	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
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Fusion gene ID: 2129

FusionGeneSummary for APBB2_NKIRAS1

Fusion gene summary

Fusion gene information	Fusion gene name: APBB2_NKIRAS1
	Fusion gene ID: 2129
		Hgene	Tgene
	Gene symbol	APBB2	NKIRAS1
	Gene ID	323	28512
	Gene name	amyloid beta precursor protein binding family B member 2	NFKB inhibitor interacting Ras like 1
	Synonyms	FE65L\|FE65L1	KBRAS1\|kappaB-Ras1
	Cytomap	4p14-p13	3p24.2
	Type of gene	protein-coding	protein-coding
	Description	amyloid-beta A4 precursor protein-binding family B member 2Fe65-like 1protein Fe65-like 1	NF-kappa-B inhibitor-interacting Ras-like protein 1I-kappa-B-interacting Ras-like protein 1NFKB inhibitor interacting Ras-like protein 1kappa B-Ras protein 1kappa B-ras 1
	Modification date	20180523	20180519
	UniProtAcc	Q92870	Q9NYS0
	Ensembl transtripts involved in fusion gene	ENST00000295974, ENST00000513140, ENST00000508593, ENST00000506352, ENST00000511572, ENST00000543538, ENST00000502841, ENST00000504305,	ENST00000421515, ENST00000388759, ENST00000443659, ENST00000425478, ENST00000437230, ENST00000412028, ENST00000415901, ENST00000416026,
Fusion gene scores	* DoF score	8 X 8 X 3=192	4 X 5 X 1=20
	# samples	8	5
	** MAII score	log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: APBB2 [Title/Abstract] AND NKIRAS1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BE172914	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000295974	ENST00000421515	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000295974	ENST00000388759	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000295974	ENST00000443659	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000295974	ENST00000425478	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000295974	ENST00000437230	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000295974	ENST00000412028	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000295974	ENST00000415901	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000295974	ENST00000416026	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000513140	ENST00000421515	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000513140	ENST00000388759	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000513140	ENST00000443659	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000513140	ENST00000425478	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000513140	ENST00000437230	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000513140	ENST00000412028	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000513140	ENST00000415901	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000513140	ENST00000416026	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000508593	ENST00000421515	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000508593	ENST00000388759	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000508593	ENST00000443659	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000508593	ENST00000425478	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000508593	ENST00000437230	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000508593	ENST00000412028	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000508593	ENST00000415901	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000508593	ENST00000416026	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000506352	ENST00000421515	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000506352	ENST00000388759	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000506352	ENST00000443659	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000506352	ENST00000425478	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000506352	ENST00000437230	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000506352	ENST00000412028	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000506352	ENST00000415901	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000506352	ENST00000416026	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000511572	ENST00000421515	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000511572	ENST00000388759	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000511572	ENST00000443659	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000511572	ENST00000425478	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000511572	ENST00000437230	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000511572	ENST00000412028	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000511572	ENST00000415901	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000511572	ENST00000416026	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000543538	ENST00000421515	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000543538	ENST00000388759	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000543538	ENST00000443659	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000543538	ENST00000425478	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000543538	ENST00000437230	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000543538	ENST00000412028	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000543538	ENST00000415901	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000543538	ENST00000416026	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000502841	ENST00000421515	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000502841	ENST00000388759	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000502841	ENST00000443659	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000502841	ENST00000425478	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000502841	ENST00000437230	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000502841	ENST00000412028	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000502841	ENST00000415901	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000502841	ENST00000416026	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000504305	ENST00000421515	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000504305	ENST00000388759	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000504305	ENST00000443659	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000504305	ENST00000425478	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000504305	ENST00000437230	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000504305	ENST00000412028	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000504305	ENST00000415901	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+
intron-intron	ENST00000504305	ENST00000416026	APBB2	chr4	41017979	+	NKIRAS1	chr3	23961845	+

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FusionProtFeatures for APBB2_NKIRAS1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
APBB2 Q92870	NKIRAS1 Q9NYS0
May modulate the internalization of amyloid-betaprecursor protein.	Atypical Ras-like protein that acts as a potentregulator of NF-kappa-B activity by preventing the degradation ofNF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining whyNFKBIB is more resistant to degradation. May act by blockingphosphorylation of NFKBIB and mediating cytoplasmic retention ofp65/RELA NF-kappa-B subunit. It is unclear whether it acts as aGTPase. Both GTP- and GDP-bound forms block phosphorylation ofNFKBIB. {ECO:0000269\|PubMed:10657303, ECO:0000269\|PubMed:12672800,ECO:0000269\|PubMed:15024091}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for APBB2_NKIRAS1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for APBB2_NKIRAS1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for APBB2_NKIRAS1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for APBB2_NKIRAS1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	APBB2	C0043094	Weight Gain	1	CTD_human

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Fusion gene ID: 2129

FusionGeneSummary for APBB2_NKIRAS1

FusionProtFeatures for APBB2_NKIRAS1

FusionGeneSequence for APBB2_NKIRAS1

FusionGenePPI for APBB2_NKIRAS1

RelatedDrugs for APBB2_NKIRAS1

RelatedDiseases for APBB2_NKIRAS1