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Fusion gene ID: 21057 |
FusionGeneSummary for MAPRE2_GAB1 |
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Fusion gene information | Fusion gene name: MAPRE2_GAB1 | Fusion gene ID: 21057 | Hgene | Tgene | Gene symbol | MAPRE2 | GAB1 | Gene ID | 10982 | 128869 |
Gene name | microtubule associated protein RP/EB family member 2 | phosphatidylinositol glycan anchor biosynthesis class U | |
Synonyms | CSCSC2|EB1|EB2|RP1 | CDC91L1|GAB1 | |
Cytomap | 18q12.1-q12.2 | 20q11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | microtubule-associated protein RP/EB family member 2APC-binding protein EB1APC-binding protein EB2T-cell activation protein, EB1 familyend-binding protein 2 | phosphatidylinositol glycan anchor biosynthesis class U proteinCDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1GPI transamidase component PIG-UGPI transamidase subunitcell division cycle 91-like 1 proteincell division cycle protein 91-li | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q15555 | Q13480 | |
Ensembl transtripts involved in fusion gene | ENST00000413393, ENST00000436190, ENST00000300249, ENST00000538170, ENST00000588910, ENST00000589699, ENST00000590793, | ENST00000262995, ENST00000262994, ENST00000505913, ENST00000515388, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 6 X 4 X 4=96 |
# samples | 2 | 6 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MAPRE2 [Title/Abstract] AND GAB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GAB1 | GO:0006506 | GPI anchor biosynthetic process | 15034568 |
Tgene | GAB1 | GO:0046425 | regulation of JAK-STAT cascade | 15034568 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA240048 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000413393 | ENST00000262995 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
5UTR-3CDS | ENST00000413393 | ENST00000262994 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
5UTR-3CDS | ENST00000413393 | ENST00000505913 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
5UTR-intron | ENST00000413393 | ENST00000515388 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
Frame-shift | ENST00000436190 | ENST00000262995 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
Frame-shift | ENST00000436190 | ENST00000262994 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
Frame-shift | ENST00000436190 | ENST00000505913 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
5CDS-intron | ENST00000436190 | ENST00000515388 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-3CDS | ENST00000300249 | ENST00000262995 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-3CDS | ENST00000300249 | ENST00000262994 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-3CDS | ENST00000300249 | ENST00000505913 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-intron | ENST00000300249 | ENST00000515388 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-3CDS | ENST00000538170 | ENST00000262995 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-3CDS | ENST00000538170 | ENST00000262994 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-3CDS | ENST00000538170 | ENST00000505913 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-intron | ENST00000538170 | ENST00000515388 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-3CDS | ENST00000588910 | ENST00000262995 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-3CDS | ENST00000588910 | ENST00000262994 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-3CDS | ENST00000588910 | ENST00000505913 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-intron | ENST00000588910 | ENST00000515388 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-3CDS | ENST00000589699 | ENST00000262995 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-3CDS | ENST00000589699 | ENST00000262994 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-3CDS | ENST00000589699 | ENST00000505913 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-intron | ENST00000589699 | ENST00000515388 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-3CDS | ENST00000590793 | ENST00000262995 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-3CDS | ENST00000590793 | ENST00000262994 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-3CDS | ENST00000590793 | ENST00000505913 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
intron-intron | ENST00000590793 | ENST00000515388 | MAPRE2 | chr18 | 32585517 | + | GAB1 | chr4 | 144354642 | + |
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FusionProtFeatures for MAPRE2_GAB1 |
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Hgene | Tgene |
MAPRE2 | GAB1 |
Adapter protein that plays a role in intracellularsignaling cascades triggered by activated receptor-type kinases.Plays a role in FGFR1 signaling. Probably involved in signaling bythe epidermal growth factor receptor (EGFR) and the insulinreceptor (INSR). |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAPRE2_GAB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAPRE2_GAB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MAPRE2 | LMO2, NIF3L1, MAPRE2, MAPRE3, APC, RNF185, AURKA, AURKB, APP, DGCR8, LRRC1, PAXIP1, TRAF3IP1, CDK2, CDK4, HUWE1, TRAF1, TRAIP, MAPRE1, TXN2, CRTAC1, DNAAF2, FGL1, MCM4, MCM7, SMC3, MCM6, CEP104, DCTN1, POC1A, CENPJ, CDC14A, HSPA8, SDF4, SNRNP27, UBC, HSPA1L, PSMB1, DYNLT1, PAFAH1B1, HSF1, TCTEX1D2, PPP1CA, LMNA | GAB1 | GRAP2, ARHGAP32, ROCK1, PIK3R1, GRB2, PLCG1, C1QBP, MAP3K3, PTPN11, EGFR, CRKL, MET, SHC1, CRK, MARK2, PRKCI, PARD3, MST1R, GAB2, BAG3, GTF2A1L, CASP1, NTRK1, DYNLT1, TRIM15, FRS2, CDH1, PTPRA, LGALS7, TUFM, ARL4C, SYP, ERBB2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAPRE2_GAB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAPRE2_GAB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MAPRE2 | C4225225 | SKIN CREASES, CONGENITAL SYMMETRIC CIRCUMFERENTIAL, 2 | 1 | UNIPROT |
Tgene | GAB1 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |