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Fusion gene ID: 21106 |
FusionGeneSummary for MARVELD2_TRIM5 |
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Fusion gene information | Fusion gene name: MARVELD2_TRIM5 | Fusion gene ID: 21106 | Hgene | Tgene | Gene symbol | MARVELD2 | TRIM5 | Gene ID | 153562 | 85363 |
Gene name | MARVEL domain containing 2 | tripartite motif containing 5 | |
Synonyms | DFNB49|MARVD2|MRVLDC2|Tric | RNF88|TRIM5alpha | |
Cytomap | 5q13.2 | 11p15.4 | |
Type of gene | protein-coding | protein-coding | |
Description | MARVEL domain-containing protein 2MARVEL (membrane-associating) domain containing 2tricellulin | tripartite motif-containing protein 5RING-type E3 ubiquitin transferase TRIM5ring finger protein 88tripartite motif containing 5 transcript variant iotatripartite motif containing 5 transcript variant kappatripartite motif protein TRIM5 | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | Q8N4S9 | Q9C035 | |
Ensembl transtripts involved in fusion gene | ENST00000325631, ENST00000413223, | ENST00000380027, ENST00000396855, ENST00000305836, ENST00000380034, ENST00000396847, ENST00000483835, ENST00000396853, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 4 X 2=32 |
# samples | 3 | 4 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MARVELD2 [Title/Abstract] AND TRIM5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TRIM5 | GO:0002218 | activation of innate immune response | 21512573 |
Tgene | TRIM5 | GO:0006914 | autophagy | 25127057 |
Tgene | TRIM5 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 23077300 |
Tgene | TRIM5 | GO:0045087 | innate immune response | 18248090 |
Tgene | TRIM5 | GO:0046597 | negative regulation of viral entry into host cell | 18248090 |
Tgene | TRIM5 | GO:0070534 | protein K63-linked ubiquitination | 21512573 |
Tgene | TRIM5 | GO:1902187 | negative regulation of viral release from host cell | 18248090 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW379451 | MARVELD2 | chr5 | 68715727 | - | TRIM5 | chr11 | 5729418 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000325631 | ENST00000380027 | MARVELD2 | chr5 | 68715727 | - | TRIM5 | chr11 | 5729418 | - |
5CDS-intron | ENST00000325631 | ENST00000396855 | MARVELD2 | chr5 | 68715727 | - | TRIM5 | chr11 | 5729418 | - |
5CDS-intron | ENST00000325631 | ENST00000305836 | MARVELD2 | chr5 | 68715727 | - | TRIM5 | chr11 | 5729418 | - |
5CDS-intron | ENST00000325631 | ENST00000380034 | MARVELD2 | chr5 | 68715727 | - | TRIM5 | chr11 | 5729418 | - |
5CDS-intron | ENST00000325631 | ENST00000396847 | MARVELD2 | chr5 | 68715727 | - | TRIM5 | chr11 | 5729418 | - |
5CDS-intron | ENST00000325631 | ENST00000483835 | MARVELD2 | chr5 | 68715727 | - | TRIM5 | chr11 | 5729418 | - |
5CDS-intron | ENST00000325631 | ENST00000396853 | MARVELD2 | chr5 | 68715727 | - | TRIM5 | chr11 | 5729418 | - |
5CDS-intron | ENST00000413223 | ENST00000380027 | MARVELD2 | chr5 | 68715727 | - | TRIM5 | chr11 | 5729418 | - |
5CDS-intron | ENST00000413223 | ENST00000396855 | MARVELD2 | chr5 | 68715727 | - | TRIM5 | chr11 | 5729418 | - |
5CDS-intron | ENST00000413223 | ENST00000305836 | MARVELD2 | chr5 | 68715727 | - | TRIM5 | chr11 | 5729418 | - |
5CDS-intron | ENST00000413223 | ENST00000380034 | MARVELD2 | chr5 | 68715727 | - | TRIM5 | chr11 | 5729418 | - |
5CDS-intron | ENST00000413223 | ENST00000396847 | MARVELD2 | chr5 | 68715727 | - | TRIM5 | chr11 | 5729418 | - |
5CDS-intron | ENST00000413223 | ENST00000483835 | MARVELD2 | chr5 | 68715727 | - | TRIM5 | chr11 | 5729418 | - |
5CDS-intron | ENST00000413223 | ENST00000396853 | MARVELD2 | chr5 | 68715727 | - | TRIM5 | chr11 | 5729418 | - |
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FusionProtFeatures for MARVELD2_TRIM5 |
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Hgene | Tgene |
MARVELD2 | TRIM5 |
Plays a role in the formation of the epithelialbarriers. The separation of the endolymphatic and perilymphaticspaces of the organ of Corti from one another by epithelialbarriers is required for normal hearing.{ECO:0000269|PubMed:17186462}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MARVELD2_TRIM5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MARVELD2_TRIM5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MARVELD2_TRIM5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MARVELD2_TRIM5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TRIM5 | C0019693 | HIV Infections | 1 | CTD_human |