACATCTTACCCCAAAATAATTGGGGATTTTTTT
GTTCCTTCTCCATTCCATGGAACCTTGTAGGGTGTTGGGATTGGGCCTCCCCTCGCCACCCGCCACATGTCTTTGTTTTTTTCTCTCTTT
TGTATGTGGAAAAATGTATTTTTGTACCATATCTCATACCTGGAGAGAAACCTTTTTTCTATCTTCAGGGCTGTAGAATATATTAGCGTA
ACACTTCACTGAATGTGACGTAAAAGCATTCTGATGAAAACTGGTTCTGTTATAATTAAGACTCAGTGTTTAAAATATCTTAATCAGTGT
TAATTTCCCAGTGTTTCAGTATCACAGTAAATACTTGTTTTACTGAGAACAGAAAATAATCCAGAAAAGGAAAAGGACCAGCCCTCTCTA
GATTGCTGGAATTGTATGGATGTGTTGGGGTTGGTTTAGTGATCTCTTCCTTGACACCCTAGCAAAGATGCTTTTGTGGAGTGCAAACCT
TTCATAAATATACTTTCCAGGCTGGGTGCAGTGGCTCAAGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACTTGCGGT
CGGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAATCCCGTCTCTACCAAAAAATACAAAAAAAAAAAAAAAAAAAAAAATAGCCAGGT
GTGGTGGTGGGTTCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGAATTGTATGAACCTGGGAGGCAGAGGTTGCAGTGAACTGA
GATCACACCACTGTACTCCAGTTGAGGCGACAGAGTGAGACCCAGTCTCAAAAAAAAAAAAAAGTGTGTGTGTGTGTATATATATGTATA
TATATATACACACACACACACTTTCCAATACCAGTCGGCATTACCCGCCCTTTGGTTTCTTTTGCTTTGGATTTCAGCCCCCATATCATT
TCTGGTAACAGAGCACAGCAATAGAATTTCTGGGAAGCAGACCTTGTGAATCGTGCCTGTGTCTTAATTCACAAAGGGTAAGTGAATGCC
GTTGAAAGGTGTTTCATACACTTACCCCAGAAATGAGAGCCTGTCTCATGCAGGAGTCGGGAGGCAGCGATGTCAGGGAACTGGGACTAT
GTCTTTATGACTGTGATGGTGGTAACCAAGTGGGGTGGTCCCCTCTGGGGAGCTGAGTAAGAACGCAAAGGTTTGGGTCAGTGATTAGGA
AGACTATAATATGACTTTGTGCATGCCCGGGAGGGCTGCCTTGTAGAGAGGATGTGAGCAGCTTAGTCGCTCATCTGGCCCTGTGATTCA
GGCTTATGGAGCGTTAAGAATAACAGCTGTCAAATGGCCTAGACATGGTTAATGCAATTTGTTGCTAGTGGAAATCCTGAATTGCTTCCT
TTCTGTGATCACTGCTACTTCTTAAGATGCTTTTGATGAATGTCATCTGCCTTACAAGTTGACACCTGATAACTTCTCCCTGATGGGTTT
CCGAACTGGCTGACTTAACCAAAAAGCCAGCTCTTGCCATCTATCTTGCATTAAAAGGAATTCCTGAGGCTCCTAAGGGGTCAGCTGCCC
CACTCCTGACTTTTTTATTTTTAATGGTCTATACCTTCTGCAACATTTTTGTTTATGGCCATTTGAATAGTTGGACTTTGACTCCTCACT
TGTGAATAATAGGAATATATTTTGCAGAATCTAACATAATACCCTTAAAATTCATACTGGACAACCATCAGTGTGATGTATAGTATCTGG
TGTAAACAAATTTTATTCAGCATATTAAATTATTCTGTGTTTTGCTTTTCCTTGATATGTAGGAGGTGCACCAGTACCAGTTTTTCTCTT
GTGGTGGCTTAAAACGCTGATTGCCATTTGCATTGTCTACTGAAAAGCTGTGGCAGCGAGTGGTATTATTGACCATGTGTTCTCATGTCT
TTTTGCAGATTTAAAGGTTTTATTGTAGTGTCCATTTAATATCTGCATGTGTGTTTAATCTCTGAATACCATGTAATTAAACTGATTAAC
TTGTGATGGTGATGGTGATTAGCACACACTAAAAACCCAATGAAGCAATTGTCTCCCTCTTCTTAACTGGAAATCACACTTGTGAGGTAT
GGTATCCATTATCAACAGTGGATTCATGATTGACTTCATATTTTGTGTATCTGGTTATAAATTTTGTATAGCATTTAATTTGGCACTTAA
TATAAATCCATTTGATTTGAATAGTGTGTGTGTGTACATGGTGTGTGTGTGTGTGTGCACTTTAGTTTCGTGAGCCTTGGGAAACTGATT
CTACAAATATCTTATATAGAGATAAATGTATCAGGCATTTTTTTGCAAAGCGATATATACATTCCTCTTATTTATTAAATCACTGGCTTT
GGTGTTATGTAGAGATATTTGTAGATCTCAGAACAGAATTAAAATATTGTGAAAATTACAGCTTAATAAATGTTTATTGTAATTTTGTTG

>In-frame_MDM2_ENST00000350057_chr12_69214154_+_BRI3BP_ENST00000341446_chr12_125509890_+_6066nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAGGTC
AGCCGGCCGGGCGGGTCCACAGTTACCAGCACGCTGTCTCAGAAAACGAAAACGGAGGAAAAAAACCCCAAACCCCAAACAATCTTAATA
AACACGACTGAGCAAGAAAGTGGCGCTGTGTAGGGCTATTTCCACCCACCCGGCAGCTCTTAGGACACATTCCCAGAAGAGCGGAAAGAT
CATTGACGTGGAACTACACACGAAGTGTAATTAGTGGGGGAAAAAATATTTTTTAAACAAAGGATATAACCATATTTAGTTGTACAGTAA
GAGAAATTTATCTGTGCATAGAGCATAAAGTTAATTTTTTCAAGCATTTAAATACATCTTTTGTAAGGTTTTTTAATAAAGGCAGATTGA
GTCAAGTTTATTAAAACTTTACATGGAGGGGAAGAATATGCTAATTTGACATTTGAGAAAAGTTTAAATGCGAGCGTTTGTTTTCACAGC
TTAGGGATTGGTGGGTGAGGTCTGTGTGCGTTATTTTCATGTTCCCAAACTGTGAGCTTTATTTCATGTTATTTTTGGTGGATGTTGACT
TAGTTCATGAATGTTGTCACTTCTAAATGTGGACAGTTGGGCTGCAGGATGCAACTCAACCTCTTTTGGATCCTAGAGACCCCTGCCAAG
CCCCCATCAGTCCTATTTTTAAATGAAGACATCGCCATTTCTAGAAGACCTGAGATTTTCTTCCCTCTGTGCTTCGATGTATTTTAACCT
CAACATTTTGAAACGGAAAATGCAAGGAGGGGCCAAGAAATGTCCTGGGGATTTGATGCCAGGAAGTACCTGGTAAGGATTGGAGATTGC
TCCAGAATCTACTGCATGTCCCAATTTGCAGTTTGCTCACTAGGGCTATATACAAAAGCTATACCCTTGAGGGTTTTTTTTTTTTTCTTT
TGATTTCCTCAGGACCTTAGAGGGAAAACAAACAGTAGCAGCTAATATTCTCAAGTATATTGCTGCTTAGAAAGATCCTCAGGAACAATT
AGCAGCAATAAGCAAGCCTTTGAAAAGATCTGAATTCTTTTTCCTGAAATATTTACGATACACAGGTGCTTTTTATCTGAAATCTGTTGT
GTCCTCCTTTTAGGCAGTCTCTGTGGGCAGAGAGTGGGACTTGCGAGGTGGACAGCTGTGGGGATCCTGGGCAAGGGAGTTTCAGAAGGT
GTGGCTCAGGGGCTGGTAGAAACCCCCTTTTGTTAGGACTTGTTTTTTAAAAAAGAAAGCCCTAGGCCAGGCGCAGTGGCTGATGCCTGT
AATCCCAGCGCTTTGGGAGGCCGAGGAGTATGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCCGTCT
CTACTAAAAATACAAAAATTAGTCAGGCATGGTGGTGGGTGCCTGTAGTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACC
TGGGAGGTGGAGGTTGCGGTGAGCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACAGAGCAAGACTTCATCTTAAAAAAAAAAAAAA
AAGCCCAGCATTTTGCAGCTTTGAAGCTGCTGGGGATCACGACTGTCTCTGTGGCCCTTACCTGGCCACAGATGTACCCTGGCAACCCGC
TCACAGTGCCCTGCGTGCAGGTTTATAGATAACCCCTGCCAGACCTGCTACAACCAAGACCTTATGGTCCAGGTCTCAGTTTGGAGAAGA
TTTAGCTGTCTACCACTTCTTGTGTAGTGTTCCTGTGAAGTTTTATTTTTGGTTGCAAGTATCTGGAAAACAGATGCAGATGTTTTTGTG
GATGTTGTTGAGACTTTTGAGACTTCTGTTTCTAAGGTACACATGATGGGACCCAAACTCTCCTGGAGAGTTCCATTCACTTCCTGAAAC
GTGCACCTGTTTCAGGTGCATGTTTATTCAGTGTGCATGGATATTTAAGATTTGCTGGAGCAGGCTGGGCAGGGTGGCTCACCCCTATAA
TCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCCGGCCAACAGAGTGAAACCCCGTCTCTA
CTAAAAATACAAAAATTAGCCAGGCCTGGTGGTGGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCTGGAGAATCGCTTGAACATG
GGAGGCGGAGGTTGCAGTCAGCTGAGATCATACCACCACACTCTAGCCTCAGCAACAGAGTGAGACTCCGTCTCAAAAAAAATTATTTGC
TGGATCGAATCTTTTTTTTTTTGAGATGGAGTCTCACTGTCAACCAGGCTGGAGTGCAGTGGCACCATCTCGGCTCACTGCAAGCTCCGC
CTCCTGGGTTCACGCCATTCTCCTACCTCAGCCTCCCAAGTAGCCGGGACTACAGGCGCCCACCATCATGCCCGGCTAATTTTTTATATT
TTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTG
GGATTACAGGCGTGAGCCACCGCGCTGGGCCTAGATCAAATCTTTATCCATGCACATTGGAACACAGGATTACTGGGTTGAAATCATTCT
AGTTTTGTCATTTAGATACTTGTAGATGAATCTATTTTAGCACAAGGTATAAATAACTCGGGAGGTCATCTCTATCTTCTTTCCTTTTGT
GCATTTGGCTATACCACGTTTAGGTACTAAAACAGCTTTGCTTATGTTGGCCAGGGGAAAACATGGCATTCTGTGCGCAAAGCTAATGAT
CGCCAGCCCTGCCTTGGCCCCTCCCTTGTTTATGGTCATTGTAAGATGCCCGCATGTTAAGGCTTAAGCTGTCACTGGGCTGGGTGTAAT
ACCCGCTTCATTCCTCCTCCCACCCTCTTACCCGAAACATGAAGGGCACTGTGCTCTATTGAGATCTCGATAAGATCATCATTTTAACTT
GTATTCAACTGAGGGAGGTAACATGATATCTGGGTGCTGGTGGATTGAGACCTCAAGCATCAATTCAAAATTGCTGTCGAAAATATGCAC
TATTTTTTTTTTCCACTCTGGCTAAGTGTAGGCTCTGAAGCCAGTTTTATAGCTTGATACATTCTGGTGAAAGATGTCTTCATTTTTAAT
GAAAGAACCTACAGTTAGTAGGTGTCACCTCAGGGTAGAAATTCTGATAGAAATTCTGATTATTTGAAACTCTGATAGAAATCCTAGATG
CTAGATTTGAAGAAAACCTGGGTTTTATTGCATAGATTTCACCTTTTCTGGGGCACATCTTACCCCAAAATAATTGGGGATTTTTTTGTT
CCTTCTCCATTCCATGGAACCTTGTAGGGTGTTGGGATTGGGCCTCCCCTCGCCACCCGCCACATGTCTTTGTTTTTTTCTCTCTTTTGT
ATGTGGAAAAATGTATTTTTGTACCATATCTCATACCTGGAGAGAAACCTTTTTTCTATCTTCAGGGCTGTAGAATATATTAGCGTAACA
CTTCACTGAATGTGACGTAAAAGCATTCTGATGAAAACTGGTTCTGTTATAATTAAGACTCAGTGTTTAAAATATCTTAATCAGTGTTAA
TTTCCCAGTGTTTCAGTATCACAGTAAATACTTGTTTTACTGAGAACAGAAAATAATCCAGAAAAGGAAAAGGACCAGCCCTCTCTAGAT
TGCTGGAATTGTATGGATGTGTTGGGGTTGGTTTAGTGATCTCTTCCTTGACACCCTAGCAAAGATGCTTTTGTGGAGTGCAAACCTTTC
ATAAATATACTTTCCAGGCTGGGTGCAGTGGCTCAAGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACTTGCGGTCGG
GAGTTCGAGACCAGCCTGGCCAACATAGTGAAATCCCGTCTCTACCAAAAAATACAAAAAAAAAAAAAAAAAAAAAAATAGCCAGGTGTG
GTGGTGGGTTCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGAATTGTATGAACCTGGGAGGCAGAGGTTGCAGTGAACTGAGAT
CACACCACTGTACTCCAGTTGAGGCGACAGAGTGAGACCCAGTCTCAAAAAAAAAAAAAAGTGTGTGTGTGTGTATATATATGTATATAT
ATATACACACACACACACTTTCCAATACCAGTCGGCATTACCCGCCCTTTGGTTTCTTTTGCTTTGGATTTCAGCCCCCATATCATTTCT
GGTAACAGAGCACAGCAATAGAATTTCTGGGAAGCAGACCTTGTGAATCGTGCCTGTGTCTTAATTCACAAAGGGTAAGTGAATGCCGTT
GAAAGGTGTTTCATACACTTACCCCAGAAATGAGAGCCTGTCTCATGCAGGAGTCGGGAGGCAGCGATGTCAGGGAACTGGGACTATGTC
TTTATGACTGTGATGGTGGTAACCAAGTGGGGTGGTCCCCTCTGGGGAGCTGAGTAAGAACGCAAAGGTTTGGGTCAGTGATTAGGAAGA
CTATAATATGACTTTGTGCATGCCCGGGAGGGCTGCCTTGTAGAGAGGATGTGAGCAGCTTAGTCGCTCATCTGGCCCTGTGATTCAGGC
TTATGGAGCGTTAAGAATAACAGCTGTCAAATGGCCTAGACATGGTTAATGCAATTTGTTGCTAGTGGAAATCCTGAATTGCTTCCTTTC
TGTGATCACTGCTACTTCTTAAGATGCTTTTGATGAATGTCATCTGCCTTACAAGTTGACACCTGATAACTTCTCCCTGATGGGTTTCCG
AACTGGCTGACTTAACCAAAAAGCCAGCTCTTGCCATCTATCTTGCATTAAAAGGAATTCCTGAGGCTCCTAAGGGGTCAGCTGCCCCAC
TCCTGACTTTTTTATTTTTAATGGTCTATACCTTCTGCAACATTTTTGTTTATGGCCATTTGAATAGTTGGACTTTGACTCCTCACTTGT
GAATAATAGGAATATATTTTGCAGAATCTAACATAATACCCTTAAAATTCATACTGGACAACCATCAGTGTGATGTATAGTATCTGGTGT
AAACAAATTTTATTCAGCATATTAAATTATTCTGTGTTTTGCTTTTCCTTGATATGTAGGAGGTGCACCAGTACCAGTTTTTCTCTTGTG
GTGGCTTAAAACGCTGATTGCCATTTGCATTGTCTACTGAAAAGCTGTGGCAGCGAGTGGTATTATTGACCATGTGTTCTCATGTCTTTT
TGCAGATTTAAAGGTTTTATTGTAGTGTCCATTTAATATCTGCATGTGTGTTTAATCTCTGAATACCATGTAATTAAACTGATTAACTTG
TGATGGTGATGGTGATTAGCACACACTAAAAACCCAATGAAGCAATTGTCTCCCTCTTCTTAACTGGAAATCACACTTGTGAGGTATGGT
ATCCATTATCAACAGTGGATTCATGATTGACTTCATATTTTGTGTATCTGGTTATAAATTTTGTATAGCATTTAATTTGGCACTTAATAT
AAATCCATTTGATTTGAATAGTGTGTGTGTGTACATGGTGTGTGTGTGTGTGTGCACTTTAGTTTCGTGAGCCTTGGGAAACTGATTCTA
CAAATATCTTATATAGAGATAAATGTATCAGGCATTTTTTTGCAAAGCGATATATACATTCCTCTTATTTATTAAATCACTGGCTTTGGT
GTTATGTAGAGATATTTGTAGATCTCAGAACAGAATTAAAATATTGTGAAAATTACAGCTTAATAAATGTTTATTGTAATTTTGTTGTAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_MDM2_ENST00000462284_chr12_69214154_+_BRI3BP_ENST00000341446_chr12_125509890_+_6547nt
GGGGCGCGCACCGAGGCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGC
CCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGC
CCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGA
GGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTG
TAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCAC
AAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATA
TTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCT
ACAGGAACTTGGTAGTAGTCAATCAGCAGGTGGAGCACCTGGAGAAGCAGGTCAGACTGCTCAACATCCGTCTCAACCGGGTGCTCGAGA
GCCTGGACCGCTCCAAGGACAAGTGAAGGTCAGCCGGCCGGGCGGGTCCACAGTTACCAGCACGCTGTCTCAGAAAACGAAAACGGAGGA
AAAAAACCCCAAACCCCAAACAATCTTAATAAACACGACTGAGCAAGAAAGTGGCGCTGTGTAGGGCTATTTCCACCCACCCGGCAGCTC
TTAGGACACATTCCCAGAAGAGCGGAAAGATCATTGACGTGGAACTACACACGAAGTGTAATTAGTGGGGGAAAAAATATTTTTTAAACA
AAGGATATAACCATATTTAGTTGTACAGTAAGAGAAATTTATCTGTGCATAGAGCATAAAGTTAATTTTTTCAAGCATTTAAATACATCT
TTTGTAAGGTTTTTTAATAAAGGCAGATTGAGTCAAGTTTATTAAAACTTTACATGGAGGGGAAGAATATGCTAATTTGACATTTGAGAA
AAGTTTAAATGCGAGCGTTTGTTTTCACAGCTTAGGGATTGGTGGGTGAGGTCTGTGTGCGTTATTTTCATGTTCCCAAACTGTGAGCTT
TATTTCATGTTATTTTTGGTGGATGTTGACTTAGTTCATGAATGTTGTCACTTCTAAATGTGGACAGTTGGGCTGCAGGATGCAACTCAA
CCTCTTTTGGATCCTAGAGACCCCTGCCAAGCCCCCATCAGTCCTATTTTTAAATGAAGACATCGCCATTTCTAGAAGACCTGAGATTTT
CTTCCCTCTGTGCTTCGATGTATTTTAACCTCAACATTTTGAAACGGAAAATGCAAGGAGGGGCCAAGAAATGTCCTGGGGATTTGATGC
CAGGAAGTACCTGGTAAGGATTGGAGATTGCTCCAGAATCTACTGCATGTCCCAATTTGCAGTTTGCTCACTAGGGCTATATACAAAAGC
TATACCCTTGAGGGTTTTTTTTTTTTTCTTTTGATTTCCTCAGGACCTTAGAGGGAAAACAAACAGTAGCAGCTAATATTCTCAAGTATA
TTGCTGCTTAGAAAGATCCTCAGGAACAATTAGCAGCAATAAGCAAGCCTTTGAAAAGATCTGAATTCTTTTTCCTGAAATATTTACGAT
ACACAGGTGCTTTTTATCTGAAATCTGTTGTGTCCTCCTTTTAGGCAGTCTCTGTGGGCAGAGAGTGGGACTTGCGAGGTGGACAGCTGT
GGGGATCCTGGGCAAGGGAGTTTCAGAAGGTGTGGCTCAGGGGCTGGTAGAAACCCCCTTTTGTTAGGACTTGTTTTTTAAAAAAGAAAG
CCCTAGGCCAGGCGCAGTGGCTGATGCCTGTAATCCCAGCGCTTTGGGAGGCCGAGGAGTATGGATCACCTGAGGTCAGGAGTTCAAGAC
CAGCCTGGCCAACATGGTGAAACCCCCGTCTCTACTAAAAATACAAAAATTAGTCAGGCATGGTGGTGGGTGCCTGTAGTCCAGCTACTC
AGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCGGTGAGCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACA
GAGCAAGACTTCATCTTAAAAAAAAAAAAAAAAGCCCAGCATTTTGCAGCTTTGAAGCTGCTGGGGATCACGACTGTCTCTGTGGCCCTT
ACCTGGCCACAGATGTACCCTGGCAACCCGCTCACAGTGCCCTGCGTGCAGGTTTATAGATAACCCCTGCCAGACCTGCTACAACCAAGA
CCTTATGGTCCAGGTCTCAGTTTGGAGAAGATTTAGCTGTCTACCACTTCTTGTGTAGTGTTCCTGTGAAGTTTTATTTTTGGTTGCAAG
TATCTGGAAAACAGATGCAGATGTTTTTGTGGATGTTGTTGAGACTTTTGAGACTTCTGTTTCTAAGGTACACATGATGGGACCCAAACT
CTCCTGGAGAGTTCCATTCACTTCCTGAAACGTGCACCTGTTTCAGGTGCATGTTTATTCAGTGTGCATGGATATTTAAGATTTGCTGGA
GCAGGCTGGGCAGGGTGGCTCACCCCTATAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCA
GCCCGGCCAACAGAGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGTGGGCGCCTGTGATCCCAGCTACTTGG
GAGGCTGAGGCTGGAGAATCGCTTGAACATGGGAGGCGGAGGTTGCAGTCAGCTGAGATCATACCACCACACTCTAGCCTCAGCAACAGA
GTGAGACTCCGTCTCAAAAAAAATTATTTGCTGGATCGAATCTTTTTTTTTTTGAGATGGAGTCTCACTGTCAACCAGGCTGGAGTGCAG
TGGCACCATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTCCTACCTCAGCCTCCCAAGTAGCCGGGACTACAGGCGC
CCACCATCATGCCCGGCTAATTTTTTATATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGT
GATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCTGGGCCTAGATCAAATCTTTATCCATGCACATTG
GAACACAGGATTACTGGGTTGAAATCATTCTAGTTTTGTCATTTAGATACTTGTAGATGAATCTATTTTAGCACAAGGTATAAATAACTC
GGGAGGTCATCTCTATCTTCTTTCCTTTTGTGCATTTGGCTATACCACGTTTAGGTACTAAAACAGCTTTGCTTATGTTGGCCAGGGGAA
AACATGGCATTCTGTGCGCAAAGCTAATGATCGCCAGCCCTGCCTTGGCCCCTCCCTTGTTTATGGTCATTGTAAGATGCCCGCATGTTA
AGGCTTAAGCTGTCACTGGGCTGGGTGTAATACCCGCTTCATTCCTCCTCCCACCCTCTTACCCGAAACATGAAGGGCACTGTGCTCTAT
TGAGATCTCGATAAGATCATCATTTTAACTTGTATTCAACTGAGGGAGGTAACATGATATCTGGGTGCTGGTGGATTGAGACCTCAAGCA
TCAATTCAAAATTGCTGTCGAAAATATGCACTATTTTTTTTTTCCACTCTGGCTAAGTGTAGGCTCTGAAGCCAGTTTTATAGCTTGATA
CATTCTGGTGAAAGATGTCTTCATTTTTAATGAAAGAACCTACAGTTAGTAGGTGTCACCTCAGGGTAGAAATTCTGATAGAAATTCTGA
TTATTTGAAACTCTGATAGAAATCCTAGATGCTAGATTTGAAGAAAACCTGGGTTTTATTGCATAGATTTCACCTTTTCTGGGGCACATC
TTACCCCAAAATAATTGGGGATTTTTTTGTTCCTTCTCCATTCCATGGAACCTTGTAGGGTGTTGGGATTGGGCCTCCCCTCGCCACCCG
CCACATGTCTTTGTTTTTTTCTCTCTTTTGTATGTGGAAAAATGTATTTTTGTACCATATCTCATACCTGGAGAGAAACCTTTTTTCTAT
CTTCAGGGCTGTAGAATATATTAGCGTAACACTTCACTGAATGTGACGTAAAAGCATTCTGATGAAAACTGGTTCTGTTATAATTAAGAC
TCAGTGTTTAAAATATCTTAATCAGTGTTAATTTCCCAGTGTTTCAGTATCACAGTAAATACTTGTTTTACTGAGAACAGAAAATAATCC
AGAAAAGGAAAAGGACCAGCCCTCTCTAGATTGCTGGAATTGTATGGATGTGTTGGGGTTGGTTTAGTGATCTCTTCCTTGACACCCTAG
CAAAGATGCTTTTGTGGAGTGCAAACCTTTCATAAATATACTTTCCAGGCTGGGTGCAGTGGCTCAAGCTTGTAATCCCAGCACTTTGGG
AGGCCAAGGCGGGTGGATCACTTGCGGTCGGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAATCCCGTCTCTACCAAAAAATACAAAA
AAAAAAAAAAAAAAAAAAATAGCCAGGTGTGGTGGTGGGTTCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGAATTGTATGAAC
CTGGGAGGCAGAGGTTGCAGTGAACTGAGATCACACCACTGTACTCCAGTTGAGGCGACAGAGTGAGACCCAGTCTCAAAAAAAAAAAAA
AGTGTGTGTGTGTGTATATATATGTATATATATATACACACACACACACTTTCCAATACCAGTCGGCATTACCCGCCCTTTGGTTTCTTT
TGCTTTGGATTTCAGCCCCCATATCATTTCTGGTAACAGAGCACAGCAATAGAATTTCTGGGAAGCAGACCTTGTGAATCGTGCCTGTGT
CTTAATTCACAAAGGGTAAGTGAATGCCGTTGAAAGGTGTTTCATACACTTACCCCAGAAATGAGAGCCTGTCTCATGCAGGAGTCGGGA
GGCAGCGATGTCAGGGAACTGGGACTATGTCTTTATGACTGTGATGGTGGTAACCAAGTGGGGTGGTCCCCTCTGGGGAGCTGAGTAAGA
ACGCAAAGGTTTGGGTCAGTGATTAGGAAGACTATAATATGACTTTGTGCATGCCCGGGAGGGCTGCCTTGTAGAGAGGATGTGAGCAGC
TTAGTCGCTCATCTGGCCCTGTGATTCAGGCTTATGGAGCGTTAAGAATAACAGCTGTCAAATGGCCTAGACATGGTTAATGCAATTTGT
TGCTAGTGGAAATCCTGAATTGCTTCCTTTCTGTGATCACTGCTACTTCTTAAGATGCTTTTGATGAATGTCATCTGCCTTACAAGTTGA
CACCTGATAACTTCTCCCTGATGGGTTTCCGAACTGGCTGACTTAACCAAAAAGCCAGCTCTTGCCATCTATCTTGCATTAAAAGGAATT
CCTGAGGCTCCTAAGGGGTCAGCTGCCCCACTCCTGACTTTTTTATTTTTAATGGTCTATACCTTCTGCAACATTTTTGTTTATGGCCAT
TTGAATAGTTGGACTTTGACTCCTCACTTGTGAATAATAGGAATATATTTTGCAGAATCTAACATAATACCCTTAAAATTCATACTGGAC
AACCATCAGTGTGATGTATAGTATCTGGTGTAAACAAATTTTATTCAGCATATTAAATTATTCTGTGTTTTGCTTTTCCTTGATATGTAG
GAGGTGCACCAGTACCAGTTTTTCTCTTGTGGTGGCTTAAAACGCTGATTGCCATTTGCATTGTCTACTGAAAAGCTGTGGCAGCGAGTG
GTATTATTGACCATGTGTTCTCATGTCTTTTTGCAGATTTAAAGGTTTTATTGTAGTGTCCATTTAATATCTGCATGTGTGTTTAATCTC
TGAATACCATGTAATTAAACTGATTAACTTGTGATGGTGATGGTGATTAGCACACACTAAAAACCCAATGAAGCAATTGTCTCCCTCTTC
TTAACTGGAAATCACACTTGTGAGGTATGGTATCCATTATCAACAGTGGATTCATGATTGACTTCATATTTTGTGTATCTGGTTATAAAT
TTTGTATAGCATTTAATTTGGCACTTAATATAAATCCATTTGATTTGAATAGTGTGTGTGTGTACATGGTGTGTGTGTGTGTGTGCACTT
TAGTTTCGTGAGCCTTGGGAAACTGATTCTACAAATATCTTATATAGAGATAAATGTATCAGGCATTTTTTTGCAAAGCGATATATACAT
TCCTCTTATTTATTAAATCACTGGCTTTGGTGTTATGTAGAGATATTTGTAGATCTCAGAACAGAATTAAAATATTGTGAAAATTACAGC

>In-frame_MDM2_ENST00000258149_chr12_69214154_+_BRI3BP_ENST00000341446_chr12_125509890_+_6532nt
GCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGC
GACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCC
GGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCC
AAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGA
TTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATA
CTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAA
ATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAG
TAGTCAATCAGCAGGTGGAGCACCTGGAGAAGCAGGTCAGACTGCTCAACATCCGTCTCAACCGGGTGCTCGAGAGCCTGGACCGCTCCA
AGGACAAGTGAAGGTCAGCCGGCCGGGCGGGTCCACAGTTACCAGCACGCTGTCTCAGAAAACGAAAACGGAGGAAAAAAACCCCAAACC
CCAAACAATCTTAATAAACACGACTGAGCAAGAAAGTGGCGCTGTGTAGGGCTATTTCCACCCACCCGGCAGCTCTTAGGACACATTCCC
AGAAGAGCGGAAAGATCATTGACGTGGAACTACACACGAAGTGTAATTAGTGGGGGAAAAAATATTTTTTAAACAAAGGATATAACCATA
TTTAGTTGTACAGTAAGAGAAATTTATCTGTGCATAGAGCATAAAGTTAATTTTTTCAAGCATTTAAATACATCTTTTGTAAGGTTTTTT
AATAAAGGCAGATTGAGTCAAGTTTATTAAAACTTTACATGGAGGGGAAGAATATGCTAATTTGACATTTGAGAAAAGTTTAAATGCGAG
CGTTTGTTTTCACAGCTTAGGGATTGGTGGGTGAGGTCTGTGTGCGTTATTTTCATGTTCCCAAACTGTGAGCTTTATTTCATGTTATTT
TTGGTGGATGTTGACTTAGTTCATGAATGTTGTCACTTCTAAATGTGGACAGTTGGGCTGCAGGATGCAACTCAACCTCTTTTGGATCCT
AGAGACCCCTGCCAAGCCCCCATCAGTCCTATTTTTAAATGAAGACATCGCCATTTCTAGAAGACCTGAGATTTTCTTCCCTCTGTGCTT
CGATGTATTTTAACCTCAACATTTTGAAACGGAAAATGCAAGGAGGGGCCAAGAAATGTCCTGGGGATTTGATGCCAGGAAGTACCTGGT
AAGGATTGGAGATTGCTCCAGAATCTACTGCATGTCCCAATTTGCAGTTTGCTCACTAGGGCTATATACAAAAGCTATACCCTTGAGGGT
TTTTTTTTTTTTCTTTTGATTTCCTCAGGACCTTAGAGGGAAAACAAACAGTAGCAGCTAATATTCTCAAGTATATTGCTGCTTAGAAAG
ATCCTCAGGAACAATTAGCAGCAATAAGCAAGCCTTTGAAAAGATCTGAATTCTTTTTCCTGAAATATTTACGATACACAGGTGCTTTTT
ATCTGAAATCTGTTGTGTCCTCCTTTTAGGCAGTCTCTGTGGGCAGAGAGTGGGACTTGCGAGGTGGACAGCTGTGGGGATCCTGGGCAA
GGGAGTTTCAGAAGGTGTGGCTCAGGGGCTGGTAGAAACCCCCTTTTGTTAGGACTTGTTTTTTAAAAAAGAAAGCCCTAGGCCAGGCGC
AGTGGCTGATGCCTGTAATCCCAGCGCTTTGGGAGGCCGAGGAGTATGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACAT
GGTGAAACCCCCGTCTCTACTAAAAATACAAAAATTAGTCAGGCATGGTGGTGGGTGCCTGTAGTCCAGCTACTCAGGAGGCTGAGGCAG
GAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCGGTGAGCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACAGAGCAAGACTTCATC
TTAAAAAAAAAAAAAAAAGCCCAGCATTTTGCAGCTTTGAAGCTGCTGGGGATCACGACTGTCTCTGTGGCCCTTACCTGGCCACAGATG
TACCCTGGCAACCCGCTCACAGTGCCCTGCGTGCAGGTTTATAGATAACCCCTGCCAGACCTGCTACAACCAAGACCTTATGGTCCAGGT
CTCAGTTTGGAGAAGATTTAGCTGTCTACCACTTCTTGTGTAGTGTTCCTGTGAAGTTTTATTTTTGGTTGCAAGTATCTGGAAAACAGA
TGCAGATGTTTTTGTGGATGTTGTTGAGACTTTTGAGACTTCTGTTTCTAAGGTACACATGATGGGACCCAAACTCTCCTGGAGAGTTCC
ATTCACTTCCTGAAACGTGCACCTGTTTCAGGTGCATGTTTATTCAGTGTGCATGGATATTTAAGATTTGCTGGAGCAGGCTGGGCAGGG
TGGCTCACCCCTATAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCCGGCCAACAGAG
TGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGTGGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCTGGA
GAATCGCTTGAACATGGGAGGCGGAGGTTGCAGTCAGCTGAGATCATACCACCACACTCTAGCCTCAGCAACAGAGTGAGACTCCGTCTC
AAAAAAAATTATTTGCTGGATCGAATCTTTTTTTTTTTGAGATGGAGTCTCACTGTCAACCAGGCTGGAGTGCAGTGGCACCATCTCGGC
TCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTCCTACCTCAGCCTCCCAAGTAGCCGGGACTACAGGCGCCCACCATCATGCCCG
GCTAATTTTTTATATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCG
GCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCTGGGCCTAGATCAAATCTTTATCCATGCACATTGGAACACAGGATTACT
GGGTTGAAATCATTCTAGTTTTGTCATTTAGATACTTGTAGATGAATCTATTTTAGCACAAGGTATAAATAACTCGGGAGGTCATCTCTA
TCTTCTTTCCTTTTGTGCATTTGGCTATACCACGTTTAGGTACTAAAACAGCTTTGCTTATGTTGGCCAGGGGAAAACATGGCATTCTGT
GCGCAAAGCTAATGATCGCCAGCCCTGCCTTGGCCCCTCCCTTGTTTATGGTCATTGTAAGATGCCCGCATGTTAAGGCTTAAGCTGTCA
CTGGGCTGGGTGTAATACCCGCTTCATTCCTCCTCCCACCCTCTTACCCGAAACATGAAGGGCACTGTGCTCTATTGAGATCTCGATAAG
ATCATCATTTTAACTTGTATTCAACTGAGGGAGGTAACATGATATCTGGGTGCTGGTGGATTGAGACCTCAAGCATCAATTCAAAATTGC
TGTCGAAAATATGCACTATTTTTTTTTTCCACTCTGGCTAAGTGTAGGCTCTGAAGCCAGTTTTATAGCTTGATACATTCTGGTGAAAGA
TGTCTTCATTTTTAATGAAAGAACCTACAGTTAGTAGGTGTCACCTCAGGGTAGAAATTCTGATAGAAATTCTGATTATTTGAAACTCTG
ATAGAAATCCTAGATGCTAGATTTGAAGAAAACCTGGGTTTTATTGCATAGATTTCACCTTTTCTGGGGCACATCTTACCCCAAAATAAT
TGGGGATTTTTTTGTTCCTTCTCCATTCCATGGAACCTTGTAGGGTGTTGGGATTGGGCCTCCCCTCGCCACCCGCCACATGTCTTTGTT
TTTTTCTCTCTTTTGTATGTGGAAAAATGTATTTTTGTACCATATCTCATACCTGGAGAGAAACCTTTTTTCTATCTTCAGGGCTGTAGA
ATATATTAGCGTAACACTTCACTGAATGTGACGTAAAAGCATTCTGATGAAAACTGGTTCTGTTATAATTAAGACTCAGTGTTTAAAATA
TCTTAATCAGTGTTAATTTCCCAGTGTTTCAGTATCACAGTAAATACTTGTTTTACTGAGAACAGAAAATAATCCAGAAAAGGAAAAGGA
CCAGCCCTCTCTAGATTGCTGGAATTGTATGGATGTGTTGGGGTTGGTTTAGTGATCTCTTCCTTGACACCCTAGCAAAGATGCTTTTGT
GGAGTGCAAACCTTTCATAAATATACTTTCCAGGCTGGGTGCAGTGGCTCAAGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTG
GATCACTTGCGGTCGGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAATCCCGTCTCTACCAAAAAATACAAAAAAAAAAAAAAAAAAA
AAAATAGCCAGGTGTGGTGGTGGGTTCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGAATTGTATGAACCTGGGAGGCAGAGGT
TGCAGTGAACTGAGATCACACCACTGTACTCCAGTTGAGGCGACAGAGTGAGACCCAGTCTCAAAAAAAAAAAAAAGTGTGTGTGTGTGT
ATATATATGTATATATATATACACACACACACACTTTCCAATACCAGTCGGCATTACCCGCCCTTTGGTTTCTTTTGCTTTGGATTTCAG
CCCCCATATCATTTCTGGTAACAGAGCACAGCAATAGAATTTCTGGGAAGCAGACCTTGTGAATCGTGCCTGTGTCTTAATTCACAAAGG
GTAAGTGAATGCCGTTGAAAGGTGTTTCATACACTTACCCCAGAAATGAGAGCCTGTCTCATGCAGGAGTCGGGAGGCAGCGATGTCAGG
GAACTGGGACTATGTCTTTATGACTGTGATGGTGGTAACCAAGTGGGGTGGTCCCCTCTGGGGAGCTGAGTAAGAACGCAAAGGTTTGGG
TCAGTGATTAGGAAGACTATAATATGACTTTGTGCATGCCCGGGAGGGCTGCCTTGTAGAGAGGATGTGAGCAGCTTAGTCGCTCATCTG
GCCCTGTGATTCAGGCTTATGGAGCGTTAAGAATAACAGCTGTCAAATGGCCTAGACATGGTTAATGCAATTTGTTGCTAGTGGAAATCC
TGAATTGCTTCCTTTCTGTGATCACTGCTACTTCTTAAGATGCTTTTGATGAATGTCATCTGCCTTACAAGTTGACACCTGATAACTTCT
CCCTGATGGGTTTCCGAACTGGCTGACTTAACCAAAAAGCCAGCTCTTGCCATCTATCTTGCATTAAAAGGAATTCCTGAGGCTCCTAAG
GGGTCAGCTGCCCCACTCCTGACTTTTTTATTTTTAATGGTCTATACCTTCTGCAACATTTTTGTTTATGGCCATTTGAATAGTTGGACT
TTGACTCCTCACTTGTGAATAATAGGAATATATTTTGCAGAATCTAACATAATACCCTTAAAATTCATACTGGACAACCATCAGTGTGAT
GTATAGTATCTGGTGTAAACAAATTTTATTCAGCATATTAAATTATTCTGTGTTTTGCTTTTCCTTGATATGTAGGAGGTGCACCAGTAC
CAGTTTTTCTCTTGTGGTGGCTTAAAACGCTGATTGCCATTTGCATTGTCTACTGAAAAGCTGTGGCAGCGAGTGGTATTATTGACCATG
TGTTCTCATGTCTTTTTGCAGATTTAAAGGTTTTATTGTAGTGTCCATTTAATATCTGCATGTGTGTTTAATCTCTGAATACCATGTAAT
TAAACTGATTAACTTGTGATGGTGATGGTGATTAGCACACACTAAAAACCCAATGAAGCAATTGTCTCCCTCTTCTTAACTGGAAATCAC
ACTTGTGAGGTATGGTATCCATTATCAACAGTGGATTCATGATTGACTTCATATTTTGTGTATCTGGTTATAAATTTTGTATAGCATTTA
ATTTGGCACTTAATATAAATCCATTTGATTTGAATAGTGTGTGTGTGTACATGGTGTGTGTGTGTGTGTGCACTTTAGTTTCGTGAGCCT
TGGGAAACTGATTCTACAAATATCTTATATAGAGATAAATGTATCAGGCATTTTTTTGCAAAGCGATATATACATTCCTCTTATTTATTA
AATCACTGGCTTTGGTGTTATGTAGAGATATTTGTAGATCTCAGAACAGAATTAAAATATTGTGAAAATTACAGCTTAATAAATGTTTAT

>In-frame_MDM2_ENST00000258148_chr12_69214154_+_BRI3BP_ENST00000341446_chr12_125509890_+_6259nt
CGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTC
CAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTA
TGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATG
ATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAG
TCAATCAGCAGGTGGAGCACCTGGAGAAGCAGGTCAGACTGCTCAACATCCGTCTCAACCGGGTGCTCGAGAGCCTGGACCGCTCCAAGG
ACAAGTGAAGGTCAGCCGGCCGGGCGGGTCCACAGTTACCAGCACGCTGTCTCAGAAAACGAAAACGGAGGAAAAAAACCCCAAACCCCA
AACAATCTTAATAAACACGACTGAGCAAGAAAGTGGCGCTGTGTAGGGCTATTTCCACCCACCCGGCAGCTCTTAGGACACATTCCCAGA
AGAGCGGAAAGATCATTGACGTGGAACTACACACGAAGTGTAATTAGTGGGGGAAAAAATATTTTTTAAACAAAGGATATAACCATATTT
AGTTGTACAGTAAGAGAAATTTATCTGTGCATAGAGCATAAAGTTAATTTTTTCAAGCATTTAAATACATCTTTTGTAAGGTTTTTTAAT
AAAGGCAGATTGAGTCAAGTTTATTAAAACTTTACATGGAGGGGAAGAATATGCTAATTTGACATTTGAGAAAAGTTTAAATGCGAGCGT
TTGTTTTCACAGCTTAGGGATTGGTGGGTGAGGTCTGTGTGCGTTATTTTCATGTTCCCAAACTGTGAGCTTTATTTCATGTTATTTTTG
GTGGATGTTGACTTAGTTCATGAATGTTGTCACTTCTAAATGTGGACAGTTGGGCTGCAGGATGCAACTCAACCTCTTTTGGATCCTAGA
GACCCCTGCCAAGCCCCCATCAGTCCTATTTTTAAATGAAGACATCGCCATTTCTAGAAGACCTGAGATTTTCTTCCCTCTGTGCTTCGA
TGTATTTTAACCTCAACATTTTGAAACGGAAAATGCAAGGAGGGGCCAAGAAATGTCCTGGGGATTTGATGCCAGGAAGTACCTGGTAAG
GATTGGAGATTGCTCCAGAATCTACTGCATGTCCCAATTTGCAGTTTGCTCACTAGGGCTATATACAAAAGCTATACCCTTGAGGGTTTT
TTTTTTTTTCTTTTGATTTCCTCAGGACCTTAGAGGGAAAACAAACAGTAGCAGCTAATATTCTCAAGTATATTGCTGCTTAGAAAGATC
CTCAGGAACAATTAGCAGCAATAAGCAAGCCTTTGAAAAGATCTGAATTCTTTTTCCTGAAATATTTACGATACACAGGTGCTTTTTATC
TGAAATCTGTTGTGTCCTCCTTTTAGGCAGTCTCTGTGGGCAGAGAGTGGGACTTGCGAGGTGGACAGCTGTGGGGATCCTGGGCAAGGG
AGTTTCAGAAGGTGTGGCTCAGGGGCTGGTAGAAACCCCCTTTTGTTAGGACTTGTTTTTTAAAAAAGAAAGCCCTAGGCCAGGCGCAGT
GGCTGATGCCTGTAATCCCAGCGCTTTGGGAGGCCGAGGAGTATGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGT
GAAACCCCCGTCTCTACTAAAAATACAAAAATTAGTCAGGCATGGTGGTGGGTGCCTGTAGTCCAGCTACTCAGGAGGCTGAGGCAGGAG
AATTGCTTGAACCTGGGAGGTGGAGGTTGCGGTGAGCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACAGAGCAAGACTTCATCTTA
AAAAAAAAAAAAAAAGCCCAGCATTTTGCAGCTTTGAAGCTGCTGGGGATCACGACTGTCTCTGTGGCCCTTACCTGGCCACAGATGTAC
CCTGGCAACCCGCTCACAGTGCCCTGCGTGCAGGTTTATAGATAACCCCTGCCAGACCTGCTACAACCAAGACCTTATGGTCCAGGTCTC
AGTTTGGAGAAGATTTAGCTGTCTACCACTTCTTGTGTAGTGTTCCTGTGAAGTTTTATTTTTGGTTGCAAGTATCTGGAAAACAGATGC
AGATGTTTTTGTGGATGTTGTTGAGACTTTTGAGACTTCTGTTTCTAAGGTACACATGATGGGACCCAAACTCTCCTGGAGAGTTCCATT
CACTTCCTGAAACGTGCACCTGTTTCAGGTGCATGTTTATTCAGTGTGCATGGATATTTAAGATTTGCTGGAGCAGGCTGGGCAGGGTGG
CTCACCCCTATAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCCGGCCAACAGAGTGA
AACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGTGGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCTGGAGAA
TCGCTTGAACATGGGAGGCGGAGGTTGCAGTCAGCTGAGATCATACCACCACACTCTAGCCTCAGCAACAGAGTGAGACTCCGTCTCAAA
AAAAATTATTTGCTGGATCGAATCTTTTTTTTTTTGAGATGGAGTCTCACTGTCAACCAGGCTGGAGTGCAGTGGCACCATCTCGGCTCA
CTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTCCTACCTCAGCCTCCCAAGTAGCCGGGACTACAGGCGCCCACCATCATGCCCGGCT
AATTTTTTATATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCC
TCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCTGGGCCTAGATCAAATCTTTATCCATGCACATTGGAACACAGGATTACTGGG
TTGAAATCATTCTAGTTTTGTCATTTAGATACTTGTAGATGAATCTATTTTAGCACAAGGTATAAATAACTCGGGAGGTCATCTCTATCT
TCTTTCCTTTTGTGCATTTGGCTATACCACGTTTAGGTACTAAAACAGCTTTGCTTATGTTGGCCAGGGGAAAACATGGCATTCTGTGCG
CAAAGCTAATGATCGCCAGCCCTGCCTTGGCCCCTCCCTTGTTTATGGTCATTGTAAGATGCCCGCATGTTAAGGCTTAAGCTGTCACTG
GGCTGGGTGTAATACCCGCTTCATTCCTCCTCCCACCCTCTTACCCGAAACATGAAGGGCACTGTGCTCTATTGAGATCTCGATAAGATC
ATCATTTTAACTTGTATTCAACTGAGGGAGGTAACATGATATCTGGGTGCTGGTGGATTGAGACCTCAAGCATCAATTCAAAATTGCTGT
CGAAAATATGCACTATTTTTTTTTTCCACTCTGGCTAAGTGTAGGCTCTGAAGCCAGTTTTATAGCTTGATACATTCTGGTGAAAGATGT
CTTCATTTTTAATGAAAGAACCTACAGTTAGTAGGTGTCACCTCAGGGTAGAAATTCTGATAGAAATTCTGATTATTTGAAACTCTGATA
GAAATCCTAGATGCTAGATTTGAAGAAAACCTGGGTTTTATTGCATAGATTTCACCTTTTCTGGGGCACATCTTACCCCAAAATAATTGG
GGATTTTTTTGTTCCTTCTCCATTCCATGGAACCTTGTAGGGTGTTGGGATTGGGCCTCCCCTCGCCACCCGCCACATGTCTTTGTTTTT
TTCTCTCTTTTGTATGTGGAAAAATGTATTTTTGTACCATATCTCATACCTGGAGAGAAACCTTTTTTCTATCTTCAGGGCTGTAGAATA
TATTAGCGTAACACTTCACTGAATGTGACGTAAAAGCATTCTGATGAAAACTGGTTCTGTTATAATTAAGACTCAGTGTTTAAAATATCT
TAATCAGTGTTAATTTCCCAGTGTTTCAGTATCACAGTAAATACTTGTTTTACTGAGAACAGAAAATAATCCAGAAAAGGAAAAGGACCA
GCCCTCTCTAGATTGCTGGAATTGTATGGATGTGTTGGGGTTGGTTTAGTGATCTCTTCCTTGACACCCTAGCAAAGATGCTTTTGTGGA
GTGCAAACCTTTCATAAATATACTTTCCAGGCTGGGTGCAGTGGCTCAAGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGAT
CACTTGCGGTCGGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAATCCCGTCTCTACCAAAAAATACAAAAAAAAAAAAAAAAAAAAAA
ATAGCCAGGTGTGGTGGTGGGTTCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGAATTGTATGAACCTGGGAGGCAGAGGTTGC
AGTGAACTGAGATCACACCACTGTACTCCAGTTGAGGCGACAGAGTGAGACCCAGTCTCAAAAAAAAAAAAAAGTGTGTGTGTGTGTATA
TATATGTATATATATATACACACACACACACTTTCCAATACCAGTCGGCATTACCCGCCCTTTGGTTTCTTTTGCTTTGGATTTCAGCCC
CCATATCATTTCTGGTAACAGAGCACAGCAATAGAATTTCTGGGAAGCAGACCTTGTGAATCGTGCCTGTGTCTTAATTCACAAAGGGTA
AGTGAATGCCGTTGAAAGGTGTTTCATACACTTACCCCAGAAATGAGAGCCTGTCTCATGCAGGAGTCGGGAGGCAGCGATGTCAGGGAA
CTGGGACTATGTCTTTATGACTGTGATGGTGGTAACCAAGTGGGGTGGTCCCCTCTGGGGAGCTGAGTAAGAACGCAAAGGTTTGGGTCA
GTGATTAGGAAGACTATAATATGACTTTGTGCATGCCCGGGAGGGCTGCCTTGTAGAGAGGATGTGAGCAGCTTAGTCGCTCATCTGGCC
CTGTGATTCAGGCTTATGGAGCGTTAAGAATAACAGCTGTCAAATGGCCTAGACATGGTTAATGCAATTTGTTGCTAGTGGAAATCCTGA
ATTGCTTCCTTTCTGTGATCACTGCTACTTCTTAAGATGCTTTTGATGAATGTCATCTGCCTTACAAGTTGACACCTGATAACTTCTCCC
TGATGGGTTTCCGAACTGGCTGACTTAACCAAAAAGCCAGCTCTTGCCATCTATCTTGCATTAAAAGGAATTCCTGAGGCTCCTAAGGGG
TCAGCTGCCCCACTCCTGACTTTTTTATTTTTAATGGTCTATACCTTCTGCAACATTTTTGTTTATGGCCATTTGAATAGTTGGACTTTG
ACTCCTCACTTGTGAATAATAGGAATATATTTTGCAGAATCTAACATAATACCCTTAAAATTCATACTGGACAACCATCAGTGTGATGTA
TAGTATCTGGTGTAAACAAATTTTATTCAGCATATTAAATTATTCTGTGTTTTGCTTTTCCTTGATATGTAGGAGGTGCACCAGTACCAG
TTTTTCTCTTGTGGTGGCTTAAAACGCTGATTGCCATTTGCATTGTCTACTGAAAAGCTGTGGCAGCGAGTGGTATTATTGACCATGTGT
TCTCATGTCTTTTTGCAGATTTAAAGGTTTTATTGTAGTGTCCATTTAATATCTGCATGTGTGTTTAATCTCTGAATACCATGTAATTAA
ACTGATTAACTTGTGATGGTGATGGTGATTAGCACACACTAAAAACCCAATGAAGCAATTGTCTCCCTCTTCTTAACTGGAAATCACACT
TGTGAGGTATGGTATCCATTATCAACAGTGGATTCATGATTGACTTCATATTTTGTGTATCTGGTTATAAATTTTGTATAGCATTTAATT
TGGCACTTAATATAAATCCATTTGATTTGAATAGTGTGTGTGTGTACATGGTGTGTGTGTGTGTGTGCACTTTAGTTTCGTGAGCCTTGG
GAAACTGATTCTACAAATATCTTATATAGAGATAAATGTATCAGGCATTTTTTTGCAAAGCGATATATACATTCCTCTTATTTATTAAAT
CACTGGCTTTGGTGTTATGTAGAGATATTTGTAGATCTCAGAACAGAATTAAAATATTGTGAAAATTACAGCTTAATAAATGTTTATTGT

>In-frame_MDM2_ENST00000350057_chr12_69214154_+_BRI3BP_ENST00000341446_chr12_125509890_+_6152nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGTGGAG
CACCTGGAGAAGCAGGTCAGACTGCTCAACATCCGTCTCAACCGGGTGCTCGAGAGCCTGGACCGCTCCAAGGACAAGTGAAGGTCAGCC
GGCCGGGCGGGTCCACAGTTACCAGCACGCTGTCTCAGAAAACGAAAACGGAGGAAAAAAACCCCAAACCCCAAACAATCTTAATAAACA
CGACTGAGCAAGAAAGTGGCGCTGTGTAGGGCTATTTCCACCCACCCGGCAGCTCTTAGGACACATTCCCAGAAGAGCGGAAAGATCATT
GACGTGGAACTACACACGAAGTGTAATTAGTGGGGGAAAAAATATTTTTTAAACAAAGGATATAACCATATTTAGTTGTACAGTAAGAGA
AATTTATCTGTGCATAGAGCATAAAGTTAATTTTTTCAAGCATTTAAATACATCTTTTGTAAGGTTTTTTAATAAAGGCAGATTGAGTCA
AGTTTATTAAAACTTTACATGGAGGGGAAGAATATGCTAATTTGACATTTGAGAAAAGTTTAAATGCGAGCGTTTGTTTTCACAGCTTAG
GGATTGGTGGGTGAGGTCTGTGTGCGTTATTTTCATGTTCCCAAACTGTGAGCTTTATTTCATGTTATTTTTGGTGGATGTTGACTTAGT
TCATGAATGTTGTCACTTCTAAATGTGGACAGTTGGGCTGCAGGATGCAACTCAACCTCTTTTGGATCCTAGAGACCCCTGCCAAGCCCC
CATCAGTCCTATTTTTAAATGAAGACATCGCCATTTCTAGAAGACCTGAGATTTTCTTCCCTCTGTGCTTCGATGTATTTTAACCTCAAC
ATTTTGAAACGGAAAATGCAAGGAGGGGCCAAGAAATGTCCTGGGGATTTGATGCCAGGAAGTACCTGGTAAGGATTGGAGATTGCTCCA
GAATCTACTGCATGTCCCAATTTGCAGTTTGCTCACTAGGGCTATATACAAAAGCTATACCCTTGAGGGTTTTTTTTTTTTTCTTTTGAT
TTCCTCAGGACCTTAGAGGGAAAACAAACAGTAGCAGCTAATATTCTCAAGTATATTGCTGCTTAGAAAGATCCTCAGGAACAATTAGCA
GCAATAAGCAAGCCTTTGAAAAGATCTGAATTCTTTTTCCTGAAATATTTACGATACACAGGTGCTTTTTATCTGAAATCTGTTGTGTCC
TCCTTTTAGGCAGTCTCTGTGGGCAGAGAGTGGGACTTGCGAGGTGGACAGCTGTGGGGATCCTGGGCAAGGGAGTTTCAGAAGGTGTGG
CTCAGGGGCTGGTAGAAACCCCCTTTTGTTAGGACTTGTTTTTTAAAAAAGAAAGCCCTAGGCCAGGCGCAGTGGCTGATGCCTGTAATC
CCAGCGCTTTGGGAGGCCGAGGAGTATGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCCGTCTCTAC
TAAAAATACAAAAATTAGTCAGGCATGGTGGTGGGTGCCTGTAGTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGG
AGGTGGAGGTTGCGGTGAGCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACAGAGCAAGACTTCATCTTAAAAAAAAAAAAAAAAGC
CCAGCATTTTGCAGCTTTGAAGCTGCTGGGGATCACGACTGTCTCTGTGGCCCTTACCTGGCCACAGATGTACCCTGGCAACCCGCTCAC
AGTGCCCTGCGTGCAGGTTTATAGATAACCCCTGCCAGACCTGCTACAACCAAGACCTTATGGTCCAGGTCTCAGTTTGGAGAAGATTTA
GCTGTCTACCACTTCTTGTGTAGTGTTCCTGTGAAGTTTTATTTTTGGTTGCAAGTATCTGGAAAACAGATGCAGATGTTTTTGTGGATG
TTGTTGAGACTTTTGAGACTTCTGTTTCTAAGGTACACATGATGGGACCCAAACTCTCCTGGAGAGTTCCATTCACTTCCTGAAACGTGC
ACCTGTTTCAGGTGCATGTTTATTCAGTGTGCATGGATATTTAAGATTTGCTGGAGCAGGCTGGGCAGGGTGGCTCACCCCTATAATCCC
AACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCCGGCCAACAGAGTGAAACCCCGTCTCTACTAA
AAATACAAAAATTAGCCAGGCCTGGTGGTGGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCTGGAGAATCGCTTGAACATGGGAG
GCGGAGGTTGCAGTCAGCTGAGATCATACCACCACACTCTAGCCTCAGCAACAGAGTGAGACTCCGTCTCAAAAAAAATTATTTGCTGGA
TCGAATCTTTTTTTTTTTGAGATGGAGTCTCACTGTCAACCAGGCTGGAGTGCAGTGGCACCATCTCGGCTCACTGCAAGCTCCGCCTCC
TGGGTTCACGCCATTCTCCTACCTCAGCCTCCCAAGTAGCCGGGACTACAGGCGCCCACCATCATGCCCGGCTAATTTTTTATATTTTTA
GTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGAT
TACAGGCGTGAGCCACCGCGCTGGGCCTAGATCAAATCTTTATCCATGCACATTGGAACACAGGATTACTGGGTTGAAATCATTCTAGTT
TTGTCATTTAGATACTTGTAGATGAATCTATTTTAGCACAAGGTATAAATAACTCGGGAGGTCATCTCTATCTTCTTTCCTTTTGTGCAT
TTGGCTATACCACGTTTAGGTACTAAAACAGCTTTGCTTATGTTGGCCAGGGGAAAACATGGCATTCTGTGCGCAAAGCTAATGATCGCC
AGCCCTGCCTTGGCCCCTCCCTTGTTTATGGTCATTGTAAGATGCCCGCATGTTAAGGCTTAAGCTGTCACTGGGCTGGGTGTAATACCC
GCTTCATTCCTCCTCCCACCCTCTTACCCGAAACATGAAGGGCACTGTGCTCTATTGAGATCTCGATAAGATCATCATTTTAACTTGTAT
TCAACTGAGGGAGGTAACATGATATCTGGGTGCTGGTGGATTGAGACCTCAAGCATCAATTCAAAATTGCTGTCGAAAATATGCACTATT
TTTTTTTTCCACTCTGGCTAAGTGTAGGCTCTGAAGCCAGTTTTATAGCTTGATACATTCTGGTGAAAGATGTCTTCATTTTTAATGAAA
GAACCTACAGTTAGTAGGTGTCACCTCAGGGTAGAAATTCTGATAGAAATTCTGATTATTTGAAACTCTGATAGAAATCCTAGATGCTAG
ATTTGAAGAAAACCTGGGTTTTATTGCATAGATTTCACCTTTTCTGGGGCACATCTTACCCCAAAATAATTGGGGATTTTTTTGTTCCTT
CTCCATTCCATGGAACCTTGTAGGGTGTTGGGATTGGGCCTCCCCTCGCCACCCGCCACATGTCTTTGTTTTTTTCTCTCTTTTGTATGT
GGAAAAATGTATTTTTGTACCATATCTCATACCTGGAGAGAAACCTTTTTTCTATCTTCAGGGCTGTAGAATATATTAGCGTAACACTTC
ACTGAATGTGACGTAAAAGCATTCTGATGAAAACTGGTTCTGTTATAATTAAGACTCAGTGTTTAAAATATCTTAATCAGTGTTAATTTC
CCAGTGTTTCAGTATCACAGTAAATACTTGTTTTACTGAGAACAGAAAATAATCCAGAAAAGGAAAAGGACCAGCCCTCTCTAGATTGCT
GGAATTGTATGGATGTGTTGGGGTTGGTTTAGTGATCTCTTCCTTGACACCCTAGCAAAGATGCTTTTGTGGAGTGCAAACCTTTCATAA
ATATACTTTCCAGGCTGGGTGCAGTGGCTCAAGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACTTGCGGTCGGGAGT
TCGAGACCAGCCTGGCCAACATAGTGAAATCCCGTCTCTACCAAAAAATACAAAAAAAAAAAAAAAAAAAAAAATAGCCAGGTGTGGTGG
TGGGTTCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGAATTGTATGAACCTGGGAGGCAGAGGTTGCAGTGAACTGAGATCACA
CCACTGTACTCCAGTTGAGGCGACAGAGTGAGACCCAGTCTCAAAAAAAAAAAAAAGTGTGTGTGTGTGTATATATATGTATATATATAT
ACACACACACACACTTTCCAATACCAGTCGGCATTACCCGCCCTTTGGTTTCTTTTGCTTTGGATTTCAGCCCCCATATCATTTCTGGTA
ACAGAGCACAGCAATAGAATTTCTGGGAAGCAGACCTTGTGAATCGTGCCTGTGTCTTAATTCACAAAGGGTAAGTGAATGCCGTTGAAA
GGTGTTTCATACACTTACCCCAGAAATGAGAGCCTGTCTCATGCAGGAGTCGGGAGGCAGCGATGTCAGGGAACTGGGACTATGTCTTTA
TGACTGTGATGGTGGTAACCAAGTGGGGTGGTCCCCTCTGGGGAGCTGAGTAAGAACGCAAAGGTTTGGGTCAGTGATTAGGAAGACTAT
AATATGACTTTGTGCATGCCCGGGAGGGCTGCCTTGTAGAGAGGATGTGAGCAGCTTAGTCGCTCATCTGGCCCTGTGATTCAGGCTTAT
GGAGCGTTAAGAATAACAGCTGTCAAATGGCCTAGACATGGTTAATGCAATTTGTTGCTAGTGGAAATCCTGAATTGCTTCCTTTCTGTG
ATCACTGCTACTTCTTAAGATGCTTTTGATGAATGTCATCTGCCTTACAAGTTGACACCTGATAACTTCTCCCTGATGGGTTTCCGAACT
GGCTGACTTAACCAAAAAGCCAGCTCTTGCCATCTATCTTGCATTAAAAGGAATTCCTGAGGCTCCTAAGGGGTCAGCTGCCCCACTCCT
GACTTTTTTATTTTTAATGGTCTATACCTTCTGCAACATTTTTGTTTATGGCCATTTGAATAGTTGGACTTTGACTCCTCACTTGTGAAT
AATAGGAATATATTTTGCAGAATCTAACATAATACCCTTAAAATTCATACTGGACAACCATCAGTGTGATGTATAGTATCTGGTGTAAAC
AAATTTTATTCAGCATATTAAATTATTCTGTGTTTTGCTTTTCCTTGATATGTAGGAGGTGCACCAGTACCAGTTTTTCTCTTGTGGTGG
CTTAAAACGCTGATTGCCATTTGCATTGTCTACTGAAAAGCTGTGGCAGCGAGTGGTATTATTGACCATGTGTTCTCATGTCTTTTTGCA
GATTTAAAGGTTTTATTGTAGTGTCCATTTAATATCTGCATGTGTGTTTAATCTCTGAATACCATGTAATTAAACTGATTAACTTGTGAT
GGTGATGGTGATTAGCACACACTAAAAACCCAATGAAGCAATTGTCTCCCTCTTCTTAACTGGAAATCACACTTGTGAGGTATGGTATCC
ATTATCAACAGTGGATTCATGATTGACTTCATATTTTGTGTATCTGGTTATAAATTTTGTATAGCATTTAATTTGGCACTTAATATAAAT
CCATTTGATTTGAATAGTGTGTGTGTGTACATGGTGTGTGTGTGTGTGTGCACTTTAGTTTCGTGAGCCTTGGGAAACTGATTCTACAAA
TATCTTATATAGAGATAAATGTATCAGGCATTTTTTTGCAAAGCGATATATACATTCCTCTTATTTATTAAATCACTGGCTTTGGTGTTA
TGTAGAGATATTTGTAGATCTCAGAACAGAATTAAAATATTGTGAAAATTACAGCTTAATAAATGTTTATTGTAATTTTGTTGTATGGAC


Top

FusionGenePPI for MDM2_BRI3BP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MDM2TP53, MDC1, CTBP1, CTBP2, TP73, PML, RPL11, RPL5, CDKN2A, NUMB, UBE2A, HIF1A, KAT5, HDAC1, EID1, MDM4, KAT2B, EP300, TBP, TAF1, MDM2, ESR1, ARRB2, ABL1, CCNG1, ARRB1, TSG101, RB1, MTBP, FKBP3, RYBP, RRM2B, RPL26, GNAS, FOXO4, IGF1R, DAXX, DHFR, GNL3, CCAR1, PSMD10, PSME3, PTK2, AR, PPM1D, USP7, COPS5, SFN, RBBP6, CDH1, CHEK2, YWHAQ, NCL, UBE2G2, UBE2U, UBE2Z, PYHIN1, BANP, DDX17, E2F1, TRIM28, UBC, GATA3, ATF3, HIST2H2BE, RPL23, YY1, AKT1, RAD23A, CDKN1A, NR3C1, UBE2I, HIST3H3, EHMT1, SUV39H1, RPS27L, RPS27, ADRB2, SIVA1, MTA1, RCHY1, UBE2D1, CASP2, RPS27A, RPS7, G3BP2, PSMD2, PAK1IP1, RPS6KB1, ZNF668, TP63, PCNA, USP10, PSMC1, PSMD4, PSMC3, PSMC5, PSMC6, PSMA7, PSMD1, RUNX3, GNL3L, TERT, APEX1, UIMC1, CREBBP, SOX4, UBE4B, TBRG1, BAIAP2L1, RFWD3, ERBB3, PA2G4, HEXIM1, CDK9, DYRK2, HSP90AA1, HSPA4, HSPA8, LAMP2, RPS3, USP2, TRIM13, XRCC6, GORAB, FOXO1, FOXO3, UCHL1, S100A1, S100A2, S100A4, S100A6, S100B, USP42, CUL1, BTRC, FBXW11, CSNK1D, RFWD2, SMURF1, NOTCH4, CSNK1A1, PDLIM7, SENP3, RN5S1@, PDE4D, NOTCH1, SNAI1, RASSF1, TRIM27, RFFL, RPS14, PPP2R4, TTF1, PSMB6, PSMA8, RASSF3, NR0B2, UBE2B, PIAS1, RANBP1, LATS1, RAD50, NBN, MRE11A, CUL4A, DTL, PIM1, GSK3B, PSMA3, ESR2, ADRBK1, AATF, HNRNPK, BUB1B, SUMO1, RASSF5, UBE2D2, POLH, NPM1, TCAP, CDK5RAP3, ARIH2, IRF2, RPS25, TPT1, ANG, RHOA, PDCD5, CDKN2AIP, LATS2, WWOX, MED1, ERCC6, ERCC8, DDB1, CUL4B, HIPK2, DHRS2, CASP3, ITCH, EEF1A1, DCD, TUBB, TUBB2A, KRT14, RPS20, GAPDH, TUBA1C, GSN, ERBB4, XIAP, HNF4A, PLK1, NME2, NEDD4, DAPK1, DAPK3, ATM, PBX1, UBE2D3, UBE3A, UBE2L3, UBE2E2, UBE2E3, RNF2, EGR1, PAK6, DLG4, IRF1, VCP, STRA13, GADD45A, RABL6, RPS26, RPL37, RPS15, RNF8, TRIM4, TRIM23, TRAF5, TRIM9, MKRN3, PHF7, RNF10, RNF126, UBE2K, LMO7, HLA-DMB, SETDB1, YY1AP1, NACA, ATF4, MYD88, RELA, SDHC, WT1, SORBS2, HRSP12, DNAJB4, GCAT, SHPK, POT1, ANKRD17, GLTSCR2, SESN2, RASSF6, JUND, EZR, RYR2, JUN, CLSTN1, APP, CLU, SREK1, SET, HSP90B1, CWC25, ZNF133, PKM, TAB1, RPL6, AURKA, NOC2L, JAK1, XPC, PGAM1, PGAM2, DNAJB1, ANAPC2, NLK, SNAI2, RBM38, FHIT, AGPS, ALDH16A1, DDX5, DHX9, DLAT, EDC4, EIF2AK1, ESYT1, GTF2I, HMHA1, HNRNPM, HNRNPU, HRNR, HSP90AB1, IARS, IFI16, IGF2BP3, ILF3, KARS, CCAR2, NEK9, OGDH, OGDHL, RARS, RBBP8, RECQL, SF3B1, SFPQ, TOP1, ZNF318, PER2, SIRT6, TSC22D3, RPS6, UBE2M, RAD54B, SMARCA2, ACACA, PTBP1, IYD, ACTB, HNRNPD, U2AF2, FUBP1, TFRC, EEF2, XPO1, KRT2, EIF3B, SND1, DCAF8, USO1, EFTUD2, EXOSC6, IPO7, SF3B3, DET1, UBE2N, RPL10A, DIRAS3, SURF2, RFPL2, CMSS1, PPARD, RPL22L1, IER2, MAGEA2, ZNF420, ELF4, ABL2, SRC, HCK, GTF2E2, ATP2A2, BRINP1, C19orf10, CANX, MS4A1, PDIA3, PPIB, RAB8A, RPS23, RUVBL2, SMARCA4, SMARCE1, SRSF11, TPR, UBTF, PPARG, VDR, FBXO31, TFIP11, SETD7, PPP1CA, RARA, DDX24, NAT10, CCND1, RLIM, IER3, FHL2, RPL23A, SUZ12, EZH2, EED, RRM1, RPL4, NOLC1, DDX42, MAP2, NUCKS1, RRP1, PDS5A, RPL36A, TP53RK, RPL15, NPIPB3, HMGN1, MAP1LC3A, PRDM2, KIAA1551, PBXIP1, SP1, SHARPIN, MAPKAPK2, USP15, USP26, FKBP1A, NGFR, SMG7, RSL1D1, SIRT1, SIRT7, SIRT2, SIRT3, KPNA1, KPNA6, MSI2, PHLDB3, CLPB, XAGE1B, ZNF550, YAF2, PDGFB, ARNTL2, RPS11, TSPYL6, HIST1H2BJ, ZNF764, MAK16, ZNF274, PPAN, RPL37A, CRTC2, CRTC3, TRIM25, CSNK2A1, CSNK2B, CSNK2A2, HEY1, RANBP2BRI3BPESR1, RNF2, AMFR, TSPAN5, GDE1, PTH1R, P2RY12, DLK1, ZACN, HTR3C, TUSC5, LCA5, TCTN2, TCTN3, TCTN1, SPPL2B, YIPF3, LPAR1, LRRC4C, TPTE, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59170_306113437MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15170_3060322MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13170_3060266MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16170_306-102322MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14170_3060297MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13170_306-92219MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12170_3060219MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14170_306-102271MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511170_306119498MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15170_306-102297MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59150_230113437PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15150_2300322PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13150_2300266PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16150_230-102322PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14150_2300297PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13150_230-92219PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12150_2300219PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14150_230-102271PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511150_230119498PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15150_230-102297PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59223_232113437USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15223_2320322USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13223_2320266USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16223_232-102322USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14223_2320297USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13223_232-92219USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12223_2320219USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14223_232-102271USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511223_232119498USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15223_232-102297USP7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MDM2_BRI3BP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMDM2Q00987DB01593ZincE3 ubiquitin-protein ligase Mdm2small moleculeapproved|investigational

Top

RelatedDiseases for MDM2_BRI3BP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMDM2C0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneMDM2C0007621Neoplastic Cell Transformation1CTD_human
HgeneMDM2C0019693HIV Infections1CTD_human
HgeneMDM2C0021364Male infertility1CTD_human
HgeneMDM2C0025202melanoma1CTD_human
HgeneMDM2C0032927Precancerous Conditions1CTD_human
HgeneMDM2C0033578Prostatic Neoplasms1CTD_human
HgeneMDM2C1458155Mammary Neoplasms1CTD_human