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Fusion gene ID: 21142 |
FusionGeneSummary for MAT2A_CNOT7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAT2A_CNOT7 | Fusion gene ID: 21142 | Hgene | Tgene | Gene symbol | MAT2A | CNOT7 | Gene ID | 4144 | 29883 |
| Gene name | methionine adenosyltransferase 2A | CCR4-NOT transcription complex subunit 7 | |
| Synonyms | MATA2|MATII|SAMS2 | CAF-1|CAF1|Caf1a|hCAF-1 | |
| Cytomap | 2p11.2 | 8p22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | S-adenosylmethionine synthase isoform type-2MAT 2MAT-IIadoMet synthase 2adoMet synthetase 2methionine adenosyltransferase 2methionine adenosyltransferase II, alphatesticular tissue protein Li 121 | CCR4-NOT transcription complex subunit 7BTG1-binding factor 1CCR4-associated factor 1carbon catabolite repressor protein (CCR4)-associative factor 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P31153 | Q9UIV1 | |
| Ensembl transtripts involved in fusion gene | ENST00000306434, ENST00000409017, ENST00000490878, | ENST00000361272, ENST00000523917, ENST00000518885, | |
| Fusion gene scores | * DoF score | 5 X 5 X 1=25 | 2 X 2 X 1=4 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: MAT2A [Title/Abstract] AND CNOT7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAT2A | GO:0006556 | S-adenosylmethionine biosynthetic process | 10644686|25075345 |
| Hgene | MAT2A | GO:0034214 | protein hexamerization | 25075345 |
| Hgene | MAT2A | GO:0051291 | protein heterooligomerization | 25075345 |
| Tgene | CNOT7 | GO:0008285 | negative regulation of cell proliferation | 19276069 |
| Tgene | CNOT7 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 20065043|21336257 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM749134 | MAT2A | chr2 | 85766396 | + | CNOT7 | chr8 | 17104270 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000306434 | ENST00000361272 | MAT2A | chr2 | 85766396 | + | CNOT7 | chr8 | 17104270 | - |
| 5UTR-5UTR | ENST00000306434 | ENST00000523917 | MAT2A | chr2 | 85766396 | + | CNOT7 | chr8 | 17104270 | - |
| 5UTR-intron | ENST00000306434 | ENST00000518885 | MAT2A | chr2 | 85766396 | + | CNOT7 | chr8 | 17104270 | - |
| intron-5UTR | ENST00000409017 | ENST00000361272 | MAT2A | chr2 | 85766396 | + | CNOT7 | chr8 | 17104270 | - |
| intron-5UTR | ENST00000409017 | ENST00000523917 | MAT2A | chr2 | 85766396 | + | CNOT7 | chr8 | 17104270 | - |
| intron-intron | ENST00000409017 | ENST00000518885 | MAT2A | chr2 | 85766396 | + | CNOT7 | chr8 | 17104270 | - |
| intron-5UTR | ENST00000490878 | ENST00000361272 | MAT2A | chr2 | 85766396 | + | CNOT7 | chr8 | 17104270 | - |
| intron-5UTR | ENST00000490878 | ENST00000523917 | MAT2A | chr2 | 85766396 | + | CNOT7 | chr8 | 17104270 | - |
| intron-intron | ENST00000490878 | ENST00000518885 | MAT2A | chr2 | 85766396 | + | CNOT7 | chr8 | 17104270 | - |
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FusionProtFeatures for MAT2A_CNOT7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAT2A | CNOT7 |
| Catalyzes the formation of S-adenosylmethionine frommethionine and ATP. The reaction comprises two steps that are bothcatalyzed by the same enzyme: formation of S-adenosylmethionine(AdoMet) and triphosphate, and subsequent hydrolysis of thetriphosphate. {ECO:0000269|PubMed:10644686,ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:25075345}. | Has 3'-5' poly(A) exoribonuclease activity for syntheticpoly(A) RNA substrate. Its function seems to be partiallyredundant with that of CNOT8. Catalytic component of the CCR4-NOTcomplex which is one of the major cellular mRNA deadenylases andis linked to various cellular processes including bulk mRNAdegradation, miRNA-mediated repression, translational repressionduring translational initiation and general transcriptionregulation. During miRNA-mediated repression the complex seemsalso to act as translational repressor during translationalinitiation. Additional complex functions may be a consequence ofits influence on mRNA expression. Associates with members of theBTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. {ECO:0000269|PubMed:19605561,ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:20634287,ECO:0000269|PubMed:23236473}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAT2A_CNOT7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAT2A_CNOT7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAT2A_CNOT7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | MAT2A | P31153 | DB00118 | Ademetionine | S-adenosylmethionine synthase isoform type-2 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for MAT2A_CNOT7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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