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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 21053

FusionGeneSummary for MAPRE1_TM9SF4

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPRE1_TM9SF4
Fusion gene ID: 21053
HgeneTgene
Gene symbol

MAPRE1

TM9SF4

Gene ID

22919

9777

Gene namemicrotubule associated protein RP/EB family member 1transmembrane 9 superfamily member 4
SynonymsEB1dJ836N17.2
Cytomap

20q11.21

20q11.21

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated protein RP/EB family member 1APC-binding protein EB1adenomatous polyposis coli-binding protein EB1end-binding protein 1transmembrane 9 superfamily member 4dinucleotide oxidase disulfide thiol exchanger 3 superfamily member 4transmembrane 9 superfamily protein member 4tumor cannibalism associated protein 1
Modification date2018052320180529
UniProtAcc

Q15691

Q92544

Ensembl transtripts involved in fusion geneENST00000375571, ENST00000398022, 
ENST00000217315, 
Fusion gene scores* DoF score8 X 6 X 6=2886 X 4 X 6=144
# samples 88
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAPRE1 [Title/Abstract] AND TM9SF4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAPRE1

GO:0031115

negative regulation of microtubule polymerization

11943150

HgeneMAPRE1

GO:0035372

protein localization to microtubule

19632184|21820309

TgeneTM9SF4

GO:0001666

response to hypoxia

25961573


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-J9-A8CN-01AMAPRE1chr20

31427662

+TM9SF4chr20

30720816

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000375571ENST00000398022MAPRE1chr20

31427662

+TM9SF4chr20

30720816

+
5CDS-5UTRENST00000375571ENST00000217315MAPRE1chr20

31427662

+TM9SF4chr20

30720816

+

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FusionProtFeatures for MAPRE1_TM9SF4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPRE1

Q15691

TM9SF4

Q92544

Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubulecytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184,PubMed:21646404, PubMed:28726242, PubMed:28814570). Promotescytoplasmic microtubule nucleation and elongation(PubMed:12388762, PubMed:16109370, PubMed:19632184,PubMed:21646404, PubMed:28726242, PubMed:28814570). May beinvolved in spindle function by stabilizing microtubules andanchoring them at centrosomes (PubMed:12388762). Also acts as aregulator of minus-end microtubule organization: interacts withthe complex formed by AKAP9 and PDE4DIP, leading to recruitCAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomalminus-end microtubules to the Golgi, an important step forpolarized cell movement (PubMed:28814570). Promotes elongation ofCAMSAP2-decorated microtubule stretches on the minus-end ofmicrotubules (PubMed:28814570). Acts as a regulator ofautophagosome transport via interaction with CAMSAP2(PubMed:28726242). May play a role in cell migration (Bysimilarity). {ECO:0000250|UniProtKB:Q61166,ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370,ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404,ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570}. Associates with proteins harboring glycine-richtransmembrane domains and ensures their efficient localization tothe cell surface (PubMed:25999474). Regulates the assembly andactivity of V-ATPase in colon cancer cells via its interactionwith V-type proton ATPase subunit H (ATP6V1H) and contributes toV-ATPase-mediated pH alterations in cancer cells which play animportant role in drug resistance and invasiveness of colon cancercells (PubMed:25659576). Plays an important role in an atypicalphagocytic activity of metastatic melanoma cells calledcannibalism and is involved in the pH regulation of theintracellular vesicles in tumor cells (PubMed:19893578).{ECO:0000269|PubMed:19893578, ECO:0000269|PubMed:25659576,ECO:0000269|PubMed:25999474}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAPRE1chr20:31427662chr20:30720816ENST00000375571+5714_116199269DomainCalponin-homology (CH)
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+01824_281-12626Topological domainExtracellular
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018303_346-12626Topological domainCytoplasmic
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018368_376-12626Topological domainExtracellular
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018398_416-12626Topological domainCytoplasmic
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018438_449-12626Topological domainExtracellular
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018471_501-12626Topological domainCytoplasmic
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018523_535-12626Topological domainExtracellular
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018557_570-12626Topological domainCytoplasmic
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018592_598-12626Topological domainExtracellular
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018620_642-12626Topological domainCytoplasmic
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+01824_2815643Topological domainExtracellular
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018303_3465643Topological domainCytoplasmic
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018368_3765643Topological domainExtracellular
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018398_4165643Topological domainCytoplasmic
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018438_4495643Topological domainExtracellular
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018471_5015643Topological domainCytoplasmic
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018523_5355643Topological domainExtracellular
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018557_5705643Topological domainCytoplasmic
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018592_5985643Topological domainExtracellular
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018620_6425643Topological domainCytoplasmic
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018282_302-12626TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018347_367-12626TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018377_397-12626TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018417_437-12626TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018450_470-12626TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018502_522-12626TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018536_556-12626TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018571_591-12626TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000217315+018599_619-12626TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018282_3025643TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018347_3675643TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018377_3975643TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018417_4375643TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018450_4705643TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018502_5225643TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018536_5565643TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018571_5915643TransmembraneHelical
TgeneTM9SF4chr20:31427662chr20:30720816ENST00000398022+018599_6195643TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAPRE1chr20:31427662chr20:30720816ENST00000375571+57185_255199269DomainEB1 C-terminal
HgeneMAPRE1chr20:31427662chr20:30720816ENST00000375571+57208_268199269RegionNote=DCTN1-binding
HgeneMAPRE1chr20:31427662chr20:30720816ENST00000375571+57220_242199269RegionNote=APC-binding


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FusionGeneSequence for MAPRE1_TM9SF4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MAPRE1_ENST00000375571_chr20_31427662_+_TM9SF4_ENST00000398022_chr20_30720816_+_837aa
MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKI
IPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVV
RKNPGVGNGDDEAAELMQQDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENL
GEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHG
YRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHW
EESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSS
LLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIW
GKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIW
ENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEFIPSLLYFGYTALMVLSF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MAPRE1_ENST00000375571_chr20_31427662_+_TM9SF4_ENST00000398022_chr20_30720816_+_2511nt
ATGGCAGTGAACGTATACTCAACGTCAGTGACCAGTGATAACCTAAGTCGACATGACATGCTGGCCTGGATCAATGAGTCTCTGCAGTTG
AATCTGACAAAGATCGAACAGTTGTGCTCAGGGGCTGCGTATTGTCAGTTTATGGACATGCTGTTCCCTGGCTCCATTGCCTTGAAGAAA
GTGAAATTCCAAGCTAAGCTAGAACACGAGTACATCCAGAACTTCAAAATACTACAAGCAGGTTTTAAGAGAATGGGTGTTGACAAAATA
ATTCCTGTGGACAAATTAGTAAAAGGAAAGTTTCAGGACAATTTTGAATTCGTTCAGTGGTTCAAGAAGTTTTTCGATGCAAACTATGAT
GGAAAAGACTATGACCCTGTGGCTGCCAGACAAGGTCAAGAAACTGCAGTGGCTCCTTCCCTTGTTGCTCCAGCTCTGAATAAACCGAAG
AAACCTCTCACTTCTAGCAGTGCAGCTCCCCAGAGGCCCATCTCAACACAGAGAACCGCTGCGGCTCCTAAGGCTGGCCCTGGTGTGGTG
CGAAAGAACCCTGGTGTGGGCAACGGAGACGACGAGGCAGCTGAGTTGATGCAGCAGGATTGGTTGCCGTGGTCTTTACTGCTTTTCTCC
CTGATGTGTGAAACAAGCGCCTTCTATGTGCCTGGGGTCGCGCCTATCAACTTCCACCAGAACGATCCCGTAGAAATCAAGGCTGTGAAG
CTCACCAGCTCTCGAACCCAGCTACCTTATGAATACTATTCACTGCCCTTCTGCCAGCCCAGCAAGATAACCTACAAGGCAGAGAATCTG
GGAGAGGTGCTGAGAGGGGACCGGATTGTCAACACCCCTTTCCAGGTTCTCATGAACAGCGAGAAGAAGTGTGAAGTTCTGTGCAGCCAG
TCCAACAAGCCAGTGACCCTGACAGTGGAGCAGAGCCGACTCGTGGCCGAGCGGATCACAGAAGACTACTACGTCCACCTCATTGCTGAC
AACCTGCCTGTGGCCACCCGGCTGGAGCTCTACTCCAACCGAGACAGCGATGACAAGAAGAAGGAAAAAGATGTGCAGTTTGAACACGGC
TACCGGCTCGGCTTCACAGATGTCAACAAGATCTACCTGCACAACCACCTCTCATTCATCCTTTACTATCATCGGGAGGACATGGAAGAG
GACCAGGAGCACACGTACCGTGTCGTCCGCTTCGAGGTGATTCCCCAGAGCATCAGGCTGGAGGACCTCAAAGCAGATGAGAAGAGTTCG
TGCACTCTGCCTGAGGGTACCAACTCCTCGCCCCAAGAAATTGACCCCACCAAGGAGAATCAGCTGTACTTCACCTACTCTGTCCACTGG
GAGGAAAGTGATATCAAATGGGCCTCTCGCTGGGACACTTACCTGACCATGAGTGACGTCCAGATCCACTGGTTTTCTATCATTAACTCC
GTTGTTGTGGTCTTCTTCCTGTCAGGTATCCTGAGCATGATTATCATTCGGACCCTCCGGAAGGACATTGCCAACTACAACAAGGAGGAT
GACATTGAAGACACCATGGAGGAGTCTGGGTGGAAGTTGGTGCACGGCGACGTCTTCAGGCCCCCCCAGTACCCCATGATCCTCAGCTCC
CTGCTGGGCTCAGGCATTCAGCTGTTCTGTATGATCCTCATCGTCATCTTTGTAGCCATGCTTGGGATGCTGTCGCCCTCCAGCCGGGGA
GCTCTCATGACCACAGCCTGCTTCCTCTTCATGTTCATGGGGGTGTTTGGCGGATTTTCTGCTGGCCGTCTGTACCGCACTTTAAAAGGC
CATCGGTGGAAGAAAGGAGCCTTCTGTACGGCAACTCTGTACCCTGGTGTGGTTTTTGGCATCTGCTTCGTATTGAATTGCTTCATTTGG
GGAAAGCACTCATCAGGAGCGGTGCCCTTTCCCACCATGGTGGCTCTGCTGTGCATGTGGTTCGGGATCTCCCTGCCCCTCGTCTACTTG
GGCTACTACTTCGGCTTCCGAAAGCAGCCATATGACAACCCTGTGCGCACCAACCAGATTCCCCGGCAGATCCCCGAGCAGCGGTGGTAC
ATGAACCGATTTGTGGGCATCCTCATGGCTGGGATCTTGCCCTTCGGCGCCATGTTCATCGAGCTCTTCTTCATCTTCAGTGCTATCTGG
GAGAATCAGTTCTATTACCTCTTTGGCTTCCTGTTCCTTGTTTTCATCATCCTGGTGGTATCCTGTTCACAAATCAGCATCGTCATGGTG
TACTTCCAGCTGTGTGCAGAGGATTACCGCTGGTGGTGGAGAAATTTCCTAGTCTCCGGGGGCTCTGCATTCTACGTCCTGGTTTATGCC
ATCTTTTATTTCGTTAACAAGCTGGACATCGTGGAGTTCATCCCCTCTCTCCTCTACTTTGGCTACACGGCCCTCATGGTCTTGTCCTTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_MAPRE1_ENST00000375571_chr20_31427662_+_TM9SF4_ENST00000398022_chr20_30720816_+_4464nt
CTTTACGTCGGCGCGTAACGAGGGGGTGCGTGTGAGGTCATCGCGCGGGCGGGCGGGCGGGGTCTGGCGGTTTGAACGAGACGAAGACGG
AACCGGAGCCGGTTGCGGGCAGTGGACGCGGTTCTGCCGAGAGCCGAAGATGGCAGTGAACGTATACTCAACGTCAGTGACCAGTGATAA
CCTAAGTCGACATGACATGCTGGCCTGGATCAATGAGTCTCTGCAGTTGAATCTGACAAAGATCGAACAGTTGTGCTCAGGGGCTGCGTA
TTGTCAGTTTATGGACATGCTGTTCCCTGGCTCCATTGCCTTGAAGAAAGTGAAATTCCAAGCTAAGCTAGAACACGAGTACATCCAGAA
CTTCAAAATACTACAAGCAGGTTTTAAGAGAATGGGTGTTGACAAAATAATTCCTGTGGACAAATTAGTAAAAGGAAAGTTTCAGGACAA
TTTTGAATTCGTTCAGTGGTTCAAGAAGTTTTTCGATGCAAACTATGATGGAAAAGACTATGACCCTGTGGCTGCCAGACAAGGTCAAGA
AACTGCAGTGGCTCCTTCCCTTGTTGCTCCAGCTCTGAATAAACCGAAGAAACCTCTCACTTCTAGCAGTGCAGCTCCCCAGAGGCCCAT
CTCAACACAGAGAACCGCTGCGGCTCCTAAGGCTGGCCCTGGTGTGGTGCGAAAGAACCCTGGTGTGGGCAACGGAGACGACGAGGCAGC
TGAGTTGATGCAGCAGGATTGGTTGCCGTGGTCTTTACTGCTTTTCTCCCTGATGTGTGAAACAAGCGCCTTCTATGTGCCTGGGGTCGC
GCCTATCAACTTCCACCAGAACGATCCCGTAGAAATCAAGGCTGTGAAGCTCACCAGCTCTCGAACCCAGCTACCTTATGAATACTATTC
ACTGCCCTTCTGCCAGCCCAGCAAGATAACCTACAAGGCAGAGAATCTGGGAGAGGTGCTGAGAGGGGACCGGATTGTCAACACCCCTTT
CCAGGTTCTCATGAACAGCGAGAAGAAGTGTGAAGTTCTGTGCAGCCAGTCCAACAAGCCAGTGACCCTGACAGTGGAGCAGAGCCGACT
CGTGGCCGAGCGGATCACAGAAGACTACTACGTCCACCTCATTGCTGACAACCTGCCTGTGGCCACCCGGCTGGAGCTCTACTCCAACCG
AGACAGCGATGACAAGAAGAAGGAAAAAGATGTGCAGTTTGAACACGGCTACCGGCTCGGCTTCACAGATGTCAACAAGATCTACCTGCA
CAACCACCTCTCATTCATCCTTTACTATCATCGGGAGGACATGGAAGAGGACCAGGAGCACACGTACCGTGTCGTCCGCTTCGAGGTGAT
TCCCCAGAGCATCAGGCTGGAGGACCTCAAAGCAGATGAGAAGAGTTCGTGCACTCTGCCTGAGGGTACCAACTCCTCGCCCCAAGAAAT
TGACCCCACCAAGGAGAATCAGCTGTACTTCACCTACTCTGTCCACTGGGAGGAAAGTGATATCAAATGGGCCTCTCGCTGGGACACTTA
CCTGACCATGAGTGACGTCCAGATCCACTGGTTTTCTATCATTAACTCCGTTGTTGTGGTCTTCTTCCTGTCAGGTATCCTGAGCATGAT
TATCATTCGGACCCTCCGGAAGGACATTGCCAACTACAACAAGGAGGATGACATTGAAGACACCATGGAGGAGTCTGGGTGGAAGTTGGT
GCACGGCGACGTCTTCAGGCCCCCCCAGTACCCCATGATCCTCAGCTCCCTGCTGGGCTCAGGCATTCAGCTGTTCTGTATGATCCTCAT
CGTCATCTTTGTAGCCATGCTTGGGATGCTGTCGCCCTCCAGCCGGGGAGCTCTCATGACCACAGCCTGCTTCCTCTTCATGTTCATGGG
GGTGTTTGGCGGATTTTCTGCTGGCCGTCTGTACCGCACTTTAAAAGGCCATCGGTGGAAGAAAGGAGCCTTCTGTACGGCAACTCTGTA
CCCTGGTGTGGTTTTTGGCATCTGCTTCGTATTGAATTGCTTCATTTGGGGAAAGCACTCATCAGGAGCGGTGCCCTTTCCCACCATGGT
GGCTCTGCTGTGCATGTGGTTCGGGATCTCCCTGCCCCTCGTCTACTTGGGCTACTACTTCGGCTTCCGAAAGCAGCCATATGACAACCC
TGTGCGCACCAACCAGATTCCCCGGCAGATCCCCGAGCAGCGGTGGTACATGAACCGATTTGTGGGCATCCTCATGGCTGGGATCTTGCC
CTTCGGCGCCATGTTCATCGAGCTCTTCTTCATCTTCAGTGCTATCTGGGAGAATCAGTTCTATTACCTCTTTGGCTTCCTGTTCCTTGT
TTTCATCATCCTGGTGGTATCCTGTTCACAAATCAGCATCGTCATGGTGTACTTCCAGCTGTGTGCAGAGGATTACCGCTGGTGGTGGAG
AAATTTCCTAGTCTCCGGGGGCTCTGCATTCTACGTCCTGGTTTATGCCATCTTTTATTTCGTTAACAAGCTGGACATCGTGGAGTTCAT
CCCCTCTCTCCTCTACTTTGGCTACACGGCCCTCATGGTCTTGTCCTTCTGGCTGCTAACGGGTACCATCGGCTTCTATGCAGCCTACAT
GTTTGTTCGCAAGATCTATGCTGCTGTGAAGATAGACTGATTGGAGTGGACCACGGCCAAGCTTGCTCCGTCCTCGGACAGGAAGCCACC
CTGCGTGGGGGACTGCAGGCACGCAAAATAAAATAACTCCTGCTCGTTTGGAATGTAACTCCTGGCACAGTGTTCCTGGATCCTGGGGCT
GCGTGGGGGGCGGGAGGGCCTGTAGATAATCTTGCGTTTTTCGTCATCTTATTCCAGTTCTGTGGGGGATGAGTTTTTTTGTGGGTTGCT
TTTTCTTCAGTGCTAAGAAAGTTCCCTCCAACAGGAACTCTCTGACCTGTTTATTCAGGTGTATTTCTGGTTTGGATTTTTTTTTCCTTC
TTTGTTTTAACAAATGGATCCAGGATGGATAAATCCACCGAGATAAGGGTTTTGGTCACTGTCTCCACCTCAGTTCCTCAGGGCTGTTGG
CCACCCTATGACTAACTGGAAGAGGACACGCCAGAGCTTCAGTGAGGTTTCCGAGCCTCTCCCTGCCCATCCTCACCACTGAGGCCACGA
CAAAGCACAGCTCCAGCTCGGACAGCACCCTCAGTGCCAGCCAGCCTCTGCCAGACCTCTCTTTCCCTCTTCTCCCCAGCCTCCTCCAGG
GCTGCCCAAGGCAGGGTTTCCAGCCAGGCCTCGGGGTCATCTTTTCACCAGGAGCAAACCCAAGTCTTAGTTGCTACAAGAAAATCCCCT
GGAAGTACTGGGGGCCAGGTTCCCCAGACAGCAGGAATTGCCCCTGTTCAGAGCAGCCGGAGTTTGCTGGACCACAAGGAAGAAGAGAAG
AGACTTGCAGTGAACTGTTTTTGTGCCAAGAAACCCTGGACCTGGGGCCAAGTATTTCCCAAGCCAAGCATCCACTTGTCTGTGTCTGGG
AAGGGATGGCCAAGGCCGCTAGGGTCCTTACCCCTCAGGATCACTCCCCAGCCCTTTCCTCAGGAGGTACCGCTCTCCAAGGTGTGCTAG
CAGTGGGCCCTGCCCAACTTCAGGCAGAACAGGGAGGCCCAGAGATTACAGATCCCCTCCTGTAAGTGGCCAGGCATTCTCTCCCTGCCC
TCTCTGGCCTCTGGGGTCATACTCACTTCTTTAGCCAGCCCCATCCCCTCCACCCCACACCTGAGTTCTTGCCTCCTCCTTTTGGGGACA
CCCAAAACACTGCTTGTGAGAAGGAAGATGGAAGGTAAGTTCTGTCGTTCTTTCCCCAATCCCCAGGAATGGACAAGAAGCCAACTTAGA
AAGAAGGGTCTCACGTGGCTGGCCTGGCTCCTCCGTAGACCCCTGTTCTTTTCAACCTCTGCCCACCCGTGCATGTCATCACAAACATTT
GCTCTTAAGTTACAAGAGACCACATCCACCCAGGGATTAGGGTTCAAGTAGCAGCTGCTAACCCTTGCACCAGCCCTTGTGGGACTCCCA
ACACAAGACAAAGCTCAGGATGCTGGTGATGCTAGGAAGATGTCCCTCCCCTCACTGCCCCACATTCTCCCAGTGGCTCTACCAGCCTCA
CCCATCAAACCAGTGAATTTCTCAATCTTGCCTCACAGTGACTGCAGCGCCAAGCGGCATCCACCAAGCATCAAGTTGGAGAAAAGGGAA
CCCAAGCAGTAGAGAGCGATATTGGAGTCTTTTGTTCATTCAAATCTTGGATTTTTTTTTTTCCCTAAGAGATTCTCTTTTTAGGGGGAA
TGGGAAACGGACACCTCATAAAGGGTTCAAAGATCATCAATTTTTCTGACTTTTTAAATCATTATCATTATTATTTTTAATTAAAAAAAT


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FusionGenePPI for MAPRE1_TM9SF4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAPRE1APC, TERF1, COPS5, COPS8, CSN3, COPS7A, HDAC6, LRP1, APP, CDK2, AURKA, AURKB, TUBB, SPTAN1, FN1, VCAM1, IQCB1, ITGA4, CLIP1, TUBA1A, BAG3, CDK5RAP2, OLA1, SNRPD2, SNRPE, SNRPF, TBCB, YWHAZ, PAFAH1B1, PRKACA, PRKACB, STIM1, NAV1, NAV2, NAV3, TRIO, LMO2, POLE2, PSMA1, PDE4DIP, TROAP, PQBP1, MAPRE2, MAPRE1, MAPRE3, SPDYE2, CYLD, IKBKG, HSPA1A, TRAF2, ABCB1, STK11, BCL3, KAT2B, KAT5, MTUS2, KIF2C, MACF1, CLASP1, CLASP2, NUPR1, ABCE1, GAS2L1, DST, PPP1R13L, AKAP9, KIF18B, UNK, CKAP5, SUMO3, UCHL3, NTRK1, EWSR1, SRPK2, CEP135, CEP290, LCA5, OFD1, CEP170, CEP104, DCTN1, CEP19, ACTN4, ACTN1, ADD1, ADD3, BLMH, CALM1, CALML3, CAPZA1, CD59, CLTA, CLTB, CLTC, CPM, CTNNA1, CTNNB1, DAB2, DBN1, DYNC1H1, DYNC1I2, EPS15, FLNA, FYN, GNAI2, HSP90AB1, ABLIM1, MYO1E, PCM1, PCNT, PLEC, PRKAR2A, QARS, SPTBN1, SSFA2, SVIL, TMOD1, TPM4, CLIP2, YES1, LUZP1, AXIN1, SORBS2, TAOK2, CEP350, SEC16A, WDR1, ACTR1A, PIBF1, DCTN2, SPAG5, RAB35, FGFR1OP, SYNPO, CEP162, CEP131, ERC1, COBL, LIMA1, SYBU, CEP72, MIB1, AFAP1, HYI, DYNLRB1, CCDC77, KNSTRN, NEXN, SPECC1, TBC1D31, SSX2IP, MISP, CD109, WDR90, TPRN, U2AF2, CDH1, KLHL21, PRKAR2B, HSPA5, PSMB1, TANC2, PPP1CA, IFT52, G3BP1TM9SF4ELAVL1, IGF2R, SPCS2, TMX2, FAM162A, LAMP1, UQCRFS1, ATP1B3, F3, ERMP1, LMAN2, RAB1A, STX12, STX7, SGPL1, TMED2, CALD1, HIST1H1B, KDM5A, RPN2, S100A6, SLC25A12, OASL, RIOK3, H1FX, PHF14, ABCF2, SCAMP3, ATP5H, SACM1L, MKRN2, ITSN2, FCF1, SIRT6, TMEM161A, CDCA7L, ZC3H15, RPAP3, CEP44, RNF170, SP140L, H2AFV, ZNF800, NSMCE2, FAM3B, TSPAN11, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMAPRE1chr20:31427662chr20:30720816ENST00000375571+57185_268199269CDK5RAP2
HgeneMAPRE1chr20:31427662chr20:30720816ENST00000375571+57124_268199269MTUS2/TIP150


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAPRE1_TM9SF4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAPRE1_TM9SF4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAPRE1C0043094Weight Gain1CTD_human
HgeneMAPRE1C0151744Myocardial Ischemia1CTD_human