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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21141

FusionGeneSummary for MAST4_UBE2V2

check button Fusion gene summary
Fusion gene informationFusion gene name: MAST4_UBE2V2
Fusion gene ID: 21141
HgeneTgene
Gene symbol

MAST4

UBE2V2

Gene ID

375449

7336

Gene namemicrotubule associated serine/threonine kinase family member 4ubiquitin conjugating enzyme E2 V2
Synonyms-DDVIT1|DDVit-1|EDAF-1|EDPF-1|EDPF1|MMS2|UEV-2|UEV2
Cytomap

5q12.3

8q11.21

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated serine/threonine-protein kinase 4ubiquitin-conjugating enzyme E2 variant 21 alpha,25-dihydroxyvitamin D3-inducibleDDVit 1MMS2 homologenterocyte differentiation promoting factorenterocyte differentiation-associated factor 1enterocyte differentiation-associated factor EDAF-1enterocy
Modification date2018052320180523
UniProtAcc

O15021

Q15819

Ensembl transtripts involved in fusion geneENST00000404260, ENST00000403625, 
ENST00000406374, ENST00000406039, 
ENST00000478569, ENST00000490016, 
ENST00000403666, ENST00000405643, 
ENST00000261569, ENST00000407621, 
ENST00000523111, ENST00000521346, 
ENST00000517630, ENST00000520809, 
Fusion gene scores* DoF score10 X 9 X 7=6305 X 2 X 8=80
# samples 108
** MAII scorelog2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/80*10)=0
Context

PubMed: MAST4 [Title/Abstract] AND UBE2V2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-DU-A7TA-01AMAST4chr5

66255122

+UBE2V2chr8

48955593

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000404260ENST00000523111MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000404260ENST00000521346MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000404260ENST00000517630MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000404260ENST00000520809MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-3CDSENST00000403625ENST00000523111MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000403625ENST00000521346MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000403625ENST00000517630MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000403625ENST00000520809MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-3CDSENST00000406374ENST00000523111MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000406374ENST00000521346MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000406374ENST00000517630MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000406374ENST00000520809MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-3CDSENST00000406039ENST00000523111MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000406039ENST00000521346MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000406039ENST00000517630MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000406039ENST00000520809MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-3CDSENST00000478569ENST00000523111MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000478569ENST00000521346MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000478569ENST00000517630MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000478569ENST00000520809MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-3CDSENST00000490016ENST00000523111MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000490016ENST00000521346MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000490016ENST00000517630MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000490016ENST00000520809MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-3CDSENST00000403666ENST00000523111MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000403666ENST00000521346MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000403666ENST00000517630MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000403666ENST00000520809MAST4chr5

66255122

+UBE2V2chr8

48955593

+
Frame-shiftENST00000405643ENST00000523111MAST4chr5

66255122

+UBE2V2chr8

48955593

+
5CDS-5UTRENST00000405643ENST00000521346MAST4chr5

66255122

+UBE2V2chr8

48955593

+
5CDS-5UTRENST00000405643ENST00000517630MAST4chr5

66255122

+UBE2V2chr8

48955593

+
5CDS-5UTRENST00000405643ENST00000520809MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-3CDSENST00000261569ENST00000523111MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000261569ENST00000521346MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000261569ENST00000517630MAST4chr5

66255122

+UBE2V2chr8

48955593

+
intron-5UTRENST00000261569ENST00000520809MAST4chr5

66255122

+UBE2V2chr8

48955593

+
Frame-shiftENST00000407621ENST00000523111MAST4chr5

66255122

+UBE2V2chr8

48955593

+
5CDS-5UTRENST00000407621ENST00000521346MAST4chr5

66255122

+UBE2V2chr8

48955593

+
5CDS-5UTRENST00000407621ENST00000517630MAST4chr5

66255122

+UBE2V2chr8

48955593

+
5CDS-5UTRENST00000407621ENST00000520809MAST4chr5

66255122

+UBE2V2chr8

48955593

+

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FusionProtFeatures for MAST4_UBE2V2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAST4

O15021

UBE2V2

Q15819

Has no ubiquitin ligase activity on its own. TheUBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonicalpoly-ubiquitin chains that are linked through 'Lys-63'. This typeof poly-ubiquitination does not lead to protein degradation by theproteasome. Mediates transcriptional activation of target genes.Plays a role in the control of progress through the cell cycle anddifferentiation. Plays a role in the error-free DNA repair pathwayand contributes to the survival of cells after DNA damage.{ECO:0000269|PubMed:10089880, ECO:0000269|PubMed:14562038,ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:9705497}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAST4_UBE2V2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAST4_UBE2V2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAST4SMAD1UBE2V2MOB4, LRIF1, IGSF21, HLTF, EGFR, XIAP, ZNRF1, SIAH1, DZIP3, MKRN3, RNF144A, RNF2, TRIM5, UBE2N, RNF8, SHPRH, TRIM32, OTUB1, UBC, TRAF2, UBE2B, RAD23B, UBE2V1, ZYX, UBXN1, ATP6V1B2, USP9X, USP34, UBXN7, SSSCA1, TTLL12, VPS26A, STUB1, UBE2L3, SEC23A, CPLX1, ZFYVE19, ZPR1, ZRANB2, UFM1, CD2BP2, RPS21, TTC9C, RNF11, BCL10, MALT1, UBE2M, RHOA, POLK, TIGD6, RC3H2, RC3H1, TP53, MUL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAST4_UBE2V2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAST4_UBE2V2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource