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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21169

FusionGeneSummary for MAX_FGR

check button Fusion gene summary
Fusion gene informationFusion gene name: MAX_FGR
Fusion gene ID: 21169
HgeneTgene
Gene symbol

MAX

FGR

Gene ID

4149

2268

Gene nameMYC associated factor XFGR proto-oncogene, Src family tyrosine kinase
SynonymsbHLHd4SRC2|c-fgr|c-src2|p55-Fgr|p55c-fgr|p58-Fgr|p58c-fgr
Cytomap

14q23.3

1p35.3

Type of geneprotein-codingprotein-coding
Descriptionprotein maxclass D basic helix-loop-helix protein 4tyrosine-protein kinase FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologc-fgr protooncogenec-src-2 proto-oncogenefeline Gardner-Rasheed sarcoma viral oncogene homologp55-c-fgr proteinproto-oncogene c-Fgrproto-oncogene tyrosine-prote
Modification date2018052320180523
UniProtAcc

P61244

P09769

Ensembl transtripts involved in fusion geneENST00000341653, ENST00000358402, 
ENST00000555932, ENST00000284165, 
ENST00000358664, ENST00000555419, 
ENST00000557277, ENST00000556979, 
ENST00000555667, ENST00000557746, 
ENST00000556443, ENST00000246163, 
ENST00000374005, ENST00000399173, 
ENST00000545953, ENST00000374004, 
ENST00000468038, 
Fusion gene scores* DoF score4 X 2 X 4=324 X 5 X 7=140
# samples 411
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/140*10)=-0.347923303420307
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAX [Title/Abstract] AND FGR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAX

GO:0000122

negative regulation of transcription by RNA polymerase II

8521822

TgeneFGR

GO:0018108

peptidyl-tyrosine phosphorylation

7519620|8327512

TgeneFGR

GO:0046777

protein autophosphorylation

2181286|8327512


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI031363MAXchr14

65545992

-FGRchr1

27939823

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000341653ENST00000374005MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000341653ENST00000399173MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000341653ENST00000545953MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000341653ENST00000374004MAXchr14

65545992

-FGRchr1

27939823

+
intron-intronENST00000341653ENST00000468038MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000358402ENST00000374005MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000358402ENST00000399173MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000358402ENST00000545953MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000358402ENST00000374004MAXchr14

65545992

-FGRchr1

27939823

+
intron-intronENST00000358402ENST00000468038MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000555932ENST00000374005MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000555932ENST00000399173MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000555932ENST00000545953MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000555932ENST00000374004MAXchr14

65545992

-FGRchr1

27939823

+
intron-intronENST00000555932ENST00000468038MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000284165ENST00000374005MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000284165ENST00000399173MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000284165ENST00000545953MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000284165ENST00000374004MAXchr14

65545992

-FGRchr1

27939823

+
intron-intronENST00000284165ENST00000468038MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000358664ENST00000374005MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000358664ENST00000399173MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000358664ENST00000545953MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000358664ENST00000374004MAXchr14

65545992

-FGRchr1

27939823

+
intron-intronENST00000358664ENST00000468038MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000555419ENST00000374005MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000555419ENST00000399173MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000555419ENST00000545953MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000555419ENST00000374004MAXchr14

65545992

-FGRchr1

27939823

+
intron-intronENST00000555419ENST00000468038MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000557277ENST00000374005MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000557277ENST00000399173MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000557277ENST00000545953MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000557277ENST00000374004MAXchr14

65545992

-FGRchr1

27939823

+
intron-intronENST00000557277ENST00000468038MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000556979ENST00000374005MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000556979ENST00000399173MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000556979ENST00000545953MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000556979ENST00000374004MAXchr14

65545992

-FGRchr1

27939823

+
intron-intronENST00000556979ENST00000468038MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000555667ENST00000374005MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000555667ENST00000399173MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000555667ENST00000545953MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000555667ENST00000374004MAXchr14

65545992

-FGRchr1

27939823

+
intron-intronENST00000555667ENST00000468038MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000557746ENST00000374005MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000557746ENST00000399173MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000557746ENST00000545953MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000557746ENST00000374004MAXchr14

65545992

-FGRchr1

27939823

+
intron-intronENST00000557746ENST00000468038MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000556443ENST00000374005MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000556443ENST00000399173MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000556443ENST00000545953MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000556443ENST00000374004MAXchr14

65545992

-FGRchr1

27939823

+
intron-intronENST00000556443ENST00000468038MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000246163ENST00000374005MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000246163ENST00000399173MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000246163ENST00000545953MAXchr14

65545992

-FGRchr1

27939823

+
intron-3CDSENST00000246163ENST00000374004MAXchr14

65545992

-FGRchr1

27939823

+
intron-intronENST00000246163ENST00000468038MAXchr14

65545992

-FGRchr1

27939823

+

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FusionProtFeatures for MAX_FGR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAX

P61244

FGR

P09769

Non-receptor tyrosine-protein kinase that transmitssignals from cell surface receptors devoid of kinase activity andcontributes to the regulation of immune responses, includingneutrophil, monocyte, macrophage and mast cell functions,cytoskeleton remodeling in response to extracellular stimuli,phagocytosis, cell adhesion and migration. Promotes mast celldegranulation, release of inflammatory cytokines and IgE-mediatedanaphylaxis. Acts downstream of receptors that bind the Fc regionof immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B.Acts downstream of ITGB1 and ITGB2, and regulates actincytoskeleton reorganization, cell spreading and adhesion.Depending on the context, activates or inhibits cellularresponses. Functions as negative regulator of ITGB2 signaling,phagocytosis and SYK activity in monocytes. Required for normalITGB1 and ITGB2 signaling, normal cell spreading and adhesion inneutrophils and macrophages. Functions as positive regulator ofcell migration and regulates cytoskeleton reorganization via RAC1activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling.Phosphorylates PLD2 in antigen-stimulated mast cells, leading toPLD2 activation and the production of the signaling moleculeslysophosphatidic acid and diacylglycerol. Promotes activation ofPIK3R1. Phosphorylates FASLG, and thereby regulates itsubiquitination and subsequent internalization. PhosphorylatesABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1,PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already beenphosphorylated by SYK, but not unphosphorylated HCLS1.{ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290,ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAX_FGR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAX_FGR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAX_FGR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFGRP09769DB01254DasatinibTyrosine-protein kinase Fgrsmall moleculeapproved|investigational

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RelatedDiseases for MAX_FGR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAXC0031511Pheochromocytoma1CTD_human
TgeneFGRC0023893Liver Cirrhosis, Experimental1CTD_human