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Fusion gene ID: 21056 |
FusionGeneSummary for MAPRE1_USP28 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAPRE1_USP28 | Fusion gene ID: 21056 | Hgene | Tgene | Gene symbol | MAPRE1 | USP28 | Gene ID | 22919 | 57646 |
| Gene name | microtubule associated protein RP/EB family member 1 | ubiquitin specific peptidase 28 | |
| Synonyms | EB1 | - | |
| Cytomap | 20q11.21 | 11q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | microtubule-associated protein RP/EB family member 1APC-binding protein EB1adenomatous polyposis coli-binding protein EB1end-binding protein 1 | ubiquitin carboxyl-terminal hydrolase 28deubiquitinating enzyme 28ubiquitin carboxyl-terminal hydrolase 28 variant 1ubiquitin thioesterase 28ubiquitin thiolesterase 28ubiquitin-specific-processing protease 28 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q15691 | Q96RU2 | |
| Ensembl transtripts involved in fusion gene | ENST00000375571, | ENST00000003302, ENST00000260188, ENST00000544967, ENST00000545540, ENST00000537706, ENST00000542033, | |
| Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 4 X 4 X 3=48 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAPRE1 [Title/Abstract] AND USP28 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAPRE1 | GO:0031115 | negative regulation of microtubule polymerization | 11943150 |
| Hgene | MAPRE1 | GO:0035372 | protein localization to microtubule | 19632184|21820309 |
| Tgene | USP28 | GO:0006974 | cellular response to DNA damage stimulus | 17873522 |
| Tgene | USP28 | GO:0010212 | response to ionizing radiation | 16901786 |
| Tgene | USP28 | GO:0016579 | protein deubiquitination | 16901786|17558397|18662541 |
| Tgene | USP28 | GO:0034644 | cellular response to UV | 17873522 |
| Tgene | USP28 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 16901786 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-7785-01A | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000375571 | ENST00000003302 | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - |
| In-frame | ENST00000375571 | ENST00000260188 | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - |
| 5CDS-intron | ENST00000375571 | ENST00000544967 | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - |
| 5CDS-intron | ENST00000375571 | ENST00000545540 | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - |
| 5CDS-intron | ENST00000375571 | ENST00000537706 | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - |
| 5CDS-5UTR | ENST00000375571 | ENST00000542033 | MAPRE1 | chr20 | 31427662 | + | USP28 | chr11 | 113705057 | - |
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FusionProtFeatures for MAPRE1_USP28 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAPRE1 | USP28 |
| Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubulecytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184,PubMed:21646404, PubMed:28726242, PubMed:28814570). Promotescytoplasmic microtubule nucleation and elongation(PubMed:12388762, PubMed:16109370, PubMed:19632184,PubMed:21646404, PubMed:28726242, PubMed:28814570). May beinvolved in spindle function by stabilizing microtubules andanchoring them at centrosomes (PubMed:12388762). Also acts as aregulator of minus-end microtubule organization: interacts withthe complex formed by AKAP9 and PDE4DIP, leading to recruitCAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomalminus-end microtubules to the Golgi, an important step forpolarized cell movement (PubMed:28814570). Promotes elongation ofCAMSAP2-decorated microtubule stretches on the minus-end ofmicrotubules (PubMed:28814570). Acts as a regulator ofautophagosome transport via interaction with CAMSAP2(PubMed:28726242). May play a role in cell migration (Bysimilarity). {ECO:0000250|UniProtKB:Q61166,ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370,ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404,ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570}. | Deubiquitinase involved in DNA damage responsecheckpoint and MYC proto-oncogene stability. Involved in DNAdamage induced apoptosis by specifically deubiquitinating proteinsof the DNA damage pathway such as CLSPN. Also involved in G2 DNAdamage checkpoint, by deubiquitinating CLSPN, and preventing itsdegradation by the anaphase promoting complex/cyclosome (APC/C).In contrast, it does not deubiquitinate PLK1. Specificallydeubiquitinates MYC in the nucleoplasm, leading to prevent MYCdegradation by the proteasome: acts by specifically interactingwith isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm andcounteracting ubiquitination of MYC by the SCF(FBW7) complex. Incontrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma)in the nucleolus, allowing MYC degradation and explaining theselective MYC degradation in the nucleolus. DeubiquitinatesZNF304, hence preventing ZNF304 degradation by the proteasome andleading to the activated KRAS-mediated promoter hypermethylationand transcriptional silencing of tumor suppressor genes (TSGs) ina subset of colorectal cancers (CRC) cells (PubMed:24623306).{ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397,ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541,ECO:0000269|PubMed:24623306}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAPRE1 | chr20:31427662 | chr11:113705057 | ENST00000375571 | + | 5 | 7 | 14_116 | 199 | 269 | Domain | Calponin-homology (CH) |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MAPRE1 | chr20:31427662 | chr11:113705057 | ENST00000375571 | + | 5 | 7 | 185_255 | 199 | 269 | Domain | EB1 C-terminal |
| Hgene | >MAPRE1 | chr20:31427662 | chr11:113705057 | ENST00000375571 | + | 5 | 7 | 208_268 | 199 | 269 | Region | Note=DCTN1-binding |
| Hgene | >MAPRE1 | chr20:31427662 | chr11:113705057 | ENST00000375571 | + | 5 | 7 | 220_242 | 199 | 269 | Region | Note=APC-binding |
| Tgene | USP28 | chr20:31427662 | chr11:113705057 | ENST00000003302 | - | 4 | 25 | 162_650 | 178 | 1078 | Domain | Note=USP |
| Tgene | USP28 | chr20:31427662 | chr11:113705057 | ENST00000003302 | - | 4 | 25 | 97_116 | 178 | 1078 | Domain | UIM |
| Tgene | USP28 | chr20:31427662 | chr11:113705057 | ENST00000260188 | - | 4 | 24 | 162_650 | 178 | 1046 | Domain | Note=USP |
| Tgene | USP28 | chr20:31427662 | chr11:113705057 | ENST00000260188 | - | 4 | 24 | 97_116 | 178 | 1046 | Domain | UIM |
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FusionGeneSequence for MAPRE1_USP28 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MAPRE1_ENST00000375571_chr20_31427662_+_USP28_ENST00000003302_chr11_113705057_-_1099aa MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKI IPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVV RKNPGVGNGDDEAAELMQQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRSS EEQQQDVSEFTHKLLDWLEDAFQLAVNVNSPRNKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNGYRNLDECLEGAMVEGDV ELLPSDHSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMDRYMYRSKELIRNKRECIRKLKEEIKILQQKLERY VKYGSGPARFPLPDMLKYVIEFASTKPASESCPPESDTHMTLPLSSVHCSVSDQTSKESTSTESSSQDVESTFSSPEDSLPKSKPLTSSR SSMEMPSQPAPRTVTDEEINFVKTCLQRWRSEIEQDIQDLKTCIASTTQTIEQMYCDPLLRQVPYRLHAVLVHEGQANAGHYWAYIYNQP RQSWLKYNDISVTESSWEEVERDSYGGLRNVSAYCLMYINDKLPYFNAEAAPTESDQMSEVEALSVELKHYIQEDNWRFEQEVEEWEEEQ SCKIPQMESSTNSSSQDYSTSQEPSVASSHGVRCLSSEHAVIVKEQTAQAIANTARAYEKSGVEAALSEVMLSPAMQGVILAIAKARQTF DRDGSEAGLIKAFHEEYSRLYQLAKETPTSHSDPRLQHVLVYFFQNEAPKRVVERTLLEQFADKNLSYDERSISIMKVAQAKLKEIGPDD MNMEEYKKWHEDYSLFRKVSVYLLTGLELYQKGKYQEALSYLVYAYQSNAALLMKGPRRGVKESVIALYRRKCLLELNAKAASLFETNDD HSVTEGINVMNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGQDIAENLQLCLGEFLPRLLDPSAEIIVLKEPPTIRPNSPYDLCS >In-frame_MAPRE1_ENST00000375571_chr20_31427662_+_USP28_ENST00000260188_chr11_113705057_-_1067aa MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKI IPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVV RKNPGVGNGDDEAAELMQQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRSS EEQQQDVSEFTHKLLDWLEDAFQLAVNVNSPRNKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNGYRNLDECLEGAMVEGDV ELLPSDHSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMDRYMYRSKELIRNKRECIRKLKEEIKILQQKLERY VKYGSGPARFPLPDMLKYVIEFASTKPASESCPPESDTHMTLPLSSVHCSVSDQTSKESTSTESSSQDVESTFSSPEDSLPKSKPLTSSR SSMEMPSQPAPRTVTDEEINFVKTCLQRWRSEIEQDIQDLKTCIASTTQTIEQMYCDPLLRQVPYRLHAVLVHEGQANAGHYWAYIYNQP RQSWLKYNDISVTESSWEEVERDSYGGLRNVSAYCLMYINDKLPYFNAEAAPTESDQMSEVEALSVELKHYIQEDNWRFEQEVEEWEEEQ SCKIPQMESSTNSSSQDYSTSQEPSVASSHGVRCLSSEHAVIVKEQTAQAIANTARAYEKSGVEAALSEAFHEEYSRLYQLAKETPTSHS DPRLQHVLVYFFQNEAPKRVVERTLLEQFADKNLSYDERSISIMKVAQAKLKEIGPDDMNMEEYKKWHEDYSLFRKVSVYLLTGLELYQK GKYQEALSYLVYAYQSNAALLMKGPRRGVKESVIALYRRKCLLELNAKAASLFETNDDHSVTEGINVMNELIIPCIHLIINNDISKDDLD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MAPRE1_ENST00000375571_chr20_31427662_+_USP28_ENST00000003302_chr11_113705057_-_3297nt ATGGCAGTGAACGTATACTCAACGTCAGTGACCAGTGATAACCTAAGTCGACATGACATGCTGGCCTGGATCAATGAGTCTCTGCAGTTG AATCTGACAAAGATCGAACAGTTGTGCTCAGGGGCTGCGTATTGTCAGTTTATGGACATGCTGTTCCCTGGCTCCATTGCCTTGAAGAAA GTGAAATTCCAAGCTAAGCTAGAACACGAGTACATCCAGAACTTCAAAATACTACAAGCAGGTTTTAAGAGAATGGGTGTTGACAAAATA ATTCCTGTGGACAAATTAGTAAAAGGAAAGTTTCAGGACAATTTTGAATTCGTTCAGTGGTTCAAGAAGTTTTTCGATGCAAACTATGAT GGAAAAGACTATGACCCTGTGGCTGCCAGACAAGGTCAAGAAACTGCAGTGGCTCCTTCCCTTGTTGCTCCAGCTCTGAATAAACCGAAG AAACCTCTCACTTCTAGCAGTGCAGCTCCCCAGAGGCCCATCTCAACACAGAGAACCGCTGCGGCTCCTAAGGCTGGCCCTGGTGTGGTG CGAAAGAACCCTGGTGTGGGCAACGGAGACGACGAGGCAGCTGAGTTGATGCAGCAGTCTCTCTTTCAATTGCCTGAATTTCGAAGACTT GTTCTCAGTTATAGTCTGCCACAAAATGTACTTGAAAATTGTCGAAGTCATACAGAAAAGAGAAATATCATGTTTATGCAAGAGCTTCAG TATTTGTTTGCTCTAATGATGGGATCAAATAGAAAATTTGTAGACCCGTCTGCAGCCCTGGATCTATTAAAGGGAGCATTCCGATCATCT GAGGAACAGCAGCAAGATGTGAGTGAATTCACACACAAGCTCCTGGATTGGCTAGAGGACGCATTCCAGCTAGCTGTTAATGTTAACAGT CCCAGGAACAAATCTGAAAATCCAATGGTGCAGCTGTTCTATGGTACTTTCCTGACTGAAGGGGTTCGTGAAGGAAAACCCTTTTGTAAC AATGAGACCTTCGGCCAGTATCCTCTTCAGGTAAACGGTTATCGCAACTTAGACGAGTGTTTGGAAGGGGCCATGGTGGAGGGTGATGTT GAGCTTCTTCCCTCCGATCACTCGGTGAAGTATGGACAAGAGCGTTGGTTTACAAAGCTACCTCCAGTGTTGACCTTTGAACTCTCAAGA TTTGAGTTTAATCAGTCCCTTGGGCAGCCAGAGAAAATTCACAATAAGCTGGAATTTCCTCAGATTATTTATATGGACAGGTACATGTAC AGGAGCAAGGAGCTTATTCGAAATAAGAGAGAGTGTATTCGAAAGTTGAAGGAGGAAATAAAAATTCTGCAGCAAAAATTGGAAAGGTAT GTGAAATATGGCTCAGGCCCAGCTCGGTTCCCGCTCCCGGACATGCTGAAATATGTTATTGAATTTGCTAGTACAAAACCTGCCTCAGAA AGCTGTCCACCTGAAAGTGACACACATATGACATTACCACTTTCTTCAGTGCACTGCTCGGTTTCTGACCAGACATCCAAGGAAAGTACA AGTACAGAAAGCTCTTCTCAGGATGTTGAAAGTACCTTTTCTTCTCCTGAAGATTCTTTACCCAAGTCTAAACCACTGACATCTTCTCGG TCTTCCATGGAAATGCCTTCACAGCCAGCTCCACGAACAGTCACAGATGAGGAGATAAATTTTGTTAAGACCTGTCTTCAGAGATGGAGG AGTGAGATTGAACAAGATATACAAGATTTAAAGACTTGTATTGCAAGTACTACTCAGACTATTGAACAGATGTACTGCGATCCTCTCCTT CGTCAGGTGCCTTATCGCTTGCATGCAGTTCTTGTTCATGAAGGACAAGCAAATGCTGGACACTATTGGGCCTATATCTATAATCAACCC CGACAGAGCTGGCTCAAGTACAATGACATCTCTGTTACTGAATCTTCCTGGGAAGAAGTTGAAAGAGATTCCTATGGAGGCCTGAGAAAT GTTAGTGCTTACTGTCTGATGTACATTAATGACAAACTACCCTACTTCAATGCAGAGGCAGCCCCAACTGAATCAGATCAAATGTCAGAA GTGGAAGCCCTATCTGTGGAACTCAAGCATTACATTCAGGAGGATAACTGGCGGTTTGAGCAGGAAGTAGAGGAGTGGGAAGAAGAGCAG TCTTGCAAAATCCCTCAAATGGAGTCCTCCACCAACTCCTCATCACAGGACTACTCTACATCACAAGAGCCTTCAGTAGCCTCTTCTCAT GGGGTTCGCTGCTTGTCGTCTGAGCATGCTGTGATTGTAAAGGAGCAAACTGCCCAGGCTATTGCAAACACAGCCCGTGCCTATGAGAAG AGCGGTGTAGAAGCGGCACTGAGTGAGGTGATGCTGAGCCCTGCCATGCAAGGGGTCATCCTGGCCATAGCTAAAGCCCGTCAGACCTTT GACCGAGATGGGTCTGAAGCAGGGCTGATTAAGGCATTCCATGAAGAATACTCCAGGCTCTATCAGCTTGCCAAAGAGACCCCCACCTCT CACAGTGATCCTCGACTTCAGCATGTCCTTGTCTACTTTTTCCAAAATGAAGCACCCAAAAGGGTAGTAGAACGAACCCTTCTGGAACAG TTTGCAGATAAAAATCTTAGCTATGATGAAAGATCAATCAGCATTATGAAGGTGGCTCAAGCGAAACTGAAGGAAATTGGTCCAGATGAC ATGAATATGGAAGAGTACAAGAAGTGGCATGAAGATTATAGTTTGTTCCGAAAAGTGTCTGTGTATCTCCTAACAGGCCTAGAACTCTAT CAAAAAGGAAAGTACCAAGAGGCACTTTCCTACCTGGTATATGCCTACCAGAGCAATGCTGCCCTGCTGATGAAGGGGCCCCGCCGGGGG GTCAAAGAATCCGTGATTGCTTTATACCGAAGAAAATGCCTTCTGGAGCTGAATGCCAAAGCAGCTTCTCTTTTTGAAACAAATGATGAT CACTCCGTAACTGAGGGCATTAATGTGATGAATGAACTGATCATCCCCTGCATTCACCTTATCATTAATAATGACATTTCCAAGGATGAT CTGGATGCCATTGAGGTCATGAGAAACCATTGGTGCTCTTACCTTGGGCAAGATATTGCAGAAAATCTGCAGCTGTGCCTAGGGGAGTTT CTACCCAGACTTCTAGATCCTTCTGCAGAAATCATCGTCTTGAAAGAGCCTCCAACAATTCGACCCAATTCTCCCTATGACCTATGTAGC >In-frame_MAPRE1_ENST00000375571_chr20_31427662_+_USP28_ENST00000260188_chr11_113705057_-_3201nt ATGGCAGTGAACGTATACTCAACGTCAGTGACCAGTGATAACCTAAGTCGACATGACATGCTGGCCTGGATCAATGAGTCTCTGCAGTTG AATCTGACAAAGATCGAACAGTTGTGCTCAGGGGCTGCGTATTGTCAGTTTATGGACATGCTGTTCCCTGGCTCCATTGCCTTGAAGAAA GTGAAATTCCAAGCTAAGCTAGAACACGAGTACATCCAGAACTTCAAAATACTACAAGCAGGTTTTAAGAGAATGGGTGTTGACAAAATA ATTCCTGTGGACAAATTAGTAAAAGGAAAGTTTCAGGACAATTTTGAATTCGTTCAGTGGTTCAAGAAGTTTTTCGATGCAAACTATGAT GGAAAAGACTATGACCCTGTGGCTGCCAGACAAGGTCAAGAAACTGCAGTGGCTCCTTCCCTTGTTGCTCCAGCTCTGAATAAACCGAAG AAACCTCTCACTTCTAGCAGTGCAGCTCCCCAGAGGCCCATCTCAACACAGAGAACCGCTGCGGCTCCTAAGGCTGGCCCTGGTGTGGTG CGAAAGAACCCTGGTGTGGGCAACGGAGACGACGAGGCAGCTGAGTTGATGCAGCAGTCTCTCTTTCAATTGCCTGAATTTCGAAGACTT GTTCTCAGTTATAGTCTGCCACAAAATGTACTTGAAAATTGTCGAAGTCATACAGAAAAGAGAAATATCATGTTTATGCAAGAGCTTCAG TATTTGTTTGCTCTAATGATGGGATCAAATAGAAAATTTGTAGACCCGTCTGCAGCCCTGGATCTATTAAAGGGAGCATTCCGATCATCT GAGGAACAGCAGCAAGATGTGAGTGAATTCACACACAAGCTCCTGGATTGGCTAGAGGACGCATTCCAGCTAGCTGTTAATGTTAACAGT CCCAGGAACAAATCTGAAAATCCAATGGTGCAGCTGTTCTATGGTACTTTCCTGACTGAAGGGGTTCGTGAAGGAAAACCCTTTTGTAAC AATGAGACCTTCGGCCAGTATCCTCTTCAGGTAAACGGTTATCGCAACTTAGACGAGTGTTTGGAAGGGGCCATGGTGGAGGGTGATGTT GAGCTTCTTCCCTCCGATCACTCGGTGAAGTATGGACAAGAGCGTTGGTTTACAAAGCTACCTCCAGTGTTGACCTTTGAACTCTCAAGA TTTGAGTTTAATCAGTCCCTTGGGCAGCCAGAGAAAATTCACAATAAGCTGGAATTTCCTCAGATTATTTATATGGACAGGTACATGTAC AGGAGCAAGGAGCTTATTCGAAATAAGAGAGAGTGTATTCGAAAGTTGAAGGAGGAAATAAAAATTCTGCAGCAAAAATTGGAAAGGTAT GTGAAATATGGCTCAGGCCCAGCTCGGTTCCCGCTCCCGGACATGCTGAAATATGTTATTGAATTTGCTAGTACAAAACCTGCCTCAGAA AGCTGTCCACCTGAAAGTGACACACATATGACATTACCACTTTCTTCAGTGCACTGCTCGGTTTCTGACCAGACATCCAAGGAAAGTACA AGTACAGAAAGCTCTTCTCAGGATGTTGAAAGTACCTTTTCTTCTCCTGAAGATTCTTTACCCAAGTCTAAACCACTGACATCTTCTCGG TCTTCCATGGAAATGCCTTCACAGCCAGCTCCACGAACAGTCACAGATGAGGAGATAAATTTTGTTAAGACCTGTCTTCAGAGATGGAGG AGTGAGATTGAACAAGATATACAAGATTTAAAGACTTGTATTGCAAGTACTACTCAGACTATTGAACAGATGTACTGCGATCCTCTCCTT CGTCAGGTGCCTTATCGCTTGCATGCAGTTCTTGTTCATGAAGGACAAGCAAATGCTGGACACTATTGGGCCTATATCTATAATCAACCC CGACAGAGCTGGCTCAAGTACAATGACATCTCTGTTACTGAATCTTCCTGGGAAGAAGTTGAAAGAGATTCCTATGGAGGCCTGAGAAAT GTTAGTGCTTACTGTCTGATGTACATTAATGACAAACTACCCTACTTCAATGCAGAGGCAGCCCCAACTGAATCAGATCAAATGTCAGAA GTGGAAGCCCTATCTGTGGAACTCAAGCATTACATTCAGGAGGATAACTGGCGGTTTGAGCAGGAAGTAGAGGAGTGGGAAGAAGAGCAG TCTTGCAAAATCCCTCAAATGGAGTCCTCCACCAACTCCTCATCACAGGACTACTCTACATCACAAGAGCCTTCAGTAGCCTCTTCTCAT GGGGTTCGCTGCTTGTCGTCTGAGCATGCTGTGATTGTAAAGGAGCAAACTGCCCAGGCTATTGCAAACACAGCCCGTGCCTATGAGAAG AGCGGTGTAGAAGCGGCACTGAGTGAGGCATTCCATGAAGAATACTCCAGGCTCTATCAGCTTGCCAAAGAGACCCCCACCTCTCACAGT GATCCTCGACTTCAGCATGTCCTTGTCTACTTTTTCCAAAATGAAGCACCCAAAAGGGTAGTAGAACGAACCCTTCTGGAACAGTTTGCA GATAAAAATCTTAGCTATGATGAAAGATCAATCAGCATTATGAAGGTGGCTCAAGCGAAACTGAAGGAAATTGGTCCAGATGACATGAAT ATGGAAGAGTACAAGAAGTGGCATGAAGATTATAGTTTGTTCCGAAAAGTGTCTGTGTATCTCCTAACAGGCCTAGAACTCTATCAAAAA GGAAAGTACCAAGAGGCACTTTCCTACCTGGTATATGCCTACCAGAGCAATGCTGCCCTGCTGATGAAGGGGCCCCGCCGGGGGGTCAAA GAATCCGTGATTGCTTTATACCGAAGAAAATGCCTTCTGGAGCTGAATGCCAAAGCAGCTTCTCTTTTTGAAACAAATGATGATCACTCC GTAACTGAGGGCATTAATGTGATGAATGAACTGATCATCCCCTGCATTCACCTTATCATTAATAATGACATTTCCAAGGATGATCTGGAT GCCATTGAGGTCATGAGAAACCATTGGTGCTCTTACCTTGGGCAAGATATTGCAGAAAATCTGCAGCTGTGCCTAGGGGAGTTTCTACCC AGACTTCTAGATCCTTCTGCAGAAATCATCGTCTTGAAAGAGCCTCCAACAATTCGACCCAATTCTCCCTATGACCTATGTAGCCGATTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MAPRE1_ENST00000375571_chr20_31427662_+_USP28_ENST00000003302_chr11_113705057_-_4802nt CTTTACGTCGGCGCGTAACGAGGGGGTGCGTGTGAGGTCATCGCGCGGGCGGGCGGGCGGGGTCTGGCGGTTTGAACGAGACGAAGACGG AACCGGAGCCGGTTGCGGGCAGTGGACGCGGTTCTGCCGAGAGCCGAAGATGGCAGTGAACGTATACTCAACGTCAGTGACCAGTGATAA CCTAAGTCGACATGACATGCTGGCCTGGATCAATGAGTCTCTGCAGTTGAATCTGACAAAGATCGAACAGTTGTGCTCAGGGGCTGCGTA TTGTCAGTTTATGGACATGCTGTTCCCTGGCTCCATTGCCTTGAAGAAAGTGAAATTCCAAGCTAAGCTAGAACACGAGTACATCCAGAA CTTCAAAATACTACAAGCAGGTTTTAAGAGAATGGGTGTTGACAAAATAATTCCTGTGGACAAATTAGTAAAAGGAAAGTTTCAGGACAA TTTTGAATTCGTTCAGTGGTTCAAGAAGTTTTTCGATGCAAACTATGATGGAAAAGACTATGACCCTGTGGCTGCCAGACAAGGTCAAGA AACTGCAGTGGCTCCTTCCCTTGTTGCTCCAGCTCTGAATAAACCGAAGAAACCTCTCACTTCTAGCAGTGCAGCTCCCCAGAGGCCCAT CTCAACACAGAGAACCGCTGCGGCTCCTAAGGCTGGCCCTGGTGTGGTGCGAAAGAACCCTGGTGTGGGCAACGGAGACGACGAGGCAGC TGAGTTGATGCAGCAGTCTCTCTTTCAATTGCCTGAATTTCGAAGACTTGTTCTCAGTTATAGTCTGCCACAAAATGTACTTGAAAATTG TCGAAGTCATACAGAAAAGAGAAATATCATGTTTATGCAAGAGCTTCAGTATTTGTTTGCTCTAATGATGGGATCAAATAGAAAATTTGT AGACCCGTCTGCAGCCCTGGATCTATTAAAGGGAGCATTCCGATCATCTGAGGAACAGCAGCAAGATGTGAGTGAATTCACACACAAGCT CCTGGATTGGCTAGAGGACGCATTCCAGCTAGCTGTTAATGTTAACAGTCCCAGGAACAAATCTGAAAATCCAATGGTGCAGCTGTTCTA TGGTACTTTCCTGACTGAAGGGGTTCGTGAAGGAAAACCCTTTTGTAACAATGAGACCTTCGGCCAGTATCCTCTTCAGGTAAACGGTTA TCGCAACTTAGACGAGTGTTTGGAAGGGGCCATGGTGGAGGGTGATGTTGAGCTTCTTCCCTCCGATCACTCGGTGAAGTATGGACAAGA GCGTTGGTTTACAAAGCTACCTCCAGTGTTGACCTTTGAACTCTCAAGATTTGAGTTTAATCAGTCCCTTGGGCAGCCAGAGAAAATTCA CAATAAGCTGGAATTTCCTCAGATTATTTATATGGACAGGTACATGTACAGGAGCAAGGAGCTTATTCGAAATAAGAGAGAGTGTATTCG AAAGTTGAAGGAGGAAATAAAAATTCTGCAGCAAAAATTGGAAAGGTATGTGAAATATGGCTCAGGCCCAGCTCGGTTCCCGCTCCCGGA CATGCTGAAATATGTTATTGAATTTGCTAGTACAAAACCTGCCTCAGAAAGCTGTCCACCTGAAAGTGACACACATATGACATTACCACT TTCTTCAGTGCACTGCTCGGTTTCTGACCAGACATCCAAGGAAAGTACAAGTACAGAAAGCTCTTCTCAGGATGTTGAAAGTACCTTTTC TTCTCCTGAAGATTCTTTACCCAAGTCTAAACCACTGACATCTTCTCGGTCTTCCATGGAAATGCCTTCACAGCCAGCTCCACGAACAGT CACAGATGAGGAGATAAATTTTGTTAAGACCTGTCTTCAGAGATGGAGGAGTGAGATTGAACAAGATATACAAGATTTAAAGACTTGTAT TGCAAGTACTACTCAGACTATTGAACAGATGTACTGCGATCCTCTCCTTCGTCAGGTGCCTTATCGCTTGCATGCAGTTCTTGTTCATGA AGGACAAGCAAATGCTGGACACTATTGGGCCTATATCTATAATCAACCCCGACAGAGCTGGCTCAAGTACAATGACATCTCTGTTACTGA ATCTTCCTGGGAAGAAGTTGAAAGAGATTCCTATGGAGGCCTGAGAAATGTTAGTGCTTACTGTCTGATGTACATTAATGACAAACTACC CTACTTCAATGCAGAGGCAGCCCCAACTGAATCAGATCAAATGTCAGAAGTGGAAGCCCTATCTGTGGAACTCAAGCATTACATTCAGGA GGATAACTGGCGGTTTGAGCAGGAAGTAGAGGAGTGGGAAGAAGAGCAGTCTTGCAAAATCCCTCAAATGGAGTCCTCCACCAACTCCTC ATCACAGGACTACTCTACATCACAAGAGCCTTCAGTAGCCTCTTCTCATGGGGTTCGCTGCTTGTCGTCTGAGCATGCTGTGATTGTAAA GGAGCAAACTGCCCAGGCTATTGCAAACACAGCCCGTGCCTATGAGAAGAGCGGTGTAGAAGCGGCACTGAGTGAGGTGATGCTGAGCCC TGCCATGCAAGGGGTCATCCTGGCCATAGCTAAAGCCCGTCAGACCTTTGACCGAGATGGGTCTGAAGCAGGGCTGATTAAGGCATTCCA TGAAGAATACTCCAGGCTCTATCAGCTTGCCAAAGAGACCCCCACCTCTCACAGTGATCCTCGACTTCAGCATGTCCTTGTCTACTTTTT CCAAAATGAAGCACCCAAAAGGGTAGTAGAACGAACCCTTCTGGAACAGTTTGCAGATAAAAATCTTAGCTATGATGAAAGATCAATCAG CATTATGAAGGTGGCTCAAGCGAAACTGAAGGAAATTGGTCCAGATGACATGAATATGGAAGAGTACAAGAAGTGGCATGAAGATTATAG TTTGTTCCGAAAAGTGTCTGTGTATCTCCTAACAGGCCTAGAACTCTATCAAAAAGGAAAGTACCAAGAGGCACTTTCCTACCTGGTATA TGCCTACCAGAGCAATGCTGCCCTGCTGATGAAGGGGCCCCGCCGGGGGGTCAAAGAATCCGTGATTGCTTTATACCGAAGAAAATGCCT TCTGGAGCTGAATGCCAAAGCAGCTTCTCTTTTTGAAACAAATGATGATCACTCCGTAACTGAGGGCATTAATGTGATGAATGAACTGAT CATCCCCTGCATTCACCTTATCATTAATAATGACATTTCCAAGGATGATCTGGATGCCATTGAGGTCATGAGAAACCATTGGTGCTCTTA CCTTGGGCAAGATATTGCAGAAAATCTGCAGCTGTGCCTAGGGGAGTTTCTACCCAGACTTCTAGATCCTTCTGCAGAAATCATCGTCTT GAAAGAGCCTCCAACAATTCGACCCAATTCTCCCTATGACCTATGTAGCCGATTTGCAGCTGTCATGGAGTCAATTCAGGGAGTTTCAAC TGTGACAGTGAAATAAGCTCCCACATGTTCAAGGCCCATTCTGGTTCCTGGCTGCCTGCCTCTTGCACAGAAGTTCGTTGTCATAGTGCT CACCTTGGGAAAAGGATTAGGTGGGCACATAAGATTCCGATCAGACCCCAACCATGCTGCATGTGTAAAGAAGGATTGAAAATAAAATTG CACTTTTTAGGTACAAAATCATAAAAGCTGTTTCACTAGAAAAGGCAGAAAGCAGTGTATTAAGGTGTTGAATTACGCCAGAAGACCTGA AATGCCTTGTACCTACAACAATGCTTAGGCTTTTCTAAGCCTCTTGCCACTTTTAAAATTATCCTTCAGGCATAAATATTTTTGACAGCA GAATAGAAGAATGATTCATGAGAACCTGAACCAGATGAACAGCTACTAGTTATTTTATCAAATACAGATGACATTTAAAAATTCTTAACT ACAAGAGATTAGAAATATAAACCTTGCCTGGCTCTTGCCAGGAGATAACAAAATGGGTTGCTGATGAACTGCACCCTTTTACATGTGGGT AGAATATAAGCTCACATGGCAGTGAGATGTTGAAAAGTCAAAAGAGACCTGTCTCTCTCCTTTCTTTTCTATCTTTAAACCAGAAAACCT CATACTCAGTCCTCAGTGAAAGAAAGTAAAGTATTAAGGACTTTAGACAGAAGAGCATTGTGTAACTTGACTGAAGATCATCCATTAATA GTTATTAGGCATTTAGGTAAAATTTTCTAATACCTAAAAATTGTCAAAAACAGTCAATAGGGCTACTGCTGGCCCAAAGACCATTTAGGT CCACCTCCTCTTTTTTGCTCTTTTTTTTTTTCTGTGACAGTTTCACTGTGTCGCCCAGGCTGGCGTTCAGTGGTGCAATCTCAGCTCACT GCAAACTCTGTCTCCTGGGCTCAAGTGATTCTCGTGCCTCAGCCTCCCGAATAGCTGGAATTACGGGCATGCACCACCACACCTGGCTAA TTTTTGTATTTTTAATAGAGATGGGGTTTCACCATATTGGCCAGGCTGATCTCTAACTCCTGGCCTCAAGTGATCTATCTGCCTCCCTCA GCCTCCCAAAGTCTGGGATTGCAGACAAGTCATCGTACCCGGCCTTCTTTTTTGCCCTTAAAAGTAAGGGATGTGGGTTTGTACAAAAAA AAAAAAAAAAAAAAAAAAACCAGCATACATATGCAAAACTATATATATATGTATATGTAGAGAAAAATACTTCCCATTGATCATTTTTAA AAGGCTTCTGATTGGATATTGTGTTTTAACCAAATTTTAAAGATTAATGGAATCATGAAAGGGAAAAAAATTGATACAACTATGCAGATT >In-frame_MAPRE1_ENST00000375571_chr20_31427662_+_USP28_ENST00000260188_chr11_113705057_-_4704nt CTTTACGTCGGCGCGTAACGAGGGGGTGCGTGTGAGGTCATCGCGCGGGCGGGCGGGCGGGGTCTGGCGGTTTGAACGAGACGAAGACGG AACCGGAGCCGGTTGCGGGCAGTGGACGCGGTTCTGCCGAGAGCCGAAGATGGCAGTGAACGTATACTCAACGTCAGTGACCAGTGATAA CCTAAGTCGACATGACATGCTGGCCTGGATCAATGAGTCTCTGCAGTTGAATCTGACAAAGATCGAACAGTTGTGCTCAGGGGCTGCGTA TTGTCAGTTTATGGACATGCTGTTCCCTGGCTCCATTGCCTTGAAGAAAGTGAAATTCCAAGCTAAGCTAGAACACGAGTACATCCAGAA CTTCAAAATACTACAAGCAGGTTTTAAGAGAATGGGTGTTGACAAAATAATTCCTGTGGACAAATTAGTAAAAGGAAAGTTTCAGGACAA TTTTGAATTCGTTCAGTGGTTCAAGAAGTTTTTCGATGCAAACTATGATGGAAAAGACTATGACCCTGTGGCTGCCAGACAAGGTCAAGA AACTGCAGTGGCTCCTTCCCTTGTTGCTCCAGCTCTGAATAAACCGAAGAAACCTCTCACTTCTAGCAGTGCAGCTCCCCAGAGGCCCAT CTCAACACAGAGAACCGCTGCGGCTCCTAAGGCTGGCCCTGGTGTGGTGCGAAAGAACCCTGGTGTGGGCAACGGAGACGACGAGGCAGC TGAGTTGATGCAGCAGTCTCTCTTTCAATTGCCTGAATTTCGAAGACTTGTTCTCAGTTATAGTCTGCCACAAAATGTACTTGAAAATTG TCGAAGTCATACAGAAAAGAGAAATATCATGTTTATGCAAGAGCTTCAGTATTTGTTTGCTCTAATGATGGGATCAAATAGAAAATTTGT AGACCCGTCTGCAGCCCTGGATCTATTAAAGGGAGCATTCCGATCATCTGAGGAACAGCAGCAAGATGTGAGTGAATTCACACACAAGCT CCTGGATTGGCTAGAGGACGCATTCCAGCTAGCTGTTAATGTTAACAGTCCCAGGAACAAATCTGAAAATCCAATGGTGCAGCTGTTCTA TGGTACTTTCCTGACTGAAGGGGTTCGTGAAGGAAAACCCTTTTGTAACAATGAGACCTTCGGCCAGTATCCTCTTCAGGTAAACGGTTA TCGCAACTTAGACGAGTGTTTGGAAGGGGCCATGGTGGAGGGTGATGTTGAGCTTCTTCCCTCCGATCACTCGGTGAAGTATGGACAAGA GCGTTGGTTTACAAAGCTACCTCCAGTGTTGACCTTTGAACTCTCAAGATTTGAGTTTAATCAGTCCCTTGGGCAGCCAGAGAAAATTCA CAATAAGCTGGAATTTCCTCAGATTATTTATATGGACAGGTACATGTACAGGAGCAAGGAGCTTATTCGAAATAAGAGAGAGTGTATTCG AAAGTTGAAGGAGGAAATAAAAATTCTGCAGCAAAAATTGGAAAGGTATGTGAAATATGGCTCAGGCCCAGCTCGGTTCCCGCTCCCGGA CATGCTGAAATATGTTATTGAATTTGCTAGTACAAAACCTGCCTCAGAAAGCTGTCCACCTGAAAGTGACACACATATGACATTACCACT TTCTTCAGTGCACTGCTCGGTTTCTGACCAGACATCCAAGGAAAGTACAAGTACAGAAAGCTCTTCTCAGGATGTTGAAAGTACCTTTTC TTCTCCTGAAGATTCTTTACCCAAGTCTAAACCACTGACATCTTCTCGGTCTTCCATGGAAATGCCTTCACAGCCAGCTCCACGAACAGT CACAGATGAGGAGATAAATTTTGTTAAGACCTGTCTTCAGAGATGGAGGAGTGAGATTGAACAAGATATACAAGATTTAAAGACTTGTAT TGCAAGTACTACTCAGACTATTGAACAGATGTACTGCGATCCTCTCCTTCGTCAGGTGCCTTATCGCTTGCATGCAGTTCTTGTTCATGA AGGACAAGCAAATGCTGGACACTATTGGGCCTATATCTATAATCAACCCCGACAGAGCTGGCTCAAGTACAATGACATCTCTGTTACTGA ATCTTCCTGGGAAGAAGTTGAAAGAGATTCCTATGGAGGCCTGAGAAATGTTAGTGCTTACTGTCTGATGTACATTAATGACAAACTACC CTACTTCAATGCAGAGGCAGCCCCAACTGAATCAGATCAAATGTCAGAAGTGGAAGCCCTATCTGTGGAACTCAAGCATTACATTCAGGA GGATAACTGGCGGTTTGAGCAGGAAGTAGAGGAGTGGGAAGAAGAGCAGTCTTGCAAAATCCCTCAAATGGAGTCCTCCACCAACTCCTC ATCACAGGACTACTCTACATCACAAGAGCCTTCAGTAGCCTCTTCTCATGGGGTTCGCTGCTTGTCGTCTGAGCATGCTGTGATTGTAAA GGAGCAAACTGCCCAGGCTATTGCAAACACAGCCCGTGCCTATGAGAAGAGCGGTGTAGAAGCGGCACTGAGTGAGGCATTCCATGAAGA ATACTCCAGGCTCTATCAGCTTGCCAAAGAGACCCCCACCTCTCACAGTGATCCTCGACTTCAGCATGTCCTTGTCTACTTTTTCCAAAA TGAAGCACCCAAAAGGGTAGTAGAACGAACCCTTCTGGAACAGTTTGCAGATAAAAATCTTAGCTATGATGAAAGATCAATCAGCATTAT GAAGGTGGCTCAAGCGAAACTGAAGGAAATTGGTCCAGATGACATGAATATGGAAGAGTACAAGAAGTGGCATGAAGATTATAGTTTGTT CCGAAAAGTGTCTGTGTATCTCCTAACAGGCCTAGAACTCTATCAAAAAGGAAAGTACCAAGAGGCACTTTCCTACCTGGTATATGCCTA CCAGAGCAATGCTGCCCTGCTGATGAAGGGGCCCCGCCGGGGGGTCAAAGAATCCGTGATTGCTTTATACCGAAGAAAATGCCTTCTGGA GCTGAATGCCAAAGCAGCTTCTCTTTTTGAAACAAATGATGATCACTCCGTAACTGAGGGCATTAATGTGATGAATGAACTGATCATCCC CTGCATTCACCTTATCATTAATAATGACATTTCCAAGGATGATCTGGATGCCATTGAGGTCATGAGAAACCATTGGTGCTCTTACCTTGG GCAAGATATTGCAGAAAATCTGCAGCTGTGCCTAGGGGAGTTTCTACCCAGACTTCTAGATCCTTCTGCAGAAATCATCGTCTTGAAAGA GCCTCCAACAATTCGACCCAATTCTCCCTATGACCTATGTAGCCGATTTGCAGCTGTCATGGAGTCAATTCAGGGAGTTTCAACTGTGAC AGTGAAATAAGCTCCCACATGTTCAAGGCCCATTCTGGTTCCTGGCTGCCTGCCTCTTGCACAGAAGTTCGTTGTCATAGTGCTCACCTT GGGAAAAGGATTAGGTGGGCACATAAGATTCCGATCAGACCCCAACCATGCTGCATGTGTAAAGAAGGATTGAAAATAAAATTGCACTTT TTAGGTACAAAATCATAAAAGCTGTTTCACTAGAAAAGGCAGAAAGCAGTGTATTAAGGTGTTGAATTACGCCAGAAGACCTGAAATGCC TTGTACCTACAACAATGCTTAGGCTTTTCTAAGCCTCTTGCCACTTTTAAAATTATCCTTCAGGCATAAATATTTTTGACAGCAGAATAG AAGAATGATTCATGAGAACCTGAACCAGATGAACAGCTACTAGTTATTTTATCAAATACAGATGACATTTAAAAATTCTTAACTACAAGA GATTAGAAATATAAACCTTGCCTGGCTCTTGCCAGGAGATAACAAAATGGGTTGCTGATGAACTGCACCCTTTTACATGTGGGTAGAATA TAAGCTCACATGGCAGTGAGATGTTGAAAAGTCAAAAGAGACCTGTCTCTCTCCTTTCTTTTCTATCTTTAAACCAGAAAACCTCATACT CAGTCCTCAGTGAAAGAAAGTAAAGTATTAAGGACTTTAGACAGAAGAGCATTGTGTAACTTGACTGAAGATCATCCATTAATAGTTATT AGGCATTTAGGTAAAATTTTCTAATACCTAAAAATTGTCAAAAACAGTCAATAGGGCTACTGCTGGCCCAAAGACCATTTAGGTCCACCT CCTCTTTTTTGCTCTTTTTTTTTTTCTGTGACAGTTTCACTGTGTCGCCCAGGCTGGCGTTCAGTGGTGCAATCTCAGCTCACTGCAAAC TCTGTCTCCTGGGCTCAAGTGATTCTCGTGCCTCAGCCTCCCGAATAGCTGGAATTACGGGCATGCACCACCACACCTGGCTAATTTTTG TATTTTTAATAGAGATGGGGTTTCACCATATTGGCCAGGCTGATCTCTAACTCCTGGCCTCAAGTGATCTATCTGCCTCCCTCAGCCTCC CAAAGTCTGGGATTGCAGACAAGTCATCGTACCCGGCCTTCTTTTTTGCCCTTAAAAGTAAGGGATGTGGGTTTGTACAAAAAAAAAAAA AAAAAAAAAAAAACCAGCATACATATGCAAAACTATATATATATGTATATGTAGAGAAAAATACTTCCCATTGATCATTTTTAAAAGGCT TCTGATTGGATATTGTGTTTTAACCAAATTTTAAAGATTAATGGAATCATGAAAGGGAAAAAAATTGATACAACTATGCAGATTTTATAA |
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FusionGenePPI for MAPRE1_USP28 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAPRE1 | APC, TERF1, COPS5, COPS8, CSN3, COPS7A, HDAC6, LRP1, APP, CDK2, AURKA, AURKB, TUBB, SPTAN1, FN1, VCAM1, IQCB1, ITGA4, CLIP1, TUBA1A, BAG3, CDK5RAP2, OLA1, SNRPD2, SNRPE, SNRPF, TBCB, YWHAZ, PAFAH1B1, PRKACA, PRKACB, STIM1, NAV1, NAV2, NAV3, TRIO, LMO2, POLE2, PSMA1, PDE4DIP, TROAP, PQBP1, MAPRE2, MAPRE1, MAPRE3, SPDYE2, CYLD, IKBKG, HSPA1A, TRAF2, ABCB1, STK11, BCL3, KAT2B, KAT5, MTUS2, KIF2C, MACF1, CLASP1, CLASP2, NUPR1, ABCE1, GAS2L1, DST, PPP1R13L, AKAP9, KIF18B, UNK, CKAP5, SUMO3, UCHL3, NTRK1, EWSR1, SRPK2, CEP135, CEP290, LCA5, OFD1, CEP170, CEP104, DCTN1, CEP19, ACTN4, ACTN1, ADD1, ADD3, BLMH, CALM1, CALML3, CAPZA1, CD59, CLTA, CLTB, CLTC, CPM, CTNNA1, CTNNB1, DAB2, DBN1, DYNC1H1, DYNC1I2, EPS15, FLNA, FYN, GNAI2, HSP90AB1, ABLIM1, MYO1E, PCM1, PCNT, PLEC, PRKAR2A, QARS, SPTBN1, SSFA2, SVIL, TMOD1, TPM4, CLIP2, YES1, LUZP1, AXIN1, SORBS2, TAOK2, CEP350, SEC16A, WDR1, ACTR1A, PIBF1, DCTN2, SPAG5, RAB35, FGFR1OP, SYNPO, CEP162, CEP131, ERC1, COBL, LIMA1, SYBU, CEP72, MIB1, AFAP1, HYI, DYNLRB1, CCDC77, KNSTRN, NEXN, SPECC1, TBC1D31, SSX2IP, MISP, CD109, WDR90, TPRN, U2AF2, CDH1, KLHL21, PRKAR2B, HSPA5, PSMB1, TANC2, PPP1CA, IFT52, G3BP1 | USP28 | SUMO2, TP53BP1, AQR, USP25, CLSPN, MDC1, ELAVL1, MYC, FBXW7, RFFL, PJA1, TRIM63, TRIM55, USP21, USP20, USP51, USP5, USP7, STAMBP, OTUB1, JOSD1, UCHL3, USP8, UCHL5, OTUB2, ATXN3L, USP33, USP15, USP28, ESPL1, SENP8, USP14, STAM, BAP1, UCHL1, UBC, USP4, ZC3H4, TWF1, USO1, ZCCHC8, CIT, PFAS, RCHY1, PLA2G2A, NSMCE2, KDM1A, MAP3K1, COMTD1, FOXK1, ZNF304, PRKD1, MRPS7, KLHL2, SPPL2B, SENP2, ST6GAL1, MTNR1A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MAPRE1 | chr20:31427662 | chr11:113705057 | ENST00000375571 | + | 5 | 7 | 185_268 | 199 | 269 | CDK5RAP2 |
| Hgene | MAPRE1 | chr20:31427662 | chr11:113705057 | ENST00000375571 | + | 5 | 7 | 124_268 | 199 | 269 | MTUS2/TIP150 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAPRE1_USP28 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAPRE1_USP28 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MAPRE1 | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | MAPRE1 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
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