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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21230

FusionGeneSummary for MBP_FEZ1

check button Fusion gene summary
Fusion gene informationFusion gene name: MBP_FEZ1
Fusion gene ID: 21230
HgeneTgene
Gene symbol

MBP

FEZ1

Gene ID

5553

9638

Gene nameproteoglycan 2, pro eosinophil major basic proteinfasciculation and elongation protein zeta 1
SynonymsBMPG|MBP|MBP1|proMBPUNC-76
Cytomap

11q12.1

11q24.2

Type of geneprotein-codingprotein-coding
Descriptionbone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)fasciculation and elongation protein zeta-1zygin Izygin-1
Modification date2018051920180523
UniProtAcc

P02686

Q99689

Ensembl transtripts involved in fusion geneENST00000382582, ENST00000355994, 
ENST00000397875, ENST00000397866, 
ENST00000397865, ENST00000527041, 
ENST00000359645, ENST00000528160, 
ENST00000397869, ENST00000354542, 
ENST00000526111, ENST00000580402, 
ENST00000579129, ENST00000578193, 
ENST00000397863, ENST00000397860, 
ENST00000487778, 
ENST00000527350, 
ENST00000278919, ENST00000366139, 
ENST00000524435, 
Fusion gene scores* DoF score13 X 13 X 3=5076 X 5 X 4=120
# samples 156
** MAII scorelog2(15/507*10)=-1.75702324650746
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MBP [Title/Abstract] AND FEZ1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AV727992MBPchr18

74691842

-FEZ1chr11

125351471

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000382582ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000382582ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000382582ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000382582ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000355994ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000355994ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000355994ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000355994ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000397875ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000397875ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000397875ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000397875ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000397866ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000397866ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000397866ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000397866ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000397865ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000397865ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000397865ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000397865ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000527041ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000527041ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000527041ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000527041ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000359645ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000359645ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000359645ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000359645ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000528160ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000528160ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000528160ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000528160ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000397869ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000397869ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000397869ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000397869ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000354542ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000354542ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000354542ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000354542ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000526111ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000526111ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000526111ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000526111ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000580402ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000580402ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000580402ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000580402ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000579129ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000579129ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000579129ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000579129ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000578193ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000578193ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000578193ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000578193ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000397863ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000397863ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000397863ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000397863ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000397860ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000397860ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000397860ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000397860ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000487778ENST00000527350MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-5UTRENST00000487778ENST00000278919MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000487778ENST00000366139MBPchr18

74691842

-FEZ1chr11

125351471

-
intron-intronENST00000487778ENST00000524435MBPchr18

74691842

-FEZ1chr11

125351471

-

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FusionProtFeatures for MBP_FEZ1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MBP

P02686

FEZ1

Q99689

May be involved in axonal outgrowth as component of thenetwork of molecules that regulate cellular morphology and axonguidance machinery. Able to restore partial locomotion and axonalfasciculation to C.elegans unc-76 mutants in germlinetransformation experiments. May participate in the transport ofmitochondria and other cargos along microtubules.{ECO:0000269|PubMed:20812761, ECO:0000269|PubMed:22354037}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MBP_FEZ1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MBP_FEZ1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MBP_FEZ1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MBP_FEZ1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMBPC0036341Schizophrenia4PSYGENET
HgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
HgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneMBPC0011303Demyelinating Diseases1CTD_human
HgeneMBPC0027873Neuromyelitis Optica1CTD_human
TgeneFEZ1C0036341Schizophrenia3PSYGENET
TgeneFEZ1C0005586Bipolar Disorder1PSYGENET
TgeneFEZ1C0033975Psychotic Disorders1PSYGENET
TgeneFEZ1C0036337Schizoaffective Disorder1PSYGENET