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Fusion gene ID: 21358 |
FusionGeneSummary for MDH1_MDH1 |
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Fusion gene information | Fusion gene name: MDH1_MDH1 | Fusion gene ID: 21358 | Hgene | Tgene | Gene symbol | MDH1 | MDH1 | Gene ID | 4190 | 4190 |
Gene name | malate dehydrogenase 1 | malate dehydrogenase 1 | |
Synonyms | HEL-S-32|MDH-s|MDHA|MGC:1375|MOR2 | HEL-S-32|MDH-s|MDHA|MGC:1375|MOR2 | |
Cytomap | 2p15 | 2p15 | |
Type of gene | protein-coding | protein-coding | |
Description | malate dehydrogenase, cytoplasmicmalate dehydrogenase, peroxisomalcytosolic malate dehydrogenasediiodophenylpyruvate reductaseepididymis secretory protein Li 32malate dehydrogenase 1, NAD (soluble)soluble malate dehydrogenase | malate dehydrogenase, cytoplasmicmalate dehydrogenase, peroxisomalcytosolic malate dehydrogenasediiodophenylpyruvate reductaseepididymis secretory protein Li 32malate dehydrogenase 1, NAD (soluble)soluble malate dehydrogenase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P40925 | P40925 | |
Ensembl transtripts involved in fusion gene | ENST00000233114, ENST00000409908, ENST00000409476, ENST00000539945, ENST00000544381, ENST00000394423, ENST00000462944, | ENST00000233114, ENST00000409908, ENST00000409476, ENST00000539945, ENST00000544381, ENST00000394423, ENST00000462944, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 6 X 6 X 4=144 |
# samples | 4 | 14 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(14/144*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MDH1 [Title/Abstract] AND MDH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG290076 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000233114 | ENST00000233114 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000233114 | ENST00000409908 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000233114 | ENST00000409476 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000233114 | ENST00000539945 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000233114 | ENST00000544381 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000233114 | ENST00000394423 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
5CDS-intron | ENST00000233114 | ENST00000462944 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000409908 | ENST00000233114 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000409908 | ENST00000409908 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000409908 | ENST00000409476 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000409908 | ENST00000539945 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000409908 | ENST00000544381 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000409908 | ENST00000394423 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
5CDS-intron | ENST00000409908 | ENST00000462944 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000409476 | ENST00000233114 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000409476 | ENST00000409908 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000409476 | ENST00000409476 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000409476 | ENST00000539945 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000409476 | ENST00000544381 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000409476 | ENST00000394423 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
5CDS-intron | ENST00000409476 | ENST00000462944 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000539945 | ENST00000233114 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000539945 | ENST00000409908 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000539945 | ENST00000409476 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000539945 | ENST00000539945 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000539945 | ENST00000544381 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000539945 | ENST00000394423 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
5CDS-intron | ENST00000539945 | ENST00000462944 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000544381 | ENST00000233114 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000544381 | ENST00000409908 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000544381 | ENST00000409476 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000544381 | ENST00000539945 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000544381 | ENST00000544381 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000544381 | ENST00000394423 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
5CDS-intron | ENST00000544381 | ENST00000462944 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000394423 | ENST00000233114 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000394423 | ENST00000409908 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000394423 | ENST00000409476 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000394423 | ENST00000539945 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000394423 | ENST00000544381 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
In-frame | ENST00000394423 | ENST00000394423 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
5CDS-intron | ENST00000394423 | ENST00000462944 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
intron-3CDS | ENST00000462944 | ENST00000233114 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
intron-3CDS | ENST00000462944 | ENST00000409908 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
intron-3CDS | ENST00000462944 | ENST00000409476 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
intron-3CDS | ENST00000462944 | ENST00000539945 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
intron-3CDS | ENST00000462944 | ENST00000544381 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
intron-3CDS | ENST00000462944 | ENST00000394423 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
intron-intron | ENST00000462944 | ENST00000462944 | MDH1 | chr2 | 63833146 | + | MDH1 | chr2 | 63831899 | + |
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FusionProtFeatures for MDH1_MDH1 |
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Hgene | Tgene |
MDH1 | MDH1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >MDH1 | chr2:63833146 | chr2:63831899 | ENST00000233114 | + | 0 | 9 | 11_17 | -145 | 335 | Nucleotide binding | NAD |
Tgene | >MDH1 | chr2:63833146 | chr2:63831899 | ENST00000233114 | + | 0 | 9 | 129_131 | -145 | 335 | Nucleotide binding | NAD |
Tgene | >MDH1 | chr2:63833146 | chr2:63831899 | ENST00000394423 | + | 0 | 9 | 11_17 | 0 | 335 | Nucleotide binding | NAD |
Tgene | >MDH1 | chr2:63833146 | chr2:63831899 | ENST00000394423 | + | 0 | 9 | 129_131 | 0 | 335 | Nucleotide binding | NAD |
Tgene | >MDH1 | chr2:63833146 | chr2:63831899 | ENST00000539945 | + | 0 | 9 | 11_17 | -32 | 353 | Nucleotide binding | NAD |
Tgene | >MDH1 | chr2:63833146 | chr2:63831899 | ENST00000539945 | + | 0 | 9 | 129_131 | -32 | 353 | Nucleotide binding | NAD |
Tgene | >MDH1 | chr2:63833146 | chr2:63831899 | ENST00000544381 | + | 0 | 8 | 11_17 | -76 | 246 | Nucleotide binding | NAD |
Tgene | >MDH1 | chr2:63833146 | chr2:63831899 | ENST00000544381 | + | 0 | 8 | 129_131 | -76 | 246 | Nucleotide binding | NAD |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MDH1_MDH1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MDH1_MDH1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MDH1_MDH1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | MDH1 | P40925 | DB11638 | Artenimol | Malate dehydrogenase, cytoplasmic | small molecule | approved|investigational |
Tgene | MDH1 | P40925 | DB11638 | Artenimol | Malate dehydrogenase, cytoplasmic | small molecule | approved|investigational |
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RelatedDiseases for MDH1_MDH1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MDH1 | C0020538 | Hypertensive disease | 1 | CTD_human |
Hgene | MDH1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | MDH1 | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human |
Hgene | MDH1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | MDH1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | MDH1 | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | MDH1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | MDH1 | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human |
Tgene | MDH1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | MDH1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |