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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2130

FusionGeneSummary for APBB2_NSUN7

check button Fusion gene summary
Fusion gene informationFusion gene name: APBB2_NSUN7
Fusion gene ID: 2130
HgeneTgene
Gene symbol

APBB2

NSUN7

Gene ID

323

79730

Gene nameamyloid beta precursor protein binding family B member 2NOP2/Sun RNA methyltransferase family member 7
SynonymsFE65L|FE65L1-
Cytomap

4p14-p13

4p14

Type of geneprotein-codingprotein-coding
Descriptionamyloid-beta A4 precursor protein-binding family B member 2Fe65-like 1protein Fe65-like 1putative methyltransferase NSUN7NOL1/NOP2/Sun domain family member 7NOP2/Sun domain family, member 7
Modification date2018052320180519
UniProtAcc

Q92870

Q8NE18

Ensembl transtripts involved in fusion geneENST00000295974, ENST00000513140, 
ENST00000508593, ENST00000506352, 
ENST00000511572, ENST00000543538, 
ENST00000502841, ENST00000504305, 
ENST00000381782, ENST00000316607, 
ENST00000463952, 
Fusion gene scores* DoF score8 X 8 X 3=1922 X 2 X 1=4
# samples 82
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: APBB2 [Title/Abstract] AND NSUN7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E9-A22E-01AAPBB2chr4

40827904

-NSUN7chr4

40810324

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000295974ENST00000381782APBB2chr4

40827904

-NSUN7chr4

40810324

+
In-frameENST00000295974ENST00000316607APBB2chr4

40827904

-NSUN7chr4

40810324

+
5CDS-intronENST00000295974ENST00000463952APBB2chr4

40827904

-NSUN7chr4

40810324

+
Frame-shiftENST00000513140ENST00000381782APBB2chr4

40827904

-NSUN7chr4

40810324

+
In-frameENST00000513140ENST00000316607APBB2chr4

40827904

-NSUN7chr4

40810324

+
5CDS-intronENST00000513140ENST00000463952APBB2chr4

40827904

-NSUN7chr4

40810324

+
Frame-shiftENST00000508593ENST00000381782APBB2chr4

40827904

-NSUN7chr4

40810324

+
In-frameENST00000508593ENST00000316607APBB2chr4

40827904

-NSUN7chr4

40810324

+
5CDS-intronENST00000508593ENST00000463952APBB2chr4

40827904

-NSUN7chr4

40810324

+
Frame-shiftENST00000506352ENST00000381782APBB2chr4

40827904

-NSUN7chr4

40810324

+
In-frameENST00000506352ENST00000316607APBB2chr4

40827904

-NSUN7chr4

40810324

+
5CDS-intronENST00000506352ENST00000463952APBB2chr4

40827904

-NSUN7chr4

40810324

+
intron-3CDSENST00000511572ENST00000381782APBB2chr4

40827904

-NSUN7chr4

40810324

+
intron-3CDSENST00000511572ENST00000316607APBB2chr4

40827904

-NSUN7chr4

40810324

+
intron-intronENST00000511572ENST00000463952APBB2chr4

40827904

-NSUN7chr4

40810324

+
Frame-shiftENST00000543538ENST00000381782APBB2chr4

40827904

-NSUN7chr4

40810324

+
Frame-shiftENST00000543538ENST00000316607APBB2chr4

40827904

-NSUN7chr4

40810324

+
5CDS-intronENST00000543538ENST00000463952APBB2chr4

40827904

-NSUN7chr4

40810324

+
Frame-shiftENST00000502841ENST00000381782APBB2chr4

40827904

-NSUN7chr4

40810324

+
Frame-shiftENST00000502841ENST00000316607APBB2chr4

40827904

-NSUN7chr4

40810324

+
5CDS-intronENST00000502841ENST00000463952APBB2chr4

40827904

-NSUN7chr4

40810324

+
Frame-shiftENST00000504305ENST00000381782APBB2chr4

40827904

-NSUN7chr4

40810324

+
Frame-shiftENST00000504305ENST00000316607APBB2chr4

40827904

-NSUN7chr4

40810324

+
5CDS-intronENST00000504305ENST00000463952APBB2chr4

40827904

-NSUN7chr4

40810324

+

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FusionProtFeatures for APBB2_NSUN7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APBB2

Q92870

NSUN7

Q8NE18

May modulate the internalization of amyloid-betaprecursor protein. May have S-adenosyl-L-methionine-dependent methyl-transferase activity. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for APBB2_NSUN7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for APBB2_NSUN7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
APBB2APP, EGFR, HSPA8, TBC1D4, OSBPL2, APLP2, APBB1, AKAP1, GOPC, TUBA1A, APLP1, CBWD1, APOL2, RAP1GDS1, SYDE2, ATP7A, WDR41, TBC1D2B, FMN2, QTRT1, LDHAL6B, WISP3, NCK1, SORT1, SYNCRIP, MRPL1, GAN, TMEM30B, ADCYAP1, VAV1, HGFACNSUN7PTPN6, SEMG1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for APBB2_NSUN7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for APBB2_NSUN7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPBB2C0043094Weight Gain1CTD_human
TgeneNSUN7C0021364Male infertility1CTD_human