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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21139

FusionGeneSummary for MAST4_PPWD1

check button Fusion gene summary
Fusion gene informationFusion gene name: MAST4_PPWD1
Fusion gene ID: 21139
HgeneTgene
Gene symbol

MAST4

PPWD1

Gene ID

375449

23398

Gene namemicrotubule associated serine/threonine kinase family member 4peptidylprolyl isomerase domain and WD repeat containing 1
Synonyms--
Cytomap

5q12.3

5q12.3

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated serine/threonine-protein kinase 4peptidylprolyl isomerase domain and WD repeat-containing protein 1spliceosome-associated cyclophilin
Modification date2018052320180523
UniProtAcc

O15021

Q96BP3

Ensembl transtripts involved in fusion geneENST00000404260, ENST00000403625, 
ENST00000406374, ENST00000406039, 
ENST00000478569, ENST00000490016, 
ENST00000403666, ENST00000405643, 
ENST00000261569, ENST00000407621, 
ENST00000261308, ENST00000535264, 
ENST00000538977, 
Fusion gene scores* DoF score10 X 9 X 7=6303 X 2 X 3=18
# samples 103
** MAII scorelog2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MAST4 [Title/Abstract] AND PPWD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPWD1

GO:0000413

protein peptidyl-prolyl isomerization

20676357


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-59-2363-01AMAST4chr5

66386059

+PPWD1chr5

64863340

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000404260ENST00000261308MAST4chr5

66386059

+PPWD1chr5

64863340

+
Frame-shiftENST00000404260ENST00000535264MAST4chr5

66386059

+PPWD1chr5

64863340

+
5CDS-intronENST00000404260ENST00000538977MAST4chr5

66386059

+PPWD1chr5

64863340

+
Frame-shiftENST00000403625ENST00000261308MAST4chr5

66386059

+PPWD1chr5

64863340

+
Frame-shiftENST00000403625ENST00000535264MAST4chr5

66386059

+PPWD1chr5

64863340

+
5CDS-intronENST00000403625ENST00000538977MAST4chr5

66386059

+PPWD1chr5

64863340

+
intron-3CDSENST00000406374ENST00000261308MAST4chr5

66386059

+PPWD1chr5

64863340

+
intron-3CDSENST00000406374ENST00000535264MAST4chr5

66386059

+PPWD1chr5

64863340

+
intron-intronENST00000406374ENST00000538977MAST4chr5

66386059

+PPWD1chr5

64863340

+
intron-3CDSENST00000406039ENST00000261308MAST4chr5

66386059

+PPWD1chr5

64863340

+
intron-3CDSENST00000406039ENST00000535264MAST4chr5

66386059

+PPWD1chr5

64863340

+
intron-intronENST00000406039ENST00000538977MAST4chr5

66386059

+PPWD1chr5

64863340

+
intron-3CDSENST00000478569ENST00000261308MAST4chr5

66386059

+PPWD1chr5

64863340

+
intron-3CDSENST00000478569ENST00000535264MAST4chr5

66386059

+PPWD1chr5

64863340

+
intron-intronENST00000478569ENST00000538977MAST4chr5

66386059

+PPWD1chr5

64863340

+
Frame-shiftENST00000490016ENST00000261308MAST4chr5

66386059

+PPWD1chr5

64863340

+
Frame-shiftENST00000490016ENST00000535264MAST4chr5

66386059

+PPWD1chr5

64863340

+
5CDS-intronENST00000490016ENST00000538977MAST4chr5

66386059

+PPWD1chr5

64863340

+
Frame-shiftENST00000403666ENST00000261308MAST4chr5

66386059

+PPWD1chr5

64863340

+
Frame-shiftENST00000403666ENST00000535264MAST4chr5

66386059

+PPWD1chr5

64863340

+
5CDS-intronENST00000403666ENST00000538977MAST4chr5

66386059

+PPWD1chr5

64863340

+
Frame-shiftENST00000405643ENST00000261308MAST4chr5

66386059

+PPWD1chr5

64863340

+
Frame-shiftENST00000405643ENST00000535264MAST4chr5

66386059

+PPWD1chr5

64863340

+
5CDS-intronENST00000405643ENST00000538977MAST4chr5

66386059

+PPWD1chr5

64863340

+
Frame-shiftENST00000261569ENST00000261308MAST4chr5

66386059

+PPWD1chr5

64863340

+
Frame-shiftENST00000261569ENST00000535264MAST4chr5

66386059

+PPWD1chr5

64863340

+
5CDS-intronENST00000261569ENST00000538977MAST4chr5

66386059

+PPWD1chr5

64863340

+
intron-3CDSENST00000407621ENST00000261308MAST4chr5

66386059

+PPWD1chr5

64863340

+
intron-3CDSENST00000407621ENST00000535264MAST4chr5

66386059

+PPWD1chr5

64863340

+
intron-intronENST00000407621ENST00000538977MAST4chr5

66386059

+PPWD1chr5

64863340

+

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FusionProtFeatures for MAST4_PPWD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAST4

O15021

PPWD1

Q96BP3

PPIase that catalyzes the cis-trans isomerization ofproline imidic peptide bonds in oligopeptides and may thereforeassist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638). {ECO:0000269|PubMed:11991638,ECO:0000269|PubMed:20676357}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAST4_PPWD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAST4_PPWD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAST4SMAD1PPWD1EED, ADRBK1, ACOX1, DDX6, PTPRF, PTBP3, NTRK1, SEC13, ZNF232


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAST4_PPWD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAST4_PPWD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource