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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2125

FusionGeneSummary for APBB2_APBB2

check button Fusion gene summary
Fusion gene informationFusion gene name: APBB2_APBB2
Fusion gene ID: 2125
HgeneTgene
Gene symbol

APBB2

APBB2

Gene ID

323

323

Gene nameamyloid beta precursor protein binding family B member 2amyloid beta precursor protein binding family B member 2
SynonymsFE65L|FE65L1FE65L|FE65L1
Cytomap

4p14-p13

4p14-p13

Type of geneprotein-codingprotein-coding
Descriptionamyloid-beta A4 precursor protein-binding family B member 2Fe65-like 1protein Fe65-like 1amyloid-beta A4 precursor protein-binding family B member 2Fe65-like 1protein Fe65-like 1
Modification date2018052320180523
UniProtAcc

Q92870

Q92870

Ensembl transtripts involved in fusion geneENST00000295974, ENST00000513140, 
ENST00000508593, ENST00000506352, 
ENST00000511572, ENST00000543538, 
ENST00000502841, ENST00000504305, 
ENST00000295974, ENST00000513140, 
ENST00000508593, ENST00000506352, 
ENST00000511572, ENST00000543538, 
ENST00000502841, ENST00000504305, 
Fusion gene scores* DoF score8 X 8 X 3=1925 X 5 X 6=150
# samples 88
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APBB2 [Title/Abstract] AND APBB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN266502APBB2chr4

40814963

+APBB2chr4

40814934

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000295974ENST00000295974APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000295974ENST00000513140APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000295974ENST00000508593APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000295974ENST00000506352APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000295974ENST00000511572APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-3UTRENST00000295974ENST00000543538APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000295974ENST00000502841APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000295974ENST00000504305APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-3UTRENST00000513140ENST00000295974APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000513140ENST00000513140APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000513140ENST00000508593APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000513140ENST00000506352APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000513140ENST00000511572APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-3UTRENST00000513140ENST00000543538APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000513140ENST00000502841APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000513140ENST00000504305APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-3UTRENST00000508593ENST00000295974APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000508593ENST00000513140APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000508593ENST00000508593APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000508593ENST00000506352APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000508593ENST00000511572APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-3UTRENST00000508593ENST00000543538APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000508593ENST00000502841APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000508593ENST00000504305APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-3UTRENST00000506352ENST00000295974APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000506352ENST00000513140APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000506352ENST00000508593APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000506352ENST00000506352APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000506352ENST00000511572APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-3UTRENST00000506352ENST00000543538APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000506352ENST00000502841APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000506352ENST00000504305APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-3UTRENST00000511572ENST00000295974APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000511572ENST00000513140APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000511572ENST00000508593APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000511572ENST00000506352APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000511572ENST00000511572APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-3UTRENST00000511572ENST00000543538APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000511572ENST00000502841APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000511572ENST00000504305APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-3UTRENST00000543538ENST00000295974APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000543538ENST00000513140APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000543538ENST00000508593APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000543538ENST00000506352APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000543538ENST00000511572APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-3UTRENST00000543538ENST00000543538APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000543538ENST00000502841APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000543538ENST00000504305APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-3UTRENST00000502841ENST00000295974APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000502841ENST00000513140APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000502841ENST00000508593APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000502841ENST00000506352APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000502841ENST00000511572APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-3UTRENST00000502841ENST00000543538APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000502841ENST00000502841APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000502841ENST00000504305APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-3UTRENST00000504305ENST00000295974APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000504305ENST00000513140APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000504305ENST00000508593APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000504305ENST00000506352APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000504305ENST00000511572APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-3UTRENST00000504305ENST00000543538APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000504305ENST00000502841APBB2chr4

40814963

+APBB2chr4

40814934

-
intron-intronENST00000504305ENST00000504305APBB2chr4

40814963

+APBB2chr4

40814934

-

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FusionProtFeatures for APBB2_APBB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APBB2

Q92870

APBB2

Q92870

May modulate the internalization of amyloid-betaprecursor protein. May modulate the internalization of amyloid-betaprecursor protein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for APBB2_APBB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for APBB2_APBB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for APBB2_APBB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for APBB2_APBB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPBB2C0043094Weight Gain1CTD_human
TgeneAPBB2C0043094Weight Gain1CTD_human