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Fusion gene ID: 21092 |
FusionGeneSummary for MARK3_SLC25A21 |
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Fusion gene information | Fusion gene name: MARK3_SLC25A21 | Fusion gene ID: 21092 | Hgene | Tgene | Gene symbol | MARK3 | SLC25A21 | Gene ID | 4140 | 89874 |
Gene name | microtubule affinity regulating kinase 3 | solute carrier family 25 member 21 | |
Synonyms | CTAK1|KP78|PAR1A|Par-1a | ODC|ODC1 | |
Cytomap | 14q32.32-q32.33 | 14q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | MAP/microtubule affinity-regulating kinase 3C-TAK1ELKL motif kinase 2EMK-2cdc25C-associated protein kinase 1protein kinase STK10ser/Thr protein kinase PAR-1serine/threonine-protein kinase p78 | mitochondrial 2-oxodicarboxylate carrieroxodicarboxylate carriersolute carrier family 25 (mitochondrial oxoadipate carrier), member 21solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P27448 | Q9BQT8 | |
Ensembl transtripts involved in fusion gene | ENST00000440884, ENST00000416682, ENST00000429436, ENST00000303622, ENST00000216288, ENST00000553942, ENST00000335102, ENST00000561071, | ENST00000555449, ENST00000331299, ENST00000557611, | |
Fusion gene scores | * DoF score | 17 X 13 X 8=1768 | 8 X 4 X 6=192 |
# samples | 20 | 9 | |
** MAII score | log2(20/1768*10)=-3.14404636961671 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/192*10)=-1.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MARK3 [Title/Abstract] AND SLC25A21 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MARK3 | GO:0018105 | peptidyl-serine phosphorylation | 9543386 |
Hgene | MARK3 | GO:0032092 | positive regulation of protein binding | 9543386 |
Hgene | MARK3 | GO:0035331 | negative regulation of hippo signaling | 28087714 |
Hgene | MARK3 | GO:0036289 | peptidyl-serine autophosphorylation | 9543386 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-GM-A2DD-01A | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000440884 | ENST00000555449 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
Frame-shift | ENST00000440884 | ENST00000331299 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
5CDS-5UTR | ENST00000440884 | ENST00000557611 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
Frame-shift | ENST00000416682 | ENST00000555449 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
Frame-shift | ENST00000416682 | ENST00000331299 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
5CDS-5UTR | ENST00000416682 | ENST00000557611 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
Frame-shift | ENST00000429436 | ENST00000555449 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
Frame-shift | ENST00000429436 | ENST00000331299 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
5CDS-5UTR | ENST00000429436 | ENST00000557611 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
Frame-shift | ENST00000303622 | ENST00000555449 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
Frame-shift | ENST00000303622 | ENST00000331299 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
5CDS-5UTR | ENST00000303622 | ENST00000557611 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
Frame-shift | ENST00000216288 | ENST00000555449 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
Frame-shift | ENST00000216288 | ENST00000331299 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
5CDS-5UTR | ENST00000216288 | ENST00000557611 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
Frame-shift | ENST00000553942 | ENST00000555449 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
Frame-shift | ENST00000553942 | ENST00000331299 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
5CDS-5UTR | ENST00000553942 | ENST00000557611 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
Frame-shift | ENST00000335102 | ENST00000555449 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
Frame-shift | ENST00000335102 | ENST00000331299 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
5CDS-5UTR | ENST00000335102 | ENST00000557611 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
intron-3CDS | ENST00000561071 | ENST00000555449 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
intron-3CDS | ENST00000561071 | ENST00000331299 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
intron-5UTR | ENST00000561071 | ENST00000557611 | MARK3 | chr14 | 103941547 | + | SLC25A21 | chr14 | 37344209 | - |
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FusionProtFeatures for MARK3_SLC25A21 |
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Hgene | Tgene |
MARK3 | SLC25A21 |
Transports C5-C7 oxodicarboxylates across the innermembranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent,pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, andcitrate. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MARK3_SLC25A21 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MARK3_SLC25A21 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MARK3 | SFN, YWHAB, YWHAG, YWHAQ, RASGRF1, ATP6V0C, CHGB, SAAL1, PMPCB, PNPLA2, VPS11, TCEA2, TTR, USP21, MARK2, HDAC7, HDAC4, HDAC5, TADA2A, TERF2, PRKAA1, YWHAZ, YWHAH, MITF, MAP2, YWHAE, CDC25C, KSR1, PKP2, PIM1, MARK3, ASB13, MAPT, CAPZA1, CAPZB, CNBP, DLG5, HNRNPDL, MTCL1, ALYREF, CASQ2, NTRK1, CEP192, TMEM17, CTBP2, PPP2CB, CPSF3, MEX3C, CDH1, COL4A3BP, NRROS, TMCC2, NUAK2, PCDHGB4, CDH19, MANSC1, TRIM25, HEY1 | SLC25A21 | FBXO6, TBX20, NOSIP, DNASE1L2, PPIE |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MARK3_SLC25A21 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MARK3_SLC25A21 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |