![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 21279 |
FusionGeneSummary for MCF2L_LAMA5 |
![]() |
Fusion gene information | Fusion gene name: MCF2L_LAMA5 | Fusion gene ID: 21279 | Hgene | Tgene | Gene symbol | MCF2L | LAMA5 | Gene ID | 23263 | 3911 |
Gene name | MCF.2 cell line derived transforming sequence like | laminin subunit alpha 5 | |
Synonyms | ARHGEF14|DBS|OST | - | |
Cytomap | 13q34 | 20q13.33 | |
Type of gene | protein-coding | protein-coding | |
Description | guanine nucleotide exchange factor DBSDBL's big sisterMCF2 transforming sequence-like protein | laminin subunit alpha-5laminin alpha-5 chainlaminin-10 subunit alphalaminin-11 subunit alphalaminin-15 subunit alpha | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | O15068 | O15230 | |
Ensembl transtripts involved in fusion gene | ENST00000375608, ENST00000442652, ENST00000375604, ENST00000397030, ENST00000535094, ENST00000421756, ENST00000375601, ENST00000397036, ENST00000434480, ENST00000423482, ENST00000375597, ENST00000397024, ENST00000480321, ENST00000397021, | ENST00000492698, ENST00000252999, ENST00000370692, ENST00000370677, | |
Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 8 X 7 X 4=224 |
# samples | 6 | 8 | |
** MAII score | log2(6/252*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MCF2L [Title/Abstract] AND LAMA5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | LAMA5 | GO:0016477 | cell migration | 11821406 |
Tgene | LAMA5 | GO:0034446 | substrate adhesion-dependent cell spreading | 16236823 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-CG-4443-01A | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000375608 | ENST00000492698 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000375608 | ENST00000252999 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000375608 | ENST00000370692 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000375608 | ENST00000370677 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000442652 | ENST00000492698 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000442652 | ENST00000252999 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000442652 | ENST00000370692 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000442652 | ENST00000370677 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000375604 | ENST00000492698 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000375604 | ENST00000252999 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000375604 | ENST00000370692 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000375604 | ENST00000370677 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000397030 | ENST00000492698 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000397030 | ENST00000252999 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000397030 | ENST00000370692 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000397030 | ENST00000370677 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000535094 | ENST00000492698 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000535094 | ENST00000252999 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000535094 | ENST00000370692 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000535094 | ENST00000370677 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000421756 | ENST00000492698 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000421756 | ENST00000252999 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000421756 | ENST00000370692 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000421756 | ENST00000370677 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000375601 | ENST00000492698 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000375601 | ENST00000252999 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000375601 | ENST00000370692 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000375601 | ENST00000370677 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
intron-intron | ENST00000397036 | ENST00000492698 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
intron-intron | ENST00000397036 | ENST00000252999 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
intron-intron | ENST00000397036 | ENST00000370692 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
intron-intron | ENST00000397036 | ENST00000370677 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000434480 | ENST00000492698 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000434480 | ENST00000252999 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000434480 | ENST00000370692 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000434480 | ENST00000370677 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000423482 | ENST00000492698 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000423482 | ENST00000252999 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000423482 | ENST00000370692 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000423482 | ENST00000370677 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000375597 | ENST00000492698 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000375597 | ENST00000252999 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000375597 | ENST00000370692 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000375597 | ENST00000370677 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000397024 | ENST00000492698 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000397024 | ENST00000252999 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000397024 | ENST00000370692 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
5CDS-intron | ENST00000397024 | ENST00000370677 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
intron-intron | ENST00000480321 | ENST00000492698 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
intron-intron | ENST00000480321 | ENST00000252999 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
intron-intron | ENST00000480321 | ENST00000370692 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
intron-intron | ENST00000480321 | ENST00000370677 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
intron-intron | ENST00000397021 | ENST00000492698 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
intron-intron | ENST00000397021 | ENST00000252999 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
intron-intron | ENST00000397021 | ENST00000370692 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
intron-intron | ENST00000397021 | ENST00000370677 | MCF2L | chr13 | 113679072 | + | LAMA5 | chr20 | 60922084 | - |
Top |
FusionProtFeatures for MCF2L_LAMA5 |
![]() |
Hgene | Tgene |
MCF2L | LAMA5 |
Binding to cells via a high affinity receptor, lamininis thought to mediate the attachment, migration and organizationof cells into tissues during embryonic development by interactingwith other extracellular matrix components. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MCF2L_LAMA5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MCF2L_LAMA5 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MCF2L | RAC1, CDC42, RHOA, YAE1D1, RABAC1, AIMP2, GNB1, TRIM25 | LAMA5 | MEP1A, COL7A1, FBLN2, BCAM, DAG1, CRKL, MYOC, USP4, SMAD2, FBXO6, SUSD4, TMEM25, PTPRK, LAMC1, RNASEH2A, CRP, OS9, SCGB2A2, DEFA1, DKK3, C4orf26, INSL5, UBC, TRIM25 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MCF2L_LAMA5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MCF2L_LAMA5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |