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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2126

FusionGeneSummary for APBB2_CCNB1

check button Fusion gene summary
Fusion gene informationFusion gene name: APBB2_CCNB1
Fusion gene ID: 2126
HgeneTgene
Gene symbol

APBB2

CCNB1

Gene ID

323

891

Gene nameamyloid beta precursor protein binding family B member 2cyclin B1
SynonymsFE65L|FE65L1CCNB
Cytomap

4p14-p13

5q13.2

Type of geneprotein-codingprotein-coding
Descriptionamyloid-beta A4 precursor protein-binding family B member 2Fe65-like 1protein Fe65-like 1G2/mitotic-specific cyclin-B1
Modification date2018052320180523
UniProtAcc

Q92870

P14635

Ensembl transtripts involved in fusion geneENST00000295974, ENST00000513140, 
ENST00000508593, ENST00000506352, 
ENST00000511572, ENST00000543538, 
ENST00000502841, ENST00000504305, 
ENST00000256442, 
Fusion gene scores* DoF score8 X 8 X 3=1923 X 3 X 3=27
# samples 83
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: APBB2 [Title/Abstract] AND CCNB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCNB1

GO:0010971

positive regulation of G2/M transition of mitotic cell cycle

24746669

TgeneCCNB1

GO:1905448

positive regulation of mitochondrial ATP synthesis coupled electron transport

24746669


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC018868APBB2chr4

40816464

+CCNB1chr5

68462964

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000295974ENST00000256442APBB2chr4

40816464

+CCNB1chr5

68462964

+
intron-5UTRENST00000513140ENST00000256442APBB2chr4

40816464

+CCNB1chr5

68462964

+
intron-5UTRENST00000508593ENST00000256442APBB2chr4

40816464

+CCNB1chr5

68462964

+
intron-5UTRENST00000506352ENST00000256442APBB2chr4

40816464

+CCNB1chr5

68462964

+
intron-5UTRENST00000511572ENST00000256442APBB2chr4

40816464

+CCNB1chr5

68462964

+
intron-5UTRENST00000543538ENST00000256442APBB2chr4

40816464

+CCNB1chr5

68462964

+
intron-5UTRENST00000502841ENST00000256442APBB2chr4

40816464

+CCNB1chr5

68462964

+
intron-5UTRENST00000504305ENST00000256442APBB2chr4

40816464

+CCNB1chr5

68462964

+

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FusionProtFeatures for APBB2_CCNB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APBB2

Q92870

CCNB1

P14635

May modulate the internalization of amyloid-betaprecursor protein. Essential for the control of the cell cycle at the G2/M(mitosis) transition. {ECO:0000269|PubMed:17495531,ECO:0000269|PubMed:17495533}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for APBB2_CCNB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for APBB2_CCNB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for APBB2_CCNB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for APBB2_CCNB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPBB2C0043094Weight Gain1CTD_human
TgeneCCNB1C0032460Polycystic Ovary Syndrome1CTD_human