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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21106

FusionGeneSummary for MARVELD2_TRIM5

check button Fusion gene summary
Fusion gene informationFusion gene name: MARVELD2_TRIM5
Fusion gene ID: 21106
HgeneTgene
Gene symbol

MARVELD2

TRIM5

Gene ID

153562

85363

Gene nameMARVEL domain containing 2tripartite motif containing 5
SynonymsDFNB49|MARVD2|MRVLDC2|TricRNF88|TRIM5alpha
Cytomap

5q13.2

11p15.4

Type of geneprotein-codingprotein-coding
DescriptionMARVEL domain-containing protein 2MARVEL (membrane-associating) domain containing 2tricellulintripartite motif-containing protein 5RING-type E3 ubiquitin transferase TRIM5ring finger protein 88tripartite motif containing 5 transcript variant iotatripartite motif containing 5 transcript variant kappatripartite motif protein TRIM5
Modification date2018052720180519
UniProtAcc

Q8N4S9

Q9C035

Ensembl transtripts involved in fusion geneENST00000325631, ENST00000413223, 
ENST00000380027, ENST00000396855, 
ENST00000305836, ENST00000380034, 
ENST00000396847, ENST00000483835, 
ENST00000396853, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 4 X 2=32
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MARVELD2 [Title/Abstract] AND TRIM5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRIM5

GO:0002218

activation of innate immune response

21512573

TgeneTRIM5

GO:0006914

autophagy

25127057

TgeneTRIM5

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

23077300

TgeneTRIM5

GO:0045087

innate immune response

18248090

TgeneTRIM5

GO:0046597

negative regulation of viral entry into host cell

18248090

TgeneTRIM5

GO:0070534

protein K63-linked ubiquitination

21512573

TgeneTRIM5

GO:1902187

negative regulation of viral release from host cell

18248090


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW379451MARVELD2chr5

68715727

-TRIM5chr11

5729418

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000325631ENST00000380027MARVELD2chr5

68715727

-TRIM5chr11

5729418

-
5CDS-intronENST00000325631ENST00000396855MARVELD2chr5

68715727

-TRIM5chr11

5729418

-
5CDS-intronENST00000325631ENST00000305836MARVELD2chr5

68715727

-TRIM5chr11

5729418

-
5CDS-intronENST00000325631ENST00000380034MARVELD2chr5

68715727

-TRIM5chr11

5729418

-
5CDS-intronENST00000325631ENST00000396847MARVELD2chr5

68715727

-TRIM5chr11

5729418

-
5CDS-intronENST00000325631ENST00000483835MARVELD2chr5

68715727

-TRIM5chr11

5729418

-
5CDS-intronENST00000325631ENST00000396853MARVELD2chr5

68715727

-TRIM5chr11

5729418

-
5CDS-intronENST00000413223ENST00000380027MARVELD2chr5

68715727

-TRIM5chr11

5729418

-
5CDS-intronENST00000413223ENST00000396855MARVELD2chr5

68715727

-TRIM5chr11

5729418

-
5CDS-intronENST00000413223ENST00000305836MARVELD2chr5

68715727

-TRIM5chr11

5729418

-
5CDS-intronENST00000413223ENST00000380034MARVELD2chr5

68715727

-TRIM5chr11

5729418

-
5CDS-intronENST00000413223ENST00000396847MARVELD2chr5

68715727

-TRIM5chr11

5729418

-
5CDS-intronENST00000413223ENST00000483835MARVELD2chr5

68715727

-TRIM5chr11

5729418

-
5CDS-intronENST00000413223ENST00000396853MARVELD2chr5

68715727

-TRIM5chr11

5729418

-

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FusionProtFeatures for MARVELD2_TRIM5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MARVELD2

Q8N4S9

TRIM5

Q9C035

Plays a role in the formation of the epithelialbarriers. The separation of the endolymphatic and perilymphaticspaces of the organ of Corti from one another by epithelialbarriers is required for normal hearing.{ECO:0000269|PubMed:17186462}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MARVELD2_TRIM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MARVELD2_TRIM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MARVELD2_TRIM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MARVELD2_TRIM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTRIM5C0019693HIV Infections1CTD_human