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Fusion gene ID: 21353 |
FusionGeneSummary for MDGA2_CSTA |
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Fusion gene information | Fusion gene name: MDGA2_CSTA | Fusion gene ID: 21353 | Hgene | Tgene | Gene symbol | MDGA2 | CSTA | Gene ID | 161357 | 1475 |
Gene name | MAM domain containing glycosylphosphatidylinositol anchor 2 | cystatin A | |
Synonyms | MAMDC1|c14_5286 | AREI|PSS4|STF1|STFA | |
Cytomap | 14q21.3 | 3q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | MAM domain-containing glycosylphosphatidylinositol anchor protein 2MAM domain containing 1 | cystatin-Acystatin A (stefin A)cystatin AS | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q7Z553 | P01040 | |
Ensembl transtripts involved in fusion gene | ENST00000426342, ENST00000399232, ENST00000399222, ENST00000357362, ENST00000439988, ENST00000472499, | ENST00000264474, ENST00000479204, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 7 X 6 X 4=168 |
# samples | 2 | 7 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MDGA2 [Title/Abstract] AND CSTA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CSTA | GO:0010466 | negative regulation of peptidase activity | 6203523 |
Tgene | CSTA | GO:0018149 | peptide cross-linking | 10908733 |
Tgene | CSTA | GO:0030216 | keratinocyte differentiation | 10908733 |
Tgene | CSTA | GO:0045861 | negative regulation of proteolysis | 3488317 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE840752 | MDGA2 | chr14 | 47730706 | + | CSTA | chr3 | 122044117 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000426342 | ENST00000264474 | MDGA2 | chr14 | 47730706 | + | CSTA | chr3 | 122044117 | + |
intron-5UTR | ENST00000426342 | ENST00000479204 | MDGA2 | chr14 | 47730706 | + | CSTA | chr3 | 122044117 | + |
intron-5UTR | ENST00000399232 | ENST00000264474 | MDGA2 | chr14 | 47730706 | + | CSTA | chr3 | 122044117 | + |
intron-5UTR | ENST00000399232 | ENST00000479204 | MDGA2 | chr14 | 47730706 | + | CSTA | chr3 | 122044117 | + |
intron-5UTR | ENST00000399222 | ENST00000264474 | MDGA2 | chr14 | 47730706 | + | CSTA | chr3 | 122044117 | + |
intron-5UTR | ENST00000399222 | ENST00000479204 | MDGA2 | chr14 | 47730706 | + | CSTA | chr3 | 122044117 | + |
intron-5UTR | ENST00000357362 | ENST00000264474 | MDGA2 | chr14 | 47730706 | + | CSTA | chr3 | 122044117 | + |
intron-5UTR | ENST00000357362 | ENST00000479204 | MDGA2 | chr14 | 47730706 | + | CSTA | chr3 | 122044117 | + |
intron-5UTR | ENST00000439988 | ENST00000264474 | MDGA2 | chr14 | 47730706 | + | CSTA | chr3 | 122044117 | + |
intron-5UTR | ENST00000439988 | ENST00000479204 | MDGA2 | chr14 | 47730706 | + | CSTA | chr3 | 122044117 | + |
intron-5UTR | ENST00000472499 | ENST00000264474 | MDGA2 | chr14 | 47730706 | + | CSTA | chr3 | 122044117 | + |
intron-5UTR | ENST00000472499 | ENST00000479204 | MDGA2 | chr14 | 47730706 | + | CSTA | chr3 | 122044117 | + |
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FusionProtFeatures for MDGA2_CSTA |
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Hgene | Tgene |
MDGA2 | CSTA |
May be involved in cell-cell interactions.{ECO:0000250}. | This is an intracellular thiol proteinase inhibitor. Hasan important role in desmosome-mediated cell-cell adhesion in thelower levels of the epidermis. {ECO:0000269|PubMed:21944047}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MDGA2_CSTA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MDGA2_CSTA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MDGA2_CSTA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MDGA2_CSTA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CSTA | C0017636 | Glioblastoma | 1 | CTD_human |
Tgene | CSTA | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | CSTA | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |