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Fusion gene ID: 21230 |
FusionGeneSummary for MBP_FEZ1 |
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Fusion gene information | Fusion gene name: MBP_FEZ1 | Fusion gene ID: 21230 | Hgene | Tgene | Gene symbol | MBP | FEZ1 | Gene ID | 5553 | 9638 |
Gene name | proteoglycan 2, pro eosinophil major basic protein | fasciculation and elongation protein zeta 1 | |
Synonyms | BMPG|MBP|MBP1|proMBP | UNC-76 | |
Cytomap | 11q12.1 | 11q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | fasciculation and elongation protein zeta-1zygin Izygin-1 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P02686 | Q99689 | |
Ensembl transtripts involved in fusion gene | ENST00000382582, ENST00000355994, ENST00000397875, ENST00000397866, ENST00000397865, ENST00000527041, ENST00000359645, ENST00000528160, ENST00000397869, ENST00000354542, ENST00000526111, ENST00000580402, ENST00000579129, ENST00000578193, ENST00000397863, ENST00000397860, ENST00000487778, | ENST00000527350, ENST00000278919, ENST00000366139, ENST00000524435, | |
Fusion gene scores | * DoF score | 13 X 13 X 3=507 | 6 X 5 X 4=120 |
# samples | 15 | 6 | |
** MAII score | log2(15/507*10)=-1.75702324650746 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MBP [Title/Abstract] AND FEZ1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AV727992 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000382582 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000382582 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000382582 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000382582 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000355994 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000355994 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000355994 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000355994 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000397875 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000397875 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000397875 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000397875 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000397866 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000397866 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000397866 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000397866 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000397865 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000397865 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000397865 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000397865 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000527041 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000527041 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000527041 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000527041 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000359645 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000359645 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000359645 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000359645 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000528160 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000528160 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000528160 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000528160 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000397869 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000397869 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000397869 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000397869 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000354542 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000354542 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000354542 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000354542 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000526111 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000526111 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000526111 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000526111 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000580402 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000580402 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000580402 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000580402 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000579129 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000579129 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000579129 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000579129 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000578193 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000578193 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000578193 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000578193 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000397863 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000397863 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000397863 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000397863 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000397860 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000397860 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000397860 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000397860 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000487778 | ENST00000527350 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-5UTR | ENST00000487778 | ENST00000278919 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000487778 | ENST00000366139 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
intron-intron | ENST00000487778 | ENST00000524435 | MBP | chr18 | 74691842 | - | FEZ1 | chr11 | 125351471 | - |
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FusionProtFeatures for MBP_FEZ1 |
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Hgene | Tgene |
MBP | FEZ1 |
May be involved in axonal outgrowth as component of thenetwork of molecules that regulate cellular morphology and axonguidance machinery. Able to restore partial locomotion and axonalfasciculation to C.elegans unc-76 mutants in germlinetransformation experiments. May participate in the transport ofmitochondria and other cargos along microtubules.{ECO:0000269|PubMed:20812761, ECO:0000269|PubMed:22354037}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MBP_FEZ1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MBP_FEZ1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MBP_FEZ1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MBP_FEZ1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MBP | C0036341 | Schizophrenia | 4 | PSYGENET |
Hgene | MBP | C0014072 | Experimental Autoimmune Encephalomyelitis | 3 | CTD_human |
Hgene | MBP | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | MBP | C0011303 | Demyelinating Diseases | 1 | CTD_human |
Hgene | MBP | C0027873 | Neuromyelitis Optica | 1 | CTD_human |
Tgene | FEZ1 | C0036341 | Schizophrenia | 3 | PSYGENET |
Tgene | FEZ1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | FEZ1 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Tgene | FEZ1 | C0036337 | Schizoaffective Disorder | 1 | PSYGENET |