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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21279

FusionGeneSummary for MCF2L_LAMA5

check button Fusion gene summary
Fusion gene informationFusion gene name: MCF2L_LAMA5
Fusion gene ID: 21279
HgeneTgene
Gene symbol

MCF2L

LAMA5

Gene ID

23263

3911

Gene nameMCF.2 cell line derived transforming sequence likelaminin subunit alpha 5
SynonymsARHGEF14|DBS|OST-
Cytomap

13q34

20q13.33

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide exchange factor DBSDBL's big sisterMCF2 transforming sequence-like proteinlaminin subunit alpha-5laminin alpha-5 chainlaminin-10 subunit alphalaminin-11 subunit alphalaminin-15 subunit alpha
Modification date2018051920180522
UniProtAcc

O15068

O15230

Ensembl transtripts involved in fusion geneENST00000375608, ENST00000442652, 
ENST00000375604, ENST00000397030, 
ENST00000535094, ENST00000421756, 
ENST00000375601, ENST00000397036, 
ENST00000434480, ENST00000423482, 
ENST00000375597, ENST00000397024, 
ENST00000480321, ENST00000397021, 
ENST00000492698, ENST00000252999, 
ENST00000370692, ENST00000370677, 
Fusion gene scores* DoF score7 X 6 X 6=2528 X 7 X 4=224
# samples 68
** MAII scorelog2(6/252*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MCF2L [Title/Abstract] AND LAMA5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLAMA5

GO:0016477

cell migration

11821406

TgeneLAMA5

GO:0034446

substrate adhesion-dependent cell spreading

16236823


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-CG-4443-01AMCF2Lchr13

113679072

+LAMA5chr20

60922084

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000375608ENST00000492698MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000375608ENST00000252999MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000375608ENST00000370692MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000375608ENST00000370677MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000442652ENST00000492698MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000442652ENST00000252999MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000442652ENST00000370692MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000442652ENST00000370677MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000375604ENST00000492698MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000375604ENST00000252999MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000375604ENST00000370692MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000375604ENST00000370677MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000397030ENST00000492698MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000397030ENST00000252999MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000397030ENST00000370692MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000397030ENST00000370677MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000535094ENST00000492698MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000535094ENST00000252999MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000535094ENST00000370692MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000535094ENST00000370677MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000421756ENST00000492698MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000421756ENST00000252999MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000421756ENST00000370692MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000421756ENST00000370677MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000375601ENST00000492698MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000375601ENST00000252999MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000375601ENST00000370692MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000375601ENST00000370677MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
intron-intronENST00000397036ENST00000492698MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
intron-intronENST00000397036ENST00000252999MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
intron-intronENST00000397036ENST00000370692MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
intron-intronENST00000397036ENST00000370677MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000434480ENST00000492698MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000434480ENST00000252999MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000434480ENST00000370692MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000434480ENST00000370677MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000423482ENST00000492698MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000423482ENST00000252999MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000423482ENST00000370692MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000423482ENST00000370677MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000375597ENST00000492698MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000375597ENST00000252999MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000375597ENST00000370692MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000375597ENST00000370677MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000397024ENST00000492698MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000397024ENST00000252999MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000397024ENST00000370692MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
5CDS-intronENST00000397024ENST00000370677MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
intron-intronENST00000480321ENST00000492698MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
intron-intronENST00000480321ENST00000252999MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
intron-intronENST00000480321ENST00000370692MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
intron-intronENST00000480321ENST00000370677MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
intron-intronENST00000397021ENST00000492698MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
intron-intronENST00000397021ENST00000252999MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
intron-intronENST00000397021ENST00000370692MCF2Lchr13

113679072

+LAMA5chr20

60922084

-
intron-intronENST00000397021ENST00000370677MCF2Lchr13

113679072

+LAMA5chr20

60922084

-

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FusionProtFeatures for MCF2L_LAMA5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MCF2L

O15068

LAMA5

O15230

Binding to cells via a high affinity receptor, lamininis thought to mediate the attachment, migration and organizationof cells into tissues during embryonic development by interactingwith other extracellular matrix components.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MCF2L_LAMA5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MCF2L_LAMA5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MCF2LRAC1, CDC42, RHOA, YAE1D1, RABAC1, AIMP2, GNB1, TRIM25LAMA5MEP1A, COL7A1, FBLN2, BCAM, DAG1, CRKL, MYOC, USP4, SMAD2, FBXO6, SUSD4, TMEM25, PTPRK, LAMC1, RNASEH2A, CRP, OS9, SCGB2A2, DEFA1, DKK3, C4orf26, INSL5, UBC, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MCF2L_LAMA5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MCF2L_LAMA5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource