![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 2118 |
FusionGeneSummary for APBA2_C12orf60 |
![]() |
Fusion gene information | Fusion gene name: APBA2_C12orf60 | Fusion gene ID: 2118 | Hgene | Tgene | Gene symbol | APBA2 | C12orf60 | Gene ID | 321 | 144608 |
Gene name | amyloid beta precursor protein binding family A member 2 | chromosome 12 open reading frame 60 | |
Synonyms | D15S1518E|HsT16821|LIN-10|MGC:14091|MINT2|X11-BETA|X11L | - | |
Cytomap | 15q13.1 | 12p13.1-p12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | amyloid-beta A4 precursor protein-binding family A member 2X11-like proteinadapter protein X11betaamyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like)mint-2neuron-specific X11L proteinneuronal munc18-1-interacting protein 2pho | uncharacterized protein C12orf60 | |
Modification date | 20180523 | 20180331 | |
UniProtAcc | Q99767 | Q5U649 | |
Ensembl transtripts involved in fusion gene | ENST00000561069, ENST00000558402, ENST00000558330, ENST00000411764, ENST00000558259, | ENST00000330828, ENST00000527783, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 3 X 2 X 3=18 |
# samples | 4 | 3 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: APBA2 [Title/Abstract] AND C12orf60 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-97-7554-01A | APBA2 | chr15 | 29131424 | + | C12orf60 | chr12 | 14975846 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000561069 | ENST00000330828 | APBA2 | chr15 | 29131424 | + | C12orf60 | chr12 | 14975846 | + |
intron-intron | ENST00000561069 | ENST00000527783 | APBA2 | chr15 | 29131424 | + | C12orf60 | chr12 | 14975846 | + |
5UTR-5UTR | ENST00000558402 | ENST00000330828 | APBA2 | chr15 | 29131424 | + | C12orf60 | chr12 | 14975846 | + |
5UTR-intron | ENST00000558402 | ENST00000527783 | APBA2 | chr15 | 29131424 | + | C12orf60 | chr12 | 14975846 | + |
5UTR-5UTR | ENST00000558330 | ENST00000330828 | APBA2 | chr15 | 29131424 | + | C12orf60 | chr12 | 14975846 | + |
5UTR-intron | ENST00000558330 | ENST00000527783 | APBA2 | chr15 | 29131424 | + | C12orf60 | chr12 | 14975846 | + |
intron-5UTR | ENST00000411764 | ENST00000330828 | APBA2 | chr15 | 29131424 | + | C12orf60 | chr12 | 14975846 | + |
intron-intron | ENST00000411764 | ENST00000527783 | APBA2 | chr15 | 29131424 | + | C12orf60 | chr12 | 14975846 | + |
intron-5UTR | ENST00000558259 | ENST00000330828 | APBA2 | chr15 | 29131424 | + | C12orf60 | chr12 | 14975846 | + |
intron-intron | ENST00000558259 | ENST00000527783 | APBA2 | chr15 | 29131424 | + | C12orf60 | chr12 | 14975846 | + |
Top |
FusionProtFeatures for APBA2_C12orf60 |
![]() |
Hgene | Tgene |
APBA2 | C12orf60 |
Putative function in synaptic vesicle exocytosis bybinding to STXBP1, an essential component of the synaptic vesicleexocytotic machinery. May modulate processing of the amyloid-betaprecursor protein (APP) and hence formation of APP-beta. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for APBA2_C12orf60 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for APBA2_C12orf60 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
APBA2 | CLSTN1, APP, PSEN2, LRP2, LRP1, LRP8, NECAB3, RELA, USP20, MAPK6, STXBP1, APBA1, IQSEC2, KLRG2, TRIM41, TJAP1, IQSEC1, AAGAB, APEX2, BTRC, USP33, PLD1, FBXW11, DMWD, ZNF518A, DDX24, HERC2 | C12orf60 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for APBA2_C12orf60 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for APBA2_C12orf60 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | APBA2 | C0036341 | Schizophrenia | 1 | PSYGENET |