|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 21177 |
FusionGeneSummary for MBD2_DOCK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MBD2_DOCK2 | Fusion gene ID: 21177 | Hgene | Tgene | Gene symbol | MBD2 | DOCK2 | Gene ID | 64174 | 1794 |
| Gene name | dipeptidase 2 | dedicator of cytokinesis 2 | |
| Synonyms | MBD2 | IMD40 | |
| Cytomap | 16q22.1 | 5q35.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dipeptidase 2 | dedicator of cytokinesis protein 2dedicator of cyto-kinesis 2 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9UBB5 | Q92608 | |
| Ensembl transtripts involved in fusion gene | ENST00000256429, ENST00000579025, ENST00000398398, ENST00000583046, | ENST00000256935, ENST00000540750, ENST00000520908, ENST00000523351, | |
| Fusion gene scores | * DoF score | 5 X 4 X 2=40 | 9 X 7 X 6=378 |
| # samples | 5 | 9 | |
| ** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MBD2 [Title/Abstract] AND DOCK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AR-A1AY-01A | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000256429 | ENST00000256935 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| In-frame | ENST00000256429 | ENST00000540750 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| In-frame | ENST00000256429 | ENST00000520908 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| 5CDS-3UTR | ENST00000256429 | ENST00000523351 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| intron-3CDS | ENST00000579025 | ENST00000256935 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| intron-3CDS | ENST00000579025 | ENST00000540750 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| intron-3CDS | ENST00000579025 | ENST00000520908 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| intron-3UTR | ENST00000579025 | ENST00000523351 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| intron-3CDS | ENST00000398398 | ENST00000256935 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| intron-3CDS | ENST00000398398 | ENST00000540750 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| intron-3CDS | ENST00000398398 | ENST00000520908 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| intron-3UTR | ENST00000398398 | ENST00000523351 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| intron-3CDS | ENST00000583046 | ENST00000256935 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| intron-3CDS | ENST00000583046 | ENST00000540750 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| intron-3CDS | ENST00000583046 | ENST00000520908 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
| intron-3UTR | ENST00000583046 | ENST00000523351 | MBD2 | chr18 | 51715244 | - | DOCK2 | chr5 | 169502951 | + |
Top |
FusionProtFeatures for MBD2_DOCK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MBD2 | DOCK2 |
| Binds CpG islands in promoters where the DNA ismethylated at position 5 of cytosine within CpG dinucleotides.Binds hemimethylated DNA as well. Recruits histone deacetylasesand DNA methyltransferases. Acts as transcriptional repressor andplays a role in gene silencing. Functions as a scaffold protein,targeting GATAD2A and GATAD2B to chromatin to promote repression.May enhance the activation of some unmethylated cAMP-responsivepromoters. {ECO:0000269|PubMed:10471499,ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568,ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:24307175,ECO:0000269|PubMed:9774669}. | Involved in cytoskeletal rearrangements required forlymphocyte migration in response of chemokines. Activates RAC1 andRAC2, but not CDC42, by functioning as a guanine nucleotideexchange factor (GEF), which exchanges bound GDP for free GTP. Mayalso participate in IL2 transcriptional activation via theactivation of RAC2. {ECO:0000269|PubMed:21613211}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MBD2 | chr18:51715244 | chr5:169502951 | ENST00000256429 | - | 3 | 7 | 50_96 | 280 | 1015 | Compositional bias | Note=Arg-rich |
| Hgene | MBD2 | chr18:51715244 | chr5:169502951 | ENST00000256429 | - | 3 | 7 | 6_140 | 280 | 1015 | Compositional bias | Note=Gly-rich |
| Hgene | MBD2 | chr18:51715244 | chr5:169502951 | ENST00000256429 | - | 3 | 7 | 145_213 | 280 | 1015 | Domain | MBD |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MBD2 | chr18:51715244 | chr5:169502951 | ENST00000583046 | - | 1 | 3 | 50_96 | -20 | 303 | Compositional bias | Note=Arg-rich |
| Hgene | >MBD2 | chr18:51715244 | chr5:169502951 | ENST00000583046 | - | 1 | 3 | 6_140 | -20 | 303 | Compositional bias | Note=Gly-rich |
| Hgene | >MBD2 | chr18:51715244 | chr5:169502951 | ENST00000583046 | - | 1 | 3 | 145_213 | -20 | 303 | Domain | MBD |
| Tgene | DOCK2 | chr18:51715244 | chr5:169502951 | ENST00000256935 | + | 45 | 52 | 1211_1622 | 1576 | 1831 | Domain | DHR-2 |
| Tgene | DOCK2 | chr18:51715244 | chr5:169502951 | ENST00000256935 | + | 45 | 52 | 423_607 | 1576 | 1831 | Domain | DHR-1 |
| Tgene | DOCK2 | chr18:51715244 | chr5:169502951 | ENST00000256935 | + | 45 | 52 | 8_69 | 1576 | 1831 | Domain | SH3 |
Top |
FusionGeneSequence for MBD2_DOCK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MBD2_ENST00000256429_chr18_51715244_-_DOCK2_ENST00000256935_chr5_169502951_+_535aa MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAGRGGGVCGRGRGRGRGRGRGRGR GRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYF SPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSD PQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRVGRPRSMLRSYRQMSIISLASMNSDCS TPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSRKHEFMSDTNLSEHAAIPLKAS >In-frame_MBD2_ENST00000256429_chr18_51715244_-_DOCK2_ENST00000540750_chr5_169502951_+_535aa MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAGRGGGVCGRGRGRGRGRGRGRGR GRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYF SPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSD PQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRVGRPRSMLRSYRQMSIISLASMNSDCS TPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSRKHEFMSDTNLSEHAAIPLKAS >In-frame_MBD2_ENST00000256429_chr18_51715244_-_DOCK2_ENST00000520908_chr5_169502951_+_535aa MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAGRGGGVCGRGRGRGRGRGRGRGR GRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYF SPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSD PQRMNEQPRQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRVGRPRSMLRSYRQMSIISLASMNSDCS TPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSRKHEFMSDTNLSEHAAIPLKAS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MBD2_ENST00000256429_chr18_51715244_-_DOCK2_ENST00000256935_chr5_169502951_+_1605nt ATGCGCGCGCACCCGGGGGGAGGCCGCTGCTGCCCGGAGCAGGAGGAGGGGGAGAGTGCGGCGGGCGGCAGCGGCGCTGGCGGCGACTCC GCCATAGAGCAGGGGGGCCAGGGCAGCGCGCTCGCCCCGTCCCCGGTGAGCGGCGTGCGCAGGGAAGGCGCTCGGGGCGGCGGCCGTGGC CGGGGGCGGTGGAAGCAGGCGGGCCGGGGCGGCGGCGTCTGTGGCCGTGGCCGGGGCCGGGGCCGTGGCCGGGGACGGGGACGGGGCCGG GGCCGGGGCCGCGGCCGTCCCCCGAGTGGCGGCAGCGGCCTTGGCGGCGACGGCGGCGGCTGCGGCGGCGGCGGCAGCGGTGGCGGCGGC GCCCCCCGGCGGGAGCCGGTCCCTTTCCCGTCGGGGAGCGCGGGGCCGGGGCCCAGGGGACCCCGGGCCACGGAGAGCGGGAAGAGGATG GATTGCCCGGCCCTCCCCCCCGGATGGAAGAAGGAGGAAGTGATCCGAAAATCTGGGCTAAGTGCTGGCAAGAGCGATGTCTACTACTTC AGTCCAAGTGGTAAGAAGTTCAGAAGCAAGCCTCAGTTGGCAAGGTACCTGGGAAATACTGTTGATCTCAGCAGTTTTGACTTCAGAACT GGAAAGATGATGCCTAGTAAATTACAGAAGAACAAACAGAGACTGCGAAACGATCCTCTCAATCAAAATAAGGGTAAACCAGACTTGAAT ACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACAACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGAC CCACAACGAATGAATGAACAGCCACGTCAGATCCCCTTCTTGGGAGCTGGGATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGA CCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAAAATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGAC GACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATACAGACAGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGC ACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATTAGCATCACCCAAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCG GGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAAGAGGACAAAGAGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCA GAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCATGAGTGACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCT GTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTACCATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAG GCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACTCTCAGATGGTGACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTC >In-frame_MBD2_ENST00000256429_chr18_51715244_-_DOCK2_ENST00000540750_chr5_169502951_+_1605nt ATGCGCGCGCACCCGGGGGGAGGCCGCTGCTGCCCGGAGCAGGAGGAGGGGGAGAGTGCGGCGGGCGGCAGCGGCGCTGGCGGCGACTCC GCCATAGAGCAGGGGGGCCAGGGCAGCGCGCTCGCCCCGTCCCCGGTGAGCGGCGTGCGCAGGGAAGGCGCTCGGGGCGGCGGCCGTGGC CGGGGGCGGTGGAAGCAGGCGGGCCGGGGCGGCGGCGTCTGTGGCCGTGGCCGGGGCCGGGGCCGTGGCCGGGGACGGGGACGGGGCCGG GGCCGGGGCCGCGGCCGTCCCCCGAGTGGCGGCAGCGGCCTTGGCGGCGACGGCGGCGGCTGCGGCGGCGGCGGCAGCGGTGGCGGCGGC GCCCCCCGGCGGGAGCCGGTCCCTTTCCCGTCGGGGAGCGCGGGGCCGGGGCCCAGGGGACCCCGGGCCACGGAGAGCGGGAAGAGGATG GATTGCCCGGCCCTCCCCCCCGGATGGAAGAAGGAGGAAGTGATCCGAAAATCTGGGCTAAGTGCTGGCAAGAGCGATGTCTACTACTTC AGTCCAAGTGGTAAGAAGTTCAGAAGCAAGCCTCAGTTGGCAAGGTACCTGGGAAATACTGTTGATCTCAGCAGTTTTGACTTCAGAACT GGAAAGATGATGCCTAGTAAATTACAGAAGAACAAACAGAGACTGCGAAACGATCCTCTCAATCAAAATAAGGGTAAACCAGACTTGAAT ACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACAACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGAC CCACAACGAATGAATGAACAGCCACGTCAGATCCCCTTCTTGGGAGCTGGGATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGA CCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAAAATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGAC GACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATACAGACAGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGC ACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATTAGCATCACCCAAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCG GGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAAGAGGACAAAGAGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCA GAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCATGAGTGACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCT GTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTACCATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAG GCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACTCTCAGATGGTGACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTC >In-frame_MBD2_ENST00000256429_chr18_51715244_-_DOCK2_ENST00000520908_chr5_169502951_+_1605nt ATGCGCGCGCACCCGGGGGGAGGCCGCTGCTGCCCGGAGCAGGAGGAGGGGGAGAGTGCGGCGGGCGGCAGCGGCGCTGGCGGCGACTCC GCCATAGAGCAGGGGGGCCAGGGCAGCGCGCTCGCCCCGTCCCCGGTGAGCGGCGTGCGCAGGGAAGGCGCTCGGGGCGGCGGCCGTGGC CGGGGGCGGTGGAAGCAGGCGGGCCGGGGCGGCGGCGTCTGTGGCCGTGGCCGGGGCCGGGGCCGTGGCCGGGGACGGGGACGGGGCCGG GGCCGGGGCCGCGGCCGTCCCCCGAGTGGCGGCAGCGGCCTTGGCGGCGACGGCGGCGGCTGCGGCGGCGGCGGCAGCGGTGGCGGCGGC GCCCCCCGGCGGGAGCCGGTCCCTTTCCCGTCGGGGAGCGCGGGGCCGGGGCCCAGGGGACCCCGGGCCACGGAGAGCGGGAAGAGGATG GATTGCCCGGCCCTCCCCCCCGGATGGAAGAAGGAGGAAGTGATCCGAAAATCTGGGCTAAGTGCTGGCAAGAGCGATGTCTACTACTTC AGTCCAAGTGGTAAGAAGTTCAGAAGCAAGCCTCAGTTGGCAAGGTACCTGGGAAATACTGTTGATCTCAGCAGTTTTGACTTCAGAACT GGAAAGATGATGCCTAGTAAATTACAGAAGAACAAACAGAGACTGCGAAACGATCCTCTCAATCAAAATAAGGGTAAACCAGACTTGAAT ACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACAACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGAC CCACAACGAATGAATGAACAGCCACGTCAGATCCCCTTCTTGGGAGCTGGGATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGA CCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAAAATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGAC GACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATACAGACAGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGC ACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATTAGCATCACCCAAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCG GGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAAGAGGACAAAGAGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCA GAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCATGAGTGACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCT GTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTACCATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAG GCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACTCTCAGATGGTGACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MBD2_ENST00000256429_chr18_51715244_-_DOCK2_ENST00000256935_chr5_169502951_+_2358nt GGGGGCGTGGCCCCGAGAAGGCGGAGACAAGATGGCCGCCCATAGCGCTTGGAGGACCTAAGAGGCGGTGGCCGGGGCCACGCCCCGGGC AGGAGGGCCGCTCTGTGCGCGCCCGCTCTATGATGCTTGCGCGCGTCCCCCGCGCGCCGCGCTGCGGGCGGGGCGGGTCTCCGGGATTCC AAGGGCTCGGTTACGGAAGAAGCGCAGCGCCGGCTGGGGAGGGGGCTGGATGCGCGCGCACCCGGGGGGAGGCCGCTGCTGCCCGGAGCA GGAGGAGGGGGAGAGTGCGGCGGGCGGCAGCGGCGCTGGCGGCGACTCCGCCATAGAGCAGGGGGGCCAGGGCAGCGCGCTCGCCCCGTC CCCGGTGAGCGGCGTGCGCAGGGAAGGCGCTCGGGGCGGCGGCCGTGGCCGGGGGCGGTGGAAGCAGGCGGGCCGGGGCGGCGGCGTCTG TGGCCGTGGCCGGGGCCGGGGCCGTGGCCGGGGACGGGGACGGGGCCGGGGCCGGGGCCGCGGCCGTCCCCCGAGTGGCGGCAGCGGCCT TGGCGGCGACGGCGGCGGCTGCGGCGGCGGCGGCAGCGGTGGCGGCGGCGCCCCCCGGCGGGAGCCGGTCCCTTTCCCGTCGGGGAGCGC GGGGCCGGGGCCCAGGGGACCCCGGGCCACGGAGAGCGGGAAGAGGATGGATTGCCCGGCCCTCCCCCCCGGATGGAAGAAGGAGGAAGT GATCCGAAAATCTGGGCTAAGTGCTGGCAAGAGCGATGTCTACTACTTCAGTCCAAGTGGTAAGAAGTTCAGAAGCAAGCCTCAGTTGGC AAGGTACCTGGGAAATACTGTTGATCTCAGCAGTTTTGACTTCAGAACTGGAAAGATGATGCCTAGTAAATTACAGAAGAACAAACAGAG ACTGCGAAACGATCCTCTCAATCAAAATAAGGGTAAACCAGACTTGAATACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACA ACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAATGAATGAACAGCCACGTCAGATCCCCTTCTT GGGAGCTGGGATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAA AATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATA CAGACAGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGCACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATT AGCATCACCCAAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAA GAGGACAAAGAGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCAT GAGTGACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCTGTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTAC CATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACT CTCAGATGGTGACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGCTGAAGAAGGCAA ACAGATCCCAGACTCGCTGTCCACGGACCTGTGAGCTGCTGCTGACTAGGGCTGCATGGGAGAGCCAGGGAGGGGAGTTTCTGGAAGAGG AAAGCCATGCGTGGAACATCGAAGCCTCAGAGAGTGGGAGACTGTCCCCATCAGTTGTCCTTACTTAGAGGAGACAGAGAGGCCAATCAG GTCCCAGAGCTTGAATGCTAACAAGCCCAGCATCCCCTGGGGCTGTGATCATGGTGGATGAGGAAGCCTCAACGTAGATTCCTGAACTCA AGGTACCAGCAAGAATGCCTTCTCCCAGTGTGCTCTCCCCAACATCCTAGGCACAGCTTTCATAACCCAGTTTCTTAGGTGTAAGAAACT GTTTTTATCTCATTTATTAAGTCTCAGAACTTAACAGAAAAGGAAGCCTTTTAAATATTCTTTTTAATTTTATTTTAGATTAACAGTTTT GTACTTTACATTTTTTTATACAACCAACCAGTTTCTTTTCTAGCCAATCATCTCTGAAGAGTTGCTGTTTCTTACTGACAATAAAAAATG >In-frame_MBD2_ENST00000256429_chr18_51715244_-_DOCK2_ENST00000540750_chr5_169502951_+_2353nt GGGGGCGTGGCCCCGAGAAGGCGGAGACAAGATGGCCGCCCATAGCGCTTGGAGGACCTAAGAGGCGGTGGCCGGGGCCACGCCCCGGGC AGGAGGGCCGCTCTGTGCGCGCCCGCTCTATGATGCTTGCGCGCGTCCCCCGCGCGCCGCGCTGCGGGCGGGGCGGGTCTCCGGGATTCC AAGGGCTCGGTTACGGAAGAAGCGCAGCGCCGGCTGGGGAGGGGGCTGGATGCGCGCGCACCCGGGGGGAGGCCGCTGCTGCCCGGAGCA GGAGGAGGGGGAGAGTGCGGCGGGCGGCAGCGGCGCTGGCGGCGACTCCGCCATAGAGCAGGGGGGCCAGGGCAGCGCGCTCGCCCCGTC CCCGGTGAGCGGCGTGCGCAGGGAAGGCGCTCGGGGCGGCGGCCGTGGCCGGGGGCGGTGGAAGCAGGCGGGCCGGGGCGGCGGCGTCTG TGGCCGTGGCCGGGGCCGGGGCCGTGGCCGGGGACGGGGACGGGGCCGGGGCCGGGGCCGCGGCCGTCCCCCGAGTGGCGGCAGCGGCCT TGGCGGCGACGGCGGCGGCTGCGGCGGCGGCGGCAGCGGTGGCGGCGGCGCCCCCCGGCGGGAGCCGGTCCCTTTCCCGTCGGGGAGCGC GGGGCCGGGGCCCAGGGGACCCCGGGCCACGGAGAGCGGGAAGAGGATGGATTGCCCGGCCCTCCCCCCCGGATGGAAGAAGGAGGAAGT GATCCGAAAATCTGGGCTAAGTGCTGGCAAGAGCGATGTCTACTACTTCAGTCCAAGTGGTAAGAAGTTCAGAAGCAAGCCTCAGTTGGC AAGGTACCTGGGAAATACTGTTGATCTCAGCAGTTTTGACTTCAGAACTGGAAAGATGATGCCTAGTAAATTACAGAAGAACAAACAGAG ACTGCGAAACGATCCTCTCAATCAAAATAAGGGTAAACCAGACTTGAATACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACA ACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAATGAATGAACAGCCACGTCAGATCCCCTTCTT GGGAGCTGGGATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAA AATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATA CAGACAGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGCACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATT AGCATCACCCAAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAA GAGGACAAAGAGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCAT GAGTGACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCTGTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTAC CATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACT CTCAGATGGTGACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGCTGAAGAAGGCAA ACAGATCCCAGACTCGCTGTCCACGGACCTGTGAGCTGCTGCTGACTAGGGCTGCATGGGAGAGCCAGGGAGGGGAGTTTCTGGAAGAGG AAAGCCATGCGTGGAACATCGAAGCCTCAGAGAGTGGGAGACTGTCCCCATCAGTTGTCCTTACTTAGAGGAGACAGAGAGGCCAATCAG GTCCCAGAGCTTGAATGCTAACAAGCCCAGCATCCCCTGGGGCTGTGATCATGGTGGATGAGGAAGCCTCAACGTAGATTCCTGAACTCA AGGTACCAGCAAGAATGCCTTCTCCCAGTGTGCTCTCCCCAACATCCTAGGCACAGCTTTCATAACCCAGTTTCTTAGGTGTAAGAAACT GTTTTTATCTCATTTATTAAGTCTCAGAACTTAACAGAAAAGGAAGCCTTTTAAATATTCTTTTTAATTTTATTTTAGATTAACAGTTTT GTACTTTACATTTTTTTATACAACCAACCAGTTTCTTTTCTAGCCAATCATCTCTGAAGAGTTGCTGTTTCTTACTGACAATAAAAAATG >In-frame_MBD2_ENST00000256429_chr18_51715244_-_DOCK2_ENST00000520908_chr5_169502951_+_2355nt GGGGGCGTGGCCCCGAGAAGGCGGAGACAAGATGGCCGCCCATAGCGCTTGGAGGACCTAAGAGGCGGTGGCCGGGGCCACGCCCCGGGC AGGAGGGCCGCTCTGTGCGCGCCCGCTCTATGATGCTTGCGCGCGTCCCCCGCGCGCCGCGCTGCGGGCGGGGCGGGTCTCCGGGATTCC AAGGGCTCGGTTACGGAAGAAGCGCAGCGCCGGCTGGGGAGGGGGCTGGATGCGCGCGCACCCGGGGGGAGGCCGCTGCTGCCCGGAGCA GGAGGAGGGGGAGAGTGCGGCGGGCGGCAGCGGCGCTGGCGGCGACTCCGCCATAGAGCAGGGGGGCCAGGGCAGCGCGCTCGCCCCGTC CCCGGTGAGCGGCGTGCGCAGGGAAGGCGCTCGGGGCGGCGGCCGTGGCCGGGGGCGGTGGAAGCAGGCGGGCCGGGGCGGCGGCGTCTG TGGCCGTGGCCGGGGCCGGGGCCGTGGCCGGGGACGGGGACGGGGCCGGGGCCGGGGCCGCGGCCGTCCCCCGAGTGGCGGCAGCGGCCT TGGCGGCGACGGCGGCGGCTGCGGCGGCGGCGGCAGCGGTGGCGGCGGCGCCCCCCGGCGGGAGCCGGTCCCTTTCCCGTCGGGGAGCGC GGGGCCGGGGCCCAGGGGACCCCGGGCCACGGAGAGCGGGAAGAGGATGGATTGCCCGGCCCTCCCCCCCGGATGGAAGAAGGAGGAAGT GATCCGAAAATCTGGGCTAAGTGCTGGCAAGAGCGATGTCTACTACTTCAGTCCAAGTGGTAAGAAGTTCAGAAGCAAGCCTCAGTTGGC AAGGTACCTGGGAAATACTGTTGATCTCAGCAGTTTTGACTTCAGAACTGGAAAGATGATGCCTAGTAAATTACAGAAGAACAAACAGAG ACTGCGAAACGATCCTCTCAATCAAAATAAGGGTAAACCAGACTTGAATACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACA ACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAATGAATGAACAGCCACGTCAGATCCCCTTCTT GGGAGCTGGGATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAA AATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATA CAGACAGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGCACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATT AGCATCACCCAAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAA GAGGACAAAGAGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCAT GAGTGACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCTGTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTAC CATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACT CTCAGATGGTGACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGCTGAAGAAGGCAA ACAGATCCCAGACTCGCTGTCCACGGACCTGTGAGCTGCTGCTGACTAGGGCTGCATGGGAGAGCCAGGGAGGGGAGTTTCTGGAAGAGG AAAGCCATGCGTGGAACATCGAAGCCTCAGAGAGTGGGAGACTGTCCCCATCAGTTGTCCTTACTTAGAGGAGACAGAGAGGCCAATCAG GTCCCAGAGCTTGAATGCTAACAAGCCCAGCATCCCCTGGGGCTGTGATCATGGTGGATGAGGAAGCCTCAACGTAGATTCCTGAACTCA AGGTACCAGCAAGAATGCCTTCTCCCAGTGTGCTCTCCCCAACATCCTAGGCACAGCTTTCATAACCCAGTTTCTTAGGTGTAAGAAACT GTTTTTATCTCATTTATTAAGTCTCAGAACTTAACAGAAAAGGAAGCCTTTTAAATATTCTTTTTAATTTTATTTTAGATTAACAGTTTT GTACTTTACATTTTTTTATACAACCAACCAGTTTCTTTTCTAGCCAATCATCTCTGAAGAGTTGCTGTTTCTTACTGACAATAAAAAATG |
Top |
FusionGenePPI for MBD2_DOCK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MBD2 | GPN1, MBD3, MBD3L1, DHX9, GATAD2A, HDAC1, HDAC2, GATAD2B, RBBP4, CHD3, MTA2, SIN3A, HINFP, MBD2, DNMT1, TRIM27, PTK2B, PRMT1, PRMT5, WDR77, TACC3, MBD3L2, RBBP7, KDM1A, ESR1, CDK2AP1, KDM5B, TFAP4, MTA3, SOX2, LAMTOR3, ZNF219, PHF20L1, CHD5, MTA1, POLR2A, IFI16, HMG20A, ZMYND8, CDCA5, KDM5C, RBPJ, TBP, RFX3 | DOCK2 | RAC1, RAC2, PAK2, CD247, CRKL, VAV1, TERF1, KHDRBS1, TRIM23, HNRNPK, KRTAP5-9, MDFI, PLSCR1, CALCOCO2, MTUS2, CCNDBP1, KRTAP9-2, KRTAP9-4, KRTAP4-2, KRT40, KHDRBS2, KRTAP10-9, KRTAP10-1, KRTAP10-8, KRTAP10-3, NOTCH2NL, MCM2, SNW1, ELMO1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | DOCK2 | chr18:51715244 | chr5:169502951 | ENST00000256935 | + | 45 | 52 | 939_1476 | 1576 | 1831 | CRKL |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MBD2_DOCK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MBD2_DOCK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MBD2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | MBD2 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | DOCK2 | C0279628 | Adenocarcinoma Of Esophagus | 1 | CTD_human |
| Tgene | DOCK2 | C4225328 | IMMUNODEFICIENCY 40 | 1 | ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|