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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21338

FusionGeneSummary for MCTP2_PARP6

check button Fusion gene summary
Fusion gene informationFusion gene name: MCTP2_PARP6
Fusion gene ID: 21338
HgeneTgene
Gene symbol

MCTP2

PARP6

Gene ID

55784

56965

Gene namemultiple C2 and transmembrane domain containing 2poly(ADP-ribose) polymerase family member 6
Synonyms-ARTD17|PARP-6-B1|PARP-6-C|pART17
Cytomap

15q26.2

15q23

Type of geneprotein-codingprotein-coding
Descriptionmultiple C2 and transmembrane domain-containing protein 2multiple C2 domains, transmembrane 2multiple C2-domains with two transmembrane regions 2 1poly [ADP-ribose] polymerase 6ADP-ribosyltransferase diphtheria toxin-like 17PARP-6
Modification date2018052320180523
UniProtAcc

Q6DN12

Q2NL67

Ensembl transtripts involved in fusion geneENST00000543482, ENST00000331706, 
ENST00000451018, ENST00000357742, 
ENST00000557742, ENST00000449432, 
ENST00000569795, ENST00000413097, 
ENST00000260376, ENST00000287196, 
Fusion gene scores* DoF score4 X 4 X 4=644 X 5 X 5=100
# samples 46
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MCTP2 [Title/Abstract] AND PARP6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-C5-A7X3-01AMCTP2chr15

94901841

+PARP6chr15

72563628

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000543482ENST00000569795MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-intronENST00000543482ENST00000413097MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-intronENST00000543482ENST00000260376MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-intronENST00000543482ENST00000287196MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-5UTRENST00000331706ENST00000569795MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-intronENST00000331706ENST00000413097MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-intronENST00000331706ENST00000260376MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-intronENST00000331706ENST00000287196MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-5UTRENST00000451018ENST00000569795MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-intronENST00000451018ENST00000413097MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-intronENST00000451018ENST00000260376MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-intronENST00000451018ENST00000287196MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-5UTRENST00000357742ENST00000569795MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-intronENST00000357742ENST00000413097MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-intronENST00000357742ENST00000260376MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-intronENST00000357742ENST00000287196MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-5UTRENST00000557742ENST00000569795MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-intronENST00000557742ENST00000413097MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-intronENST00000557742ENST00000260376MCTP2chr15

94901841

+PARP6chr15

72563628

-
5CDS-intronENST00000557742ENST00000287196MCTP2chr15

94901841

+PARP6chr15

72563628

-
intron-5UTRENST00000449432ENST00000569795MCTP2chr15

94901841

+PARP6chr15

72563628

-
intron-intronENST00000449432ENST00000413097MCTP2chr15

94901841

+PARP6chr15

72563628

-
intron-intronENST00000449432ENST00000260376MCTP2chr15

94901841

+PARP6chr15

72563628

-
intron-intronENST00000449432ENST00000287196MCTP2chr15

94901841

+PARP6chr15

72563628

-

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FusionProtFeatures for MCTP2_PARP6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MCTP2

Q6DN12

PARP6

Q2NL67

Might play a role in the development of cardiac outflowtract. {ECO:0000269|PubMed:23773997}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MCTP2_PARP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MCTP2_PARP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MCTP2APPPARP6ANKMY2, ARIH2, NSFL1C, CBS, HK1, PLAA, UBA5, PLIN3, RPRD1A, SURF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MCTP2_PARP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MCTP2_PARP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMCTP2C0036341Schizophrenia1PSYGENET
HgeneMCTP2C0041696Unipolar Depression1PSYGENET
HgeneMCTP2C1269683Major Depressive Disorder1PSYGENET