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Fusion gene ID: 21238 |
FusionGeneSummary for MBP_SWAP70 |
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Fusion gene information | Fusion gene name: MBP_SWAP70 | Fusion gene ID: 21238 | Hgene | Tgene | Gene symbol | MBP | SWAP70 | Gene ID | 5553 | 23075 |
Gene name | proteoglycan 2, pro eosinophil major basic protein | switching B cell complex subunit SWAP70 | |
Synonyms | BMPG|MBP|MBP1|proMBP | HSPC321|SWAP-70 | |
Cytomap | 11q12.1 | 11p15.4 | |
Type of gene | protein-coding | protein-coding | |
Description | bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | switch-associated protein 70SWAP switching B-cell complex 70kDa subunitSWAP switching B-cell complex subunit 70 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P02686 | Q9UH65 | |
Ensembl transtripts involved in fusion gene | ENST00000382582, ENST00000355994, ENST00000397875, ENST00000397866, ENST00000397865, ENST00000527041, ENST00000359645, ENST00000528160, ENST00000397869, ENST00000354542, ENST00000526111, ENST00000580402, ENST00000579129, ENST00000578193, ENST00000397863, ENST00000397860, ENST00000487778, | ENST00000447399, ENST00000318950, | |
Fusion gene scores | * DoF score | 13 X 13 X 3=507 | 1 X 1 X 1=1 |
# samples | 15 | 1 | |
** MAII score | log2(15/507*10)=-1.75702324650746 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: MBP [Title/Abstract] AND SWAP70 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CA436904 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000382582 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000382582 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000355994 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000355994 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000397875 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000397875 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000397866 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000397866 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000397865 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000397865 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000527041 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000527041 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000359645 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000359645 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000528160 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000528160 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000397869 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000397869 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000354542 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000354542 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000526111 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000526111 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000580402 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000580402 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000579129 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000579129 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000578193 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000578193 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000397863 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000397863 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000397860 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000397860 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000487778 | ENST00000447399 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
intron-3CDS | ENST00000487778 | ENST00000318950 | MBP | chr18 | 74725036 | + | SWAP70 | chr11 | 9769533 | - |
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FusionProtFeatures for MBP_SWAP70 |
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Hgene | Tgene |
MBP | SWAP70 |
Phosphatidylinositol 3,4,5-trisphosphate-dependentguanine nucleotide exchange factor (GEF) which, independently ofRAS, transduces signals from tyrosine kinase receptors to RAC. Italso mediates signaling of membrane ruffling. Regulates the actincytoskeleton as an effector or adapter protein in response toagonist stimulated phosphatidylinositol (3,4)-bisphosphateproduction and cell protrusion (By similarity). {ECO:0000250,ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MBP_SWAP70 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MBP_SWAP70 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MBP_SWAP70 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MBP_SWAP70 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MBP | C0036341 | Schizophrenia | 4 | PSYGENET |
Hgene | MBP | C0014072 | Experimental Autoimmune Encephalomyelitis | 3 | CTD_human |
Hgene | MBP | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | MBP | C0011303 | Demyelinating Diseases | 1 | CTD_human |
Hgene | MBP | C0027873 | Neuromyelitis Optica | 1 | CTD_human |