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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21226

FusionGeneSummary for MBP_AEBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: MBP_AEBP2
Fusion gene ID: 21226
HgeneTgene
Gene symbol

MBP

AEBP2

Gene ID

5553

121536

Gene nameproteoglycan 2, pro eosinophil major basic proteinAE binding protein 2
SynonymsBMPG|MBP|MBP1|proMBP-
Cytomap

11q12.1

12p12.3

Type of geneprotein-codingprotein-coding
Descriptionbone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)zinc finger protein AEBP2AE(adipocyte enhancer)-binding protein 2adipocyte enhancer-binding protein 2
Modification date2018051920180519
UniProtAcc

P02686

Q6ZN18

Ensembl transtripts involved in fusion geneENST00000382582, ENST00000355994, 
ENST00000397875, ENST00000397866, 
ENST00000397865, ENST00000527041, 
ENST00000359645, ENST00000528160, 
ENST00000397869, ENST00000354542, 
ENST00000526111, ENST00000580402, 
ENST00000579129, ENST00000578193, 
ENST00000397863, ENST00000397860, 
ENST00000487778, 		ENST00000541908, 
ENST00000398864, ENST00000266508, 
ENST00000360995, 
Fusion gene scores* DoF score13 X 13 X 3=5078 X 7 X 5=280
# samples 158
** MAII scorelog2(15/507*10)=-1.75702324650746
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MBP [Title/Abstract] AND AEBP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-66-2754-01AMBPchr18

74778254

-AEBP2chr12

19705787

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000382582ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000382582ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000382582ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000382582ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000355994ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000355994ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000355994ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000355994ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397875ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397875ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397875ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397875ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397866ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397866ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397866ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397866ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397865ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397865ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397865ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397865ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000527041ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000527041ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000527041ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000527041ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000359645ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000359645ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000359645ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000359645ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000528160ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000528160ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000528160ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000528160ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397869ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397869ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397869ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397869ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000354542ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000354542ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000354542ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000354542ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000526111ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000526111ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000526111ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000526111ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000580402ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000580402ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000580402ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000580402ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000579129ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000579129ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000579129ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000579129ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000578193ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000578193ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000578193ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000578193ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397863ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397863ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397863ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397863ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397860ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397860ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397860ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397860ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
5UTR-intronENST00000487778ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
5UTR-intronENST00000487778ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
5UTR-intronENST00000487778ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
5UTR-intronENST00000487778ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+

Top

FusionProtFeatures for MBP_AEBP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MBP

P02686

AEBP2

Q6ZN18

DNA-binding transcriptional repressor. May interact withand stimulate the activity of the PRC2 complex, which methylates'Lys-9' and 'Lys-27' residues of histone H3.{ECO:0000269|PubMed:15225548}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MBP_AEBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MBP_AEBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MBPTRPM7, PRMT5, STK39, HLA-DRA, PLP1, TSSK6, IRAK4, PRKCA, PRKCI, PRKCZ, PPP2R5C, LIMK1, LIMK2, TBK1, IKBKE, STK3, APTX, ATN1, ATXN1, MAPK14, LRRK2, PRKDC, MAPK12, MAPK11, MAPK13, MAPK3, MAPK1, CDK1, CDK5, MAP3K5, TLK1, RPS6KA6, DDX58, MELK, CDK7, CDK8, CDK9, HIPK2, SQSTM1, PKN1, ULK1, PRKCB, MAP3K3, CTDSP1, ABL1, MUS81, RPS6KA5, MYH6, MAP3K1, MAPK8, CTDSPL, NLN, IDE, PTPRA, PRKCDAEBP2LDOC1, RALYL, EED, SUZ12, RBBP4, HIST1H1A, HIST1H1C, SETD8, ELAVL1, APP, JMJD6, FBXW11, HMBOX1, JARID2, EZH2, RBBP7, ATXN3, KBTBD7, BTRC, THAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MBP_AEBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MBP_AEBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMBPC0036341Schizophrenia4PSYGENET
HgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
HgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneMBPC0011303Demyelinating Diseases1CTD_human
HgeneMBPC0027873Neuromyelitis Optica1CTD_human