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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21278

FusionGeneSummary for MCF2L_GRK1

check button Fusion gene summary
Fusion gene informationFusion gene name: MCF2L_GRK1
Fusion gene ID: 21278
HgeneTgene
Gene symbol

MCF2L

GRK1

Gene ID

23263

6011

Gene nameMCF.2 cell line derived transforming sequence likeG protein-coupled receptor kinase 1
SynonymsARHGEF14|DBS|OSTGPRK1|RHOK|RK
Cytomap

13q34

13q34

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide exchange factor DBSDBL's big sisterMCF2 transforming sequence-like proteinrhodopsin kinase
Modification date2018051920180519
UniProtAcc

O15068

Q15835

Ensembl transtripts involved in fusion geneENST00000375608, ENST00000442652, 
ENST00000375604, ENST00000397030, 
ENST00000535094, ENST00000421756, 
ENST00000375601, ENST00000397036, 
ENST00000434480, ENST00000423482, 
ENST00000375597, ENST00000397024, 
ENST00000480321, ENST00000397021, 
ENST00000335678, ENST00000545304, 
Fusion gene scores* DoF score7 X 6 X 6=2521 X 1 X 1=1
# samples 61
** MAII scorelog2(6/252*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: MCF2L [Title/Abstract] AND GRK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGRK1

GO:0022400

regulation of rhodopsin mediated signaling pathway

15946941


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-09-0364-01AMCF2Lchr13

113556685

+GRK1chr13

114435857

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000375608ENST00000335678MCF2Lchr13

113556685

+GRK1chr13

114435857

+
5CDS-3UTRENST00000375608ENST00000545304MCF2Lchr13

113556685

+GRK1chr13

114435857

+
Frame-shitENST00000442652ENST00000335678MCF2Lchr13

113556685

+GRK1chr13

114435857

+
5CDS-3UTRENST00000442652ENST00000545304MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3CDSENST00000375604ENST00000335678MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3UTRENST00000375604ENST00000545304MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3CDSENST00000397030ENST00000335678MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3UTRENST00000397030ENST00000545304MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3CDSENST00000535094ENST00000335678MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3UTRENST00000535094ENST00000545304MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3CDSENST00000421756ENST00000335678MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3UTRENST00000421756ENST00000545304MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3CDSENST00000375601ENST00000335678MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3UTRENST00000375601ENST00000545304MCF2Lchr13

113556685

+GRK1chr13

114435857

+
Frame-shitENST00000397036ENST00000335678MCF2Lchr13

113556685

+GRK1chr13

114435857

+
5CDS-3UTRENST00000397036ENST00000545304MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3CDSENST00000434480ENST00000335678MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3UTRENST00000434480ENST00000545304MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3CDSENST00000423482ENST00000335678MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3UTRENST00000423482ENST00000545304MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3CDSENST00000375597ENST00000335678MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3UTRENST00000375597ENST00000545304MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3CDSENST00000397024ENST00000335678MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3UTRENST00000397024ENST00000545304MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3CDSENST00000480321ENST00000335678MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3UTRENST00000480321ENST00000545304MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3CDSENST00000397021ENST00000335678MCF2Lchr13

113556685

+GRK1chr13

114435857

+
intron-3UTRENST00000397021ENST00000545304MCF2Lchr13

113556685

+GRK1chr13

114435857

+

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FusionProtFeatures for MCF2L_GRK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MCF2L

O15068

GRK1

Q15835

Retina-specific kinase involved in the signal turnoffvia phosphorylation of rhodopsin (RHO), the G protein- coupledreceptor that initiates the phototransduction cascade. This rapiddesensitization is essential for scotopic vision and permits rapidadaptation to changes in illumination.{ECO:0000269|PubMed:15946941}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MCF2L_GRK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MCF2L_GRK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MCF2LRAC1, CDC42, RHOA, YAE1D1, RABAC1, AIMP2, GNB1, TRIM25GRK1CAV1, RHO, RCVRN, SNCA, SNCB, SNCG, MYC, H2AFV, ADRB2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MCF2L_GRK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MCF2L_GRK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGRK1C3150678OGUCHI DISEASE 22UNIPROT