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Fusion gene ID: 21258 |
FusionGeneSummary for MCAT_GTSE1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MCAT_GTSE1 | Fusion gene ID: 21258 | Hgene | Tgene | Gene symbol | MCAT | GTSE1 | Gene ID | 27349 | 51512 |
| Gene name | malonyl-CoA-acyl carrier protein transacylase | G2 and S-phase expressed 1 | |
| Synonyms | FASN2C|MCT|MCT1|MT|NET62|fabD | B99 | |
| Cytomap | 22q13.2 | 22q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | malonyl-CoA-acyl carrier protein transacylase, mitochondrial[Acyl-carrier-protein] malonyltransferase[acyl-carrier-protein] S-malonyltransferasemalonyl CoA:ACP acyltransferase (mitochondrial)mitochondrial malonyl CoA:ACP acyltransferasemitochondrial | G2 and S phase-expressed protein 1G-2 and S-phase expressed 1protein B99 homolog | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q8IVS2 | Q9NYZ3 | |
| Ensembl transtripts involved in fusion gene | ENST00000290429, ENST00000327555, ENST00000464244, | ENST00000454366, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 6 X 7=294 |
| # samples | 1 | 9 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(9/294*10)=-1.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MCAT [Title/Abstract] AND GTSE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MCAT | GO:0006633 | fatty acid biosynthetic process | 12882974 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-ER-A197-06A | MCAT | chr22 | 43533087 | - | GTSE1 | chr22 | 46708038 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000290429 | ENST00000454366 | MCAT | chr22 | 43533087 | - | GTSE1 | chr22 | 46708038 | + |
| intron-3CDS | ENST00000327555 | ENST00000454366 | MCAT | chr22 | 43533087 | - | GTSE1 | chr22 | 46708038 | + |
| intron-3CDS | ENST00000464244 | ENST00000454366 | MCAT | chr22 | 43533087 | - | GTSE1 | chr22 | 46708038 | + |
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FusionProtFeatures for MCAT_GTSE1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MCAT | GTSE1 |
| Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of themitochondrial ACP protein (NDUFAB1). This suggests the existenceof the biosynthesis of fatty acids in mitochondria.{ECO:0000269|PubMed:12882974}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | GTSE1 | chr22:43533087 | chr22:46708038 | ENST00000454366 | + | 3 | 12 | 22_27 | 254 | 740 | Compositional bias | Note=Poly-Ser |
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FusionGeneSequence for MCAT_GTSE1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MCAT_ENST00000290429_chr22_43533087_-_GTSE1_ENST00000454366_chr22_46708038_+_729aa MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVREL YAAARRVLGYDLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGLYAVKIRAE AMQEASEAVPSGMLSVLGQPQSKFNFACLEAREHCKSLGIENPVCEVSNYLFPDCRVISGHQEPKKEIPASPSRTKIPAEKESHRDVLPD KPAPGAVNVPAAGSHLGQGKRAIPVPNKLGLKKTLLKAPGSTSNLARKSSSGPVWSGASSACTSPAVGKAKSSEFASIPANSSRPLSNIS KSGRMGPAMLRPALPAGPVGASSWQAKRVDVSELAAEQLTAPPSASPTQPQTPEGGGQWLNSSCAWSESSQLNKTRSIRRRDSCLNSKTK VMPTPTNQFKIPKFSIGDSPDSSTPKLSRAQRPQSCTSVGRVTVHSTPVRRSSGPAPQSLLSAWRVSALPTPASRRCSGLPPMTPKTMPR AVGSPLCVPARRRSSEPRKNSAMRTEPTRESNRKTDSRLVDVSPDRGSPPSRVPQALNFSPEESDSTFSKSTATEVAREEAKPGGDAAPS EALLVDIKLEPLAVTPDAASQPLIDLPLIDFCDTPEAHVAVGSESRPLIDLMTNTPDMNKNVAKPSPVVGQLIDLSSPLIQLSPEADKEN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MCAT_ENST00000290429_chr22_43533087_-_GTSE1_ENST00000454366_chr22_46708038_+_2187nt ATGAGCGTCCGGGTCGCACGGGTAGCGTGGGTCAGGGGCTTGGGCGCCAGCTACCGCCGCGGCGCCTCGAGCTTCCCGGTGCCTCCGCCG GGCGCCCAGGGTGTAGCGGAGCTGCTGCGAGATGCGACCGGGGCGGAGGAGGAGGCGCCCTGGGCGGCGACGGAGCGGCGAATGCCGGGC CAGTGCTCCGTGCTGCTCTTCCCGGGCCAGGGCAGCCAGGTGGTGGGCATGGGCCGCGGTCTGCTCAACTACCCGCGCGTCCGCGAACTC TACGCCGCCGCCCGCCGCGTGCTGGGCTACGACCTGCTGGAACTGAGCCTGCACGGGCCGCAGGAGACCCTGGACCGCACCGTGCACTGT CAGCCCGCGATCTTCGTGGCATCGCTGGCCGCTGTCGAGAAACTACATCACCTGCAGCCCTCGGTGATTGAGAACTGTGTTGCTGCTGCT GGATTCAGTGTGGGAGAGTTTGCAGCCCTAGTGTTTGCCGGAGCCATGGAATTTGCTGAAGGTTTGTATGCAGTGAAAATCCGAGCTGAG GCCATGCAGGAAGCTTCAGAAGCTGTCCCCAGTGGGATGCTGTCTGTCCTCGGCCAGCCTCAGTCCAAGTTCAACTTCGCCTGTTTGGAA GCCCGGGAACACTGCAAGTCTTTAGGCATAGAGAACCCCGTATGTGAAGTGTCCAACTACCTCTTTCCAGATTGCAGGGTGATTTCAGGA CACCAAGAGCCCAAGAAAGAGATTCCAGCTAGTCCTTCCAGGACAAAAATCCCAGCTGAGAAGGAATCCCACCGGGATGTTCTCCCTGAC AAACCTGCCCCGGGTGCTGTCAATGTGCCGGCCGCCGGAAGCCACTTGGGCCAGGGCAAGCGGGCGATCCCTGTTCCAAACAAGTTGGGG CTGAAGAAGACCCTGTTAAAAGCACCCGGCTCTACCAGCAATCTCGCAAGGAAGTCCTCCTCGGGGCCTGTTTGGAGCGGGGCATCCAGT GCGTGCACATCCCCAGCAGTGGGCAAAGCTAAATCAAGTGAATTTGCAAGTATTCCTGCAAATAGCTCCCGGCCTCTGTCAAACATCAGC AAGTCAGGCAGAATGGGACCCGCCATGCTGCGGCCAGCTCTGCCTGCAGGCCCTGTGGGGGCATCCTCCTGGCAGGCCAAGCGGGTCGAT GTTTCTGAGCTGGCAGCGGAGCAGCTCACGGCACCCCCCTCAGCATCCCCCACCCAACCCCAGACTCCGGAAGGTGGCGGCCAGTGGCTG AACTCCAGTTGCGCTTGGTCAGAATCTTCTCAATTGAATAAGACTAGAAGTATCAGACGGCGAGATTCCTGTCTAAATTCCAAGACAAAG GTTATGCCTACTCCTACAAATCAATTTAAAATTCCTAAGTTTTCTATTGGTGACTCCCCGGACAGCTCAACACCAAAGCTTTCGCGGGCA CAGCGGCCGCAGTCGTGCACGTCAGTTGGCAGGGTCACTGTCCACAGCACCCCGGTTAGACGCTCATCTGGGCCAGCACCACAAAGCCTG CTGAGCGCATGGCGTGTGTCAGCCTTGCCCACACCCGCCAGCCGGCGCTGCTCTGGCCTTCCACCGATGACCCCCAAAACGATGCCCAGG GCCGTGGGCTCTCCCCTGTGTGTGCCAGCTCGGAGACGTTCCTCTGAGCCCCGCAAGAACTCTGCAATGAGAACTGAACCAACAAGGGAG AGCAACAGAAAGACAGATTCCAGGCTGGTGGATGTGTCCCCTGACAGGGGTTCTCCTCCTTCCCGTGTGCCTCAGGCACTTAACTTTTCT CCAGAGGAAAGCGATTCTACTTTCTCCAAAAGTACTGCCACAGAAGTAGCTCGGGAGGAAGCCAAGCCGGGTGGAGATGCAGCCCCTAGT GAGGCTCTTCTTGTAGATATCAAACTGGAACCACTCGCGGTCACTCCAGATGCTGCAAGCCAGCCCCTCATTGACCTTCCTCTCATCGAC TTCTGCGATACCCCAGAAGCACACGTGGCTGTAGGATCTGAAAGCAGGCCTCTGATCGACCTCATGACAAACACTCCAGACATGAATAAA AATGTGGCCAAACCTTCACCGGTGGTGGGACAGCTCATAGACCTGAGCTCCCCTCTGATCCAGCTGAGCCCTGAGGCTGACAAGGAGAAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MCAT_ENST00000290429_chr22_43533087_-_GTSE1_ENST00000454366_chr22_46708038_+_2913nt TCGGGCCTCGGTCGCCACGGTAACGCGCGCGGGCAGGTGTCCGACCATGAGCGTCCGGGTCGCACGGGTAGCGTGGGTCAGGGGCTTGGG CGCCAGCTACCGCCGCGGCGCCTCGAGCTTCCCGGTGCCTCCGCCGGGCGCCCAGGGTGTAGCGGAGCTGCTGCGAGATGCGACCGGGGC GGAGGAGGAGGCGCCCTGGGCGGCGACGGAGCGGCGAATGCCGGGCCAGTGCTCCGTGCTGCTCTTCCCGGGCCAGGGCAGCCAGGTGGT GGGCATGGGCCGCGGTCTGCTCAACTACCCGCGCGTCCGCGAACTCTACGCCGCCGCCCGCCGCGTGCTGGGCTACGACCTGCTGGAACT GAGCCTGCACGGGCCGCAGGAGACCCTGGACCGCACCGTGCACTGTCAGCCCGCGATCTTCGTGGCATCGCTGGCCGCTGTCGAGAAACT ACATCACCTGCAGCCCTCGGTGATTGAGAACTGTGTTGCTGCTGCTGGATTCAGTGTGGGAGAGTTTGCAGCCCTAGTGTTTGCCGGAGC CATGGAATTTGCTGAAGGTTTGTATGCAGTGAAAATCCGAGCTGAGGCCATGCAGGAAGCTTCAGAAGCTGTCCCCAGTGGGATGCTGTC TGTCCTCGGCCAGCCTCAGTCCAAGTTCAACTTCGCCTGTTTGGAAGCCCGGGAACACTGCAAGTCTTTAGGCATAGAGAACCCCGTATG TGAAGTGTCCAACTACCTCTTTCCAGATTGCAGGGTGATTTCAGGACACCAAGAGCCCAAGAAAGAGATTCCAGCTAGTCCTTCCAGGAC AAAAATCCCAGCTGAGAAGGAATCCCACCGGGATGTTCTCCCTGACAAACCTGCCCCGGGTGCTGTCAATGTGCCGGCCGCCGGAAGCCA CTTGGGCCAGGGCAAGCGGGCGATCCCTGTTCCAAACAAGTTGGGGCTGAAGAAGACCCTGTTAAAAGCACCCGGCTCTACCAGCAATCT CGCAAGGAAGTCCTCCTCGGGGCCTGTTTGGAGCGGGGCATCCAGTGCGTGCACATCCCCAGCAGTGGGCAAAGCTAAATCAAGTGAATT TGCAAGTATTCCTGCAAATAGCTCCCGGCCTCTGTCAAACATCAGCAAGTCAGGCAGAATGGGACCCGCCATGCTGCGGCCAGCTCTGCC TGCAGGCCCTGTGGGGGCATCCTCCTGGCAGGCCAAGCGGGTCGATGTTTCTGAGCTGGCAGCGGAGCAGCTCACGGCACCCCCCTCAGC ATCCCCCACCCAACCCCAGACTCCGGAAGGTGGCGGCCAGTGGCTGAACTCCAGTTGCGCTTGGTCAGAATCTTCTCAATTGAATAAGAC TAGAAGTATCAGACGGCGAGATTCCTGTCTAAATTCCAAGACAAAGGTTATGCCTACTCCTACAAATCAATTTAAAATTCCTAAGTTTTC TATTGGTGACTCCCCGGACAGCTCAACACCAAAGCTTTCGCGGGCACAGCGGCCGCAGTCGTGCACGTCAGTTGGCAGGGTCACTGTCCA CAGCACCCCGGTTAGACGCTCATCTGGGCCAGCACCACAAAGCCTGCTGAGCGCATGGCGTGTGTCAGCCTTGCCCACACCCGCCAGCCG GCGCTGCTCTGGCCTTCCACCGATGACCCCCAAAACGATGCCCAGGGCCGTGGGCTCTCCCCTGTGTGTGCCAGCTCGGAGACGTTCCTC TGAGCCCCGCAAGAACTCTGCAATGAGAACTGAACCAACAAGGGAGAGCAACAGAAAGACAGATTCCAGGCTGGTGGATGTGTCCCCTGA CAGGGGTTCTCCTCCTTCCCGTGTGCCTCAGGCACTTAACTTTTCTCCAGAGGAAAGCGATTCTACTTTCTCCAAAAGTACTGCCACAGA AGTAGCTCGGGAGGAAGCCAAGCCGGGTGGAGATGCAGCCCCTAGTGAGGCTCTTCTTGTAGATATCAAACTGGAACCACTCGCGGTCAC TCCAGATGCTGCAAGCCAGCCCCTCATTGACCTTCCTCTCATCGACTTCTGCGATACCCCAGAAGCACACGTGGCTGTAGGATCTGAAAG CAGGCCTCTGATCGACCTCATGACAAACACTCCAGACATGAATAAAAATGTGGCCAAACCTTCACCGGTGGTGGGACAGCTCATAGACCT GAGCTCCCCTCTGATCCAGCTGAGCCCTGAGGCTGACAAGGAGAACGTGGATTCCCCACTCCTCAAGTTCTAAGCCGAACCAAATCCTTT GCCTTGAAAGAACAGCCCTAAAGTGGTTTTCAACCCTCAGAAACAAGCTTTAGGCTGGTCGCAGTGGCTTACACTTGTAACCCTAGAACT TGGGAGGCTGAGGTGGGCGGATTACTTGAGCCCAGGAGTTCGGGACCAGCCTGGGAAATATAGTGAAACTCCTGTCCCTACAAAAAATAC AAAAATTAGCCGGGTGTGGTAGTGCATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGTGGGAGGATGGCCTGAGCTCAAGGAGATGCA GGCTGCAGTGGGCTGTGATTGTGCCACTGCACTCCAGCCTGGGCACCAATGTGAGAACCTGTCTTGGAAAAAAAAAAAAAGAAACATGTT TTAGTAGAAGTTTTATTTGAAAAAGAAAAATAAGCATAAATATATTCCCAGTGCTGGAGAGGGTGGGCTGAGGGACTGGGGCCAGCACGG ACCACCCAAGGCCTCTGCTTCCCGCCGCCACCCTCCTCGCTGCCATTCTCTGGGCTGGAATGTGAAGCCTCAGTCACTCTAAATGAAGAA TTTTCTTTTGAATGTTTTGTATGTAAAATAGCAAGTGGCTATTTTTAAAGTTAAGTTTGTATAAATAGTTAGATATTCTAGATTTACATT |
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FusionGenePPI for MCAT_GTSE1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MCAT | ICT1, MRPS16, ITGAV, SPCS2, PTPN1, RAVER1, SPTAN1, SHMT1, EWSR1, TAP1, AGMAT, TMEM43, HNRNPDL, MRPL4, HNRNPA1, MRPL39, POLR2M, RBMX, ERAL1, RPUSD2, MYC, RXRB, REEP5, TFEB, SLC33A1, MMGT1, USF1, ALAS1, TAF5, RBM3, ZNF324B, DDX28, MRPS34, METTL17, MRPS15, ZYG11B, MRPS11, MALSU1 | GTSE1 | USP11, SH3KBP1, BARD1, HNRNPD, CCDC8, KPTN, KIAA0753, CEP170, SPICE1, CNTRL, NINL, DCTN1, LCA5, POC1A, XPO1, AP2A1, AP2A2, AP1B1, AP2B1, AP1G1, CALU, CDC42, AP2M1, AP1S1, CLTA, CLTB, CLTC, CSNK1A1, CSNK1E, DAB2, EPS15, GAK, GNAI3, GOLGA2, HIP1, IGF2R, NBR1, MYO6, NDUFA9, OCRL, PER1, PIK3C2A, PKP2, RAB1A, RCN1, SEC13, RAB7A, CLTCL1, PICALM, PKP4, USO1, NUMB, TNK1, SYNJ1, AP1M1, HERC2, HIP1R, NUMBL, SEC24C, KIAA0430, CLINT1, SEC16A, MVP, TNK2, DCAF7, SEC24B, RBM14, SEC23A, VTI1B, STAMBP, SEC24A, SDCCAG3, RALBP1, PKP3, SYNRG, AAK1, BTBD3, EPN2, TNRC6B, N4BP3, DNMBP, EDC4, NECAP1, PHGDH, TNRC6A, PPP2R3B, EPN1, SNX9, LIMA1, CAPZA2, DBN1, MYH9, IQGAP1, THOC1, ANLN, MYO19, ARX, BOD1L1, DNAJB11, BMP2K, SCYL2, ERBB2IP, KIDINS220, STAMBPL1, DENND1A, ZNF106, SMAP2, CRTC3, WNK1, ACAD11, LZTS2, MYPN, REPS1, STON2, FCHO2, FAM109B, CRTC2, FAM83B, FAM83H, FAM21A, PRKACA, FOXJ2, GAST, CAV3, XAGE3, PPP2R3A, DDB2, IL17RA, NCAPH2, P4HA2, KBTBD7, CARM1, C6orf141, CDC16 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MCAT_GTSE1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MCAT_GTSE1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MCAT | C0036341 | Schizophrenia | 1 | PSYGENET |
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