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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21218

FusionGeneSummary for MBOAT2_ARHGAP25

check button Fusion gene summary
Fusion gene informationFusion gene name: MBOAT2_ARHGAP25
Fusion gene ID: 21218
HgeneTgene
Gene symbol

MBOAT2

ARHGAP25

Gene ID

129642

9938

Gene namemembrane bound O-acyltransferase domain containing 2Rho GTPase activating protein 25
SynonymsLPAAT|LPCAT4|LPEAT|LPLAT 2|OACT2HEL-S-308|KAIA0053
Cytomap

2p25.1

2p13.3

Type of geneprotein-codingprotein-coding
Descriptionlysophospholipid acyltransferase 21-acylglycerophosphate O-acyltransferase1-acylglycerophosphoethanolamine O-acyltransferaseO-acyltransferase (membrane bound) domain containing 2lyso-PA acyltransferaselyso-PE acyltransferaselysophosphatidic acid acyrho GTPase-activating protein 25epididymis secretory protein Li 308rho-type GTPase-activating protein 25
Modification date2018051920180519
UniProtAcc

Q6ZWT7

P42331

Ensembl transtripts involved in fusion geneENST00000305997, ENST00000486484, 
ENST00000544262, ENST00000295381, 
ENST00000409202, ENST00000456116, 
ENST00000467265, ENST00000409030, 
ENST00000409220, ENST00000497079, 
ENST00000479844, 
Fusion gene scores* DoF score6 X 2 X 5=603 X 2 X 3=18
# samples 63
** MAII scorelog2(6/60*10)=0log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MBOAT2 [Title/Abstract] AND ARHGAP25 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E2-A14R-01AMBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000305997ENST00000544262MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000305997ENST00000295381MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5CDS-5UTRENST00000305997ENST00000409202MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000305997ENST00000456116MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000305997ENST00000467265MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000305997ENST00000409030MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000305997ENST00000409220MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5CDS-3UTRENST00000305997ENST00000497079MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5CDS-intronENST00000305997ENST00000479844MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5UTR-5UTRENST00000486484ENST00000544262MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5UTR-5UTRENST00000486484ENST00000295381MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5UTR-5UTRENST00000486484ENST00000409202MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5UTR-3UTRENST00000486484ENST00000456116MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5UTR-3UTRENST00000486484ENST00000467265MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5UTR-3UTRENST00000486484ENST00000409030MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5UTR-3UTRENST00000486484ENST00000409220MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5UTR-3UTRENST00000486484ENST00000497079MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+
5UTR-intronENST00000486484ENST00000479844MBOAT2chr2

9013238

-ARHGAP25chr2

69002353

+

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FusionProtFeatures for MBOAT2_ARHGAP25


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MBOAT2

Q6ZWT7

ARHGAP25

P42331

Acyltransferase which mediates the conversion oflysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity).Catalyzes also the acylation of lysophosphatidic acid (LPA) intophosphatidic acid (PA) (LPAAT activity). Has also a very weaklysophosphatidylcholine acyltransferase (LPCAT activity). Prefersoleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases(LPLATs) catalyze the reacylation step of the phospholipidremodeling pathway also known as the Lands cycle.{ECO:0000269|PubMed:18772128}. GTPase activator for the Rho-type GTPases by convertingthem to an inactive GDP-bound state. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MBOAT2_ARHGAP25


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MBOAT2_ARHGAP25


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MBOAT2TCTN2, TCTN3ARHGAP25DMWD, DYNC2H1, DSTYK, GTF2H2, POLD1, SEC23IP, DPYSL4, ACACA, TBL3, CAMK2D, CAMK2G, UBA6, DDX11L8, MSTO1, ATG7, DPP9, PER1, HERC3, ANGEL1, VWA9, RECQL4, THUMPD3, C2orf44, KDM5C, NPRL3, TRIM27, AP5B1, TRIM65, WRAP53


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MBOAT2_ARHGAP25


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MBOAT2_ARHGAP25


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource