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Fusion gene ID: 21268 |
FusionGeneSummary for MCC_DBN1 |
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Fusion gene information | Fusion gene name: MCC_DBN1 | Fusion gene ID: 21268 | Hgene | Tgene | Gene symbol | MCC | DBN1 | Gene ID | 4163 | 1627 |
Gene name | MCC, WNT signaling pathway regulator | drebrin 1 | |
Synonyms | MCC1 | D0S117E | |
Cytomap | 5q22.2 | 5q35.3 | |
Type of gene | protein-coding | protein-coding | |
Description | colorectal mutant cancer proteinmutated in colorectal cancers | drebrindevelopmentally-regulated brain proteindrebrin Adrebrin Edrebrin E2 | |
Modification date | 20180522 | 20180525 | |
UniProtAcc | P23508 | Q16643 | |
Ensembl transtripts involved in fusion gene | ENST00000302475, ENST00000514701, ENST00000515367, ENST00000408903, | ENST00000309007, ENST00000292385, ENST00000393565, ENST00000393563, ENST00000512501, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 8 X 7 X 6=336 |
# samples | 6 | 9 | |
** MAII score | log2(6/60*10)=0 | log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MCC [Title/Abstract] AND DBN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MCC | GO:0045184 | establishment of protein localization | 18591935 |
Hgene | MCC | GO:0050680 | negative regulation of epithelial cell proliferation | 18591935 |
Hgene | MCC | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 18591935 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-BC-A10T-01A | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000302475 | ENST00000309007 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
In-frame | ENST00000302475 | ENST00000292385 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
In-frame | ENST00000302475 | ENST00000393565 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
5CDS-5UTR | ENST00000302475 | ENST00000393563 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
5CDS-5UTR | ENST00000302475 | ENST00000512501 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
5UTR-3CDS | ENST00000514701 | ENST00000309007 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
5UTR-3CDS | ENST00000514701 | ENST00000292385 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
5UTR-3CDS | ENST00000514701 | ENST00000393565 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
5UTR-5UTR | ENST00000514701 | ENST00000393563 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
5UTR-5UTR | ENST00000514701 | ENST00000512501 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
intron-3CDS | ENST00000515367 | ENST00000309007 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
intron-3CDS | ENST00000515367 | ENST00000292385 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
intron-3CDS | ENST00000515367 | ENST00000393565 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
intron-5UTR | ENST00000515367 | ENST00000393563 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
intron-5UTR | ENST00000515367 | ENST00000512501 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
intron-3CDS | ENST00000408903 | ENST00000309007 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
intron-3CDS | ENST00000408903 | ENST00000292385 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
intron-3CDS | ENST00000408903 | ENST00000393565 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
intron-5UTR | ENST00000408903 | ENST00000393563 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
intron-5UTR | ENST00000408903 | ENST00000512501 | MCC | chr5 | 112630026 | - | DBN1 | chr5 | 176887704 | - |
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FusionProtFeatures for MCC_DBN1 |
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Hgene | Tgene |
MCC | DBN1 |
Candidate for the putative colorectal tumor suppressorgene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA bindingof b-catenin/TCF/LEF transcription factors. Involved in cellmigration independently of RAC1, CDC42 and p21-activated kinase(PAK) activation (PubMed:18591935, PubMed:19555689,PubMed:22480440). Represses the beta-catenin pathway (canonicalWnt signaling pathway) in a CCAR2-dependent manner by sequesteringCCAR2 to the cytoplasm, thereby impairing its ability to inhibitSIRT1 which is involved in the deacetylation and negativeregulation of beta-catenin (CTNB1) transcriptional activity(PubMed:24824780). {ECO:0000269|PubMed:18591935,ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440,ECO:0000269|PubMed:24824780}. | Drebrins might play some role in cell migration,extension of neuronal processes and plasticity of dendrites.Required for actin polymerization at immunological synapses (IS)and for CXCR4 recruitment to IS. {ECO:0000269|PubMed:20215400}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >MCC | chr5:112630026 | chr5:176887704 | ENST00000302475 | - | 1 | 17 | 766_782 | 19 | 830 | Motif | Nuclear localization signal |
Hgene | >MCC | chr5:112630026 | chr5:176887704 | ENST00000302475 | - | 1 | 17 | 826_829 | 19 | 830 | Motif | Note=PDZ-binding |
Hgene | >MCC | chr5:112630026 | chr5:176887704 | ENST00000408903 | - | 1 | 19 | 766_782 | -139 | 1020 | Motif | Nuclear localization signal |
Hgene | >MCC | chr5:112630026 | chr5:176887704 | ENST00000408903 | - | 1 | 19 | 826_829 | -139 | 1020 | Motif | Note=PDZ-binding |
Tgene | DBN1 | chr5:112630026 | chr5:176887704 | ENST00000292385 | - | 8 | 15 | 3_134 | 259 | 652 | Domain | ADF-H |
Tgene | DBN1 | chr5:112630026 | chr5:176887704 | ENST00000309007 | - | 7 | 14 | 3_134 | 257 | 650 | Domain | ADF-H |
Tgene | DBN1 | chr5:112630026 | chr5:176887704 | ENST00000393565 | - | 7 | 15 | 3_134 | 257 | 696 | Domain | ADF-H |
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FusionGeneSequence for MCC_DBN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_MCC_ENST00000302475_chr5_112630026_-_DBN1_ENST00000309007_chr5_176887704_-_412aa MNSGVAMKYGNDSSAELSEGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRM APTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPA EDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAE VPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYF >In-frame_MCC_ENST00000302475_chr5_112630026_-_DBN1_ENST00000292385_chr5_176887704_-_412aa MNSGVAMKYGNDSSAELSEGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRM APTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPA EDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAE VPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYF >In-frame_MCC_ENST00000302475_chr5_112630026_-_DBN1_ENST00000393565_chr5_176887704_-_458aa MNSGVAMKYGNDSSAELSEGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGRPYCPFIKA SDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPCSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPP PAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADT TVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGE SLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEE |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_MCC_ENST00000302475_chr5_112630026_-_DBN1_ENST00000309007_chr5_176887704_-_1236nt ATGAATTCCGGAGTTGCCATGAAATATGGAAACGACTCCTCGGCCGAGCTGAGTGAGGGTGACCATCGGGATGAGGAGGAAGAGACCCAC ATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGACAACCCAAGGGAGTTCTTCAAGCAGCAGGAA AGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTACCCTCGCCCTTCAACCATCGACCAGGCAGCCACCTGGACAGCCACCGGAGGATG GCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGACTCCAGCACCGCCTCCACCCCTGTCGCTGAGCAGATAGAGCGGGCCCTGGATGAG GTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCACCCCCACCAGCCCAAGAGACCCAGGAGCCCAGCCCCATCCTAGACAGTGAGGAG ACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCCATGGAGGAGCCCCCTCAGGCACAGGCGCCTCCCCGGGGGCCAGGCAGCCCTGCA GAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCTGTCCTGGCTGCTCCCGTGGAGCCTGCCACAGCTGACGCCACGGAGATCCACGAT GCAGCTGACACCATTGAAACTGACACTGCCACTGCTGACACCACTGTTGCCAACAACGTACCCCCCGCCGCCACCAGCCTCATTGACCTA TGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAGGGTGAGCCCAGGGCCCCCACGCCACCCTCGGGTACTGAGGTCACCCTGGCAGAG GTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTGCTGCCAGCAGGCGAAGGCTGTGCCACCCTTCTCAACTTTGATGAGCTGCCTGAG CCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAAGGGGAGTCCCTGGCTGCCCCCCAGACCCCAACTCTGCCCTCAGCCCTTGAGGAG CTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTAACCAATGGCGAGACCACCCAGAAGGAGGGGACCCAGGCCAGTGAGGGGTACTTC AGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTGTTCTACAACAAGCCTCCAGAGATC >In-frame_MCC_ENST00000302475_chr5_112630026_-_DBN1_ENST00000292385_chr5_176887704_-_1236nt ATGAATTCCGGAGTTGCCATGAAATATGGAAACGACTCCTCGGCCGAGCTGAGTGAGGGTGACCATCGGGATGAGGAGGAAGAGACCCAC ATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGACAACCCAAGGGAGTTCTTCAAGCAGCAGGAA AGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTACCCTCGCCCTTCAACCATCGACCAGGCAGCCACCTGGACAGCCACCGGAGGATG GCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGACTCCAGCACCGCCTCCACCCCTGTCGCTGAGCAGATAGAGCGGGCCCTGGATGAG GTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCACCCCCACCAGCCCAAGAGACCCAGGAGCCCAGCCCCATCCTAGACAGTGAGGAG ACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCCATGGAGGAGCCCCCTCAGGCACAGGCGCCTCCCCGGGGGCCAGGCAGCCCTGCA GAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCTGTCCTGGCTGCTCCCGTGGAGCCTGCCACAGCTGACGCCACGGAGATCCACGAT GCAGCTGACACCATTGAAACTGACACTGCCACTGCTGACACCACTGTTGCCAACAACGTACCCCCCGCCGCCACCAGCCTCATTGACCTA TGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAGGGTGAGCCCAGGGCCCCCACGCCACCCTCGGGTACTGAGGTCACCCTGGCAGAG GTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTGCTGCCAGCAGGCGAAGGCTGTGCCACCCTTCTCAACTTTGATGAGCTGCCTGAG CCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAAGGGGAGTCCCTGGCTGCCCCCCAGACCCCAACTCTGCCCTCAGCCCTTGAGGAG CTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTAACCAATGGCGAGACCACCCAGAAGGAGGGGACCCAGGCCAGTGAGGGGTACTTC AGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTGTTCTACAACAAGCCTCCAGAGATC >In-frame_MCC_ENST00000302475_chr5_112630026_-_DBN1_ENST00000393565_chr5_176887704_-_1374nt ATGAATTCCGGAGTTGCCATGAAATATGGAAACGACTCCTCGGCCGAGCTGAGTGAGGGTGACCATCGGGATGAGGAGGAAGAGACCCAC ATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGACAACCCAAGGGAGTTCTTCAAGCAGCAGGAA AGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTACCCTCGCCCTTCAACCATCGACCAGGTCGTCCGTACTGCCCTTTCATAAAGGCA TCGGACAGTGGGCCTTCCTCCTCCTCCTCTTCCTCCTCCTCCCCTCCACGGACTCCCTTTCCCTATATCACCTGCCACCGCACCCCAAAC CTCTCTTCCTCCCTCCCATGCAGCCACCTGGACAGCCACCGGAGGATGGCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGACTCCAGC ACCGCCTCCACCCCTGTCGCTGAGCAGATAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCACCCCCA CCAGCCCAAGAGACCCAGGAGCCCAGCCCCATCCTAGACAGTGAGGAGACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCCATGGAG GAGCCCCCTCAGGCACAGGCGCCTCCCCGGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCTGTCCTG GCTGCTCCCGTGGAGCCTGCCACAGCTGACGCCACGGAGATCCACGATGCAGCTGACACCATTGAAACTGACACTGCCACTGCTGACACC ACTGTTGCCAACAACGTACCCCCCGCCGCCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAGGGTGAG CCCAGGGCCCCCACGCCACCCTCGGGTACTGAGGTCACCCTGGCAGAGGTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTGCTGCCA GCAGGCGAAGGCTGTGCCACCCTTCTCAACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAAGGGGAG TCCCTGGCTGCCCCCCAGACCCCAACTCTGCCCTCAGCCCTTGAGGAGCTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTAACCAAT GGCGAGACCACCCAGAAGGAGGGGACCCAGGCCAGTGAGGGGTACTTCAGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAAGAGCTC TGTGCCAAGGCTCCGCCTCCTGTGTTCTACAACAAGCCTCCAGAGATCGACATCACATGCTGGGATGCAGACCCAGTTCCAGAAGAGGAG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_MCC_ENST00000302475_chr5_112630026_-_DBN1_ENST00000309007_chr5_176887704_-_2625nt AGAAACCACTTACAACTCCAGACGATTCGAAGGGGAAACTTCGGCGTGAAGTGCAGCTCCGCTCCGGCTCCCTCTAGCTTTCTTTCCTTC TCTGGAATCCGAGGCGCGGATCTTCCTCGCCCCACCGCCCTAGTTTTTTCGGGAGCTCGCCGGTGCCCTCTAGGGTGTCGGCTCGTGCTG GGAAGTGCCCTCCATCCTGGTAATGGGGGGCGGCGAGGCACCGTAGGAGTGGCGAGGCGGCGCCCAGGGTGGCACTGCCCCGGAACGGGG CGCTGGGTGCGCGCGGGAGGGTCCCCGCGCGGGCTCCGCCGCTGCCGCAGCTGCGAGCGCGCCGCGCCACCGAGCCTCCTGCAGCAATGG CTCGTCCGTGAAACGCGAGCCACGGCTGCTCTTTTTAAGAGTGCCTGCATCCTCCGTTTGCGCTTCGCAACTGTCCTGGGTGAAAATGGC TGTCTAGACTAAAATGTGGCAGAAGGGACCAAGCAGTGGATATTGAGCCTGTGAAGTCCAACTCTTAAGCTCCGAGACCTGGGGGACTGA GAGCCCAGCTCTGAAAAGTGCATCATGAATTCCGGAGTTGCCATGAAATATGGAAACGACTCCTCGGCCGAGCTGAGTGAGGGTGACCAT CGGGATGAGGAGGAAGAGACCCACATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGACAACCCA AGGGAGTTCTTCAAGCAGCAGGAAAGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTACCCTCGCCCTTCAACCATCGACCAGGCAGC CACCTGGACAGCCACCGGAGGATGGCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGACTCCAGCACCGCCTCCACCCCTGTCGCTGAG CAGATAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCACCCCCACCAGCCCAAGAGACCCAGGAGCCC AGCCCCATCCTAGACAGTGAGGAGACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCCATGGAGGAGCCCCCTCAGGCACAGGCGCCT CCCCGGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCTGTCCTGGCTGCTCCCGTGGAGCCTGCCACA GCTGACGCCACGGAGATCCACGATGCAGCTGACACCATTGAAACTGACACTGCCACTGCTGACACCACTGTTGCCAACAACGTACCCCCC GCCGCCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAGGGTGAGCCCAGGGCCCCCACGCCACCCTCG GGTACTGAGGTCACCCTGGCAGAGGTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTGCTGCCAGCAGGCGAAGGCTGTGCCACCCTT CTCAACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAAGGGGAGTCCCTGGCTGCCCCCCAGACCCCA ACTCTGCCCTCAGCCCTTGAGGAGCTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTAACCAATGGCGAGACCACCCAGAAGGAGGGG ACCCAGGCCAGTGAGGGGTACTTCAGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTG TTCTACAACAAGCCTCCAGAGATCGACATCACATGCTGGGATGCAGACCCAGTTCCAGAAGAGGAGGAGGGCTTCGAGGGTGGTGATTAG CGGTGGCGCCAGCCCTAGGCTACCCTTGCCAAGGCCGCCCACCTGCATCAGCCTCTGGCCAGACGGCCCGCCGTGCCTGCATTCGCAGCA GCTCCGCCTGGCACCCACTCCGGATTCCGGCCCTGGCTGGGGACTTGGCCGCTTCCCTACCCACAGGGCCTGACTTTTACAGCTTTTCTC TTTTTTTAAAAAGTTGATAGGAGACTTGTACAGTTGACTGGCTTTCCTCTCGTTGGTAGTTGAGACGCTGTTGCAAATTCCACCCCTCCT TCCCTGGTCCAGATTGTAGCTCTTAGTCCTCCCTGCTCAGCTGGCCGGGTTGGAGGCCTCACCCTGCTTGGGGCCTGGCGTGGGGGGAGC TCTGGTGGGAAAATGTCCCCCACCTCTTTTCCTAGTTTTATGTTTCTTGGGAAAATATCACTTTGTATTCTCTGTCCAGGGCTTCAGATA TTTTGCACGAATTTTAAAACATGGCAATAAATGGCTCGTGGGCTCTGGCTCCCTGGGACCCCCTCCCCGCCCTTCTTTTGACCCCTTCCT GTCTGGCCCAAAGGAAGTAGCAGGCCCAGCTGGGGCCCCTCGGCTACCCCCCGTCTCCTGCCGGGCAGGTCCCAGGTTGGAGGCCCTAGG CGCGGTTCAGGTCAGGGCTATGGATGGGGCCCAGGGGCTTTGGTGGCCCCTCCCCAACTCCTTCCTCTTTGCTTGGGTTCCTTTTTCACG TTTAGTAACTGTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGAAAGCACAAACTTCTGTAACGGGTCGTGCTCATGTCTGTTAATAAAGAA >In-frame_MCC_ENST00000302475_chr5_112630026_-_DBN1_ENST00000292385_chr5_176887704_-_2306nt AGAAACCACTTACAACTCCAGACGATTCGAAGGGGAAACTTCGGCGTGAAGTGCAGCTCCGCTCCGGCTCCCTCTAGCTTTCTTTCCTTC TCTGGAATCCGAGGCGCGGATCTTCCTCGCCCCACCGCCCTAGTTTTTTCGGGAGCTCGCCGGTGCCCTCTAGGGTGTCGGCTCGTGCTG GGAAGTGCCCTCCATCCTGGTAATGGGGGGCGGCGAGGCACCGTAGGAGTGGCGAGGCGGCGCCCAGGGTGGCACTGCCCCGGAACGGGG CGCTGGGTGCGCGCGGGAGGGTCCCCGCGCGGGCTCCGCCGCTGCCGCAGCTGCGAGCGCGCCGCGCCACCGAGCCTCCTGCAGCAATGG CTCGTCCGTGAAACGCGAGCCACGGCTGCTCTTTTTAAGAGTGCCTGCATCCTCCGTTTGCGCTTCGCAACTGTCCTGGGTGAAAATGGC TGTCTAGACTAAAATGTGGCAGAAGGGACCAAGCAGTGGATATTGAGCCTGTGAAGTCCAACTCTTAAGCTCCGAGACCTGGGGGACTGA GAGCCCAGCTCTGAAAAGTGCATCATGAATTCCGGAGTTGCCATGAAATATGGAAACGACTCCTCGGCCGAGCTGAGTGAGGGTGACCAT CGGGATGAGGAGGAAGAGACCCACATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGACAACCCA AGGGAGTTCTTCAAGCAGCAGGAAAGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTACCCTCGCCCTTCAACCATCGACCAGGCAGC CACCTGGACAGCCACCGGAGGATGGCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGACTCCAGCACCGCCTCCACCCCTGTCGCTGAG CAGATAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCACCCCCACCAGCCCAAGAGACCCAGGAGCCC AGCCCCATCCTAGACAGTGAGGAGACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCCATGGAGGAGCCCCCTCAGGCACAGGCGCCT CCCCGGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCTGTCCTGGCTGCTCCCGTGGAGCCTGCCACA GCTGACGCCACGGAGATCCACGATGCAGCTGACACCATTGAAACTGACACTGCCACTGCTGACACCACTGTTGCCAACAACGTACCCCCC GCCGCCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAGGGTGAGCCCAGGGCCCCCACGCCACCCTCG GGTACTGAGGTCACCCTGGCAGAGGTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTGCTGCCAGCAGGCGAAGGCTGTGCCACCCTT CTCAACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAAGGGGAGTCCCTGGCTGCCCCCCAGACCCCA ACTCTGCCCTCAGCCCTTGAGGAGCTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTAACCAATGGCGAGACCACCCAGAAGGAGGGG ACCCAGGCCAGTGAGGGGTACTTCAGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTG TTCTACAACAAGCCTCCAGAGATCGACATCACATGCTGGGATGCAGACCCAGTTCCAGAAGAGGAGGAGGGCTTCGAGGGTGGTGATTAG CGGTGGCGCCAGCCCTAGGCTACCCTTGCCAAGGCCGCCCACCTGCATCAGCCTCTGGCCAGACGGCCCGCCGTGCCTGCATTCGCAGCA GCTCCGCCTGGCACCCACTCCGGATTCCGGCCCTGGCTGGGGACTTGGCCGCTTCCCTACCCACAGGGCCTGACTTTTACAGCTTTTCTC TTTTTTTAAAAAGTTGATAGGAGACTTGTACAGTTGACTGGCTTTCCTCTCGTTGGTAGTTGAGACGCTGTTGCAAATTCCACCCCTCCT TCCCTGGTCCAGATTGTAGCTCTTAGTCCTCCCTGCTCAGCTGGCCGGGTTGGAGGCCTCACCCTGCTTGGGGCCTGGCGTGGGGGGAGC TCTGGTGGGAAAATGTCCCCCACCTCTTTTCCTAGTTTTATGTTTCTTGGGAAAATATCACTTTGTATTCTCTGTCCAGGGCTTCAGATA >In-frame_MCC_ENST00000302475_chr5_112630026_-_DBN1_ENST00000393565_chr5_176887704_-_2435nt AGAAACCACTTACAACTCCAGACGATTCGAAGGGGAAACTTCGGCGTGAAGTGCAGCTCCGCTCCGGCTCCCTCTAGCTTTCTTTCCTTC TCTGGAATCCGAGGCGCGGATCTTCCTCGCCCCACCGCCCTAGTTTTTTCGGGAGCTCGCCGGTGCCCTCTAGGGTGTCGGCTCGTGCTG GGAAGTGCCCTCCATCCTGGTAATGGGGGGCGGCGAGGCACCGTAGGAGTGGCGAGGCGGCGCCCAGGGTGGCACTGCCCCGGAACGGGG CGCTGGGTGCGCGCGGGAGGGTCCCCGCGCGGGCTCCGCCGCTGCCGCAGCTGCGAGCGCGCCGCGCCACCGAGCCTCCTGCAGCAATGG CTCGTCCGTGAAACGCGAGCCACGGCTGCTCTTTTTAAGAGTGCCTGCATCCTCCGTTTGCGCTTCGCAACTGTCCTGGGTGAAAATGGC TGTCTAGACTAAAATGTGGCAGAAGGGACCAAGCAGTGGATATTGAGCCTGTGAAGTCCAACTCTTAAGCTCCGAGACCTGGGGGACTGA GAGCCCAGCTCTGAAAAGTGCATCATGAATTCCGGAGTTGCCATGAAATATGGAAACGACTCCTCGGCCGAGCTGAGTGAGGGTGACCAT CGGGATGAGGAGGAAGAGACCCACATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGACAACCCA AGGGAGTTCTTCAAGCAGCAGGAAAGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTACCCTCGCCCTTCAACCATCGACCAGGTCGT CCGTACTGCCCTTTCATAAAGGCATCGGACAGTGGGCCTTCCTCCTCCTCCTCTTCCTCCTCCTCCCCTCCACGGACTCCCTTTCCCTAT ATCACCTGCCACCGCACCCCAAACCTCTCTTCCTCCCTCCCATGCAGCCACCTGGACAGCCACCGGAGGATGGCGCCCACTCCCATCCCC ACGCGGAGCCCGTCTGACTCCAGCACCGCCTCCACCCCTGTCGCTGAGCAGATAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCT CCACCACTGCCACCGCCACCCCCACCAGCCCAAGAGACCCAGGAGCCCAGCCCCATCCTAGACAGTGAGGAGACCAGAGCAGCAGCCCCT CAGGCCTGGGCCGGCCCCATGGAGGAGCCCCCTCAGGCACAGGCGCCTCCCCGGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATG GAGTCTGCAGAGCAGGCTGTCCTGGCTGCTCCCGTGGAGCCTGCCACAGCTGACGCCACGGAGATCCACGATGCAGCTGACACCATTGAA ACTGACACTGCCACTGCTGACACCACTGTTGCCAACAACGTACCCCCCGCCGCCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAA GGGGCCTCCACACTCCAGGGTGAGCCCAGGGCCCCCACGCCACCCTCGGGTACTGAGGTCACCCTGGCAGAGGTGCCCCTGCTGGATGAG GTGGCTCCGGAGCCACTGCTGCCAGCAGGCGAAGGCTGTGCCACCCTTCTCAACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGT GACCCAGAGGAAGTGGAAGGGGAGTCCCTGGCTGCCCCCCAGACCCCAACTCTGCCCTCAGCCCTTGAGGAGCTGGAGCAAGAGCAGGAG CCGGAGCCCCACCTGCTAACCAATGGCGAGACCACCCAGAAGGAGGGGACCCAGGCCAGTGAGGGGTACTTCAGTCAATCACAGGAGGAG GAGTTTGCCCAATCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTGTTCTACAACAAGCCTCCAGAGATCGACATCACATGCTGGGAT GCAGACCCAGTTCCAGAAGAGGAGGAGGGCTTCGAGGGTGGTGATTAGCGGTGGCGCCAGCCCTAGGCTACCCTTGCCAAGGCCGCCCAC CTGCATCAGCCTCTGGCCAGACGGCCCGCCGTGCCTGCATTCGCAGCAGCTCCGCCTGGCACCCACTCCGGATTCCGGCCCTGGCTGGGG ACTTGGCCGCTTCCCTACCCACAGGGCCTGACTTTTACAGCTTTTCTCTTTTTTTAAAAAGTTGATAGGAGACTTGTACAGTTGACTGGC TTTCCTCTCGTTGGTAGTTGAGACGCTGTTGCAAATTCCACCCCTCCTTCCCTGGTCCAGATTGTAGCTCTTAGTCCTCCCTGCTCAGCT GGCCGGGTTGGAGGCCTCACCCTGCTTGGGGCCTGGCGTGGGGGGAGCTCTGGTGGGAAAATGTCCCCCACCTCTTTTCCTAGTTTTATG TTTCTTGGGAAAATATCACTTTGTATTCTCTGTCCAGGGCTTCAGATATTTTGCACGAATTTTAAAACATGGCAATAAATGGCTCGTGGG |
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FusionGenePPI for MCC_DBN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MCC | CLTC, STRN, STK24, STRN3, STRN4, EPRS, PPP2R1A, VCP, CSNK1D, MYH10, KRT18, TPM3, CSNK1E, EIF3A, PFAS, IARS, TARS, PFKP, SNRNP200, MTHFD1, PDCD10, DFFA, PSME3, MARS, CBR1, VDAC1, STRIP1, HPRT1, PSMD2, CCNA1, EZR, VHL, PAICS, VPS35, LTA4H, DYNC1I1, NEK2, APP, ERBB2IP, GTF2E2, CBX5, CCAR2, NFKBIB, MAGEE1, SYNC, CCDC83, DAB2IP, DFNB31, MTNR1A | DBN1 | DNMBP, SNUPN, BAK1, NUDT21, MEST, NUDT3, DUSP23, MAPK6, FHL1, BTRC, TPT1, MAP1LC3B, UBE2D3, TAB1, CDK2AP2, ARRB2, SP1, UBE2Q2, FBXO25, TERF1, TINF2, ACD, POT1, LRRK2, TPM1, CALU, ZC3H4, TPM4, RPLP0, TXNDC5, FLNA, MTHFD1, NUP133, JUP, ECE1, CDH2, SPTBN1, SPTAN1, HNRNPUL1, MARCKS, ESR1, MAGOH, BTK, FN1, PHB, PAN2, PIK3C3, FBXO6, LRCH3, TP53, MOV10, EZH2, SUZ12, BMI1, USP7, NTRK1, GRB2, RABGAP1L, PTEN, HIST1H3E, ACTG1, ACTN4, ACTN1, AP2A1, AP2A2, AP2B1, ANXA2, ATP6V1A, ATP6AP1, DST, CALM1, CAMK2G, CAPZA2, CAPZB, CAV1, CD44, CD59, CDC42, CFL1, CFL2, AP2M1, CLTA, CLTB, CLTC, CPM, DAB2, CDK2, GAK, MYH9, MYO1C, PPP1CB, IQGAP1, ACTR2, SYNPO, MAPRE1, LIMA1, ANLN, MYO19, MYO18A, DSG2, CTTN, STOM, EPS15, FLII, FLNB, FLOT2, GART, GNAS, GNB2, GSN, HSP90AB1, IARS, ITPKA, LGALS1, ABLIM1, LMO7, MYO1B, MYO1E, MYO5A, MYO5B, MYO6, PPP1R12A, NAP1L1, NAP1L4, NF2, PALM, PIK3C2A, PPP1CA, PPP1CC, TWF1, RAB1A, SDC4, SIPA1, FSCN1, SSFA2, SVIL, TMOD1, CORO2A, YES1, LUZP1, CLTCL1, PICALM, SORBS2, NUMB, GPRC5A, LRRFIP1, LRRFIP2, XPR1, ABCG2, HOMER3, HOMER1, CLINT1, ARHGAP11A, SEC16A, WDR1, ARPC5, ARPC4, ARPC3, ARPC1B, ACTR3, ARPC2, FLOT1, BASP1, DCTN2, ARPC1A, ERLIN1, AKAP2, RRAS2, CEP162, TAB2, MPRIP, COBL, SPECC1L, CORO1C, ZDHHC5, PLEKHG3, RAI14, TIMM13, UHRF1, PACSIN3, TMOD3, CARD10, GTSE1, C14orf166, PALMD, BMP2K, PPP1R9A, ERBB2IP, MYO5C, CGN, ARHGAP21, AFAP1, INF2, CYBRD1, ARPC5L, KCTD10, DCTN5, PPP1R9B, STON2, DIXDC1, SSH2, NEXN, SPECC1, FCHO2, MISP, CHMP4B, PPP1R18, PTRF, TPRN, MCM5, CDH1, HOMER2, ACTA2, ACTB, ACTBL2, TMOD2, COX15, DLST, DNM1L, PARK7, PDHA1, RNF168, TES |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MCC_DBN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MCC_DBN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MCC | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | MCC | C0032580 | Adenomatous Polyposis Coli | 1 | CTD_human |
Hgene | MCC | C0034885 | Rectal Neoplasms | 1 | CTD_human |
Hgene | MCC | C3714756 | Intellectual Disability | 1 | CTD_human |
Tgene | DBN1 | C0036341 | Schizophrenia | 3 | PSYGENET |
Tgene | DBN1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |