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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 21105

FusionGeneSummary for MARVELD2_PIK3R1

check button Fusion gene summary
Fusion gene informationFusion gene name: MARVELD2_PIK3R1
Fusion gene ID: 21105
HgeneTgene
Gene symbol

MARVELD2

PIK3R1

Gene ID

153562

5295

Gene nameMARVEL domain containing 2phosphoinositide-3-kinase regulatory subunit 1
SynonymsDFNB49|MARVD2|MRVLDC2|TricAGM7|GRB1|IMD36|p85|p85-ALPHA
Cytomap

5q13.2

5q13.1

Type of geneprotein-codingprotein-coding
DescriptionMARVEL domain-containing protein 2MARVEL (membrane-associating) domain containing 2tricellulinphosphatidylinositol 3-kinase regulatory subunit alphaPI3-kinase subunit p85-alphaPI3K regulatory subunit alphaphosphatidylinositol 3-kinase 85 kDa regulatory subunit alphaphosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)ph
Modification date2018052720180523
UniProtAcc

Q8N4S9

P27986

Ensembl transtripts involved in fusion geneENST00000325631, ENST00000413223, 
ENST00000521381, ENST00000521657, 
ENST00000517643, ENST00000274335, 
ENST00000396611, ENST00000320694, 
ENST00000336483, ENST00000523872, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 6 X 3=108
# samples 36
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MARVELD2 [Title/Abstract] AND PIK3R1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePIK3R1

GO:0014065

phosphatidylinositol 3-kinase signaling

7782332

TgenePIK3R1

GO:0034976

response to endoplasmic reticulum stress

20348923

TgenePIK3R1

GO:0042307

positive regulation of protein import into nucleus

20348923

TgenePIK3R1

GO:0048009

insulin-like growth factor receptor signaling pathway

7782332

TgenePIK3R1

GO:0050821

protein stabilization

20348923

TgenePIK3R1

GO:0060396

growth hormone receptor signaling pathway

7782332


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-AP-A5FX-01AMARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000325631ENST00000521381MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
In-frameENST00000325631ENST00000521657MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
5CDS-intronENST00000325631ENST00000517643MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
5CDS-intronENST00000325631ENST00000274335MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
5CDS-intronENST00000325631ENST00000396611MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
5CDS-intronENST00000325631ENST00000320694MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
5CDS-intronENST00000325631ENST00000336483MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
5CDS-intronENST00000325631ENST00000523872MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
In-frameENST00000413223ENST00000521381MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
In-frameENST00000413223ENST00000521657MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
5CDS-intronENST00000413223ENST00000517643MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
5CDS-intronENST00000413223ENST00000274335MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
5CDS-intronENST00000413223ENST00000396611MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
5CDS-intronENST00000413223ENST00000320694MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
5CDS-intronENST00000413223ENST00000336483MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+
5CDS-intronENST00000413223ENST00000523872MARVELD2chr5

68720463

+PIK3R1chr5

67589537

+

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FusionProtFeatures for MARVELD2_PIK3R1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MARVELD2

Q8N4S9

PIK3R1

P27986

Plays a role in the formation of the epithelialbarriers. The separation of the endolymphatic and perilymphaticspaces of the organ of Corti from one another by epithelialbarriers is required for normal hearing.{ECO:0000269|PubMed:17186462}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+3745_52394559Compositional biasNote=Poly-Pro
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37188_367394559DomainMARVEL
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+371_194394559Topological domainCytoplasmic
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37216_223394559Topological domainExtracellular
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37245_254394559Topological domainCytoplasmic
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37276_291394559Topological domainExtracellular
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37313_319394559Topological domainCytoplasmic
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37338_341394559Topological domainExtracellular
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37195_215394559TransmembraneHelical
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37224_244394559TransmembraneHelical
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37255_275394559TransmembraneHelical
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37292_312394559TransmembraneHelical
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37320_337394559TransmembraneHelical
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37342_362394559TransmembraneHelical
TgenePIK3R1chr5:68720463chr5:67589537ENST00000274335+815624_718433725DomainSH2 2
TgenePIK3R1chr5:68720463chr5:67589537ENST00000320694+310333_428133425DomainSH2 1
TgenePIK3R1chr5:68720463chr5:67589537ENST00000320694+310624_718133425DomainSH2 2
TgenePIK3R1chr5:68720463chr5:67589537ENST00000336483+310333_428163455DomainSH2 1
TgenePIK3R1chr5:68720463chr5:67589537ENST00000336483+310624_718163455DomainSH2 2
TgenePIK3R1chr5:68720463chr5:67589537ENST00000396611+815624_718433733DomainSH2 2
TgenePIK3R1chr5:68720463chr5:67589537ENST00000521381+916624_718433725DomainSH2 2
TgenePIK3R1chr5:68720463chr5:67589537ENST00000521657+916624_718433725DomainSH2 2
TgenePIK3R1chr5:68720463chr5:67589537ENST00000523872+29113_30170362DomainRho-GAP
TgenePIK3R1chr5:68720463chr5:67589537ENST00000523872+29333_42870362DomainSH2 1
TgenePIK3R1chr5:68720463chr5:67589537ENST00000523872+29624_71870362DomainSH2 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37466_490394559Coiled coilOntology_term=ECO:0000255
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37524_548394559Coiled coilOntology_term=ECO:0000255
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37514_517394559Compositional biasNote=Poly-Lys
HgeneMARVELD2chr5:68720463chr5:67589537ENST00000325631+37363_558394559Topological domainCytoplasmic
TgenePIK3R1chr5:68720463chr5:67589537ENST00000274335+815113_301433725DomainRho-GAP
TgenePIK3R1chr5:68720463chr5:67589537ENST00000274335+815333_428433725DomainSH2 1
TgenePIK3R1chr5:68720463chr5:67589537ENST00000274335+8153_79433725DomainSH3
TgenePIK3R1chr5:68720463chr5:67589537ENST00000320694+310113_301133425DomainRho-GAP
TgenePIK3R1chr5:68720463chr5:67589537ENST00000320694+3103_79133425DomainSH3
TgenePIK3R1chr5:68720463chr5:67589537ENST00000336483+310113_301163455DomainRho-GAP
TgenePIK3R1chr5:68720463chr5:67589537ENST00000336483+3103_79163455DomainSH3
TgenePIK3R1chr5:68720463chr5:67589537ENST00000396611+815113_301433733DomainRho-GAP
TgenePIK3R1chr5:68720463chr5:67589537ENST00000396611+815333_428433733DomainSH2 1
TgenePIK3R1chr5:68720463chr5:67589537ENST00000396611+8153_79433733DomainSH3
TgenePIK3R1chr5:68720463chr5:67589537ENST00000521381+916113_301433725DomainRho-GAP
TgenePIK3R1chr5:68720463chr5:67589537ENST00000521381+916333_428433725DomainSH2 1
TgenePIK3R1chr5:68720463chr5:67589537ENST00000521381+9163_79433725DomainSH3
TgenePIK3R1chr5:68720463chr5:67589537ENST00000521657+916113_301433725DomainRho-GAP
TgenePIK3R1chr5:68720463chr5:67589537ENST00000521657+916333_428433725DomainSH2 1
TgenePIK3R1chr5:68720463chr5:67589537ENST00000521657+9163_79433725DomainSH3
TgenePIK3R1chr5:68720463chr5:67589537ENST00000523872+293_7970362DomainSH3


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FusionGeneSequence for MARVELD2_PIK3R1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MARVELD2_ENST00000325631_chr5_68720463_+_PIK3R1_ENST00000521381_chr5_67589537_+_686aa
MSNDGRSRNRDRRYDEVPSDLPTQDTTIRTHPTLHDSERAVSADPLPPPPLPLQPPFGPDFYSSDTEEPAIAPDLKPVRRFVPDSWKNFF
RGKKKDPEWDKPVSDIRYISDGVECSPPASPARPNHRSPLNSCKDPYGGSEGTFSSRKEADAVFPRDPTGSLDRHTQTVRTYSEKVEETN
LRYSYMKSWAGLLRILGVVELLLGAGVFACVTAYIHKDSEWYNLFGTSQPTGMGGVGGLGSMTGGTYYTGPKTPFVLVVAGLAWITTIII
LVLGMSMTYRTILLDSNWWPLTEFGINVALFILTMAAAIVTVNDTNRGGLCYTPLFNTPVNAVFCRVEGGQIAAMIFLFVTMIVTLISAL
VCLKLWRHEAARRHRETMEQQEINEPSLSSKRKMDQVVKEDNIEAVGKKLHETNTQFQEKSRETDRLTEETTRTSQEIQMKRTAIEAFNE
TIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNTDKLKSRISEIIDSRRRLEEDLKKQAAETREIDKRMNSIKPDLIQLRKTRDQ
YLMWLTQKGVRQKKLNEWLGNENTEDQTSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCTACSVVVDGEVKH

>In-frame_MARVELD2_ENST00000325631_chr5_68720463_+_PIK3R1_ENST00000521657_chr5_67589537_+_686aa
MSNDGRSRNRDRRYDEVPSDLPTQDTTIRTHPTLHDSERAVSADPLPPPPLPLQPPFGPDFYSSDTEEPAIAPDLKPVRRFVPDSWKNFF
RGKKKDPEWDKPVSDIRYISDGVECSPPASPARPNHRSPLNSCKDPYGGSEGTFSSRKEADAVFPRDPTGSLDRHTQTVRTYSEKVEETN
LRYSYMKSWAGLLRILGVVELLLGAGVFACVTAYIHKDSEWYNLFGTSQPTGMGGVGGLGSMTGGTYYTGPKTPFVLVVAGLAWITTIII
LVLGMSMTYRTILLDSNWWPLTEFGINVALFILTMAAAIVTVNDTNRGGLCYTPLFNTPVNAVFCRVEGGQIAAMIFLFVTMIVTLISAL
VCLKLWRHEAARRHRETMEQQEINEPSLSSKRKMDQVVKEDNIEAVGKKLHETNTQFQEKSRETDRLTEETTRTSQEIQMKRTAIEAFNE
TIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNTDKLKSRISEIIDSRRRLEEDLKKQAAETREIDKRMNSIKPDLIQLRKTRDQ
YLMWLTQKGVRQKKLNEWLGNENTEDQTSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCTACSVVVDGEVKH

>In-frame_MARVELD2_ENST00000413223_chr5_68720463_+_PIK3R1_ENST00000521381_chr5_67589537_+_570aa
MSNDGRSRNRDRRYDEVPSDLPTQDTTIRTHPTLHDSERAVSADPLPPPPLPLQPPFGPDFYSSDTEEPAIAPDLKPVRRFVPDSWKNFF
RGKKKDPEWDKPVSDIRYISDGVECSPPASPARPNHRSPLNSCKDPYGGSEGTFSSRKEADAVFPRDPTGSLDRHTQTVRTYSEKVEETN
LRYSYMKSWAGLLRILGVVELLLGAGVFACVTAYIHKDSEWYNLFGTSQPTGMGGVGGLGSIALVCLKLWRHEAARRHRETMEQQEINEP
SLSSKRKMDQVVKEDNIEAVGKKLHETNTQFQEKSRETDRLTEETTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKRE
GNEKEIQRIMHNTDKLKSRISEIIDSRRRLEEDLKKQAAETREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTED
QTSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCTACSVVVDGEVKHCVINKTATGTGFAEPTNLYSSLKELV

>In-frame_MARVELD2_ENST00000413223_chr5_68720463_+_PIK3R1_ENST00000521657_chr5_67589537_+_570aa
MSNDGRSRNRDRRYDEVPSDLPTQDTTIRTHPTLHDSERAVSADPLPPPPLPLQPPFGPDFYSSDTEEPAIAPDLKPVRRFVPDSWKNFF
RGKKKDPEWDKPVSDIRYISDGVECSPPASPARPNHRSPLNSCKDPYGGSEGTFSSRKEADAVFPRDPTGSLDRHTQTVRTYSEKVEETN
LRYSYMKSWAGLLRILGVVELLLGAGVFACVTAYIHKDSEWYNLFGTSQPTGMGGVGGLGSIALVCLKLWRHEAARRHRETMEQQEINEP
SLSSKRKMDQVVKEDNIEAVGKKLHETNTQFQEKSRETDRLTEETTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKRE
GNEKEIQRIMHNTDKLKSRISEIIDSRRRLEEDLKKQAAETREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTED
QTSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCTACSVVVDGEVKHCVINKTATGTGFAEPTNLYSSLKELV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MARVELD2_ENST00000325631_chr5_68720463_+_PIK3R1_ENST00000521381_chr5_67589537_+_2058nt
ATGTCAAATGATGGAAGATCCAGGAATCGGGACAGGCGCTACGATGAGGTCCCAAGCGACCTGCCCTATCAAGATACCACCATAAGAACC
CACCCAACTCTTCATGACAGTGAGCGGGCAGTGAGCGCTGATCCCTTGCCACCACCCCCTCTCCCATTACAGCCACCATTCGGCCCAGAC
TTCTACTCAAGTGACACAGAAGAACCAGCTATAGCGCCAGATCTCAAACCAGTAAGGCGCTTTGTCCCTGACTCCTGGAAGAACTTTTTC
AGAGGGAAGAAAAAGGACCCCGAATGGGATAAGCCGGTGTCTGATATCAGGTACATCTCCGATGGAGTGGAGTGTTCACCACCAGCCTCT
CCAGCAAGACCAAACCACCGTTCGCCCCTCAACTCCTGCAAAGATCCCTACGGAGGGTCAGAAGGAACCTTTAGTTCCCGGAAAGAGGCT
GACGCAGTGTTTCCCCGGGATCCCTATGGATCTCTAGACCGACACACACAAACAGTTCGAACATACAGTGAGAAGGTGGAGGAGTATAAC
CTGAGATACTCCTACATGAAGTCGTGGGCAGGCCTGCTGAGAATACTGGGTGTGGTGGAGCTGCTTTTGGGGGCCGGTGTCTTTGCTTGT
GTCACAGCTTACATTCACAAGGACAGTGAGTGGTACAACTTGTTTGGATATTCACAACCGTATGGCATGGGAGGCGTTGGTGGATTGGGC
AGTATGTATGGGGGCTATTACTACACTGGCCCTAAGACCCCTTTTGTACTCGTGGTTGCTGGATTAGCTTGGATCACCACCATTATTATT
CTGGTTCTTGGCATGTCCATGTATTACCGGACCATTCTTCTGGACTCTAATTGGTGGCCCCTAACTGAATTTGGAATTAACGTTGCCTTG
TTTATTTTGTATATGGCCGCAGCCATAGTCTATGTGAATGATACCAACCGAGGTGGCCTCTGCTACTATCCGTTATTTAATACACCAGTG
AATGCAGTGTTCTGCCGGGTAGAAGGAGGACAGATAGCTGCAATGATCTTCCTGTTTGTCACCATGATAGTTTATCTCATTAGTGCTTTG
GTTTGCCTAAAGTTATGGAGGCATGAGGCAGCTCGGAGACATAGAGAATATATGGAACAACAGGAGATAAATGAGCCATCATTGTCATCG
AAAAGGAAAATGGATCAAGTTGTCAAAGAAGATAATATTGAAGCTGTAGGGAAAAAATTACATGAATATAACACTCAGTTTCAAGAAAAA
AGTCGAGAATATGATAGATTATATGAAGAATATACCCGCACATCCCAGGAAATCCAAATGAAAAGGACAGCTATTGAAGCATTTAATGAA
ACCATAAAAATATTTGAAGAACAGTGCCAGACCCAAGAGCGGTACAGCAAAGAATACATAGAAAAGTTTAAACGTGAAGGCAATGAGAAA
GAAATACAAAGGATTATGCATAATTATGATAAGTTGAAGTCTCGAATCAGTGAAATTATTGACAGTAGAAGAAGATTGGAAGAAGACTTG
AAGAAGCAGGCAGCTGAGTATCGAGAAATTGACAAACGTATGAACAGCATTAAACCAGACCTTATCCAGCTGAGAAAGACGAGAGACCAA
TACTTGATGTGGTTGACTCAAAAAGGTGTTCGGCAAAAGAAGTTGAACGAGTGGTTGGGCAATGAAAACACTGAAGACCAATATTCACTG
GTGGAAGATGATGAAGATTTGCCCCATCATGATGAGAAGACATGGAATGTTGGAAGCAGCAACCGAAACAAAGCTGAAAACCTGTTGCGA
GGGAAGCGAGATGGCACTTTTCTTGTCCGGGAGAGCAGTAAACAGGGCTGCTATGCCTGCTCTGTAGTGGTGGACGGCGAAGTAAAGCAT
TGTGTCATAAACAAAACAGCAACTGGCTATGGCTTTGCCGAGCCCTATAACTTGTACAGCTCTCTGAAAGAACTGGTGCTACATTACCAA

>In-frame_MARVELD2_ENST00000325631_chr5_68720463_+_PIK3R1_ENST00000521657_chr5_67589537_+_2058nt
ATGTCAAATGATGGAAGATCCAGGAATCGGGACAGGCGCTACGATGAGGTCCCAAGCGACCTGCCCTATCAAGATACCACCATAAGAACC
CACCCAACTCTTCATGACAGTGAGCGGGCAGTGAGCGCTGATCCCTTGCCACCACCCCCTCTCCCATTACAGCCACCATTCGGCCCAGAC
TTCTACTCAAGTGACACAGAAGAACCAGCTATAGCGCCAGATCTCAAACCAGTAAGGCGCTTTGTCCCTGACTCCTGGAAGAACTTTTTC
AGAGGGAAGAAAAAGGACCCCGAATGGGATAAGCCGGTGTCTGATATCAGGTACATCTCCGATGGAGTGGAGTGTTCACCACCAGCCTCT
CCAGCAAGACCAAACCACCGTTCGCCCCTCAACTCCTGCAAAGATCCCTACGGAGGGTCAGAAGGAACCTTTAGTTCCCGGAAAGAGGCT
GACGCAGTGTTTCCCCGGGATCCCTATGGATCTCTAGACCGACACACACAAACAGTTCGAACATACAGTGAGAAGGTGGAGGAGTATAAC
CTGAGATACTCCTACATGAAGTCGTGGGCAGGCCTGCTGAGAATACTGGGTGTGGTGGAGCTGCTTTTGGGGGCCGGTGTCTTTGCTTGT
GTCACAGCTTACATTCACAAGGACAGTGAGTGGTACAACTTGTTTGGATATTCACAACCGTATGGCATGGGAGGCGTTGGTGGATTGGGC
AGTATGTATGGGGGCTATTACTACACTGGCCCTAAGACCCCTTTTGTACTCGTGGTTGCTGGATTAGCTTGGATCACCACCATTATTATT
CTGGTTCTTGGCATGTCCATGTATTACCGGACCATTCTTCTGGACTCTAATTGGTGGCCCCTAACTGAATTTGGAATTAACGTTGCCTTG
TTTATTTTGTATATGGCCGCAGCCATAGTCTATGTGAATGATACCAACCGAGGTGGCCTCTGCTACTATCCGTTATTTAATACACCAGTG
AATGCAGTGTTCTGCCGGGTAGAAGGAGGACAGATAGCTGCAATGATCTTCCTGTTTGTCACCATGATAGTTTATCTCATTAGTGCTTTG
GTTTGCCTAAAGTTATGGAGGCATGAGGCAGCTCGGAGACATAGAGAATATATGGAACAACAGGAGATAAATGAGCCATCATTGTCATCG
AAAAGGAAAATGGATCAAGTTGTCAAAGAAGATAATATTGAAGCTGTAGGGAAAAAATTACATGAATATAACACTCAGTTTCAAGAAAAA
AGTCGAGAATATGATAGATTATATGAAGAATATACCCGCACATCCCAGGAAATCCAAATGAAAAGGACAGCTATTGAAGCATTTAATGAA
ACCATAAAAATATTTGAAGAACAGTGCCAGACCCAAGAGCGGTACAGCAAAGAATACATAGAAAAGTTTAAACGTGAAGGCAATGAGAAA
GAAATACAAAGGATTATGCATAATTATGATAAGTTGAAGTCTCGAATCAGTGAAATTATTGACAGTAGAAGAAGATTGGAAGAAGACTTG
AAGAAGCAGGCAGCTGAGTATCGAGAAATTGACAAACGTATGAACAGCATTAAACCAGACCTTATCCAGCTGAGAAAGACGAGAGACCAA
TACTTGATGTGGTTGACTCAAAAAGGTGTTCGGCAAAAGAAGTTGAACGAGTGGTTGGGCAATGAAAACACTGAAGACCAATATTCACTG
GTGGAAGATGATGAAGATTTGCCCCATCATGATGAGAAGACATGGAATGTTGGAAGCAGCAACCGAAACAAAGCTGAAAACCTGTTGCGA
GGGAAGCGAGATGGCACTTTTCTTGTCCGGGAGAGCAGTAAACAGGGCTGCTATGCCTGCTCTGTAGTGGTGGACGGCGAAGTAAAGCAT
TGTGTCATAAACAAAACAGCAACTGGCTATGGCTTTGCCGAGCCCTATAACTTGTACAGCTCTCTGAAAGAACTGGTGCTACATTACCAA

>In-frame_MARVELD2_ENST00000413223_chr5_68720463_+_PIK3R1_ENST00000521381_chr5_67589537_+_1710nt
ATGTCAAATGATGGAAGATCCAGGAATCGGGACAGGCGCTACGATGAGGTCCCAAGCGACCTGCCCTATCAAGATACCACCATAAGAACC
CACCCAACTCTTCATGACAGTGAGCGGGCAGTGAGCGCTGATCCCTTGCCACCACCCCCTCTCCCATTACAGCCACCATTCGGCCCAGAC
TTCTACTCAAGTGACACAGAAGAACCAGCTATAGCGCCAGATCTCAAACCAGTAAGGCGCTTTGTCCCTGACTCCTGGAAGAACTTTTTC
AGAGGGAAGAAAAAGGACCCCGAATGGGATAAGCCGGTGTCTGATATCAGGTACATCTCCGATGGAGTGGAGTGTTCACCACCAGCCTCT
CCAGCAAGACCAAACCACCGTTCGCCCCTCAACTCCTGCAAAGATCCCTACGGAGGGTCAGAAGGAACCTTTAGTTCCCGGAAAGAGGCT
GACGCAGTGTTTCCCCGGGATCCCTATGGATCTCTAGACCGACACACACAAACAGTTCGAACATACAGTGAGAAGGTGGAGGAGTATAAC
CTGAGATACTCCTACATGAAGTCGTGGGCAGGCCTGCTGAGAATACTGGGTGTGGTGGAGCTGCTTTTGGGGGCCGGTGTCTTTGCTTGT
GTCACAGCTTACATTCACAAGGACAGTGAGTGGTACAACTTGTTTGGATATTCACAACCGTATGGCATGGGAGGCGTTGGTGGATTGGGC
AGTATTGCTTTGGTTTGCCTAAAGTTATGGAGGCATGAGGCAGCTCGGAGACATAGAGAATATATGGAACAACAGGAGATAAATGAGCCA
TCATTGTCATCGAAAAGGAAAATGGATCAAGTTGTCAAAGAAGATAATATTGAAGCTGTAGGGAAAAAATTACATGAATATAACACTCAG
TTTCAAGAAAAAAGTCGAGAATATGATAGATTATATGAAGAATATACCCGCACATCCCAGGAAATCCAAATGAAAAGGACAGCTATTGAA
GCATTTAATGAAACCATAAAAATATTTGAAGAACAGTGCCAGACCCAAGAGCGGTACAGCAAAGAATACATAGAAAAGTTTAAACGTGAA
GGCAATGAGAAAGAAATACAAAGGATTATGCATAATTATGATAAGTTGAAGTCTCGAATCAGTGAAATTATTGACAGTAGAAGAAGATTG
GAAGAAGACTTGAAGAAGCAGGCAGCTGAGTATCGAGAAATTGACAAACGTATGAACAGCATTAAACCAGACCTTATCCAGCTGAGAAAG
ACGAGAGACCAATACTTGATGTGGTTGACTCAAAAAGGTGTTCGGCAAAAGAAGTTGAACGAGTGGTTGGGCAATGAAAACACTGAAGAC
CAATATTCACTGGTGGAAGATGATGAAGATTTGCCCCATCATGATGAGAAGACATGGAATGTTGGAAGCAGCAACCGAAACAAAGCTGAA
AACCTGTTGCGAGGGAAGCGAGATGGCACTTTTCTTGTCCGGGAGAGCAGTAAACAGGGCTGCTATGCCTGCTCTGTAGTGGTGGACGGC
GAAGTAAAGCATTGTGTCATAAACAAAACAGCAACTGGCTATGGCTTTGCCGAGCCCTATAACTTGTACAGCTCTCTGAAAGAACTGGTG
CTACATTACCAACACACCTCCCTTGTGCAGCACAACGACTCCCTCAATGTCACACTAGCCTACCCAGTATATGCACAGCAGAGGCGATGA

>In-frame_MARVELD2_ENST00000413223_chr5_68720463_+_PIK3R1_ENST00000521657_chr5_67589537_+_1710nt
ATGTCAAATGATGGAAGATCCAGGAATCGGGACAGGCGCTACGATGAGGTCCCAAGCGACCTGCCCTATCAAGATACCACCATAAGAACC
CACCCAACTCTTCATGACAGTGAGCGGGCAGTGAGCGCTGATCCCTTGCCACCACCCCCTCTCCCATTACAGCCACCATTCGGCCCAGAC
TTCTACTCAAGTGACACAGAAGAACCAGCTATAGCGCCAGATCTCAAACCAGTAAGGCGCTTTGTCCCTGACTCCTGGAAGAACTTTTTC
AGAGGGAAGAAAAAGGACCCCGAATGGGATAAGCCGGTGTCTGATATCAGGTACATCTCCGATGGAGTGGAGTGTTCACCACCAGCCTCT
CCAGCAAGACCAAACCACCGTTCGCCCCTCAACTCCTGCAAAGATCCCTACGGAGGGTCAGAAGGAACCTTTAGTTCCCGGAAAGAGGCT
GACGCAGTGTTTCCCCGGGATCCCTATGGATCTCTAGACCGACACACACAAACAGTTCGAACATACAGTGAGAAGGTGGAGGAGTATAAC
CTGAGATACTCCTACATGAAGTCGTGGGCAGGCCTGCTGAGAATACTGGGTGTGGTGGAGCTGCTTTTGGGGGCCGGTGTCTTTGCTTGT
GTCACAGCTTACATTCACAAGGACAGTGAGTGGTACAACTTGTTTGGATATTCACAACCGTATGGCATGGGAGGCGTTGGTGGATTGGGC
AGTATTGCTTTGGTTTGCCTAAAGTTATGGAGGCATGAGGCAGCTCGGAGACATAGAGAATATATGGAACAACAGGAGATAAATGAGCCA
TCATTGTCATCGAAAAGGAAAATGGATCAAGTTGTCAAAGAAGATAATATTGAAGCTGTAGGGAAAAAATTACATGAATATAACACTCAG
TTTCAAGAAAAAAGTCGAGAATATGATAGATTATATGAAGAATATACCCGCACATCCCAGGAAATCCAAATGAAAAGGACAGCTATTGAA
GCATTTAATGAAACCATAAAAATATTTGAAGAACAGTGCCAGACCCAAGAGCGGTACAGCAAAGAATACATAGAAAAGTTTAAACGTGAA
GGCAATGAGAAAGAAATACAAAGGATTATGCATAATTATGATAAGTTGAAGTCTCGAATCAGTGAAATTATTGACAGTAGAAGAAGATTG
GAAGAAGACTTGAAGAAGCAGGCAGCTGAGTATCGAGAAATTGACAAACGTATGAACAGCATTAAACCAGACCTTATCCAGCTGAGAAAG
ACGAGAGACCAATACTTGATGTGGTTGACTCAAAAAGGTGTTCGGCAAAAGAAGTTGAACGAGTGGTTGGGCAATGAAAACACTGAAGAC
CAATATTCACTGGTGGAAGATGATGAAGATTTGCCCCATCATGATGAGAAGACATGGAATGTTGGAAGCAGCAACCGAAACAAAGCTGAA
AACCTGTTGCGAGGGAAGCGAGATGGCACTTTTCTTGTCCGGGAGAGCAGTAAACAGGGCTGCTATGCCTGCTCTGTAGTGGTGGACGGC
GAAGTAAAGCATTGTGTCATAAACAAAACAGCAACTGGCTATGGCTTTGCCGAGCCCTATAACTTGTACAGCTCTCTGAAAGAACTGGTG
CTACATTACCAACACACCTCCCTTGTGCAGCACAACGACTCCCTCAATGTCACACTAGCCTACCCAGTATATGCACAGCAGAGGCGATGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_MARVELD2_ENST00000325631_chr5_68720463_+_PIK3R1_ENST00000521381_chr5_67589537_+_6352nt
GCCCGATACCGGTTTCAGAGTCCTGGGCAGCGTGCGCGCTCTTCCTGGCGGCTGCGCAGGTGTGAAAATCACAAATGTCAAATGATGGAA
GATCCAGGAATCGGGACAGGCGCTACGATGAGGTCCCAAGCGACCTGCCCTATCAAGATACCACCATAAGAACCCACCCAACTCTTCATG
ACAGTGAGCGGGCAGTGAGCGCTGATCCCTTGCCACCACCCCCTCTCCCATTACAGCCACCATTCGGCCCAGACTTCTACTCAAGTGACA
CAGAAGAACCAGCTATAGCGCCAGATCTCAAACCAGTAAGGCGCTTTGTCCCTGACTCCTGGAAGAACTTTTTCAGAGGGAAGAAAAAGG
ACCCCGAATGGGATAAGCCGGTGTCTGATATCAGGTACATCTCCGATGGAGTGGAGTGTTCACCACCAGCCTCTCCAGCAAGACCAAACC
ACCGTTCGCCCCTCAACTCCTGCAAAGATCCCTACGGAGGGTCAGAAGGAACCTTTAGTTCCCGGAAAGAGGCTGACGCAGTGTTTCCCC
GGGATCCCTATGGATCTCTAGACCGACACACACAAACAGTTCGAACATACAGTGAGAAGGTGGAGGAGTATAACCTGAGATACTCCTACA
TGAAGTCGTGGGCAGGCCTGCTGAGAATACTGGGTGTGGTGGAGCTGCTTTTGGGGGCCGGTGTCTTTGCTTGTGTCACAGCTTACATTC
ACAAGGACAGTGAGTGGTACAACTTGTTTGGATATTCACAACCGTATGGCATGGGAGGCGTTGGTGGATTGGGCAGTATGTATGGGGGCT
ATTACTACACTGGCCCTAAGACCCCTTTTGTACTCGTGGTTGCTGGATTAGCTTGGATCACCACCATTATTATTCTGGTTCTTGGCATGT
CCATGTATTACCGGACCATTCTTCTGGACTCTAATTGGTGGCCCCTAACTGAATTTGGAATTAACGTTGCCTTGTTTATTTTGTATATGG
CCGCAGCCATAGTCTATGTGAATGATACCAACCGAGGTGGCCTCTGCTACTATCCGTTATTTAATACACCAGTGAATGCAGTGTTCTGCC
GGGTAGAAGGAGGACAGATAGCTGCAATGATCTTCCTGTTTGTCACCATGATAGTTTATCTCATTAGTGCTTTGGTTTGCCTAAAGTTAT
GGAGGCATGAGGCAGCTCGGAGACATAGAGAATATATGGAACAACAGGAGATAAATGAGCCATCATTGTCATCGAAAAGGAAAATGGATC
AAGTTGTCAAAGAAGATAATATTGAAGCTGTAGGGAAAAAATTACATGAATATAACACTCAGTTTCAAGAAAAAAGTCGAGAATATGATA
GATTATATGAAGAATATACCCGCACATCCCAGGAAATCCAAATGAAAAGGACAGCTATTGAAGCATTTAATGAAACCATAAAAATATTTG
AAGAACAGTGCCAGACCCAAGAGCGGTACAGCAAAGAATACATAGAAAAGTTTAAACGTGAAGGCAATGAGAAAGAAATACAAAGGATTA
TGCATAATTATGATAAGTTGAAGTCTCGAATCAGTGAAATTATTGACAGTAGAAGAAGATTGGAAGAAGACTTGAAGAAGCAGGCAGCTG
AGTATCGAGAAATTGACAAACGTATGAACAGCATTAAACCAGACCTTATCCAGCTGAGAAAGACGAGAGACCAATACTTGATGTGGTTGA
CTCAAAAAGGTGTTCGGCAAAAGAAGTTGAACGAGTGGTTGGGCAATGAAAACACTGAAGACCAATATTCACTGGTGGAAGATGATGAAG
ATTTGCCCCATCATGATGAGAAGACATGGAATGTTGGAAGCAGCAACCGAAACAAAGCTGAAAACCTGTTGCGAGGGAAGCGAGATGGCA
CTTTTCTTGTCCGGGAGAGCAGTAAACAGGGCTGCTATGCCTGCTCTGTAGTGGTGGACGGCGAAGTAAAGCATTGTGTCATAAACAAAA
CAGCAACTGGCTATGGCTTTGCCGAGCCCTATAACTTGTACAGCTCTCTGAAAGAACTGGTGCTACATTACCAACACACCTCCCTTGTGC
AGCACAACGACTCCCTCAATGTCACACTAGCCTACCCAGTATATGCACAGCAGAGGCGATGAAGCGCTTACTCTTTGATCCTTCTCCTGA
AGTTCAGCCACCCTGAGGCCTCTGGAAAGCAAAGGGCTCCTCTCCAGTCTGATCTGTGAATTGAGCTGCAGAAACGAAGCCATCTTTCTT
TGGATGGGACTAGAGCTTTCTTTCACAAAAAAGAAGTAGGGGAAGACATGCAGCCTAAGGCTGTATGATGACCACACGTTCCTAAGCTGG
AGTGCTTATCCCTTCTTTTTCTTTTTTTCTTTGGTTTAATTTAAAGCCACAACCACATACAACACAAAGAGAAAAAGAAATGCAAAAATC
TCTGCGTGCAGGGACAAAGAGGCCTTTAACCATGGTGCTTGTTAATGCTTTCTGAAGCTTTACCAGCTGAAAGTTGGGACTCTGGAGAGC
GGAGGAGAGAGAGGCAGAAGAACCCTGGCCTGAGAAGGTTTGGTCCAGCCTGGTTTAGCCTGGATGTTGCTGTGCACGGTGGACCCAGAC
ACATCGCACTGTGGATTATTTCATTTTGTAACAAATGAACGATATGTAGCAGAAAGGCACGTCCACTCACAAGGGACGCTTTGGGAGAAT
GTCAGTTCATGTATGTTCAGAAGAAATTCTGTCATAGAAAGTGCCAGAAAGTGTTTAACTTGTCAAAAAACAAAAACCCAGCAACAGAAA
AATGGAGTTTGGAAAACAGGACTTAAAATGACATTCAGTATATAAAATATGTACATAATATTGGATGACTAACTATCAAATAGATGGATT
TGTATCAATACCAAATAGCTTCTGTTTTGTTTTGCTGAAGGCTAAATTCACAGCGCTATGCAATTCTTAATTTTCATTAAGTTGTTATTT
CAGTTTTAAATGTACCTTCAGAATAAGCTTCCCCACCCCAGTTTTTGTTGCTTGAAAATATTGTTGTCCCGGATTTTTGTTAATATTCAT
TTTTGTTATCCTTTTTTAAAAGTAAATGTACAGGATGCCAGTAAAAAAAAAAAATGGCTTCAGAATTAAAACTATGAAATATTTTACAGT
TTTTCTTGTACAGAGTACTTGGCTGTTAGCCCAAGGTTAAAAAGTTCATAACAGATTTTTTTTGGACTGTTTTGTTGGGCAGTGCCTGAT
AAGCTTCAAAGCTGCTTTATTCAATAAAAAAAAGAAATGAAAAAGATATATGAATATGACAAAGTATTGCTGAGTCCAACAATGTTGTTT
TAAGACTCTTAAAATACGGTACCTGGCAATGTTTATTTCATAAAGAATTGTGAACTTCTTGAATCTAGGGAGGGGGAATGTAGTGAAGGG
ATGTATCAAGTGGGGTGGTGGGAGGGGGAGGCAAGGTTATATGCACTTTCTCATGATTTACAGAGAAGTGAATAACTGCAAAGTGAAGTT
GCTTCTTCTACTTCAGTCTTCTCTCACTTTGATTTGCTAGTTGTTATCAATTAATGACAATTACAAACCTACTGTATCTCTAATACAGTG
TGACTGGTCAGGTATTTCAGTTCTTAGGAAGGAAGTGCCAAGTTTGTTTTTGGGTTCCTGGAACAGCGCTCACCTTTGTTTAGAACACTG
GTTTAAAGGGATAATCATCTCTGTCACATTAGACTATCCATCATGACCAGCAAATACTCATTTTAGGAAAAAAAAAAGCATGATCTGAAA
AATACTTTTGGTGGTATGTTGGTTACCCTCCTAGCTTTCCATTTGGTTTAGAACATAAAGCAAATAGACACAGTCATACTGTCACTGCTC
TGGACTGTGTGGAGCTCGCTAAAGTCATGGTCATTGCAGGAATCCAAGTGGCAGTCCTTCTCATTCATTCTAATCATTGTATGTGCTTCA
CTACGGGGGGGAGAAGGAAACGTTAGCATCATGTTTCCCATTTAGGGCAGGAGTGAGAGGTCTCTCTTCCTGATTTAGATATGCAAAAGC
TGGTATGTTCAGTAGGAACTGTACATGTGTTGGGAGGCATAAAGACTAATTAGCAACCATAATATGGTCACTACCCTAATAGACTAAATG
AAATCTTGCAATTTCAAATTACTCTTTCTCCATATTAGATTTACCCACAGCTATATTTCTGTTTAAGTACTAGGGTGAGGGTTTTCTGTT
ACTTTGTTTTTTAATGTTGTTCCTTTTGAAAGAATCAGTCTTGCAGCTGAGTGAAAAATCTGTGGAATGTATTATTTGTCCTCTTTACAT
GAAACTACTCATACTTAAGCAAAAGTCAGTCTTATAGCAAGACTGTTAGCCCTCAAACTTGACTCTACTGATCTGACCATTTCCCTCTCA
TCGCCAGACAACTGACGATTTCCCTGGTTTTAGTCTGCGTCTCTGCTTTAAAGTTATTGTGATATCCTTCTAGATCATACACAAGTCTAA
CAGTTAATTAGTTAACAGTTTTTAAACTAGGTTTGTGGGTATTTTTTTGGTAGCACATGTATGCTATTACATACAAATTTTTATTTCTAA
AATATAAGATCTGAGATTGAATATTTTCATTAAAAGCTACAGTTTTGTGAATCTTTGTGCTTCAACATTCTTTGCAAGATGATACGGTAT
TTAGGCATTTGCCTTATTTTTGCATCTCACAAACATAAGTGCAATAGATCTTTTCATTGAACAGCAAAGTAGGATTCATCATTCCATATG
ACTTGAGTTACACCAGACCTGTTCTGCCCAATGCCTTTTTGATTACAGTGTAGCTTGCCCACCGCATTTGTCGTTTTAGATACTTTGCTA
GCCGGCCACTTTGGATTTCATCAGACAGTCCTAACAATATTGTCTGAACGGCTGAATATGAATAGATACAGCAGAGGCACTCCTGATATA
TGATTTTTATCCATGCGTCAGTTTTTCCCACCCAGTGTAGCATCCTAAAGATAAAGCCAGAAGCTAAGCTGCAGTGAGGCTGTGATTGGG
CGTAGAAGTGGGAGCATTGGGACCTCACATTACACACACGAGAGATCATAACCATGTGAAAAGGCAAAAAGCATGTGTTTGCAACATCTG
ATAACTTCATGGCCTTTGATAAATGTATATATGTATATGTGCATGGACTGTGTTTCCAGTACACCTTTCAGCCAAAACAGATCCACAGTA
GTTGTTGAGTTCAAGTACATAAAGTACATAACAAGCGAACGTCTAGTACAATTCTTACTTATGTGTATGGGATTTTTCCCTTTGAGGTTG
CTTTGTTTTGTCTTACAAAGGTGAAAATTGTTTGTAAGTGAAGTGAGAAGTTCATATTTCTTTGGCTTTTTTGTGTTTTTAAAAGTTACT
CCTTTTAGGGAGCTGGTCTGATGACTTGCTTAGCTTGGAAATCCTTGTTTTCAGTGTGTCGAGTCAAAATGTGTTTATGTGAGCTGTCAC
TGTGGGGAACCAATTGCTTTGTCATATAGCTGGTTATGAACTAGTAACATGTTTGGGAAGTCCTACTGATGTTCCTTTGGAAGAAAAAAT
CTGCTGGTTTTAACAACTGTGCTTTTGCTATGTATGGTATCCAAGTTAGTTGAAACGCAGACACTGAGATCTGTTTGAGTTTAGGGTCAT
TTTTAGAAAGGGGCAGTTTAAAGCACAATGTCTCACATGGGACAAAGTTCCAAAATGCCAAATTCTTATTTTTTAAAAAGCTAGTTCTAT
AAAATACTGGTATTATGGGTGGGGAGGAAATAGAATTGAGTCAATTGGAAAGACTATCCAACTTAACATGAAACTTGTCACCATGAGATA
GCATTAGCTGCCCAGGATGCTGCTATATATATATATATATATATATATGTGTGTGTGTGTGTGTGTGTGTGTGTATATATATATATATAT
ATATATATATATATATATATATATGTGTGTGTATATATATATATATGTGTATATATATATGTATATACATATATGTATATATATGCACAT
ATATATATGTATTTAAAAAAATCAAAACAAAAAAAAACTCATTTATACCTGTGTATTTTTTAAAGCTACAATCTGTTCAATGTTTTTAAA
AATCTGTTTATATGACATTGTTAAAATAAAGTTGGTCTTTTGACGAGAGGGAGGATGTCACGGTCAGTTGTAACTTTGCCTTCACAAGGC
AACTGGGGTGGGGGGTGGGGGTAGTGTGCCTCCTTGACATTTCGTTCAAGTTATAGATTCAATGGAGCTATGTCTTGTTTTAAGTTGCTT

>In-frame_MARVELD2_ENST00000325631_chr5_68720463_+_PIK3R1_ENST00000521657_chr5_67589537_+_3284nt
GCCCGATACCGGTTTCAGAGTCCTGGGCAGCGTGCGCGCTCTTCCTGGCGGCTGCGCAGGTGTGAAAATCACAAATGTCAAATGATGGAA
GATCCAGGAATCGGGACAGGCGCTACGATGAGGTCCCAAGCGACCTGCCCTATCAAGATACCACCATAAGAACCCACCCAACTCTTCATG
ACAGTGAGCGGGCAGTGAGCGCTGATCCCTTGCCACCACCCCCTCTCCCATTACAGCCACCATTCGGCCCAGACTTCTACTCAAGTGACA
CAGAAGAACCAGCTATAGCGCCAGATCTCAAACCAGTAAGGCGCTTTGTCCCTGACTCCTGGAAGAACTTTTTCAGAGGGAAGAAAAAGG
ACCCCGAATGGGATAAGCCGGTGTCTGATATCAGGTACATCTCCGATGGAGTGGAGTGTTCACCACCAGCCTCTCCAGCAAGACCAAACC
ACCGTTCGCCCCTCAACTCCTGCAAAGATCCCTACGGAGGGTCAGAAGGAACCTTTAGTTCCCGGAAAGAGGCTGACGCAGTGTTTCCCC
GGGATCCCTATGGATCTCTAGACCGACACACACAAACAGTTCGAACATACAGTGAGAAGGTGGAGGAGTATAACCTGAGATACTCCTACA
TGAAGTCGTGGGCAGGCCTGCTGAGAATACTGGGTGTGGTGGAGCTGCTTTTGGGGGCCGGTGTCTTTGCTTGTGTCACAGCTTACATTC
ACAAGGACAGTGAGTGGTACAACTTGTTTGGATATTCACAACCGTATGGCATGGGAGGCGTTGGTGGATTGGGCAGTATGTATGGGGGCT
ATTACTACACTGGCCCTAAGACCCCTTTTGTACTCGTGGTTGCTGGATTAGCTTGGATCACCACCATTATTATTCTGGTTCTTGGCATGT
CCATGTATTACCGGACCATTCTTCTGGACTCTAATTGGTGGCCCCTAACTGAATTTGGAATTAACGTTGCCTTGTTTATTTTGTATATGG
CCGCAGCCATAGTCTATGTGAATGATACCAACCGAGGTGGCCTCTGCTACTATCCGTTATTTAATACACCAGTGAATGCAGTGTTCTGCC
GGGTAGAAGGAGGACAGATAGCTGCAATGATCTTCCTGTTTGTCACCATGATAGTTTATCTCATTAGTGCTTTGGTTTGCCTAAAGTTAT
GGAGGCATGAGGCAGCTCGGAGACATAGAGAATATATGGAACAACAGGAGATAAATGAGCCATCATTGTCATCGAAAAGGAAAATGGATC
AAGTTGTCAAAGAAGATAATATTGAAGCTGTAGGGAAAAAATTACATGAATATAACACTCAGTTTCAAGAAAAAAGTCGAGAATATGATA
GATTATATGAAGAATATACCCGCACATCCCAGGAAATCCAAATGAAAAGGACAGCTATTGAAGCATTTAATGAAACCATAAAAATATTTG
AAGAACAGTGCCAGACCCAAGAGCGGTACAGCAAAGAATACATAGAAAAGTTTAAACGTGAAGGCAATGAGAAAGAAATACAAAGGATTA
TGCATAATTATGATAAGTTGAAGTCTCGAATCAGTGAAATTATTGACAGTAGAAGAAGATTGGAAGAAGACTTGAAGAAGCAGGCAGCTG
AGTATCGAGAAATTGACAAACGTATGAACAGCATTAAACCAGACCTTATCCAGCTGAGAAAGACGAGAGACCAATACTTGATGTGGTTGA
CTCAAAAAGGTGTTCGGCAAAAGAAGTTGAACGAGTGGTTGGGCAATGAAAACACTGAAGACCAATATTCACTGGTGGAAGATGATGAAG
ATTTGCCCCATCATGATGAGAAGACATGGAATGTTGGAAGCAGCAACCGAAACAAAGCTGAAAACCTGTTGCGAGGGAAGCGAGATGGCA
CTTTTCTTGTCCGGGAGAGCAGTAAACAGGGCTGCTATGCCTGCTCTGTAGTGGTGGACGGCGAAGTAAAGCATTGTGTCATAAACAAAA
CAGCAACTGGCTATGGCTTTGCCGAGCCCTATAACTTGTACAGCTCTCTGAAAGAACTGGTGCTACATTACCAACACACCTCCCTTGTGC
AGCACAACGACTCCCTCAATGTCACACTAGCCTACCCAGTATATGCACAGCAGAGGCGATGAAGCGCTTACTCTTTGATCCTTCTCCTGA
AGTTCAGCCACCCTGAGGCCTCTGGAAAGCAAAGGGCTCCTCTCCAGTCTGATCTGTGAATTGAGCTGCAGAAACGAAGCCATCTTTCTT
TGGATGGGACTAGAGCTTTCTTTCACAAAAAAGAAGTAGGGGAAGACATGCAGCCTAAGGCTGTATGATGACCACACGTTCCTAAGCTGG
AGTGCTTATCCCTTCTTTTTCTTTTTTTCTTTGGTTTAATTTAAAGCCACAACCACATACAACACAAAGAGAAAAAGAAATGCAAAAATC
TCTGCGTGCAGGGACAAAGAGGCCTTTAACCATGGTGCTTGTTAATGCTTTCTGAAGCTTTACCAGCTGAAAGTTGGGACTCTGGAGAGC
GGAGGAGAGAGAGGCAGAAGAACCCTGGCCTGAGAAGGTTTGGTCCAGCCTGGTTTAGCCTGGATGTTGCTGTGCACGGTGGACCCAGAC
ACATCGCACTGTGGATTATTTCATTTTGTAACAAATGAACGATATGTAGCAGAAAGGCACGTCCACTCACAAGGGACGCTTTGGGAGAAT
GTCAGTTCATGTATGTTCAGAAGAAATTCTGTCATAGAAAGTGCCAGAAAGTGTTTAACTTGTCAAAAAACAAAAACCCAGCAACAGAAA
AATGGAGTTTGGAAAACAGGACTTAAAATGACATTCAGTATATAAAATATGTACATAATATTGGATGACTAACTATCAAATAGATGGATT
TGTATCAATACCAAATAGCTTCTGTTTTGTTTTGCTGAAGGCTAAATTCACAGCGCTATGCAATTCTTAATTTTCATTAAGTTGTTATTT
CAGTTTTAAATGTACCTTCAGAATAAGCTTCCCCACCCCAGTTTTTGTTGCTTGAAAATATTGTTGTCCCGGATTTTTGTTAATATTCAT
TTTTGTTATCCTTTTTTAAAAGTAAATGTACAGGATGCCAGTAAAAAAAAAAAATGGCTTCAGAATTAAAACTATGAAATATTTTACAGT
TTTTCTTGTACAGAGTACTTGGCTGTTAGCCCAAGGTTAAAAAGTTCATAACAGATTTTTTTTGGACTGTTTTGTTGGGCAGTGCCTGAT

>In-frame_MARVELD2_ENST00000413223_chr5_68720463_+_PIK3R1_ENST00000521381_chr5_67589537_+_5948nt
CAGGTGTGAAAATCACAAATGTCAAATGATGGAAGATCCAGGAATCGGGACAGGCGCTACGATGAGGTCCCAAGCGACCTGCCCTATCAA
GATACCACCATAAGAACCCACCCAACTCTTCATGACAGTGAGCGGGCAGTGAGCGCTGATCCCTTGCCACCACCCCCTCTCCCATTACAG
CCACCATTCGGCCCAGACTTCTACTCAAGTGACACAGAAGAACCAGCTATAGCGCCAGATCTCAAACCAGTAAGGCGCTTTGTCCCTGAC
TCCTGGAAGAACTTTTTCAGAGGGAAGAAAAAGGACCCCGAATGGGATAAGCCGGTGTCTGATATCAGGTACATCTCCGATGGAGTGGAG
TGTTCACCACCAGCCTCTCCAGCAAGACCAAACCACCGTTCGCCCCTCAACTCCTGCAAAGATCCCTACGGAGGGTCAGAAGGAACCTTT
AGTTCCCGGAAAGAGGCTGACGCAGTGTTTCCCCGGGATCCCTATGGATCTCTAGACCGACACACACAAACAGTTCGAACATACAGTGAG
AAGGTGGAGGAGTATAACCTGAGATACTCCTACATGAAGTCGTGGGCAGGCCTGCTGAGAATACTGGGTGTGGTGGAGCTGCTTTTGGGG
GCCGGTGTCTTTGCTTGTGTCACAGCTTACATTCACAAGGACAGTGAGTGGTACAACTTGTTTGGATATTCACAACCGTATGGCATGGGA
GGCGTTGGTGGATTGGGCAGTATTGCTTTGGTTTGCCTAAAGTTATGGAGGCATGAGGCAGCTCGGAGACATAGAGAATATATGGAACAA
CAGGAGATAAATGAGCCATCATTGTCATCGAAAAGGAAAATGGATCAAGTTGTCAAAGAAGATAATATTGAAGCTGTAGGGAAAAAATTA
CATGAATATAACACTCAGTTTCAAGAAAAAAGTCGAGAATATGATAGATTATATGAAGAATATACCCGCACATCCCAGGAAATCCAAATG
AAAAGGACAGCTATTGAAGCATTTAATGAAACCATAAAAATATTTGAAGAACAGTGCCAGACCCAAGAGCGGTACAGCAAAGAATACATA
GAAAAGTTTAAACGTGAAGGCAATGAGAAAGAAATACAAAGGATTATGCATAATTATGATAAGTTGAAGTCTCGAATCAGTGAAATTATT
GACAGTAGAAGAAGATTGGAAGAAGACTTGAAGAAGCAGGCAGCTGAGTATCGAGAAATTGACAAACGTATGAACAGCATTAAACCAGAC
CTTATCCAGCTGAGAAAGACGAGAGACCAATACTTGATGTGGTTGACTCAAAAAGGTGTTCGGCAAAAGAAGTTGAACGAGTGGTTGGGC
AATGAAAACACTGAAGACCAATATTCACTGGTGGAAGATGATGAAGATTTGCCCCATCATGATGAGAAGACATGGAATGTTGGAAGCAGC
AACCGAAACAAAGCTGAAAACCTGTTGCGAGGGAAGCGAGATGGCACTTTTCTTGTCCGGGAGAGCAGTAAACAGGGCTGCTATGCCTGC
TCTGTAGTGGTGGACGGCGAAGTAAAGCATTGTGTCATAAACAAAACAGCAACTGGCTATGGCTTTGCCGAGCCCTATAACTTGTACAGC
TCTCTGAAAGAACTGGTGCTACATTACCAACACACCTCCCTTGTGCAGCACAACGACTCCCTCAATGTCACACTAGCCTACCCAGTATAT
GCACAGCAGAGGCGATGAAGCGCTTACTCTTTGATCCTTCTCCTGAAGTTCAGCCACCCTGAGGCCTCTGGAAAGCAAAGGGCTCCTCTC
CAGTCTGATCTGTGAATTGAGCTGCAGAAACGAAGCCATCTTTCTTTGGATGGGACTAGAGCTTTCTTTCACAAAAAAGAAGTAGGGGAA
GACATGCAGCCTAAGGCTGTATGATGACCACACGTTCCTAAGCTGGAGTGCTTATCCCTTCTTTTTCTTTTTTTCTTTGGTTTAATTTAA
AGCCACAACCACATACAACACAAAGAGAAAAAGAAATGCAAAAATCTCTGCGTGCAGGGACAAAGAGGCCTTTAACCATGGTGCTTGTTA
ATGCTTTCTGAAGCTTTACCAGCTGAAAGTTGGGACTCTGGAGAGCGGAGGAGAGAGAGGCAGAAGAACCCTGGCCTGAGAAGGTTTGGT
CCAGCCTGGTTTAGCCTGGATGTTGCTGTGCACGGTGGACCCAGACACATCGCACTGTGGATTATTTCATTTTGTAACAAATGAACGATA
TGTAGCAGAAAGGCACGTCCACTCACAAGGGACGCTTTGGGAGAATGTCAGTTCATGTATGTTCAGAAGAAATTCTGTCATAGAAAGTGC
CAGAAAGTGTTTAACTTGTCAAAAAACAAAAACCCAGCAACAGAAAAATGGAGTTTGGAAAACAGGACTTAAAATGACATTCAGTATATA
AAATATGTACATAATATTGGATGACTAACTATCAAATAGATGGATTTGTATCAATACCAAATAGCTTCTGTTTTGTTTTGCTGAAGGCTA
AATTCACAGCGCTATGCAATTCTTAATTTTCATTAAGTTGTTATTTCAGTTTTAAATGTACCTTCAGAATAAGCTTCCCCACCCCAGTTT
TTGTTGCTTGAAAATATTGTTGTCCCGGATTTTTGTTAATATTCATTTTTGTTATCCTTTTTTAAAAGTAAATGTACAGGATGCCAGTAA
AAAAAAAAAATGGCTTCAGAATTAAAACTATGAAATATTTTACAGTTTTTCTTGTACAGAGTACTTGGCTGTTAGCCCAAGGTTAAAAAG
TTCATAACAGATTTTTTTTGGACTGTTTTGTTGGGCAGTGCCTGATAAGCTTCAAAGCTGCTTTATTCAATAAAAAAAAGAAATGAAAAA
GATATATGAATATGACAAAGTATTGCTGAGTCCAACAATGTTGTTTTAAGACTCTTAAAATACGGTACCTGGCAATGTTTATTTCATAAA
GAATTGTGAACTTCTTGAATCTAGGGAGGGGGAATGTAGTGAAGGGATGTATCAAGTGGGGTGGTGGGAGGGGGAGGCAAGGTTATATGC
ACTTTCTCATGATTTACAGAGAAGTGAATAACTGCAAAGTGAAGTTGCTTCTTCTACTTCAGTCTTCTCTCACTTTGATTTGCTAGTTGT
TATCAATTAATGACAATTACAAACCTACTGTATCTCTAATACAGTGTGACTGGTCAGGTATTTCAGTTCTTAGGAAGGAAGTGCCAAGTT
TGTTTTTGGGTTCCTGGAACAGCGCTCACCTTTGTTTAGAACACTGGTTTAAAGGGATAATCATCTCTGTCACATTAGACTATCCATCAT
GACCAGCAAATACTCATTTTAGGAAAAAAAAAAGCATGATCTGAAAAATACTTTTGGTGGTATGTTGGTTACCCTCCTAGCTTTCCATTT
GGTTTAGAACATAAAGCAAATAGACACAGTCATACTGTCACTGCTCTGGACTGTGTGGAGCTCGCTAAAGTCATGGTCATTGCAGGAATC
CAAGTGGCAGTCCTTCTCATTCATTCTAATCATTGTATGTGCTTCACTACGGGGGGGAGAAGGAAACGTTAGCATCATGTTTCCCATTTA
GGGCAGGAGTGAGAGGTCTCTCTTCCTGATTTAGATATGCAAAAGCTGGTATGTTCAGTAGGAACTGTACATGTGTTGGGAGGCATAAAG
ACTAATTAGCAACCATAATATGGTCACTACCCTAATAGACTAAATGAAATCTTGCAATTTCAAATTACTCTTTCTCCATATTAGATTTAC
CCACAGCTATATTTCTGTTTAAGTACTAGGGTGAGGGTTTTCTGTTACTTTGTTTTTTAATGTTGTTCCTTTTGAAAGAATCAGTCTTGC
AGCTGAGTGAAAAATCTGTGGAATGTATTATTTGTCCTCTTTACATGAAACTACTCATACTTAAGCAAAAGTCAGTCTTATAGCAAGACT
GTTAGCCCTCAAACTTGACTCTACTGATCTGACCATTTCCCTCTCATCGCCAGACAACTGACGATTTCCCTGGTTTTAGTCTGCGTCTCT
GCTTTAAAGTTATTGTGATATCCTTCTAGATCATACACAAGTCTAACAGTTAATTAGTTAACAGTTTTTAAACTAGGTTTGTGGGTATTT
TTTTGGTAGCACATGTATGCTATTACATACAAATTTTTATTTCTAAAATATAAGATCTGAGATTGAATATTTTCATTAAAAGCTACAGTT
TTGTGAATCTTTGTGCTTCAACATTCTTTGCAAGATGATACGGTATTTAGGCATTTGCCTTATTTTTGCATCTCACAAACATAAGTGCAA
TAGATCTTTTCATTGAACAGCAAAGTAGGATTCATCATTCCATATGACTTGAGTTACACCAGACCTGTTCTGCCCAATGCCTTTTTGATT
ACAGTGTAGCTTGCCCACCGCATTTGTCGTTTTAGATACTTTGCTAGCCGGCCACTTTGGATTTCATCAGACAGTCCTAACAATATTGTC
TGAACGGCTGAATATGAATAGATACAGCAGAGGCACTCCTGATATATGATTTTTATCCATGCGTCAGTTTTTCCCACCCAGTGTAGCATC
CTAAAGATAAAGCCAGAAGCTAAGCTGCAGTGAGGCTGTGATTGGGCGTAGAAGTGGGAGCATTGGGACCTCACATTACACACACGAGAG
ATCATAACCATGTGAAAAGGCAAAAAGCATGTGTTTGCAACATCTGATAACTTCATGGCCTTTGATAAATGTATATATGTATATGTGCAT
GGACTGTGTTTCCAGTACACCTTTCAGCCAAAACAGATCCACAGTAGTTGTTGAGTTCAAGTACATAAAGTACATAACAAGCGAACGTCT
AGTACAATTCTTACTTATGTGTATGGGATTTTTCCCTTTGAGGTTGCTTTGTTTTGTCTTACAAAGGTGAAAATTGTTTGTAAGTGAAGT
GAGAAGTTCATATTTCTTTGGCTTTTTTGTGTTTTTAAAAGTTACTCCTTTTAGGGAGCTGGTCTGATGACTTGCTTAGCTTGGAAATCC
TTGTTTTCAGTGTGTCGAGTCAAAATGTGTTTATGTGAGCTGTCACTGTGGGGAACCAATTGCTTTGTCATATAGCTGGTTATGAACTAG
TAACATGTTTGGGAAGTCCTACTGATGTTCCTTTGGAAGAAAAAATCTGCTGGTTTTAACAACTGTGCTTTTGCTATGTATGGTATCCAA
GTTAGTTGAAACGCAGACACTGAGATCTGTTTGAGTTTAGGGTCATTTTTAGAAAGGGGCAGTTTAAAGCACAATGTCTCACATGGGACA
AAGTTCCAAAATGCCAAATTCTTATTTTTTAAAAAGCTAGTTCTATAAAATACTGGTATTATGGGTGGGGAGGAAATAGAATTGAGTCAA
TTGGAAAGACTATCCAACTTAACATGAAACTTGTCACCATGAGATAGCATTAGCTGCCCAGGATGCTGCTATATATATATATATATATAT
ATATGTGTGTGTGTGTGTGTGTGTGTGTGTATATATATATATATATATATATATATATATATATATATATGTGTGTGTATATATATATAT
ATGTGTATATATATATGTATATACATATATGTATATATATGCACATATATATATGTATTTAAAAAAATCAAAACAAAAAAAAACTCATTT
ATACCTGTGTATTTTTTAAAGCTACAATCTGTTCAATGTTTTTAAAAATCTGTTTATATGACATTGTTAAAATAAAGTTGGTCTTTTGAC
GAGAGGGAGGATGTCACGGTCAGTTGTAACTTTGCCTTCACAAGGCAACTGGGGTGGGGGGTGGGGGTAGTGTGCCTCCTTGACATTTCG
TTCAAGTTATAGATTCAATGGAGCTATGTCTTGTTTTAAGTTGCTTTAATGCATTGTATTAGATCTTCAAACAGAATAAAGGTTGTTTTG

>In-frame_MARVELD2_ENST00000413223_chr5_68720463_+_PIK3R1_ENST00000521657_chr5_67589537_+_2880nt
CAGGTGTGAAAATCACAAATGTCAAATGATGGAAGATCCAGGAATCGGGACAGGCGCTACGATGAGGTCCCAAGCGACCTGCCCTATCAA
GATACCACCATAAGAACCCACCCAACTCTTCATGACAGTGAGCGGGCAGTGAGCGCTGATCCCTTGCCACCACCCCCTCTCCCATTACAG
CCACCATTCGGCCCAGACTTCTACTCAAGTGACACAGAAGAACCAGCTATAGCGCCAGATCTCAAACCAGTAAGGCGCTTTGTCCCTGAC
TCCTGGAAGAACTTTTTCAGAGGGAAGAAAAAGGACCCCGAATGGGATAAGCCGGTGTCTGATATCAGGTACATCTCCGATGGAGTGGAG
TGTTCACCACCAGCCTCTCCAGCAAGACCAAACCACCGTTCGCCCCTCAACTCCTGCAAAGATCCCTACGGAGGGTCAGAAGGAACCTTT
AGTTCCCGGAAAGAGGCTGACGCAGTGTTTCCCCGGGATCCCTATGGATCTCTAGACCGACACACACAAACAGTTCGAACATACAGTGAG
AAGGTGGAGGAGTATAACCTGAGATACTCCTACATGAAGTCGTGGGCAGGCCTGCTGAGAATACTGGGTGTGGTGGAGCTGCTTTTGGGG
GCCGGTGTCTTTGCTTGTGTCACAGCTTACATTCACAAGGACAGTGAGTGGTACAACTTGTTTGGATATTCACAACCGTATGGCATGGGA
GGCGTTGGTGGATTGGGCAGTATTGCTTTGGTTTGCCTAAAGTTATGGAGGCATGAGGCAGCTCGGAGACATAGAGAATATATGGAACAA
CAGGAGATAAATGAGCCATCATTGTCATCGAAAAGGAAAATGGATCAAGTTGTCAAAGAAGATAATATTGAAGCTGTAGGGAAAAAATTA
CATGAATATAACACTCAGTTTCAAGAAAAAAGTCGAGAATATGATAGATTATATGAAGAATATACCCGCACATCCCAGGAAATCCAAATG
AAAAGGACAGCTATTGAAGCATTTAATGAAACCATAAAAATATTTGAAGAACAGTGCCAGACCCAAGAGCGGTACAGCAAAGAATACATA
GAAAAGTTTAAACGTGAAGGCAATGAGAAAGAAATACAAAGGATTATGCATAATTATGATAAGTTGAAGTCTCGAATCAGTGAAATTATT
GACAGTAGAAGAAGATTGGAAGAAGACTTGAAGAAGCAGGCAGCTGAGTATCGAGAAATTGACAAACGTATGAACAGCATTAAACCAGAC
CTTATCCAGCTGAGAAAGACGAGAGACCAATACTTGATGTGGTTGACTCAAAAAGGTGTTCGGCAAAAGAAGTTGAACGAGTGGTTGGGC
AATGAAAACACTGAAGACCAATATTCACTGGTGGAAGATGATGAAGATTTGCCCCATCATGATGAGAAGACATGGAATGTTGGAAGCAGC
AACCGAAACAAAGCTGAAAACCTGTTGCGAGGGAAGCGAGATGGCACTTTTCTTGTCCGGGAGAGCAGTAAACAGGGCTGCTATGCCTGC
TCTGTAGTGGTGGACGGCGAAGTAAAGCATTGTGTCATAAACAAAACAGCAACTGGCTATGGCTTTGCCGAGCCCTATAACTTGTACAGC
TCTCTGAAAGAACTGGTGCTACATTACCAACACACCTCCCTTGTGCAGCACAACGACTCCCTCAATGTCACACTAGCCTACCCAGTATAT
GCACAGCAGAGGCGATGAAGCGCTTACTCTTTGATCCTTCTCCTGAAGTTCAGCCACCCTGAGGCCTCTGGAAAGCAAAGGGCTCCTCTC
CAGTCTGATCTGTGAATTGAGCTGCAGAAACGAAGCCATCTTTCTTTGGATGGGACTAGAGCTTTCTTTCACAAAAAAGAAGTAGGGGAA
GACATGCAGCCTAAGGCTGTATGATGACCACACGTTCCTAAGCTGGAGTGCTTATCCCTTCTTTTTCTTTTTTTCTTTGGTTTAATTTAA
AGCCACAACCACATACAACACAAAGAGAAAAAGAAATGCAAAAATCTCTGCGTGCAGGGACAAAGAGGCCTTTAACCATGGTGCTTGTTA
ATGCTTTCTGAAGCTTTACCAGCTGAAAGTTGGGACTCTGGAGAGCGGAGGAGAGAGAGGCAGAAGAACCCTGGCCTGAGAAGGTTTGGT
CCAGCCTGGTTTAGCCTGGATGTTGCTGTGCACGGTGGACCCAGACACATCGCACTGTGGATTATTTCATTTTGTAACAAATGAACGATA
TGTAGCAGAAAGGCACGTCCACTCACAAGGGACGCTTTGGGAGAATGTCAGTTCATGTATGTTCAGAAGAAATTCTGTCATAGAAAGTGC
CAGAAAGTGTTTAACTTGTCAAAAAACAAAAACCCAGCAACAGAAAAATGGAGTTTGGAAAACAGGACTTAAAATGACATTCAGTATATA
AAATATGTACATAATATTGGATGACTAACTATCAAATAGATGGATTTGTATCAATACCAAATAGCTTCTGTTTTGTTTTGCTGAAGGCTA
AATTCACAGCGCTATGCAATTCTTAATTTTCATTAAGTTGTTATTTCAGTTTTAAATGTACCTTCAGAATAAGCTTCCCCACCCCAGTTT
TTGTTGCTTGAAAATATTGTTGTCCCGGATTTTTGTTAATATTCATTTTTGTTATCCTTTTTTAAAAGTAAATGTACAGGATGCCAGTAA
AAAAAAAAAATGGCTTCAGAATTAAAACTATGAAATATTTTACAGTTTTTCTTGTACAGAGTACTTGGCTGTTAGCCCAAGGTTAAAAAG
TTCATAACAGATTTTTTTTGGACTGTTTTGTTGGGCAGTGCCTGATAAGCTTCAAAGCTGCTTTATTCAATAAAAAAAAGAAATGAAAAA


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FusionGenePPI for MARVELD2_PIK3R1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MARVELD2ELAVL1, MOV10, NXF1, TMEM17, TMEM216, CDH1, CTDSPL, STK38, TTL, CTBS, ACAD9, BAIAP2L1, NDUFAF1, RAP2A, ECSIT, GAP43, ITCHPIK3R1LCP2, CTNNB1, SRC, ABL1, FYN, LCK, PIK3R1, SHC1, GNAQ, WAS, IRS2, FCGR2A, VAV1, GAB1, IRS1, PIK3CA, RRAS2, KIT, AXL, DOK1, EPOR, KHDRBS1, CBLB, IL1R1, EZR, BCAR1, CD28, LAT, PIK3CD, GRB2, ERBB3, PTPN6, CD3E, EPHA2, ARHGAP17, ARAF, IFNAR1, TYRO3, ARHGAP32, CSF2RA, NFKBIA, GAB2, TUBA1B, TGFBR1, TGFBR2, HRAS, PTK2, AGAP2, PECAM1, CBL, CRKL, CD7, ARHGAP1, FES, SH3KBP1, PTPN11, INPP5D, PIK3CB, ADAM12, IL6ST, HCST, ESR1, SHB, NTRK2, SYN1, PDGFRB, LTK, FGFR2, NPM1, SOCS6, PXK, YWHAG, EGFR, ADAMTS2, CXCL2, CYP4A11, TTR, HDAC3, ITSN1, SYNM, RAB5A, ERBB2, CRK, NCK1, CSF1R, SYK, ZAP70, FLT3, PDGFRA, CUL3, GRB10, BRCA1, JAK2, ALK, SELPLG, TNIP1, CMIP, INPPL1, PIK3R2, EP300, HTT, MED28, ABI1, APPL1, TNFRSF1A, FBXL2, TLR3, DAB2IP, MAP3K5, DLX2, GSPT1, HOXA1, CCL14, CD40, ALOX5, EPN1, IRS4, NCL, ZDHHC17, SQSTM1, SIRT1, EFNB2, CD244, VSIG4, PRMT2, PTGER3, PCBP1, NTRK1, CLNK, SH2D2A, SOCS1, STAT3, TNS4, FER, PDE4D, TMEM17, CHAF1A, NYAP2, FASLG, FGFR1, IGF1R, PLCG2, SOS1, PXN, RXRA, FLT1, RASD2, DNM2, CD247, KBTBD2, WEE1, VHL, MAPT, AKT1, GNB1, ACTA1, BCR, PTPRK, FLRT1, PIK3R3, DEFA5, RNF19B, SNX32, NLGN3, HAVCR2, IL20RA, PROM1, NYAP1, MYO16, FAS, NISCH, PTTG1, WDR26


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MARVELD2_PIK3R1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePIK3R1P27986DB01064IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit alphasmall moleculeapproved|investigational

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RelatedDiseases for MARVELD2_PIK3R1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePIK3R1C0001973Alcoholic Intoxication, Chronic2PSYGENET
TgenePIK3R1C0878684SHORT syndrome2ORPHANET;UNIPROT
TgenePIK3R1C0006413Burkitt Lymphoma1CTD_human
TgenePIK3R1C0021655Insulin Resistance1CTD_human
TgenePIK3R1C0024667Animal Mammary Neoplasms1CTD_human
TgenePIK3R1C0024668Mammary Neoplasms, Experimental1CTD_human