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Fusion gene ID: 2128 |
FusionGeneSummary for APBB2_IGKC |
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Fusion gene information | Fusion gene name: APBB2_IGKC | Fusion gene ID: 2128 | Hgene | Tgene | Gene symbol | APBB2 | IGKC | Gene ID | 323 | 3514 |
Gene name | amyloid beta precursor protein binding family B member 2 | immunoglobulin kappa constant | |
Synonyms | FE65L|FE65L1 | HCAK1|IGKCD|Km | |
Cytomap | 4p14-p13 | 2p11.2 | |
Type of gene | protein-coding | other | |
Description | amyloid-beta A4 precursor protein-binding family B member 2Fe65-like 1protein Fe65-like 1 | immunoglobulin kappa (invariant region)immunoglobulin kappa constant regionimmunoglobulin kappa light chain (VJ) | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q92870 | P01834 | |
Ensembl transtripts involved in fusion gene | ENST00000295974, ENST00000513140, ENST00000508593, ENST00000506352, ENST00000511572, ENST00000543538, ENST00000502841, ENST00000504305, | ENST00000390237, | |
Fusion gene scores | * DoF score | 8 X 8 X 3=192 | 21 X 29 X 2=1218 |
# samples | 8 | 35 | |
** MAII score | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(35/1218*10)=-1.799087306074 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: APBB2 [Title/Abstract] AND IGKC [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE012048 | APBB2 | chr4 | 41002936 | - | IGKC | chr2 | 89157134 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000295974 | ENST00000390237 | APBB2 | chr4 | 41002936 | - | IGKC | chr2 | 89157134 | + |
intron-3CDS | ENST00000513140 | ENST00000390237 | APBB2 | chr4 | 41002936 | - | IGKC | chr2 | 89157134 | + |
intron-3CDS | ENST00000508593 | ENST00000390237 | APBB2 | chr4 | 41002936 | - | IGKC | chr2 | 89157134 | + |
intron-3CDS | ENST00000506352 | ENST00000390237 | APBB2 | chr4 | 41002936 | - | IGKC | chr2 | 89157134 | + |
intron-3CDS | ENST00000511572 | ENST00000390237 | APBB2 | chr4 | 41002936 | - | IGKC | chr2 | 89157134 | + |
intron-3CDS | ENST00000543538 | ENST00000390237 | APBB2 | chr4 | 41002936 | - | IGKC | chr2 | 89157134 | + |
intron-3CDS | ENST00000502841 | ENST00000390237 | APBB2 | chr4 | 41002936 | - | IGKC | chr2 | 89157134 | + |
intron-3CDS | ENST00000504305 | ENST00000390237 | APBB2 | chr4 | 41002936 | - | IGKC | chr2 | 89157134 | + |
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FusionProtFeatures for APBB2_IGKC |
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Hgene | Tgene |
APBB2 | IGKC |
May modulate the internalization of amyloid-betaprecursor protein. | Constant region of immunoglobulin heavy chains.Immunoglobulins, also known as antibodies, are membrane-bound orsecreted glycoproteins produced by B lymphocytes. In therecognition phase of humoral immunity, the membrane-boundimmunoglobulins serve as receptors which, upon binding of aspecific antigen, trigger the clonal expansion and differentiationof B lymphocytes into immunoglobulins-secreting plasma cells.Secreted immunoglobulins mediate the effector phase of humoralimmunity, which results in the elimination of bound antigens(PubMed:22158414, PubMed:20176268). The antigen binding site isformed by the variable domain of one heavy chain, together withthat of its associated light chain. Thus, each immunoglobulin hastwo antigen binding sites with remarkable affinity for aparticular antigen. The variable domains are assembled by aprocess called V-(D)-J rearrangement and can then be subjected tosomatic hypermutations which, after exposure to antigen andselection, allow affinity maturation for a particular antigen(PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170,ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for APBB2_IGKC |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for APBB2_IGKC |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for APBB2_IGKC |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for APBB2_IGKC |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | APBB2 | C0043094 | Weight Gain | 1 | CTD_human |
Tgene | IGKC | C0013374 | Dysgammaglobulinemia | 1 | CTD_human |
Tgene | IGKC | C0027121 | Myositis | 1 | CTD_human |
Tgene | IGKC | C3279824 | Kappa-Chain Deficiency | 1 | ORPHANET;UNIPROT |