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Fusion gene ID: 21278 |
FusionGeneSummary for MCF2L_GRK1 |
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Fusion gene information | Fusion gene name: MCF2L_GRK1 | Fusion gene ID: 21278 | Hgene | Tgene | Gene symbol | MCF2L | GRK1 | Gene ID | 23263 | 6011 |
Gene name | MCF.2 cell line derived transforming sequence like | G protein-coupled receptor kinase 1 | |
Synonyms | ARHGEF14|DBS|OST | GPRK1|RHOK|RK | |
Cytomap | 13q34 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | guanine nucleotide exchange factor DBSDBL's big sisterMCF2 transforming sequence-like protein | rhodopsin kinase | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O15068 | Q15835 | |
Ensembl transtripts involved in fusion gene | ENST00000375608, ENST00000442652, ENST00000375604, ENST00000397030, ENST00000535094, ENST00000421756, ENST00000375601, ENST00000397036, ENST00000434480, ENST00000423482, ENST00000375597, ENST00000397024, ENST00000480321, ENST00000397021, | ENST00000335678, ENST00000545304, | |
Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/252*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: MCF2L [Title/Abstract] AND GRK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GRK1 | GO:0022400 | regulation of rhodopsin mediated signaling pathway | 15946941 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-09-0364-01A | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000375608 | ENST00000335678 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
5CDS-3UTR | ENST00000375608 | ENST00000545304 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
Frame-shift | ENST00000442652 | ENST00000335678 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
5CDS-3UTR | ENST00000442652 | ENST00000545304 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3CDS | ENST00000375604 | ENST00000335678 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3UTR | ENST00000375604 | ENST00000545304 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3CDS | ENST00000397030 | ENST00000335678 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3UTR | ENST00000397030 | ENST00000545304 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3CDS | ENST00000535094 | ENST00000335678 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3UTR | ENST00000535094 | ENST00000545304 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3CDS | ENST00000421756 | ENST00000335678 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3UTR | ENST00000421756 | ENST00000545304 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3CDS | ENST00000375601 | ENST00000335678 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3UTR | ENST00000375601 | ENST00000545304 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
Frame-shift | ENST00000397036 | ENST00000335678 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
5CDS-3UTR | ENST00000397036 | ENST00000545304 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3CDS | ENST00000434480 | ENST00000335678 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3UTR | ENST00000434480 | ENST00000545304 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3CDS | ENST00000423482 | ENST00000335678 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3UTR | ENST00000423482 | ENST00000545304 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3CDS | ENST00000375597 | ENST00000335678 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3UTR | ENST00000375597 | ENST00000545304 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3CDS | ENST00000397024 | ENST00000335678 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3UTR | ENST00000397024 | ENST00000545304 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3CDS | ENST00000480321 | ENST00000335678 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3UTR | ENST00000480321 | ENST00000545304 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3CDS | ENST00000397021 | ENST00000335678 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
intron-3UTR | ENST00000397021 | ENST00000545304 | MCF2L | chr13 | 113556685 | + | GRK1 | chr13 | 114435857 | + |
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FusionProtFeatures for MCF2L_GRK1 |
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Hgene | Tgene |
MCF2L | GRK1 |
Retina-specific kinase involved in the signal turnoffvia phosphorylation of rhodopsin (RHO), the G protein- coupledreceptor that initiates the phototransduction cascade. This rapiddesensitization is essential for scotopic vision and permits rapidadaptation to changes in illumination.{ECO:0000269|PubMed:15946941}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MCF2L_GRK1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MCF2L_GRK1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MCF2L | RAC1, CDC42, RHOA, YAE1D1, RABAC1, AIMP2, GNB1, TRIM25 | GRK1 | CAV1, RHO, RCVRN, SNCA, SNCB, SNCG, MYC, H2AFV, ADRB2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MCF2L_GRK1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MCF2L_GRK1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GRK1 | C3150678 | OGUCHI DISEASE 2 | 2 | UNIPROT |