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Fusion gene ID: 2110 |
FusionGeneSummary for AP5M1_MAPRE1 |
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Fusion gene information | Fusion gene name: AP5M1_MAPRE1 | Fusion gene ID: 2110 | Hgene | Tgene | Gene symbol | AP5M1 | MAPRE1 | Gene ID | 55745 | 22919 |
Gene name | adaptor related protein complex 5 subunit mu 1 | microtubule associated protein RP/EB family member 1 | |
Synonyms | C14orf108|MUDENG|Mu5|MuD | EB1 | |
Cytomap | 14q22.3 | 20q11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | AP-5 complex subunit mu-1AP-5 complex subunit muMHD domain-containing death-inducing proteinMU-2/AP1M2 domain containing, death-inducingMu-2 related death-inducingadapter-related protein complex 5 mu subunitadapter-related protein complex 5 subunit | microtubule-associated protein RP/EB family member 1APC-binding protein EB1adenomatous polyposis coli-binding protein EB1end-binding protein 1 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9H0R1 | Q15691 | |
Ensembl transtripts involved in fusion gene | ENST00000261558, ENST00000431972, ENST00000556723, | ENST00000375571, | |
Fusion gene scores | * DoF score | 2 X 3 X 1=6 | 6 X 5 X 3=90 |
# samples | 3 | 6 | |
** MAII score | log2(3/6*10)=2.32192809488736 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: AP5M1 [Title/Abstract] AND MAPRE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MAPRE1 | GO:0031115 | negative regulation of microtubule polymerization | 11943150 |
Tgene | MAPRE1 | GO:0035372 | protein localization to microtubule | 19632184|21820309 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA250860 | AP5M1 | chr14 | 57741156 | + | MAPRE1 | chr20 | 31436476 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000261558 | ENST00000375571 | AP5M1 | chr14 | 57741156 | + | MAPRE1 | chr20 | 31436476 | + |
In-frame | ENST00000431972 | ENST00000375571 | AP5M1 | chr14 | 57741156 | + | MAPRE1 | chr20 | 31436476 | + |
intron-3CDS | ENST00000556723 | ENST00000375571 | AP5M1 | chr14 | 57741156 | + | MAPRE1 | chr20 | 31436476 | + |
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FusionProtFeatures for AP5M1_MAPRE1 |
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Hgene | Tgene |
AP5M1 | MAPRE1 |
As part of AP-5, a probable fifth adaptor proteincomplex it may be involved in endosomal transport. According toPubMed:18395520, it may play a role in cell death.{ECO:0000269|PubMed:18395520, ECO:0000269|PubMed:22022230}. | Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubulecytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184,PubMed:21646404, PubMed:28726242, PubMed:28814570). Promotescytoplasmic microtubule nucleation and elongation(PubMed:12388762, PubMed:16109370, PubMed:19632184,PubMed:21646404, PubMed:28726242, PubMed:28814570). May beinvolved in spindle function by stabilizing microtubules andanchoring them at centrosomes (PubMed:12388762). Also acts as aregulator of minus-end microtubule organization: interacts withthe complex formed by AKAP9 and PDE4DIP, leading to recruitCAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomalminus-end microtubules to the Golgi, an important step forpolarized cell movement (PubMed:28814570). Promotes elongation ofCAMSAP2-decorated microtubule stretches on the minus-end ofmicrotubules (PubMed:28814570). Acts as a regulator ofautophagosome transport via interaction with CAMSAP2(PubMed:28726242). May play a role in cell migration (Bysimilarity). {ECO:0000250|UniProtKB:Q61166,ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370,ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404,ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | MAPRE1 | chr14:57741156 | chr20:31436476 | ENST00000375571 | + | 5 | 7 | 14_116 | 250 | 269 | Domain | Calponin-homology (CH) |
Tgene | MAPRE1 | chr14:57741156 | chr20:31436476 | ENST00000375571 | + | 5 | 7 | 185_255 | 250 | 269 | Domain | EB1 C-terminal |
Tgene | MAPRE1 | chr14:57741156 | chr20:31436476 | ENST00000375571 | + | 5 | 7 | 208_268 | 250 | 269 | Region | Note=DCTN1-binding |
Tgene | MAPRE1 | chr14:57741156 | chr20:31436476 | ENST00000375571 | + | 5 | 7 | 220_242 | 250 | 269 | Region | Note=APC-binding |
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FusionGeneSequence for AP5M1_MAPRE1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_AP5M1_ENST00000261558_chr14_57741156_+_MAPRE1_ENST00000375571_chr20_31436476_+_54aa >In-frame_AP5M1_ENST00000431972_chr14_57741156_+_MAPRE1_ENST00000375571_chr20_31436476_+_54aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_AP5M1_ENST00000261558_chr14_57741156_+_MAPRE1_ENST00000375571_chr20_31436476_+_162nt GCTTTGGTGAAGCACGTGCAGTCTAAAGGATACCCAAATGAACGTTTTGAACTTCTCACCAACTTTCCTCGAAGGAAATTATCTCATCTG >In-frame_AP5M1_ENST00000431972_chr14_57741156_+_MAPRE1_ENST00000375571_chr20_31436476_+_162nt GCTTTGGTGAAGCACGTGCAGTCTAAAGGATACCCAAATGAACGTTTTGAACTTCTCACCAACTTTCCTCGAAGGAAATTATCTCATCTG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_AP5M1_ENST00000261558_chr14_57741156_+_MAPRE1_ENST00000375571_chr20_31436476_+_1734nt GAAGGCTTTGTGATACCTGATGAAGGGGGCCCACAGGAGGAGCAAGAAGAGTATTAACAGCCTGGACCAGCAGAGCAACATCGGAATTCT TCACTCCAAATCATGTGCTTAACTGTAAAATACTCCCTTTTGTTATCCTTAGAGGACTCACTGGTTTCTTTTCATAAGCAAAAAGTACCT CTTCTTAAAGTGCACTTTGCAGACGTTTCACTCCTTTTCCAATAAGTTTGAGTTAGGAGCTTTTACCTTGTAGCAGAGCAGTATTAACAC CTAGTTGGTTCACCTGGAAAACAGAGAGGCTGACCGTGGGGCTCACCATGCGGATGCGGGTCACACTGAATGCTGGAGAGATGTTATGTA ATATGCTGAGGTGGCGACCTCAGTGGAGAAATGTAAAGACTGAATTGAATTTTAAGCTAATGTGAAATCAGAGAATGTTGTAATAAGTAA ATGCCTTAAGAGTATTTAAAATATGCTTCCACATTTCAAAATATAAAATGTAACATGACAAGAGATTTTGCGTTTGACATTGTGTCTGGG AAGGAAGGGCCAGACCTTGGAACCTTTGGAACCTGCTGTCAACAGGTCTTACAGGGCTGCTTGAACCCTCATAGGCCTAGGCTTTGGTCT AAAAGGAACATTTAAAAAGTTGCCCTGTAAAGTTATTTGGTGTCATTGACCAATTGCATCCCAGCTAAAAAGCAAGAGGCATCGTTGCCT GGATAATAGAGGATGTGTTTCAGCCCTGAGATGTTACAGTTGAAGAGCTTGGTTTTCATTGAGCATTTCTCTATTTTTCCAGTTATCCCC GAAATTTCTATGTATTATATTTTTTGGGGAAGTGAGGTGTGCCCAGTTTTTTAATCTAACAACTACTTTTGGGGACTTGCCCACATCTCT GGGATTTGAATGGGGATTGTATCCCATTTTACTGTCTTTTAGGTTTACATTTACCACGTTTCTCTTCTCTGCTCCCCTTGCCCACTGGGG ACTCCTCTTTGGCTCCTTGAAGTTTGCTGCTTAGAGTTGGAAGTGCAGCAGGCAGGTGATCATGCTGCAAGTTCTTTCTGGACCTCTGGC AAAGGGAGTGGTCAGTGAAGGCCATCGTTACCTTGGGATCTGCCAGGCTGGGGTGTTTTCGGTATCTGCTGTTCACAGCTCTCCACTGTA ATCCGAATACTTTGCCAGTGCACTAATCTCTTTGGAGATAAAATTCATTAGTGTGTTACTAAATGTTAATTTTCTTTTGCGGAAAATACA GTACCGTGTCTGAATTAATTATTAATATTTAAAATACTTCATTCCTTAACTCTCCCTCATTTGCTTTGCCCACAGCCTATTCAGTTCCTT TGTTTGGCAGGATTCTGCAAAATGTGTCTCACCCACTACTGAGATTGTTCAGCCCCTGATGTATTTGTATTGATTTGTTTCTGGTGGTAG CTTGTCCTGAAATGTGTGTAGAAAGCAAGTATTTTATGATAAAAATGTTGTGTAGTGCATGCTCTGTGTGGAATTCAGAGGAAAACCCAG ATTCAGTGATTAACAATGCCAAAAAATGCAAGTAACTAGCCATTGTTCAAATGACAGTGGTGCTATTTCTCTTTTGTGGCCTTTTAGACT TTTGTTGCCCTAAAATTCCATTTTATTGGGAACCCATTTTCCACCTGGTCTTTCTTGACAGGGTTTTTTTCTACTTTAAACAGTTTCTAA >In-frame_AP5M1_ENST00000431972_chr14_57741156_+_MAPRE1_ENST00000375571_chr20_31436476_+_1734nt GAAGGCTTTGTGATACCTGATGAAGGGGGCCCACAGGAGGAGCAAGAAGAGTATTAACAGCCTGGACCAGCAGAGCAACATCGGAATTCT TCACTCCAAATCATGTGCTTAACTGTAAAATACTCCCTTTTGTTATCCTTAGAGGACTCACTGGTTTCTTTTCATAAGCAAAAAGTACCT CTTCTTAAAGTGCACTTTGCAGACGTTTCACTCCTTTTCCAATAAGTTTGAGTTAGGAGCTTTTACCTTGTAGCAGAGCAGTATTAACAC CTAGTTGGTTCACCTGGAAAACAGAGAGGCTGACCGTGGGGCTCACCATGCGGATGCGGGTCACACTGAATGCTGGAGAGATGTTATGTA ATATGCTGAGGTGGCGACCTCAGTGGAGAAATGTAAAGACTGAATTGAATTTTAAGCTAATGTGAAATCAGAGAATGTTGTAATAAGTAA ATGCCTTAAGAGTATTTAAAATATGCTTCCACATTTCAAAATATAAAATGTAACATGACAAGAGATTTTGCGTTTGACATTGTGTCTGGG AAGGAAGGGCCAGACCTTGGAACCTTTGGAACCTGCTGTCAACAGGTCTTACAGGGCTGCTTGAACCCTCATAGGCCTAGGCTTTGGTCT AAAAGGAACATTTAAAAAGTTGCCCTGTAAAGTTATTTGGTGTCATTGACCAATTGCATCCCAGCTAAAAAGCAAGAGGCATCGTTGCCT GGATAATAGAGGATGTGTTTCAGCCCTGAGATGTTACAGTTGAAGAGCTTGGTTTTCATTGAGCATTTCTCTATTTTTCCAGTTATCCCC GAAATTTCTATGTATTATATTTTTTGGGGAAGTGAGGTGTGCCCAGTTTTTTAATCTAACAACTACTTTTGGGGACTTGCCCACATCTCT GGGATTTGAATGGGGATTGTATCCCATTTTACTGTCTTTTAGGTTTACATTTACCACGTTTCTCTTCTCTGCTCCCCTTGCCCACTGGGG ACTCCTCTTTGGCTCCTTGAAGTTTGCTGCTTAGAGTTGGAAGTGCAGCAGGCAGGTGATCATGCTGCAAGTTCTTTCTGGACCTCTGGC AAAGGGAGTGGTCAGTGAAGGCCATCGTTACCTTGGGATCTGCCAGGCTGGGGTGTTTTCGGTATCTGCTGTTCACAGCTCTCCACTGTA ATCCGAATACTTTGCCAGTGCACTAATCTCTTTGGAGATAAAATTCATTAGTGTGTTACTAAATGTTAATTTTCTTTTGCGGAAAATACA GTACCGTGTCTGAATTAATTATTAATATTTAAAATACTTCATTCCTTAACTCTCCCTCATTTGCTTTGCCCACAGCCTATTCAGTTCCTT TGTTTGGCAGGATTCTGCAAAATGTGTCTCACCCACTACTGAGATTGTTCAGCCCCTGATGTATTTGTATTGATTTGTTTCTGGTGGTAG CTTGTCCTGAAATGTGTGTAGAAAGCAAGTATTTTATGATAAAAATGTTGTGTAGTGCATGCTCTGTGTGGAATTCAGAGGAAAACCCAG ATTCAGTGATTAACAATGCCAAAAAATGCAAGTAACTAGCCATTGTTCAAATGACAGTGGTGCTATTTCTCTTTTGTGGCCTTTTAGACT TTTGTTGCCCTAAAATTCCATTTTATTGGGAACCCATTTTCCACCTGGTCTTTCTTGACAGGGTTTTTTTCTACTTTAAACAGTTTCTAA |
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FusionGenePPI for AP5M1_MAPRE1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | MAPRE1 | chr14:57741156 | chr20:31436476 | ENST00000375571 | + | 5 | 7 | 185_268 | 250 | 269 | CDK5RAP2 |
Tgene | MAPRE1 | chr14:57741156 | chr20:31436476 | ENST00000375571 | + | 5 | 7 | 124_268 | 250 | 269 | MTUS2/TIP150 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AP5M1_MAPRE1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AP5M1_MAPRE1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AP5M1 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | MAPRE1 | C0043094 | Weight Gain | 1 | CTD_human |
Tgene | MAPRE1 | C0151744 | Myocardial Ischemia | 1 | CTD_human |