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Fusion gene ID: 21294 |
FusionGeneSummary for MCM10_OPTN |
Fusion gene summary |
Fusion gene information | Fusion gene name: MCM10_OPTN | Fusion gene ID: 21294 | Hgene | Tgene | Gene symbol | MCM10 | OPTN | Gene ID | 55388 | 10133 |
Gene name | minichromosome maintenance 10 replication initiation factor | optineurin | |
Synonyms | CNA43|DNA43|PRO2249 | ALS12|FIP2|GLC1E|HIP7|HYPL|NRP|TFIIIA-INTP | |
Cytomap | 10p13 | 10p13 | |
Type of gene | protein-coding | protein-coding | |
Description | protein MCM10 homologMCM10 minichromosome maintenance deficient 10homolog of yeast MCM10hsMCM10minichromosome maintenance complex component 10 | optineurinE3-14.7K-interacting proteinFIP-2HIP-7Huntingtin interacting protein Lhuntingtin yeast partner Lhuntingtin-interacting protein 7huntingtin-interacting protein Lnemo-related proteinoptic neuropathy-inducing proteintranscription factor I | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q7L590 | Q96CV9 | |
Ensembl transtripts involved in fusion gene | ENST00000378714, ENST00000484800, ENST00000378694, | ENST00000263036, ENST00000378764, ENST00000482140, ENST00000378757, ENST00000378752, ENST00000378748, ENST00000378747, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 3=18 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MCM10 [Title/Abstract] AND OPTN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | OPTN | GO:0010508 | positive regulation of autophagy | 21617041 |
Tgene | OPTN | GO:0090161 | Golgi ribbon formation | 15837803 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A07L-01A | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000378714 | ENST00000263036 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
In-frame | ENST00000378714 | ENST00000378764 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
5CDS-3UTR | ENST00000378714 | ENST00000482140 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
5CDS-3UTR | ENST00000378714 | ENST00000378757 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
5CDS-3UTR | ENST00000378714 | ENST00000378752 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
5CDS-3UTR | ENST00000378714 | ENST00000378748 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
5CDS-3UTR | ENST00000378714 | ENST00000378747 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
In-frame | ENST00000484800 | ENST00000263036 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
In-frame | ENST00000484800 | ENST00000378764 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
5CDS-3UTR | ENST00000484800 | ENST00000482140 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
5CDS-3UTR | ENST00000484800 | ENST00000378757 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
5CDS-3UTR | ENST00000484800 | ENST00000378752 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
5CDS-3UTR | ENST00000484800 | ENST00000378748 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
5CDS-3UTR | ENST00000484800 | ENST00000378747 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
In-frame | ENST00000378694 | ENST00000263036 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
In-frame | ENST00000378694 | ENST00000378764 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
5CDS-3UTR | ENST00000378694 | ENST00000482140 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
5CDS-3UTR | ENST00000378694 | ENST00000378757 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
5CDS-3UTR | ENST00000378694 | ENST00000378752 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
5CDS-3UTR | ENST00000378694 | ENST00000378748 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
5CDS-3UTR | ENST00000378694 | ENST00000378747 | MCM10 | chr10 | 13225100 | + | OPTN | chr10 | 13154453 | + |
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FusionProtFeatures for MCM10_OPTN |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MCM10 | OPTN |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MCM10 | chr10:13225100 | chr10:13154453 | ENST00000378714 | + | 8 | 20 | 104_142 | 366 | 875 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | MCM10 | chr10:13225100 | chr10:13154453 | ENST00000484800 | + | 8 | 20 | 104_142 | 367 | 876 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | MCM10 | chr10:13225100 | chr10:13154453 | ENST00000378714 | + | 8 | 20 | 1_156 | 366 | 875 | Region | N-terminal domain |
Hgene | MCM10 | chr10:13225100 | chr10:13154453 | ENST00000484800 | + | 8 | 20 | 1_156 | 367 | 876 | Region | N-terminal domain |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000263036 | + | 3 | 15 | 239_508 | 123 | 578 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378747 | + | 3 | 15 | 239_508 | 123 | 578 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378748 | + | 4 | 16 | 239_508 | 123 | 578 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378752 | + | 4 | 16 | 239_508 | 123 | 572 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378757 | + | 2 | 14 | 239_508 | 123 | 578 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378764 | + | 3 | 15 | 239_508 | 123 | 572 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000263036 | + | 3 | 15 | 176_181 | 123 | 578 | Motif | Note=LIR |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000263036 | + | 3 | 15 | 474_479 | 123 | 578 | Motif | Note=UBAN |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378747 | + | 3 | 15 | 176_181 | 123 | 578 | Motif | Note=LIR |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378747 | + | 3 | 15 | 474_479 | 123 | 578 | Motif | Note=UBAN |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378748 | + | 4 | 16 | 176_181 | 123 | 578 | Motif | Note=LIR |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378748 | + | 4 | 16 | 474_479 | 123 | 578 | Motif | Note=UBAN |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378752 | + | 4 | 16 | 176_181 | 123 | 572 | Motif | Note=LIR |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378752 | + | 4 | 16 | 474_479 | 123 | 572 | Motif | Note=UBAN |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378757 | + | 2 | 14 | 176_181 | 123 | 578 | Motif | Note=LIR |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378757 | + | 2 | 14 | 474_479 | 123 | 578 | Motif | Note=UBAN |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378764 | + | 3 | 15 | 176_181 | 123 | 572 | Motif | Note=LIR |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378764 | + | 3 | 15 | 474_479 | 123 | 572 | Motif | Note=UBAN |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000263036 | + | 3 | 15 | 547_577 | 123 | 578 | Zinc finger | CCHC NOA-type |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378747 | + | 3 | 15 | 547_577 | 123 | 578 | Zinc finger | CCHC NOA-type |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378748 | + | 4 | 16 | 547_577 | 123 | 578 | Zinc finger | CCHC NOA-type |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378752 | + | 4 | 16 | 547_577 | 123 | 572 | Zinc finger | CCHC NOA-type |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378757 | + | 2 | 14 | 547_577 | 123 | 578 | Zinc finger | CCHC NOA-type |
Tgene | >OPTN | chr10:13225100 | chr10:13154453 | ENST00000378764 | + | 3 | 15 | 547_577 | 123 | 572 | Zinc finger | CCHC NOA-type |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >MCM10 | chr10:13225100 | chr10:13154453 | ENST00000378714 | + | 8 | 20 | 238_389 | 366 | 875 | Region | OB-fold domain |
Hgene | >MCM10 | chr10:13225100 | chr10:13154453 | ENST00000378714 | + | 8 | 20 | 390_415 | 366 | 875 | Region | Note=Zinc finger-like 1 |
Hgene | >MCM10 | chr10:13225100 | chr10:13154453 | ENST00000378714 | + | 8 | 20 | 783_802 | 366 | 875 | Region | Zinc finger-like 2 |
Hgene | >MCM10 | chr10:13225100 | chr10:13154453 | ENST00000378714 | + | 8 | 20 | 816_836 | 366 | 875 | Region | Zinc finger-like 3 |
Hgene | >MCM10 | chr10:13225100 | chr10:13154453 | ENST00000484800 | + | 8 | 20 | 238_389 | 367 | 876 | Region | OB-fold domain |
Hgene | >MCM10 | chr10:13225100 | chr10:13154453 | ENST00000484800 | + | 8 | 20 | 390_415 | 367 | 876 | Region | Note=Zinc finger-like 1 |
Hgene | >MCM10 | chr10:13225100 | chr10:13154453 | ENST00000484800 | + | 8 | 20 | 783_802 | 367 | 876 | Region | Zinc finger-like 2 |
Hgene | >MCM10 | chr10:13225100 | chr10:13154453 | ENST00000484800 | + | 8 | 20 | 816_836 | 367 | 876 | Region | Zinc finger-like 3 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000263036 | + | 3 | 15 | 38_170 | 123 | 578 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378747 | + | 3 | 15 | 38_170 | 123 | 578 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378748 | + | 4 | 16 | 38_170 | 123 | 578 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378752 | + | 4 | 16 | 38_170 | 123 | 572 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378757 | + | 2 | 14 | 38_170 | 123 | 578 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378764 | + | 3 | 15 | 38_170 | 123 | 572 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for MCM10_OPTN |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MCM10_OPTN |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MCM10 | KRT15, CEP70, HOOK2, ZBTB43, CCDC85B, CALCOCO2, CEP72, DPPA2, TRIM37, NINL, MCM6, CCND3, ZBTB8A, MCM7, ORC2, RPAP1, IKBKG, DDB1, RBX1, CUL4A, VPRBP, APP, ORC4, CDC45, MCM2, CDC7, MCM3, CDC5L, CDC6, CCND1, CDK6, ORC3, CDKN2A, CDKN1A, GOLGA2, TEX264, TMEM171, MCMBP, MCM4, SIRT1, NTRK1, HIST1H2BG, PCM1, TNIP1, POLR2G, SUPT5H, OFD1, CCDC14, USP37, YWHAE, IKZF5, CAV3, KLHL40, TPH1, RELL2, CACNG5 | OPTN | CCDC53, TBC1D17, HTT, RAB8A, WDR20, CYLD, RIPK1, CDKN1A, TAX1BP1, CALM1, EIF5A2, KCTD17, MPP1, MPP6, TBK1, YWHAB, YWHAG, YWHAH, YWHAQ, YWHAZ, ZNF384, TFRC, GABARAPL1, MAP1LC3A, MAP1LC3B, UBC, TRAF3, OPTN, MYO6, GRM1, TRADD, SOD1, RNF11, TNFRSF1A, TNF, RAB14, RAB11A, EPS15, TNIP1, PIAS4, RAB12, UQCRQ, FAM178A, GNAS, BRE, RAB25, RAB11B, HACE1, SQSTM1, PARK2, CDC23, DAZAP2, RAB10, ZNF398, TBC1D15, ZNF329, ZNF670, ZDHHC17, GABARAP, GABARAPL2, STX12, RAB3IL1, HSPB1, LNX2, FAM189A2, NRL, MAP1LC3C, MYH6, ATG5, IKBKG, CASP8, AIMP1, ZMYM6, TRIM16, IRAK1, ATG16L1, WIPI2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000263036 | + | 3 | 15 | 411_577 | 123 | 578 | HD |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378747 | + | 3 | 15 | 411_577 | 123 | 578 | HD |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378748 | + | 4 | 16 | 411_577 | 123 | 578 | HD |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378752 | + | 4 | 16 | 411_577 | 123 | 572 | HD |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378757 | + | 2 | 14 | 411_577 | 123 | 578 | HD |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378764 | + | 3 | 15 | 411_577 | 123 | 572 | HD |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000263036 | + | 3 | 15 | 412_520 | 123 | 578 | MYO6 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378747 | + | 3 | 15 | 412_520 | 123 | 578 | MYO6 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378748 | + | 4 | 16 | 412_520 | 123 | 578 | MYO6 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378752 | + | 4 | 16 | 412_520 | 123 | 572 | MYO6 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378757 | + | 2 | 14 | 412_520 | 123 | 578 | MYO6 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378764 | + | 3 | 15 | 412_520 | 123 | 572 | MYO6 |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000263036 | + | 3 | 15 | 58_209 | 123 | 578 | Rab8 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378747 | + | 3 | 15 | 58_209 | 123 | 578 | Rab8 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378748 | + | 4 | 16 | 58_209 | 123 | 578 | Rab8 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378752 | + | 4 | 16 | 58_209 | 123 | 572 | Rab8 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378757 | + | 2 | 14 | 58_209 | 123 | 578 | Rab8 |
Tgene | OPTN | chr10:13225100 | chr10:13154453 | ENST00000378764 | + | 3 | 15 | 58_209 | 123 | 572 | Rab8 |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MCM10_OPTN |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MCM10_OPTN |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | OPTN | C0339573 | Glaucoma, Primary Open Angle | 11 | CTD_human;HPO;UNIPROT |
Tgene | OPTN | C0029401 | Osteitis Deformans | 1 | CTD_human |
Tgene | OPTN | C3150692 | AMYOTROPHIC LATERAL SCLEROSIS 12 | 1 | CTD_human;UNIPROT |