|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 21281 |
FusionGeneSummary for MCF2L_STK24 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MCF2L_STK24 | Fusion gene ID: 21281 | Hgene | Tgene | Gene symbol | MCF2L | STK24 | Gene ID | 23263 | 8428 |
| Gene name | MCF.2 cell line derived transforming sequence like | serine/threonine kinase 24 | |
| Synonyms | ARHGEF14|DBS|OST | HEL-S-95|MST3|MST3B|STE20|STK3 | |
| Cytomap | 13q34 | 13q32.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | guanine nucleotide exchange factor DBSDBL's big sisterMCF2 transforming sequence-like protein | serine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O15068 | Q9Y6E0 | |
| Ensembl transtripts involved in fusion gene | ENST00000375608, ENST00000442652, ENST00000375604, ENST00000397030, ENST00000535094, ENST00000421756, ENST00000375601, ENST00000397036, ENST00000434480, ENST00000423482, ENST00000375597, ENST00000397024, ENST00000480321, ENST00000397021, | ENST00000397517, ENST00000539966, ENST00000481288, ENST00000376547, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 4 X 3 X 3=36 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/252*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MCF2L [Title/Abstract] AND STK24 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | STK24 | GO:0006468 | protein phosphorylation | 19604147 |
| Tgene | STK24 | GO:0042542 | response to hydrogen peroxide | 22291017 |
| Tgene | STK24 | GO:0046777 | protein autophosphorylation | 17046825|17657516 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-DK-A2I4-01A | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000375608 | ENST00000397517 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000375608 | ENST00000539966 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000375608 | ENST00000481288 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000375608 | ENST00000376547 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000442652 | ENST00000397517 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000442652 | ENST00000539966 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000442652 | ENST00000481288 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000442652 | ENST00000376547 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| Frame-shift | ENST00000375604 | ENST00000397517 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| Frame-shift | ENST00000375604 | ENST00000539966 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| 5CDS-5UTR | ENST00000375604 | ENST00000481288 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| 5CDS-5UTR | ENST00000375604 | ENST00000376547 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| Frame-shift | ENST00000397030 | ENST00000397517 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| Frame-shift | ENST00000397030 | ENST00000539966 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| 5CDS-5UTR | ENST00000397030 | ENST00000481288 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| 5CDS-5UTR | ENST00000397030 | ENST00000376547 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000535094 | ENST00000397517 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000535094 | ENST00000539966 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000535094 | ENST00000481288 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000535094 | ENST00000376547 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000421756 | ENST00000397517 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000421756 | ENST00000539966 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000421756 | ENST00000481288 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000421756 | ENST00000376547 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000375601 | ENST00000397517 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000375601 | ENST00000539966 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000375601 | ENST00000481288 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000375601 | ENST00000376547 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000397036 | ENST00000397517 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000397036 | ENST00000539966 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000397036 | ENST00000481288 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000397036 | ENST00000376547 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000434480 | ENST00000397517 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000434480 | ENST00000539966 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000434480 | ENST00000481288 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000434480 | ENST00000376547 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000423482 | ENST00000397517 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000423482 | ENST00000539966 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000423482 | ENST00000481288 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000423482 | ENST00000376547 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000375597 | ENST00000397517 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000375597 | ENST00000539966 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000375597 | ENST00000481288 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000375597 | ENST00000376547 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000397024 | ENST00000397517 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000397024 | ENST00000539966 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000397024 | ENST00000481288 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000397024 | ENST00000376547 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000480321 | ENST00000397517 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000480321 | ENST00000539966 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000480321 | ENST00000481288 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000480321 | ENST00000376547 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000397021 | ENST00000397517 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-3CDS | ENST00000397021 | ENST00000539966 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000397021 | ENST00000481288 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
| intron-5UTR | ENST00000397021 | ENST00000376547 | MCF2L | chr13 | 113623028 | + | STK24 | chr13 | 99171727 | - |
Top |
FusionProtFeatures for MCF2L_STK24 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MCF2L | STK24 |
| Serine/threonine-protein kinase that acts on both serineand threonine residues and promotes apoptosis in response tostress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2(MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) duringoxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nucleartranslocation of AIFM1 and ENDOG and the DNase activity associatedwith ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates itskinase activity. In association with STK26 negatively regulatesGolgi reorientation in polarized cell migration upon RHOactivation (PubMed:27807006). Regulates also cellular migrationwith alteration of PTPN12 activity and PXN phosphorylation:phosphorylates PTPN12 and inhibits its activity and may regulatePXN phosphorylation through PTPN12. May act as a key regulator ofaxon regeneration in the optic nerve and radial nerve.{ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825,ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762,ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MCF2L_STK24 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MCF2L_STK24 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MCF2L | RAC1, CDC42, RHOA, YAE1D1, RABAC1, AIMP2, GNB1, TRIM25 | STK24 | PDCD10, STRN, MCC, STRN3, PPP2R1A, STRN4, MOB4, STK25, STRIP1, PPP2CB, SLMAP, APOD, DDX5, G3BP2, HNRNPH3, PDCD6IP, ZBTB24, JPH3, SYNCRIP, HNRNPA3, FABP5, DSP, CTTNBP2NL, SIKE1, PPP2CA, PPP2R1B, STRIP2, CCT2, CCT8, CTTNBP2, CCT3, TCP1, CCT5, FGFR1OP2, CCT6A, CCT7, CCT4, TRAF3IP3, NEDD4, VAV2, ELAVL1, LRRK2, CEP135, RPL12, ALDH7A1, ASNS, EIF5, ISOC1, MAT2B, MSN, PDIA4, PPP1CA, SCPEP1, PRCP, TBCB, VCL, TUBB, XPO1, DYNLL1, PROSER2, STK26, STK24, C4orf19, MAGIX, ATP6V1C2, COG5, MAD1L1, TRMT6, TLK2, ERBB2, STK11, CEP19, LRPPRC, WRAP53, CDC5L, CDH1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MCF2L_STK24 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MCF2L_STK24 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|