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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21234

FusionGeneSummary for MBP_N4BP2L2

check button Fusion gene summary
Fusion gene informationFusion gene name: MBP_N4BP2L2
Fusion gene ID: 21234
HgeneTgene
Gene symbol

MBP

N4BP2L2

Gene ID

5553

10443

Gene nameproteoglycan 2, pro eosinophil major basic proteinNEDD4 binding protein 2 like 2
SynonymsBMPG|MBP|MBP1|proMBP92M18.3|CG005|CG016|PFAAP5
Cytomap

11q12.1

13q13.1

Type of geneprotein-codingprotein-coding
Descriptionbone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)NEDD4-binding protein 2-like 2phosphonoformate immuno-associated protein 5protein from BRCA2 region
Modification date2018051920180519
UniProtAcc

P02686

Q92802

Ensembl transtripts involved in fusion geneENST00000382582, ENST00000355994, 
ENST00000397875, ENST00000397866, 
ENST00000397865, ENST00000527041, 
ENST00000359645, ENST00000528160, 
ENST00000397869, ENST00000354542, 
ENST00000526111, ENST00000580402, 
ENST00000579129, ENST00000578193, 
ENST00000397863, ENST00000397860, 
ENST00000487778, 
ENST00000380121, 
ENST00000504114, ENST00000357505, 
ENST00000399396, ENST00000446957, 
ENST00000267068, 
Fusion gene scores* DoF score13 X 13 X 3=5075 X 6 X 1=30
# samples 1518
** MAII scorelog2(15/507*10)=-1.75702324650746
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/30*10)=2.58496250072116
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MBP [Title/Abstract] AND N4BP2L2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB312529MBPchr18

74691001

+N4BP2L2chr13

33006968

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000382582ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000382582ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000382582ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000382582ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000382582ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000382582ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000355994ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000355994ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000355994ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000355994ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000355994ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000355994ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000397875ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397875ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397875ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397875ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000397875ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000397875ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000397866ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397866ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397866ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397866ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000397866ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000397866ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000397865ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397865ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397865ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397865ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000397865ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000397865ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000527041ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000527041ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000527041ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000527041ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000527041ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000527041ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000359645ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000359645ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000359645ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000359645ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000359645ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000359645ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000528160ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000528160ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000528160ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000528160ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000528160ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000528160ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000397869ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397869ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397869ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397869ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000397869ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000397869ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000354542ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000354542ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000354542ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000354542ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000354542ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000354542ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000526111ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000526111ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000526111ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000526111ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000526111ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000526111ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000580402ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000580402ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000580402ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000580402ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000580402ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000580402ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000579129ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000579129ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000579129ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000579129ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000579129ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000579129ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000578193ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000578193ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000578193ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000578193ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000578193ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000578193ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000397863ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397863ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397863ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397863ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000397863ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000397863ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000397860ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397860ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397860ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000397860ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000397860ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000397860ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-5UTRENST00000487778ENST00000380121MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000487778ENST00000504114MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000487778ENST00000357505MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-3UTRENST00000487778ENST00000399396MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000487778ENST00000446957MBPchr18

74691001

+N4BP2L2chr13

33006968

+
intron-intronENST00000487778ENST00000267068MBPchr18

74691001

+N4BP2L2chr13

33006968

+

Top

FusionProtFeatures for MBP_N4BP2L2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MBP

P02686

N4BP2L2

Q92802


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MBP_N4BP2L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MBP_N4BP2L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MBPTRPM7, PRMT5, STK39, HLA-DRA, PLP1, TSSK6, IRAK4, PRKCA, PRKCI, PRKCZ, PPP2R5C, LIMK1, LIMK2, TBK1, IKBKE, STK3, APTX, ATN1, ATXN1, MAPK14, LRRK2, PRKDC, MAPK12, MAPK11, MAPK13, MAPK3, MAPK1, CDK1, CDK5, MAP3K5, TLK1, RPS6KA6, DDX58, MELK, CDK7, CDK8, CDK9, HIPK2, SQSTM1, PKN1, ULK1, PRKCB, MAP3K3, CTDSP1, ABL1, MUS81, RPS6KA5, MYH6, MAP3K1, MAPK8, CTDSPL, NLN, IDE, PTPRA, PRKCDN4BP2L2PRPF4, LGR4, HOXA1, LMO2, PPIH, NAA38, PRMT6, CGRRF1, TMPRSS5, WNT4, PRG2, PPIA, KIAA1683, SIRT6, HNRNPLL, PIGT, LYZL1, RFXANK, LGALS3BP, LYPD4, OLFM2, DNAJC10, NCAPH2, WNT16, PROZ, F11, IRAK2, NXF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MBP_N4BP2L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MBP_N4BP2L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMBPC0036341Schizophrenia4PSYGENET
HgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
HgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneMBPC0011303Demyelinating Diseases1CTD_human
HgeneMBPC0027873Neuromyelitis Optica1CTD_human
TgeneN4BP2L2C0037274Dermatologic disorders1CTD_human
TgeneN4BP2L2C0311375Arsenic Poisoning1CTD_human