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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2110

FusionGeneSummary for AP5M1_MAPRE1

check button Fusion gene summary
Fusion gene informationFusion gene name: AP5M1_MAPRE1
Fusion gene ID: 2110
HgeneTgene
Gene symbol

AP5M1

MAPRE1

Gene ID

55745

22919

Gene nameadaptor related protein complex 5 subunit mu 1microtubule associated protein RP/EB family member 1
SynonymsC14orf108|MUDENG|Mu5|MuDEB1
Cytomap

14q22.3

20q11.21

Type of geneprotein-codingprotein-coding
DescriptionAP-5 complex subunit mu-1AP-5 complex subunit muMHD domain-containing death-inducing proteinMU-2/AP1M2 domain containing, death-inducingMu-2 related death-inducingadapter-related protein complex 5 mu subunitadapter-related protein complex 5 subunit microtubule-associated protein RP/EB family member 1APC-binding protein EB1adenomatous polyposis coli-binding protein EB1end-binding protein 1
Modification date2018051920180523
UniProtAcc

Q9H0R1

Q15691

Ensembl transtripts involved in fusion geneENST00000261558, ENST00000431972, 
ENST00000556723, 
ENST00000375571, 
Fusion gene scores* DoF score2 X 3 X 1=66 X 5 X 3=90
# samples 36
** MAII scorelog2(3/6*10)=2.32192809488736log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AP5M1 [Title/Abstract] AND MAPRE1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAPRE1

GO:0031115

negative regulation of microtubule polymerization

11943150

TgeneMAPRE1

GO:0035372

protein localization to microtubule

19632184|21820309


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA250860AP5M1chr14

57741156

+MAPRE1chr20

31436476

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000261558ENST00000375571AP5M1chr14

57741156

+MAPRE1chr20

31436476

+
In-frameENST00000431972ENST00000375571AP5M1chr14

57741156

+MAPRE1chr20

31436476

+
intron-3CDSENST00000556723ENST00000375571AP5M1chr14

57741156

+MAPRE1chr20

31436476

+

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FusionProtFeatures for AP5M1_MAPRE1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AP5M1

Q9H0R1

MAPRE1

Q15691

As part of AP-5, a probable fifth adaptor proteincomplex it may be involved in endosomal transport. According toPubMed:18395520, it may play a role in cell death.{ECO:0000269|PubMed:18395520, ECO:0000269|PubMed:22022230}. Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubulecytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184,PubMed:21646404, PubMed:28726242, PubMed:28814570). Promotescytoplasmic microtubule nucleation and elongation(PubMed:12388762, PubMed:16109370, PubMed:19632184,PubMed:21646404, PubMed:28726242, PubMed:28814570). May beinvolved in spindle function by stabilizing microtubules andanchoring them at centrosomes (PubMed:12388762). Also acts as aregulator of minus-end microtubule organization: interacts withthe complex formed by AKAP9 and PDE4DIP, leading to recruitCAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomalminus-end microtubules to the Golgi, an important step forpolarized cell movement (PubMed:28814570). Promotes elongation ofCAMSAP2-decorated microtubule stretches on the minus-end ofmicrotubules (PubMed:28814570). Acts as a regulator ofautophagosome transport via interaction with CAMSAP2(PubMed:28726242). May play a role in cell migration (Bysimilarity). {ECO:0000250|UniProtKB:Q61166,ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370,ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404,ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAPRE1chr14:57741156chr20:31436476ENST00000375571+5714_116250269DomainCalponin-homology (CH)
TgeneMAPRE1chr14:57741156chr20:31436476ENST00000375571+57185_255250269DomainEB1 C-terminal
TgeneMAPRE1chr14:57741156chr20:31436476ENST00000375571+57208_268250269RegionNote=DCTN1-binding
TgeneMAPRE1chr14:57741156chr20:31436476ENST00000375571+57220_242250269RegionNote=APC-binding


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FusionGeneSequence for AP5M1_MAPRE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AP5M1_ENST00000261558_chr14_57741156_+_MAPRE1_ENST00000375571_chr20_31436476_+_54aa

>In-frame_AP5M1_ENST00000431972_chr14_57741156_+_MAPRE1_ENST00000375571_chr20_31436476_+_54aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AP5M1_ENST00000261558_chr14_57741156_+_MAPRE1_ENST00000375571_chr20_31436476_+_162nt
GCTTTGGTGAAGCACGTGCAGTCTAAAGGATACCCAAATGAACGTTTTGAACTTCTCACCAACTTTCCTCGAAGGAAATTATCTCATCTG

>In-frame_AP5M1_ENST00000431972_chr14_57741156_+_MAPRE1_ENST00000375571_chr20_31436476_+_162nt
GCTTTGGTGAAGCACGTGCAGTCTAAAGGATACCCAAATGAACGTTTTGAACTTCTCACCAACTTTCCTCGAAGGAAATTATCTCATCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_AP5M1_ENST00000261558_chr14_57741156_+_MAPRE1_ENST00000375571_chr20_31436476_+_1734nt
GAAGGCTTTGTGATACCTGATGAAGGGGGCCCACAGGAGGAGCAAGAAGAGTATTAACAGCCTGGACCAGCAGAGCAACATCGGAATTCT
TCACTCCAAATCATGTGCTTAACTGTAAAATACTCCCTTTTGTTATCCTTAGAGGACTCACTGGTTTCTTTTCATAAGCAAAAAGTACCT
CTTCTTAAAGTGCACTTTGCAGACGTTTCACTCCTTTTCCAATAAGTTTGAGTTAGGAGCTTTTACCTTGTAGCAGAGCAGTATTAACAC
CTAGTTGGTTCACCTGGAAAACAGAGAGGCTGACCGTGGGGCTCACCATGCGGATGCGGGTCACACTGAATGCTGGAGAGATGTTATGTA
ATATGCTGAGGTGGCGACCTCAGTGGAGAAATGTAAAGACTGAATTGAATTTTAAGCTAATGTGAAATCAGAGAATGTTGTAATAAGTAA
ATGCCTTAAGAGTATTTAAAATATGCTTCCACATTTCAAAATATAAAATGTAACATGACAAGAGATTTTGCGTTTGACATTGTGTCTGGG
AAGGAAGGGCCAGACCTTGGAACCTTTGGAACCTGCTGTCAACAGGTCTTACAGGGCTGCTTGAACCCTCATAGGCCTAGGCTTTGGTCT
AAAAGGAACATTTAAAAAGTTGCCCTGTAAAGTTATTTGGTGTCATTGACCAATTGCATCCCAGCTAAAAAGCAAGAGGCATCGTTGCCT
GGATAATAGAGGATGTGTTTCAGCCCTGAGATGTTACAGTTGAAGAGCTTGGTTTTCATTGAGCATTTCTCTATTTTTCCAGTTATCCCC
GAAATTTCTATGTATTATATTTTTTGGGGAAGTGAGGTGTGCCCAGTTTTTTAATCTAACAACTACTTTTGGGGACTTGCCCACATCTCT
GGGATTTGAATGGGGATTGTATCCCATTTTACTGTCTTTTAGGTTTACATTTACCACGTTTCTCTTCTCTGCTCCCCTTGCCCACTGGGG
ACTCCTCTTTGGCTCCTTGAAGTTTGCTGCTTAGAGTTGGAAGTGCAGCAGGCAGGTGATCATGCTGCAAGTTCTTTCTGGACCTCTGGC
AAAGGGAGTGGTCAGTGAAGGCCATCGTTACCTTGGGATCTGCCAGGCTGGGGTGTTTTCGGTATCTGCTGTTCACAGCTCTCCACTGTA
ATCCGAATACTTTGCCAGTGCACTAATCTCTTTGGAGATAAAATTCATTAGTGTGTTACTAAATGTTAATTTTCTTTTGCGGAAAATACA
GTACCGTGTCTGAATTAATTATTAATATTTAAAATACTTCATTCCTTAACTCTCCCTCATTTGCTTTGCCCACAGCCTATTCAGTTCCTT
TGTTTGGCAGGATTCTGCAAAATGTGTCTCACCCACTACTGAGATTGTTCAGCCCCTGATGTATTTGTATTGATTTGTTTCTGGTGGTAG
CTTGTCCTGAAATGTGTGTAGAAAGCAAGTATTTTATGATAAAAATGTTGTGTAGTGCATGCTCTGTGTGGAATTCAGAGGAAAACCCAG
ATTCAGTGATTAACAATGCCAAAAAATGCAAGTAACTAGCCATTGTTCAAATGACAGTGGTGCTATTTCTCTTTTGTGGCCTTTTAGACT
TTTGTTGCCCTAAAATTCCATTTTATTGGGAACCCATTTTCCACCTGGTCTTTCTTGACAGGGTTTTTTTCTACTTTAAACAGTTTCTAA

>In-frame_AP5M1_ENST00000431972_chr14_57741156_+_MAPRE1_ENST00000375571_chr20_31436476_+_1734nt
GAAGGCTTTGTGATACCTGATGAAGGGGGCCCACAGGAGGAGCAAGAAGAGTATTAACAGCCTGGACCAGCAGAGCAACATCGGAATTCT
TCACTCCAAATCATGTGCTTAACTGTAAAATACTCCCTTTTGTTATCCTTAGAGGACTCACTGGTTTCTTTTCATAAGCAAAAAGTACCT
CTTCTTAAAGTGCACTTTGCAGACGTTTCACTCCTTTTCCAATAAGTTTGAGTTAGGAGCTTTTACCTTGTAGCAGAGCAGTATTAACAC
CTAGTTGGTTCACCTGGAAAACAGAGAGGCTGACCGTGGGGCTCACCATGCGGATGCGGGTCACACTGAATGCTGGAGAGATGTTATGTA
ATATGCTGAGGTGGCGACCTCAGTGGAGAAATGTAAAGACTGAATTGAATTTTAAGCTAATGTGAAATCAGAGAATGTTGTAATAAGTAA
ATGCCTTAAGAGTATTTAAAATATGCTTCCACATTTCAAAATATAAAATGTAACATGACAAGAGATTTTGCGTTTGACATTGTGTCTGGG
AAGGAAGGGCCAGACCTTGGAACCTTTGGAACCTGCTGTCAACAGGTCTTACAGGGCTGCTTGAACCCTCATAGGCCTAGGCTTTGGTCT
AAAAGGAACATTTAAAAAGTTGCCCTGTAAAGTTATTTGGTGTCATTGACCAATTGCATCCCAGCTAAAAAGCAAGAGGCATCGTTGCCT
GGATAATAGAGGATGTGTTTCAGCCCTGAGATGTTACAGTTGAAGAGCTTGGTTTTCATTGAGCATTTCTCTATTTTTCCAGTTATCCCC
GAAATTTCTATGTATTATATTTTTTGGGGAAGTGAGGTGTGCCCAGTTTTTTAATCTAACAACTACTTTTGGGGACTTGCCCACATCTCT
GGGATTTGAATGGGGATTGTATCCCATTTTACTGTCTTTTAGGTTTACATTTACCACGTTTCTCTTCTCTGCTCCCCTTGCCCACTGGGG
ACTCCTCTTTGGCTCCTTGAAGTTTGCTGCTTAGAGTTGGAAGTGCAGCAGGCAGGTGATCATGCTGCAAGTTCTTTCTGGACCTCTGGC
AAAGGGAGTGGTCAGTGAAGGCCATCGTTACCTTGGGATCTGCCAGGCTGGGGTGTTTTCGGTATCTGCTGTTCACAGCTCTCCACTGTA
ATCCGAATACTTTGCCAGTGCACTAATCTCTTTGGAGATAAAATTCATTAGTGTGTTACTAAATGTTAATTTTCTTTTGCGGAAAATACA
GTACCGTGTCTGAATTAATTATTAATATTTAAAATACTTCATTCCTTAACTCTCCCTCATTTGCTTTGCCCACAGCCTATTCAGTTCCTT
TGTTTGGCAGGATTCTGCAAAATGTGTCTCACCCACTACTGAGATTGTTCAGCCCCTGATGTATTTGTATTGATTTGTTTCTGGTGGTAG
CTTGTCCTGAAATGTGTGTAGAAAGCAAGTATTTTATGATAAAAATGTTGTGTAGTGCATGCTCTGTGTGGAATTCAGAGGAAAACCCAG
ATTCAGTGATTAACAATGCCAAAAAATGCAAGTAACTAGCCATTGTTCAAATGACAGTGGTGCTATTTCTCTTTTGTGGCCTTTTAGACT
TTTGTTGCCCTAAAATTCCATTTTATTGGGAACCCATTTTCCACCTGGTCTTTCTTGACAGGGTTTTTTTCTACTTTAAACAGTTTCTAA


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FusionGenePPI for AP5M1_MAPRE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMAPRE1chr14:57741156chr20:31436476ENST00000375571+57185_268250269CDK5RAP2
TgeneMAPRE1chr14:57741156chr20:31436476ENST00000375571+57124_268250269MTUS2/TIP150


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AP5M1_MAPRE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AP5M1_MAPRE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAP5M1C0007134Renal Cell Carcinoma1CTD_human
TgeneMAPRE1C0043094Weight Gain1CTD_human
TgeneMAPRE1C0151744Myocardial Ischemia1CTD_human